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Analytical chemistry articles from across Nature Portfolio

Analytical chemistry is a branch of chemistry that deals with the separation, identification and quantification of chemical compounds. Chemical analyses can be qualitative, as in the identification of the chemical components in a sample, or quantitative, as in the determination of the amount of a certain component in the sample.

research papers on analytical chemistry

Dynamic crystal structure of a molecular framework

X-ray diffraction analysis typically affords the static 3D structures of given compounds or materials, but to understand chemical processes, the visualization of fast structural changes is desirable. Time-resolved femtosecond crystallography has now been used to monitor the structural dynamics of a photoactive metal–organic framework.

  • Lauren E. Hatcher
  • Paul R. Raithby

research papers on analytical chemistry

An analytical view of disinfectant degradation and disinfection by-product formation

Proton transfer time-of-flight mass spectrometry offers a new analytical tool to measure aqueous concentrations of volatile analytes in real time by the approach of headspace sampling, holding significant promise for advancing understanding of water chlorination chemistry.

  • Said Kinani
  • Stéphane Bouchonnet

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research papers on analytical chemistry

Reproducible mass spectrometry data processing and compound annotation in MZmine 3

Untargeted mass spectrometry (MS) produces complex, multidimensional data. The MZmine open-source project enables processing of spectral data from various MS platforms, e.g., liquid chromatography–MS, gas chromatography–MS, MS–imaging and ion mobility spectrometry–MS, and is specialized for metabolomics.

  • Steffen Heuckeroth
  • Tito Damiani
  • Tomáš Pluskal

research papers on analytical chemistry

Open-source interactive design platform for 3D-printed microfluidic devices

Yushen Zhang and colleagues report an open source, interactive software platform for the efficient and convenient design of 3D printable microfluidic devices. The approach incorporates a design-for-manufacturing function, facilitating device fabrication using commercial consumer-grade printers.

  • Yushen Zhang
  • Ulf Schlichtmann

research papers on analytical chemistry

Epidermal wearable optical sensors for sweat monitoring

Wearable optical sensors offer advantages for monitoring human sweat compared to traditional electrochemistry-based approaches. Here, the working principles, advantages, and limitations of various types of optical-based devices for health monitoring of human sweat are discussed.

  • Xueji Zhang

research papers on analytical chemistry

Improved detection of magnetic interactions in proteins based on long-lived coherences

Solution NMR spectroscopy provides rich structural information on biomolecules, however, its resolution becomes limited when molecular size increases, due to short-lived nuclear magnetic responses to electromagnetic radiation. Here, the authors sustain long-lived coherences for the aliphatic protons of glycine residues within protein lysozyme, yielding substantial through-space magnetization transfers, and mapping interacting atoms in the protein structure.

  • Octavian Ianc
  • Florin Teleanu
  • Paul R. Vasos

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Cutaneous squamous cell carcinoma characterized by MALDI mass spectrometry imaging in combination with machine learning

  • Lauritz F. Brorsen
  • James S. McKenzie
  • Catharina M. Lerche

research papers on analytical chemistry

FT-Raman and FTIR spectroscopy as a tools showing marker of platinum-resistant phenomena in women suffering from ovarian cancer

  • Marta Kluz-Barłowska
  • Tomasz Kluz
  • Joanna Depciuch

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Identifying phase-separating biomolecular condensates in cells

We developed a high-throughput, unbiased strategy for the identification of endogenous biomolecular condensates by merging cell volume compression, sucrose density gradient centrifugation and quantitative mass spectrometry. We demonstrated the performance of this strategy by identifying both global condensate proteins and those responding to specific biological processes on a proteome-wide scale.

research papers on analytical chemistry

Stress monitoring with wearable technology and AI

Physicochemical-sensing electronic skins — combined with artificial intelligence — could be used to develop personalized stress management systems.

  • H. Ceren Ates

research papers on analytical chemistry

And yet it rotates!

Electrocatalysis would not be the same without the rotating disk electrode. Its invention in the mid-twentieth century enabled immense developments, which rendered it a classic technique in electrochemistry. The rotating disk electrode will remain a cornerstone of electrocatalysis with further advances that bridge the gap with real systems.

  • Serhiy Cherevko
  • Ioannis Katsounaros

research papers on analytical chemistry

Discovering cryptic natural products by substrate manipulation

Cryptic halogenation reactions result in natural products with diverse structural motifs and bioactivities. However, these halogenated species are difficult to detect with current analytical methods because the final products are often not halogenated. An approach to identify products of cryptic halogenation using halide depletion has now been discovered, opening up space for more effective natural product discovery.

  • Ludek Sehnal
  • Libera Lo Presti
  • Nadine Ziemert

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research papers on analytical chemistry

Methodological Aspects of Analytical Chemistry

  • Published: 13 February 2021
  • Volume 76 , pages 1–14, ( 2021 )

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research papers on analytical chemistry

  • Yu. A. Zolotov 1 , 2  

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The author considers the definition of analytical chemistry and discusses issues about what is this science, fundamental or applied. The reasons for the stimuli and drivers for the development of analytical chemistry, its place in the system of scientific knowledge, and its internal structure are presented. The question whether the name “analytical chemistry” is often replaced by other terms, better corresponding to the current status of this science, is also discussed.

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research papers on analytical chemistry

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Department of Chemistry, Lomonosov Moscow State University, 119991, Moscow, Russia

Yu. A. Zolotov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

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Correspondence to Yu. A. Zolotov .

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Translated by E. Rykova

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Zolotov, Y.A. Methodological Aspects of Analytical Chemistry. J Anal Chem 76 , 1–14 (2021). https://doi.org/10.1134/S1061934821010160

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Received : 23 June 2020

Revised : 15 July 2020

Accepted : 22 July 2020

Published : 13 February 2021

Issue Date : January 2021

DOI : https://doi.org/10.1134/S1061934821010160

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Analytical methods and applications in materials and life sciences

Ute resch-genger.

Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter-Straße 11, 12489 Berlin, Germany

Björn Meermann

Matthias koch, michael g. weller.

Current trends in materials and life sciences are flanked by the need to push detection limits to single molecules or single cells, enable the characterization of increasingly complex matrices or sophisticated nanostructures, speed up the time of analysis, reduce instrument complexity and costs, and improve the reliability of data. This requires suitable analytical tools such as spectroscopic, separation and imaging techniques, mass spectrometry, and hyphenated techniques as well as sensors and their adaptation to application-specific challenges in the environmental, food, consumer product, health sector, nanotechnology, and bioanalysis. Increasing concerns about health threatening known or emerging pollutants in drinking water, consumer products, and food and about the safety of nanomaterials led to a new awareness of the importance of analytical sciences. Another important driver in this direction is the increasing demand by legislation, particularly in view of the 17 sustainable development goals by the United Nations addressing clean energy, industry, and innovation, sustainable cities, clean water, and responsible consumption and production. In this respect, also the development of analytical methods that enable the characterization of material flows in production processes and support recycling concepts of precious raw materials becomes more and more relevant. In the future, this will provide the basis for greener production in the chemical industry utilizing recycled or sustainable starting materials. This makes analytical chemistry an essential player in terms of the circular economy helping to increase the sustainability of production processes. In the life sciences sector, products based on proteins, such as therapeutic and diagnostic antibodies, increase in importance. These increasingly biotechnologically produced functional biomolecules pose a high level of complexity of matrix and structural features that can be met only by highly advanced methods for separation, characterization, and detection. In addition, metrological traceability and target definition are still significant challenges for the future, particularly in the life sciences. However, innovative reference materials as required for the health and food sector and the characterization of advanced materials can only be developed when suitable analytical protocols are available. The so-called reproducibility crisis in sciences underlines the importance of improved measures of quality control for all kinds of measurements and material characterization. This calls for thorough method validation concepts, suitable reference materials, and regular interlaboratory comparisons of measurements as well as better training of scientists in analytical sciences.

The important contribution of analytical sciences to these developments is highlighted by a broad collection of research papers, trend articles, and critical reviews from these different application fields. Special emphasis is dedicated to often-overlooked quality assurance and reference materials.

Biographies

is Head of the Division Biophotonics at the Federal Institute for Materials Research and Testing (BAM). She received her Ph.D. on semiconductor quantum dots from the Technical University Berlin and has then carried out research stages at the University of Texas at Austin and the University of Ottawa focused on the development of functional optical materials and luminescent methods for their characterization. She is co-chair of the steering committee of the Methods and Applications in Fluorescence (MAF) conference series and member of the Editorial Advisory Board of the journals Bioconjugate Chemistry and Methods in Applications in Fluorescence (MAF) and serves as Editorial Board Member for Scientific Reports . She currently leads the “Expert Group Chemists for Government Agencies and the Public Sector” of the German Chemical Society (GDCh) and acts as German expert on luminescent nanomaterials in international standardization committees. Her research interests are focused on molecular and nanocrystalline emitters for the UV/vis/NIR/SWIR, stimuli-responsive optical probes, signal enhancement, multiplexing, and encoding strategies as well as concepts for validating optical-spectroscopic measurements and developing optical reference materials.

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is Head of the Division Inorganic Trace Analysis at the Federal Institute for Materials Research and Testing (BAM) and “Habilitand” in Analytical Chemistry at the Humboldt University Berlin. He studied chemistry at the University of Münster and received his Ph.D. in Analytical Chemistry. He did a postdoc at the University of Ghent in Belgium on the topic of stable isotopes in terms of speciation analysis and subsequently joined the Federal Institute of Hydrology (BfG) in Koblenz as a research associate. He is a member of the board “Expert Group Analytical Chemistry” of the German Chemical Society (GDCh) as well as Editorial Board member of the Journal of Analytical Atomic Spectrometry (JAAS). His research is located at the interface of materials and environmental sciences and the life sciences with topics like release studies of elements, elemental species, and (nano)particles from materials into the environment, their possible uptake by organisms and cells, and the assessment of the influence of (metal based) materials on the environment. Analytical techniques applied for his research include hyphenated techniques (CE, LC, GC, AF4/ICP-MS), single particle/cell-ICP-ToF-MS, and HR-CS-GFMAS for non-metal analysis.

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Object name is 216_2022_4082_Figb_HTML.jpg

is Head of the Division Organic Trace and Food Analysis at the Federal Institute for Materials Research and Testing (BAM). He studied chemistry at the Technical University Berlin and received his Ph.D. in Analytical Chemistry from the Humboldt University Berlin. For more than 20 years, he has been conducting research in the field of environmental and food analysis with a focus on the development of chromatographic methods for the detection and quantification of organic contaminants and residues in complex matrices such as soil, food, and consumer products. One of his special interests is the investigation of the fate of organic pollutants by simulating natural transformation processes and identifying transformation products by electrochemistry coupled with high resolution mass spectrometry. He is also active in the development and certification of traceable reference materials for environmental, food and consumer products and involved in the Mass Spectrometry Centre of BAM.

An external file that holds a picture, illustration, etc.
Object name is 216_2022_4082_Figc_HTML.jpg

is Head of the Division Protein Analysis at the Federal Institute for Materials Research and Testing (BAM). He received his Ph.D. from the Technical University of Munich (TUM) in the field of Analytical Chemistry. Subsequently, he joined the Division of Analytical Chemistry Research at Ciba-Geigy in Basel, Switzerland , for a postdoctoral stay. After leading a bioanalytical research group at TUM, he finished his habilitation in immunochemistry and now teaches bioanalytical chemistry at the Humboldt University Berlin. His research interests include many bioanalytical topics such as immunoassays, biosensors, microarrays, affinity chromatography, monolithic materials, quantitative protein analysis, antibody development, bioconjugation, lab-on-a-chip, and peptide libraries. Furthermore, he is engaged in the design and quality control of bioreagents to tackle and overcome the replication crisis.

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Open Access funding enabled and organized by Projekt DEAL.

Published in the topical collection Analytical Methods and Applications in the Materials and Life Sciences with guest editors Ute Resch-Genger, Matthias Koch, Björn Meermann, and Michael G. Weller.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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