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Research articles

research paper in biotechnology

Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses

Killing bacteria in tumors boosts survival in a mouse model of colon cancer.

  • Menglin Wang
  • Benoit Rousseau

research paper in biotechnology

Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes

Lineage tracing using both transcriptomics and chromatin accessibility provides mechanistic insights into cell fate.

  • Kunal Jindal
  • Mohd Tayyab Adil
  • Samantha A. Morris

research paper in biotechnology

Dissecting key regulators of transcriptome kinetics through scalable single-cell RNA profiling of pooled CRISPR screens

mRNA kinetics are described by combining single-cell combinatorial indexing with metabolic labeling and pooled CRISPR screens.

  • Andras Sziraki

research paper in biotechnology

Supervised discovery of interpretable gene programs from single-cell data

Spectra decomposes gene expression data into interpretable programs using prior knowledge.

  • Russell Z. Kunes
  • Thomas Walle

research paper in biotechnology

A DNA nanodevice for mapping sodium at single-organelle resolution

A probe reports absolute sodium levels in acidic organelles with single-organelle resolution.

  • Koushambi Mitra
  • Yamuna Krishnan

research paper in biotechnology

Identification of mobile genetic elements with geNomad

geNomad identifies mobile genetic elements in sequencing data.

  • Antonio Pedro Camargo
  • Nikos C. Kyrpides

research paper in biotechnology

Detection of transcriptome-wide microRNA–target interactions in single cells with agoTRIBE

Functional miRNA targets are identified transcriptome-wide in single cells.

  • Vaishnovi Sekar
  • Emilio Mármol-Sánchez
  • Marc R. Friedländer

research paper in biotechnology

Detecting organelle-specific activity of potassium channels with a DNA nanodevice

A potassium activity reporter detects organelle-specific channel function.

  • Palapuravan Anees
  • Anand Saminathan

research paper in biotechnology

Translocation of linearized full-length proteins through an engineered nanopore under opposing electrophoretic force

An engineered nanopore translocates untagged full-length proteins by electroosmotic force.

  • Adina Sauciuc
  • Blasco Morozzo della Rocca
  • Giovanni Maglia

research paper in biotechnology

Self-organizing models of human trunk organogenesis recapitulate spinal cord and spine co-morphogenesis

A patterned neural tube and somites in an embryonic context are generated in vitro.

  • Simona Gribaudo
  • Rémi Robert
  • Stéphane Nedelec

research paper in biotechnology

Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates

A DNA polymerase editing system offers advantages over prime editing.

  • Xiaolong Dong
  • Erik J. Sontheimer

research paper in biotechnology

BugSigDB captures patterns of differential abundance across a broad range of host-associated microbial signatures

A database of microbial signatures is used for systematic comparison of differential abundance patterns.

  • Ludwig Geistlinger
  • Chloe Mirzayi
  • Levi Waldron

research paper in biotechnology

Direct measurement of engineered cancer mutations and their transcriptional phenotypes in single cells

Engineered cancer mutations are linked with phenotypes in a multiplexed single-cell technology.

  • Heon Seok Kim
  • Susan M. Grimes
  • Hanlee P. Ji

research paper in biotechnology

Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling

A new RNA reference set improves detection of differential expression in clinical settings.

  • Yuanting Zheng

research paper in biotechnology

Protein remote homology detection and structural alignment using deep learning

Protein sequence and structural similarities in large databases are rapidly identified using machine learning.

  • Tymor Hamamsy
  • James T. Morton
  • Richard Bonneau

research paper in biotechnology

Genotoxic effects of base and prime editing in human hematopoietic stem cells

Base and prime editors induce double-strand breaks, deletions and translocations in hematopoietic cells.

  • Martina Fiumara
  • Samuele Ferrari
  • Luigi Naldini

research paper in biotechnology

Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials

Multi-omics data are readily integrated using quartet reference materials.

research paper in biotechnology

Integration of spatial and single-cell data across modalities with weakly linked features

MaxFuse enables data integration between modalities even when features are weakly correlated.

  • Shuxiao Chen
  • Zongming Ma

research paper in biotechnology

Spatial multimodal analysis of transcriptomes and metabolomes in tissues

Metabolites and RNA in a tissue section are profiled simultaneously.

  • Marco Vicari
  • Reza Mirzazadeh
  • Joakim Lundeberg

research paper in biotechnology

Imaging brain tissue architecture across millimeter to nanometer scales

Mapping fixed brain samples with extracellular labeling and optical microscopy reveals synaptic connections.

  • Julia M. Michalska
  • Julia Lyudchik
  • Johann G. Danzl

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research paper in biotechnology

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  1. Published Research Paper_IJEAB_Aug 2016

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  1. Biotechnology

    Biotechnology is a broad discipline in which biological processes, organisms, cells or cellular components are exploited to develop new technologies. New tools and products developed by...

  2. Current Research in Biotechnology

    Current Research in Biotechnology ( CRBIOT) is a new primary research, gold open access journal from Elsevier. CRBIOT publishes original papers, reviews, and short communications (including viewpoints and perspectives) resulting from research in biotechnology and biotech-associated disciplines. Cur… View full aims & scope $2280

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    Xinqi Kang Meni Wanunu Author Correction 21 Sept 2023 Decoding the building blocks of cellular processes from single-cell transcriptomics data Most features of a cell are determined by gene...

  4. Current research in biotechnology: Exploring the biotech

    Volume 1, November 2019, Pages 34-40 Current research in biotechnology: Exploring the biotech forefront Andy Wai Kan Yeung a , Nikolay T. Tzvetkov b c , Vijai K. Gupta d , Subash C. Gupta e , Gorka Orive f g h , Günther K. Bonn i j , Bernd Fiebich k , Anupam Bishayee l , Thomas Efferth m, Jianbo Xiao n , Ana Sanches Silva o p , Gian Luigi Russo q ,

  5. Research articles

    Article 25 Sept 2023 Single-cell lineage capture across genomic modalities with CellTag-multi reveals fate-specific gene regulatory changes Lineage tracing using both transcriptomics and chromatin...

  6. National Center for Biotechnology Information

    The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. ... Explore NCBI research and ...