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Research articles
Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses
Killing bacteria in tumors boosts survival in a mouse model of colon cancer.
- Menglin Wang
- Benoit Rousseau
Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes
Lineage tracing using both transcriptomics and chromatin accessibility provides mechanistic insights into cell fate.
- Kunal Jindal
- Mohd Tayyab Adil
- Samantha A. Morris
Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens
mRNA kinetics are described by combining single-cell combinatorial indexing with metabolic labeling and pooled CRISPR screens.
- Andras Sziraki
Supervised discovery of interpretable gene programs from single-cell data
Spectra decomposes gene expression data into interpretable programs using prior knowledge.
- Russell Z. Kunes
- Thomas Walle
A DNA nanodevice for mapping sodium at single-organelle resolution
A probe reports absolute sodium levels in acidic organelles with single-organelle resolution.
- Koushambi Mitra
- Yamuna Krishnan
Identification of mobile genetic elements with geNomad
geNomad identifies mobile genetic elements in sequencing data.
- Antonio Pedro Camargo
- Nikos C. Kyrpides
Detection of transcriptome-wide microRNA–target interactions in single cells with agoTRIBE
Functional miRNA targets are identified transcriptome-wide in single cells.
- Vaishnovi Sekar
- Emilio Mármol-Sánchez
- Marc R. Friedländer
Detecting organelle-specific activity of potassium channels with a DNA nanodevice
A potassium activity reporter detects organelle-specific channel function.
- Palapuravan Anees
- Anand Saminathan
Translocation of linearized full-length proteins through an engineered nanopore under opposing electrophoretic force
An engineered nanopore translocates untagged full-length proteins by electroosmotic force.
- Adina Sauciuc
- Blasco Morozzo della Rocca
- Giovanni Maglia
Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis
A patterned neural tube and somites in an embryonic context are generated in vitro.
- Simona Gribaudo
- Rémi Robert
- Stéphane Nedelec
Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates
A DNA polymerase editing system offers advantages over prime editing.
- Xiaolong Dong
- Erik J. Sontheimer
BugSigDB captures patterns of differential abundance across a broad range of host-associated microbial signatures
A database of microbial signatures is used for systematic comparison of differential abundance patterns.
- Ludwig Geistlinger
- Chloe Mirzayi
- Levi Waldron
Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells
Engineered cancer mutations are linked with phenotypes in a multiplexed single-cell technology.
- Heon Seok Kim
- Susan M. Grimes
- Hanlee P. Ji
Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling
A new RNA reference set improves detection of differential expression in clinical settings.
- Yuanting Zheng
Protein remote homology detection and structural alignment using deep learning
Protein sequence and structural similarities in large databases are rapidly identified using machine learning.
- Tymor Hamamsy
- James T. Morton
- Richard Bonneau
Genotoxic effects of base and prime editing in human hematopoietic stem cells
Base and prime editors induce double-strand breaks, deletions and translocations in hematopoietic cells.
- Martina Fiumara
- Samuele Ferrari
- Luigi Naldini
Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials
Multi-omics data are readily integrated using quartet reference materials.
Integration of spatial and single-cell data across modalities with weakly linked features
MaxFuse enables data integration between modalities even when features are weakly correlated.
- Shuxiao Chen
- Zongming Ma
Spatial multimodal analysis of transcriptomes and metabolomes in tissues
Metabolites and RNA in a tissue section are profiled simultaneously.
- Marco Vicari
- Reza Mirzazadeh
- Joakim Lundeberg
Imaging brain tissue architecture across millimeter to nanometer scales
Mapping fixed brain samples with extracellular labeling and optical microscopy reveals synaptic connections.
- Julia M. Michalska
- Julia Lyudchik
- Johann G. Danzl
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Biotechnology is a broad discipline in which biological processes, organisms, cells or cellular components are exploited to develop new technologies. New tools and products developed by...
Current Research in Biotechnology ( CRBIOT) is a new primary research, gold open access journal from Elsevier. CRBIOT publishes original papers, reviews, and short communications (including viewpoints and perspectives) resulting from research in biotechnology and biotech-associated disciplines. Cur… View full aims & scope $2280
Xinqi Kang Meni Wanunu Author Correction 21 Sept 2023 Decoding the building blocks of cellular processes from single-cell transcriptomics data Most features of a cell are determined by gene...
Volume 1, November 2019, Pages 34-40 Current research in biotechnology: Exploring the biotech forefront Andy Wai Kan Yeung a , Nikolay T. Tzvetkov b c , Vijai K. Gupta d , Subash C. Gupta e , Gorka Orive f g h , Günther K. Bonn i j , Bernd Fiebich k , Anupam Bishayee l , Thomas Efferth m, Jianbo Xiao n , Ana Sanches Silva o p , Gian Luigi Russo q ,
Article 25 Sept 2023 Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes Lineage tracing using both transcriptomics and chromatin...
The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. ... Explore NCBI research and ...