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arXiv is a free distribution service and an open-access archive for nearly 2.4 million scholarly articles in the fields of physics, mathematics, computer science, quantitative biology, quantitative finance, statistics, electrical engineering and systems science, and economics. Materials on this site are not peer-reviewed by arXiv.

arXiv is a free distribution service and an open-access archive for scholarly articles in the fields of physics, mathematics, computer science, quantitative biology, quantitative finance, statistics, electrical engineering and systems science, and economics. Materials on this site are not peer-reviewed by arXiv.

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  • Mathematics ( math new , recent , search ) includes: (see detailed description ): Algebraic Geometry ; Algebraic Topology ; Analysis of PDEs ; Category Theory ; Classical Analysis and ODEs ; Combinatorics ; Commutative Algebra ; Complex Variables ; Differential Geometry ; Dynamical Systems ; Functional Analysis ; General Mathematics ; General Topology ; Geometric Topology ; Group Theory ; History and Overview ; Information Theory ; K-Theory and Homology ; Logic ; Mathematical Physics ; Metric Geometry ; Number Theory ; Numerical Analysis ; Operator Algebras ; Optimization and Control ; Probability ; Quantum Algebra ; Representation Theory ; Rings and Algebras ; Spectral Theory ; Statistics Theory ; Symplectic Geometry

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  • Quantitative Finance ( q-fin new , recent , search ) includes: (see detailed description ): Computational Finance ; Economics ; General Finance ; Mathematical Finance ; Portfolio Management ; Pricing of Securities ; Risk Management ; Statistical Finance ; Trading and Market Microstructure
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Sci-Hub is the most controversial project in today science. The goal of Sci-Hub is to provide free and unrestricted access to all scientific knowledge ever published in journal or book form.

Today the circulation of knowledge in science is restricted by high prices. Many students and researchers cannot afford academic journals and books that are locked behind paywalls. Sci-Hub emerged in 2011 to tackle this problem. Since then, the website has revolutionized the way science is being done.

Sci-Hub is helping millions of students and researchers, medical professionals, journalists and curious people in all countries to unlock access to knowledge. The mission of Sci-Hub is to fight every obstacle that prevents open access to knowledge: be it legal, technical or otherwise.

To get more information visit the about Sci-Hub section.

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Sci-Hub is the most controversial project in today science. The goal of Sci-Hub is to provide free and unrestricted access to all scientific knowledge ever published in journal or book form.

Today the circulation of knowledge in science is restricted by high prices. Many students and researchers cannot afford academic journals and books that are locked behind paywalls. Sci-Hub emerged in 2011 to tackle this problem. Since then, the website has revolutionized the way science is being done.

Sci-Hub is helping millions of students and researchers, medical professionals, journalists and curious people in all countries to unlock access to knowledge. The mission of Sci-Hub is to fight every obstacle that prevents open access to knowledge: be it legal, technical or otherwise.

To get more information visit the about Sci-Hub section.

Thank you for joining Sci-Hub mailing list!

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ScienceOpen offers content hosting, context building and marketing services for publishers. See our tailored offerings

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ScienceOpen offers state-of-the-art technology and a range of solutions and services

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  • For funders  to develop new open access publishing paradigms
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Make an impact and build your research profile in the open with ScienceOpen

  • Search and discover relevant research in over 94 million Open Access articles and article records
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Create a Journal powered by ScienceOpen

Launching a new open access journal or an open access press? ScienceOpen now provides full end-to-end open access publishing solutions – embedded within our smart interactive discovery environment. A modular approach allows open access publishers to pick and choose among a range of services and design the platform that fits their goals and budget.

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What can a Researcher do on ScienceOpen?

ScienceOpen provides researchers with a wide range of tools to support their research – all for free. Here is a short checklist to make sure you are getting the most of the technological infrastructure and content that we have to offer. What can a researcher do on ScienceOpen? Continue reading “What can a Researcher do on ScienceOpen?”   

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JSTOR hosts a growing curated collection of more than 50,000 open research reports from 187 think tanks and research institutes from around the world. These publications are freely accessible to everyone on JSTOR and discoverable as their own content type alongside journals, books, and primary sources. We update research reports on our platform each month as they become available through contributing institutes.

Download the list (xlsx) of contributing policy institutes.

Research reports provide current analysis on many of today’s most discussed and debated issues from a diversity of ideological and international perspectives representing 40 countries and 29 languages. A sample of topics would include: climate change, border security, fake news, cybersecurity, electric vehicles, artificial intelligence, energy policy, gender issues, terrorism, remote learning, recent trends in business and economics, and various public health issues, including COVID-19.

Although the briefs, papers, and reports published by these institutes are not peer-reviewed, they are written by policy experts and members of the academic community who are fellows in residence. This is content that impacts policy, both foreign and domestic. It is also increasingly used by faculty in their classrooms for its currency, breadth, and accessibility.

JSTOR’s research reports cover seven Areas of Focus: Business & Economics, Critical Race & Ethnic Studies, Education, Gender & Sexuality, Public Health, Security Studies, and Sustainability.

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Input from faculty and librarians revealed that although research reports were for the most part freely available outside of JSTOR, they were hard to find and not easily discoverable alongside relevant material. It was also difficult for students to differentiate between the most credible research reports and a growing corpus of questionable sources on the Web.

JSTOR has attempted to redress these issues by centralizing a curated collection of think tank research reports on a single platform, making this content freely available to all JSTOR users, and enhancing its discoverability through comprehensive searching and the application of rich metadata.

SpringerOpen open access books

We offer authors the option to publish their books and chapters open access – making your research freely available to anyone with internet access!

We offer authors the option to publish open access books and chapters in a wide range of areas within science, technology and medicine (STM) and within the humanities and social sciences (HSS).

Open access allows unrestricted online access to your ebook with no reading or subscription fees. Authors retain copyright and are able to comply with funders' open access mandates.

Our open access academic books and chapters on average receive seven times more downloads, 50% more citations, and ten times more online mentions compared to non-open access books*. 

Each open access scholarly book or chapter receives the same editorial and publishing expertise, rigorous peer review and high quality production process that non-open access books receive.

Read more about why you should publish an open access book.

Contact  one of our publishing editors in your discipline to discuss your proposal. 

* From our report ' The OA Effect '.

​​​​​​​Highlights from our open access books list

Open access book: Achieving the Paris climate agreement goals

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Browse our open access books and download them free of charge from SpringerLink (HTML, PDF, ePub) or Amazon (MOBI).

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The top list of academic search engines

academic search engines

1. Google Scholar

4. science.gov, 5. semantic scholar, 6. baidu scholar, get the most out of academic search engines, frequently asked questions about academic search engines, related articles.

Academic search engines have become the number one resource to turn to in order to find research papers and other scholarly sources. While classic academic databases like Web of Science and Scopus are locked behind paywalls, Google Scholar and others can be accessed free of charge. In order to help you get your research done fast, we have compiled the top list of free academic search engines.

Google Scholar is the clear number one when it comes to academic search engines. It's the power of Google searches applied to research papers and patents. It not only lets you find research papers for all academic disciplines for free but also often provides links to full-text PDF files.

  • Coverage: approx. 200 million articles
  • Abstracts: only a snippet of the abstract is available
  • Related articles: ✔
  • References: ✔
  • Cited by: ✔
  • Links to full text: ✔
  • Export formats: APA, MLA, Chicago, Harvard, Vancouver, RIS, BibTeX

Search interface of Google Scholar

BASE is hosted at Bielefeld University in Germany. That is also where its name stems from (Bielefeld Academic Search Engine).

  • Coverage: approx. 136 million articles (contains duplicates)
  • Abstracts: ✔
  • Related articles: ✘
  • References: ✘
  • Cited by: ✘
  • Export formats: RIS, BibTeX

Search interface of Bielefeld Academic Search Engine aka BASE

CORE is an academic search engine dedicated to open-access research papers. For each search result, a link to the full-text PDF or full-text web page is provided.

  • Coverage: approx. 136 million articles
  • Links to full text: ✔ (all articles in CORE are open access)
  • Export formats: BibTeX

Search interface of the CORE academic search engine

Science.gov is a fantastic resource as it bundles and offers free access to search results from more than 15 U.S. federal agencies. There is no need anymore to query all those resources separately!

  • Coverage: approx. 200 million articles and reports
  • Links to full text: ✔ (available for some databases)
  • Export formats: APA, MLA, RIS, BibTeX (available for some databases)

Search interface of Science.gov

Semantic Scholar is the new kid on the block. Its mission is to provide more relevant and impactful search results using AI-powered algorithms that find hidden connections and links between research topics.

  • Coverage: approx. 40 million articles
  • Export formats: APA, MLA, Chicago, BibTeX

Search interface of Semantic Scholar

Although Baidu Scholar's interface is in Chinese, its index contains research papers in English as well as Chinese.

  • Coverage: no detailed statistics available, approx. 100 million articles
  • Abstracts: only snippets of the abstract are available
  • Export formats: APA, MLA, RIS, BibTeX

Search interface of Baidu Scholar

RefSeek searches more than one billion documents from academic and organizational websites. Its clean interface makes it especially easy to use for students and new researchers.

  • Coverage: no detailed statistics available, approx. 1 billion documents
  • Abstracts: only snippets of the article are available
  • Export formats: not available

Search interface of RefSeek

Consider using a reference manager like Paperpile to save, organize, and cite your references. Paperpile integrates with Google Scholar and many popular databases, so you can save references and PDFs directly to your library using the Paperpile buttons:

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Google Scholar is an academic search engine, and it is the clear number one when it comes to academic search engines. It's the power of Google searches applied to research papers and patents. It not only let's you find research papers for all academic disciplines for free, but also often provides links to full text PDF file.

Semantic Scholar is a free, AI-powered research tool for scientific literature developed at the Allen Institute for AI. Sematic Scholar was publicly released in 2015 and uses advances in natural language processing to provide summaries for scholarly papers.

BASE , as its name suggest is an academic search engine. It is hosted at Bielefeld University in Germany and that's where it name stems from (Bielefeld Academic Search Engine).

CORE is an academic search engine dedicated to open access research papers. For each search result a link to the full text PDF or full text web page is provided.

Science.gov is a fantastic resource as it bundles and offers free access to search results from more than 15 U.S. federal agencies. There is no need any more to query all those resources separately!

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Free, fast and fair: the global primary research record where researchers publish their work in full detail

Octopus is a new publishing platform for scholarly research. Funded by UKRI – the UK government research funder.

Here researchers can publish all their work for free, in full detail, enabling peer review and quality assessment, gaining credit for what they have done, and allowing the research community to build upon it.

Research Culture Report

Researchers at the University of Bristol have recently conducted an investigation into the current state of the research culture. They found academic researchers demoralised by a culture that disincentivises sharing and collaboration, encourages questionable research practices, and increases the risk of bias. These findings underline the need for a platform such as Octopus. Their results are detailed in the report "A snapshot of the academic research culture in 2023 and how it might be improved".

Recording your work on Octopus is different from publishing a paper. There are eight publication types that are aligned with the research process and designed to help researchers of all types share their work and be recognised for it.

Anyone can read anything in Octopus – it's designed to make primary research openly available to all.

Every publication in Octopus is linked to another, forming branching chains of research. You can navigate these chains from every publication page to browse areas of research and discover something new.

Before you can publish research work, you need to create an account via ORCID®. ORCID is a system of unique, persistent digital identifiers developed specifically for researchers.

Octopus is designed to incentivise best practice in research, utilise the opportunities of open access, and to improve the research culture.

Review our FAQs to find out more about how the platform works.

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Who can use and benefit from r discovery.

R Discovery is an app for students and researchers to simplify literature search and research reading, but it can be used by anyone interested in scholarly pursuits. Say goodbye to information overload and hello to seamless research reading with R Discovery, which instantly creates personalized reading feeds based on your interests, so you’re always updated on the latest, most relevant academic research for you!

What content will I find on R Discovery?

R Discovery hosts content from top aggregators like PubMed, PubMed Central, CrossRef, Unpaywall, Open Alex and top academic research publications, including Wiley, Elsevier, Springer Nature, IOP, SAGE, Taylor & Francis, NEJM, Emerald Publishing, BMJ, Karger, Underline.io and more. Elevate your research reading experience with access to 250M+ research articles, including 40M+ open access articles, across 32,000 journals as well as 2M+ preprints and 7.5M+ patents.

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Research paper

Research paper is a written report which contains the results of original scientific research (primary research article) or the review of published scientific papers on one or several science topics (review article). In primary research articles, the authors give vital information about the research that allows other members of the scientific community to evaluate it, reproduce science experiments, and also to assess the reasoning and conclusions drawn from them. Review articles are designed to analyze, evaluate, summarize or synthesize research already conducted in primary academic sources. Quite often, a science article combines these two types of scientific text, including the overview and original parts.

Currently, the number of scientific articles in open access is growing fast, but all of them are spread on numerous science websites on the Internet, and therefore it is hard for a researcher to find the necessary information for new science discoveries or download PDF due to the unreliability of websites.

CyberLeninka is intended to solve this problem. We provide platform, which aggregates a lot of free articles from various open access peer-reviewed journals . And our global goal is to build new research infrastructure for academia.

Directory of open access articles based on OECD fields of science and technology

  • Medical and Health sciences
  • Basic medicine
  • Clinical medicine
  • Health sciences
  • Health biotechnology
  • Natural sciences
  • Mathematics
  • Computer and information sciences
  • Physical sciences
  • Chemical sciences
  • Earth and related environmental sciences
  • Biological sciences
  • Engineering and Technology
  • Civil engineering
  • Electrical engineering, electronic engineering, information engineering
  • Mechanical engineering
  • Chemical engineering
  • Materials engineering
  • Medical engineering
  • Environmental engineering
  • Environmental biotechnology
  • Industrial biotechnology
  • Nano technology
  • Agricultural sciences
  • Agriculture, forestry, and fisheries
  • Animal and dairy science
  • Veterinary science
  • Agricultural biotechnology
  • Social sciences
  • Economics and business
  • Educational sciences
  • Political science
  • Social and economic geography
  • Media and communications
  • History and archaeology
  • Languages and literature
  • Philosophy, ethics and religion
  • Arts, history of arts, performing arts, music

Association "Open Science"

Panda

access millions of research papers with Paper Panda

So easy to use, such a huge life saver in terms of research and assessments !! have not come across a article i can not, not read thanks to this :D so happy and has made life easier, thank you, thank you, thank you

Kenu Taiepa

One of the most useful web extensions I have ever used, Thank you to the girl on Tiktok that recommended it. I hope both sides of her pillow are cold everyday. Thank you to the developers as well. Huge thumbs up.

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es muy bueno!!!! y muy útil!!! estoy literalmente llorando de la felicidad porque ahora puedo ver ensayos o artículos que antes necesitaba y no podía, y además es muy fácil de usar muy recomendado

Louis Smiles

It is soooooo amazing ,easy to use and it works like a charm. Helped me a great deal!! Thank you so much
Works great. Been using it only for a short while, but it didn’t fail yet. It’s also very quick. Downside is that it sometimes downloaded an early version of the paper, not the final published paper.
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Federalist Papers: Primary Documents in American History

Full text of the federalist papers.

  • Introduction
  • Federalist Nos. 1-10
  • Federalist Nos. 11-20
  • Federalist Nos. 21-30
  • Federalist Nos. 31-40
  • Federalist Nos. 41-50
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The Federalist , commonly referred to as the Federalist Papers, is a series of 85 essays written by Alexander Hamilton, John Jay, and James Madison between October 1787 and May 1788. The essays were published anonymously, under the pen name "Publius," in various New York state newspapers of the time.

The Federalist Papers were written and published to urge New Yorkers to ratify the proposed United States Constitution, which was drafted in Philadelphia in the summer of 1787. In lobbying for adoption of the Constitution over the existing Articles of Confederation, the essays explain particular provisions of the Constitution in detail. For this reason, and because Hamilton and Madison were each members of the Constitutional Convention, the Federalist Papers are often used today to help interpret the intentions of those drafting the Constitution.

The Federalist Papers were published primarily in two New York state newspapers: The New York Packet and The Independent Journal . They were reprinted in other newspapers in New York state and in several cities in other states. A bound edition, with revisions and corrections by Hamilton, was published in 1788 by printers J. and A. McLean. An edition published by printer Jacob Gideon in 1818, with revisions and corrections by Madison, was the first to identify each essay by its author's name. Because of its publishing history, the assignment of authorship, numbering, and exact wording may vary with different editions of The Federalist .

The electronic text of The Federalist used here was compiled for Project Gutenberg by scholars who drew on many available versions of the papers.

One printed edition of the text is The Federalist , edited by Jacob E. Cooke (Middletown, Conn., Wesleyan University Press, 1961). Cooke's introduction provides background information on the printing history of The Federalist; the information provided above comes in part from his work.

This web-friendly presentation of the original text of the Federalist Papers (also known as The Federalist) was obtained from the e-text archives of Project Gutenberg. Any irregularities with regard to grammar, syntax, spelling, or punctuation are as they exist in the original e-text archives.

Table of Contents

No. Title Author Publication Date
1. Hamilton For the --
2. Jay For the --
3. Jay For the --
4. Jay For the --
5. Jay For the --
6. Hamilton For the --
7. Hamilton For the --
8. Hamilton From the Tuesday, November 20, 1787
9. Hamilton For the --
10. Madison Frm the Friday, November 27, 1787
11. Hamilton For the --
12. Hamilton From the Tuesday, November 27, 1787
13. Hamilton For the --
14. Madison From the Friday, November 30, 1787
15.  Hamilton For the --
16. Hamilton From the Tuesday, December 4, 1787
17.  Hamilton For the --
18. Hamilton and Madison For the --
19. Hamilton and Madison For the --
20. Hamilton and Madison From the Tuesday, December 11, 1787
21. Hamilton For the --
22. Hamilton From the Friday, December 14, 1787
23. Hamilton From the Tuesday, December 17, 1787
24. Hamilton For the --
25. Hamilton From the Friday, December 21, 1787
26. Hamilton For the --
27. Hamilton From the Tuesday, December 25, 1787
28.  Hamilton For the --
29. Hamilton From the Thursday, January 10, 1788
30. Hamilton From the Friday, December 28, 1787
31. Hamilton From the Tuesday, January 1, 1788
32. Hamilton From the Thursday, January 3, 1788
33. Hamilton From the Thursday, January 3, 1788
34. Hamilton From the Friday, January 4, 1788
35. Hamilton For the --
36. Hamilton From the Tuesday, January 8, 1788
37. Madison From the Friday, January 11, 1788
38.  Madison From the Tuesday, January 15, 1788
39.  Madison For the --
40. Madison From the Friday, January 18, 1788
41. Madison For the --
42. Madison From the Tuesday, January 22, 1788
43. Madison For the --
44. Madison From the Friday, January 25, 1788
45. Madison For the --
46.  Madison From the Tuesday, January 29, 1788
47. Madison From the Friday, February 1, 1788
48. Madison From the Friday, February 1, 1788
49. Hamilton or Madison From the Tuesday, February 5, 1788
50. Hamilton or Madison From the Tuesday, February 5, 1788
51. Hamilton or Madison From the Friday, February 8, 1788
52.  Hamilton or Madison From the Friday, February 8, 1788
53. Hamilton or Madison From the Tuesday, February 12, 1788
54. Hamilton or Madison From the Tuesday, February 12, 1788
55.  Hamilton or Madison From the Friday, February 15, 1788
56. Hamilton or Madison From the Tuesday, February 19, 1788
57. Hamilton or Madison From the Tuesday, February 19, 1788
58. Madison -- --
59. Hamilton From the Friday, February 22, 1788
60. Hamilton From the Tuesday, February 26, 1788
61. Hamilton From the Tuesday, February 26, 1788
62.  Hamilton or Madison For the --
63. Hamilton or Madison For the --
64. Jay From the Friday, March 7, 1788
65. Hamilton From the Friday, March 7, 1788
66.  Hamilton From the Tuesday, March 11, 1788
67.  Hamilton From the Tuesday, March 11, 1788
68. Hamilton From the Friday, March 14, 1788
69.  Hamilton From the Friday, March 14, 1788
70.  Hamilton From the Friday, March 14, 1788
71. Hamilton From the Tuesday, March 18, 1788
72.  Hamilton From the Friday, March 21, 1788
73.  Hamilton From the Friday, March 21, 1788
74.  Hamilton From the Tuesday, March 25, 1788
75. Hamilton For the --
76. Hamilton From the Tuesday, April 1, 1788
77. Hamilton From the Friday, April 4, 1788
78. Hamilton From McLEAN's Edition, New York --
79. Hamilton From McLEAN's Edition, New York --
80. Hamilton From McLEAN's Edition, New York --
81. Hamilton From McLEAN's Edition --
82. Hamilton From McLEAN's Edition --
83. Hamilton From McLEAN's Edition --
84. Hamilton From McLEAN's Edition --
85. Hamilton From McLEAN's Edition --
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Jeffrey Epstein secret transcripts: Victim was asked, Do you know 'you committed a crime?'

The Jeffrey Epstein saga began — and could have ended — in Palm Beach County in 2006. The Palm Beach Post sued in 2019 to find out why it didn't. Now, secret documents detailing what happened 18 years ago when Epstein was indicted on only a single prostitution charge are public.

When presenting her case against Jeffrey Epstein to a 2006 grand jury, a Palm Beach County prosecutor asked one of two teenage victims testifying whether she was aware she "committed a crime,” according to secret transcripts published Monday in a Palm Beach Post lawsuit.

Members of the grand jury echoed the accusatory tones of assistant state attorneys Lanna Belohlavek and Mary Ann Duggan, posing questions that sounded more like condemnation.

One juror asked the girl: “Do you have any idea, deep down inside of you, that you — what you’re doing is wrong?”Victim: “Yeah. I did.”

Juror: “Have you set the goals to not do it anymore?”

Victim: “Yes.”

Juror: “And you’re well aware that — what you’re doing to your own reputation?”

Victim: “Yes. I do.”

Belohlavek: “You’re aware that you committed a crime?”

Victim: “Now I am.”

The Post sued for the release of the materials after it found in its 2019 investigation that then-Palm Beach County State Attorney Barry Krischer undermined his own case against Epstein in 2006. His office never spoke with any of the victims, according to state attorney documents, and once Epstein's famous defense attorneys came to town, his office quit communicating regularly with police.

No longer secret: Jeffrey Epstein 2006 grand jury documents are public. Read for yourself what happened

Read The Post's 2019 investigation: How Jeffrey Epstein's first prosecutors failed his victims, seeing them as prostitutes

In a highly unusual move, Krischer convened a grand jury to consider criminal charges against Epstein. During the proceeding, sources told The Post , prosecutor Belohlavek questioned only two victims. Belohlavek then undermined her own witnesses.

Those victims, one a 14-year-old girl, stood up to a man who hobnobbed with the likes of former Presidents Donald Trump and Bill Clinton.

POST EXCLUSIVE: Never-before-seen Jeffrey Epstein biography surfaces

The grand jury indicted Epstein on only one charge — felony solicitation of prostitution, what a "john" would face propositioning an adult sex worker. The mysterious outcome did not address the fact that police say they found multiple incidents of sexual abuse of about two dozen young women and underage girls.

Palm Beach police thought the crimes were more extensive. They'd found five minors who were victims and whose accusations could prompt criminal charges, according to the law at the time. Seventeen witnesses, many of whom were 16 or 17 when Epstein abused them, could have backed up their stories, which were strikingly similar.

This survivor wanted documents released: Jeffrey Epstein victim goes public: ’I want to know why’

Charges recommended by police could have put Epstein in prison for decades. He ended up spending 13 months in jail and left six days a week, 12 hours a day, on work release.

The outcome of the grand jury proceeding and another prostitution charge that Epstein pleaded guilty to allowed him to traffic, rape and molest underage girls for 11 more years after he pleaded guilty. One victim's attorney estimates Epstein abused at least 500 victims.

Hear Palm Beach Post Investigations Editor Holly Baltz discuss what the transcripts reveal (at 8:10):

StarTribune

Landmark university of minnesota papers on alzheimer's disease and stem cells retracted.

Years after questions were raised about their integrity, two of the University of Minnesota's highest-profile scientific discoveries have been retracted in one week — one that offered hope over the therapeutic potential of stem cells and another that offered a promising path toward treating Alzheimer's disease.

The studies are more than a decade old and superseded by other discoveries in their fields. But the retractions of the Alzheimer's paper on Monday and the stem cell paper on June 17 are setbacks for an institution that is fighting to move up the U.S. rankings in academic reputation and federal research dollars.

Both studies were published in the prestigious journal Nature and collectively have been cited nearly 7,000 times. Researchers worldwide were using these papers to support their work years after they had been disputed.

That shows the harm in the drawn-out university investigation and the journal's retractions, said Dr. Matthew Schrag, a neurologist who scrutinized the Alzheimer's paper in 2022 outside of his role at Vanderbilt University. "We are squandering not only resources but the credibility and reputation of our profession by failing to address obvious misconduct."

The university in a statement on Tuesday said that it has many ethics requirements that weren't in place when these papers were published that should prevent future disputes and retractions.

The discoveries were notable in their days because they offered unexpected solutions to vexing scientific and political problems.

Dr. Catherine Verfaillie and colleagues in 2002 reported that they coaxed mesenchymal stem cells from adult bone marrow into growing numerous other cell types and tissues in the body. Only stem cells from early-stage human embryos had shown such regenerative potential at that time, and they were controversial because they were derived from aborted fetuses or leftover embryos from infertility treatments. President George W. Bush had banned federal funding for embryonic research, fueling a search for alternative stem cell sources.

Dr. Karen Ashe and colleagues similarly gained global attention in 2006 when they found a molecular target that appeared influential in the onset of Alzheimer's disease, which remains incurable and a leading source of dementia and death in America's aging population. Mice mimicking that molecule, amyloid beta star 56, showed worse memory loss based on their ability to navigate a maze. Ashe theorized that a drug targeting that molecule could help people overcome or slow Alzheimer's debilitating effects.

The problems leading to the retractions were remarkably similar. Colleagues at other institutions struggled to replicate their findings, which prompted others to look closer at the images of cellular or molecular activity in mice on which their findings were based.

Peter Aldhous first raised concerns in 2006 over the stem cell discovery as a science journalist and San Francisco bureau chief for New Scientist magazine.

"The big claim that these were essentially the same as embryonic stem cells and can differentiate into anything, nobody was able to replicate that," he said.

Verfaillie and colleagues corrected the Nature paper in 2007, which contained an image of cellular activity in mice that appeared identical to an image in a different paper that supposedly came from different mice. The U then launched an investigation over complaints of image duplications or manipulations in more of Verfaillie's papers. It eventually cleared her of misconduct , but blamed her for inadequate training and oversight and claimed that a junior researcher had falsified data in a similar study published in the journal Blood. That article was retracted in 2009.

Concerns resurfaced in 2019 over the Nature stem cell paper when Elisabeth Bik, a microbiologist-turned-research detective, found more examples of image duplication.

Bik also turned out to be a key critic of Ashe's Alzheimer's discoveries, raising concerns about images in her Nature paper and related studies. Much of the blame has fallen on coauthor Sylvain Lesne, a U neuroscientist who was responsible for the published images. Lesne did not reply to a request for comment, but authorized the university to disclose that it completed its internal investigation into the Nature paper without finding evidence of misconduct. Reviews of other publications from Lesne's lab are ongoing.

Changes over the past decade at the university have sought to reduce academic scandals, including a system added in 2008 for anonymous reporting and for managing accusations. All researchers leading studies at the U are now trained in avoiding conflicts of interest, plagiarism and misconduct.

The retractions are "painful" but the university accepts the journal's decisions and remains committed to ethical research, said Shashank Priya, vice president for research and innovation. "What I know is that the vast majority of researchers ... go to their labs, their fields or their classrooms every day with a strong sense of purpose and integrity."

Even as the papers continue to be cited, researchers have turned to other targets. Ashe has pivoted to the search for a medication that can prevent dysfunctional tau proteins from disrupting the brain's thinking cells, or neurons.

Ashe said she agreed to the Nature retraction reluctantly because she had published follow-up research that offered fresh proof of her findings and recommended a correction to the Nature paper that would have further upheld those findings.

"When the editors decided not to publish the correction, however, I opted to retract the article," she said in an email, adding that "we are encouraged by results of ongoing experiments about Abeta*56, and continue to believe that it could improve our understanding of Alzheimer's disease and the development of better treatments."

Lesne was the only coauthor to disagree with the retraction, even though Nature stated that the paper contained "excessive manipulation, including splicing, duplication and the use of an eraser tool" to edit the images.

Verfaillie directed the university's stem cell institute and remained involved in its research even after returning to Belgium in 2006. The recent retiree did not reply to an email for comment, but said in a translation of a Belgium newspaper article that the retraction is "a stain on our reputation." Nature called for the correction because Verfaillie and other authors couldn't locate authentic images to prove the validity of their research.

"There is indeed a problem with a photo," she said. "We have not found the correct photo twenty years after the research was conducted. But even without that photo, the conclusion still stands."

The dispute over the utility of mesenchymal stem cells became less important in 2007, when Shinya Yamanaka revealed a process for reprogramming mouse skin cells so that they could mimic the versatility of embryonic stem cells. Others were able to repeat the process, which earned the Japanese researcher a share of the Nobel Prize for Medicine in 2012.

Aldhous said it is disappointing that it took years to resolve questions over the Alzheimer's paper, and much longer to do the same over the stem cell paper. He said he doesn't believe the university has adequately solved whether the researchers made repeated mistakes or committed intentional misconduct. The junior researcher blamed for errors in one stem cell paper was not involved in other disputed papers, he noted.

However, he said it is arguably more important to quickly correct the scientific record so that faulty or unsubstantiated research doesn't influence other scientists and send them in wrong directions.

"Why have we had to wait for so long to consign this to the trash can, essentially?" he asked. "This should have happened years ago."

Jeremy Olson is a Pulitzer Prize-winning reporter covering health care for the Star Tribune. Trained in investigative and computer-assisted reporting, Olson has covered politics, social services, and family issues.

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England

Jude Bellingham Brilliance Papers Over Cracks In England's Euro 2024 Case

Another embarrassing exit for english football at a major tournament was looming in gelsenkirchen until bellingham's acrobatic effort in the 95th minute broke slovak hearts..

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England's quest to end 58 years of hurt at Euro 2024 remains alive thanks to one moment of Jude Bellingham brilliance, but the Three Lions failed to look like future European champions in sneaking past Slovakia 2-1. Another embarrassing exit for English football at a major tournament was looming in Gelsenkirchen until Bellingham's acrobatic effort in the 95th minute broke Slovak hearts. A minute into extra-time, Harry Kane then completed the comeback to set up a meeting with Switzerland on Saturday in the quarter-finals.

However, any excitement among the England fan base at ending up on the perceived weaker side of the draw was drained away by another turgid performance from Gareth Southgate's men.

England arrived in Germany hyped as pre-tournament favourites thanks to a squad stacked with attacking talent.

Slovakia coach Francesco Calzona insisted on the eve of the game that Southgate is working with "the best squad at the Euros".

But a team featuring the Bundesliga's top scorer Kane, the Premier League's player of the year Phil Foden and a recently crowned Champions League winner in Bellingham has been laboured in possession and easy to defend against.

Until Bellingham's late intervention, England had scored just two goals in four games, while the deficiencies of a makeshift back line were also exploited by Slovakia early on.

The side ranked 45th in the world had already spurned two big chances before Ivan Schranz strolled through the heart of the England defence to slot home his third goal of the tournament on 25 minutes.

England fans dominated all but a small section of the 50,000 capacity AufSchalke Arena and made their disillusionment heard as boos greeted the half-time whistle.

Southgate's men marginally improved after the break but bar a header Kane sent wide from a free-kick and a Declan Rice shot from distance that came back off the post, they had created little as Slovakia sat deep to defend their lead.

After a 0-0 draw against Slovenia that had guaranteed top spot in Group C, Southgate had bemoaned an "unusual atmosphere" as he was pelted with empty beer cups by disgruntled supporters.

'Scoring goals is my release'

The England manager and his players were braced for an even more severe outpouring of rage until Bellingham produced a moment of brilliance that allowed him to answer his critics after two underwhelming performances against Denmark and Slovenia.

"Playing for England, it's a lot of pleasure but you also hear a lot of people talk a lot of rubbish. It's nice when you deliver you can give them a little bit back," said the Real Madrid star of his goal celebration.

"For me playing football, being on the pitch, scoring goals is my release and it's maybe a message to a few people."

Southgate was more understanding of the wave of criticism that is still set to come his side's way before they face the Swiss in Duesseldorf.

"We're putting a plaster over things and giving young players opportunities," said Southgate.

"We're somehow finding a way. I can imagine how everyone is going to react even though we've won but we are still in there. The one thing that cannot be questioned is the desire, the commitment, the character."

The spotlight is on Southgate to find a solution over the next six days to avoid failing again to deliver major tournament glory at his fourth attempt.

Switzerland made light work of beating holders Italy 2-0 on Saturday and are a significant step-up in quality from Slovakia.

The England boss hailed the impact of his substitutes. 

Eberechi Eze and Ivan Toney played a part in Kane's winning goal, while Cole Palmer added some thrust from midfield.

However, the fact it took 66 minutes for Southgate to make any changes and his stubbornness in starting 10 of the same 11 in all four games so far has left his judgement open to question.

Bellingham's intervention ensures Southgate will take charge of his country for the 100th time in the quarter-finals.

But England will need to be much improved if he is to stay in his job beyond the century mark.

(This story has not been edited by NDTV staff and is auto-generated from a syndicated feed.)

England

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New York Times Editorial Board: Biden should drop out after debate with Donald Trump

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The New York Times Editorial Board is calling for President Joe Biden to drop out of the 2024 presidential race after his disastrous debate performance Thursday night with former President Donald Trump.

"The United States needs a stronger opponent to the presumptive Republican nominee," said the Times editorial board, which operates separately from its newsroom. Editorial writers cited the "stakes for the country and the uneven abilities of Mr. Biden."

Biden's debate performance against Trump Thursday night has sparked panic amongst Democrats and numerous calls for him to step down from the presidential ticket. His voice sounded unsteady and feeble and he noticeably froze while attempting to answer a question about the economy.

The Times argues in its op-ed piece that "the president is engaged in a reckless gamble," adding that "it's too big a bet to simply hope Americans will overlook or discount Mr. Biden's age and infirmity that they see with their own eyes."

Biden attempted to reframe the debate at a boisterous campaign rally in Raleigh, N.C. on Friday, where he addressed the sparring match with Trump. "I know I'm not a young man − to state the obvious," Biden said. "Folks, I don't walk as easy as I used to. I don't speak as smoothly as I used to. I don't debate as well as I used to. But I know what I do know: I know how to tell the truth."

Biden vowed not to drop out of the campaign and said he was confident he could do the job if reelected. If he were to serve a full second term, he would be 86 by the time he left office. Trump, 78, and Biden are the oldest presumptive nominees for president in American history.

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