assignment #3 nutritional analysis

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StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

StatPearls [Internet].

Nutritional Assessment

Aditi Kesari ; Julia Y. Noel .

Affiliations

Last Update: April 10, 2023 .

• Continuing Education Activity

Evaluation of nutritional status is critical, either to identify if an individual has nutritional imbalance due to an underlying condition or to assess if an individual is likely to develop a pathological condition due to nutritional imbalance. A detailed, systematic evaluation of a patient's nutritional status conducted by healthcare providers in a team-based setting to diagnose malnutrition and identify underlying pathologies to plan intervention constitutes nutritional assessment. This article provides an overview of nutritional evaluation, including components of nutritional assessment, factors that affect nutritional status, and the role of interprofessional teams involved in managing patients at nutritional risks.

• Explain the significance of nutritional assessment and summarize its components.
• Identify factors that affect the nutritional status of individuals.
• Describe challenges involved in nutritional assessment.
• Summarize the role of interprofessional collaboration in performing the nutritional assessment of patients.
• Introduction

Food and nutrition are basic indispensable needs of humans. Nutrition plays a critical role in maintaining the health and well-being of individuals and is also an essential component of the healthcare delivery system. The nutritional status of individuals affects the clinical outcomes. Essential nutrients are classified into six groups, namely carbohydrates, proteins, lipids, minerals, vitamins, and water.

Nutritional requirements of healthy individuals depend on various factors, such as age, sex, and activity. Hence, recommended values of dietary intakes vary for each group of individuals. In the United States, the Food and Nutrition Board of the Institutes of Medicine (IOM) under the National Academy of Sciences issues nutrition recommendations for populations throughout the life span called Dietary Reference Intakes (DRIs). [1]

An imbalance in nutritional intake leads to malnutrition. The word ‘malnutrition’ is defined in multiple ways, and there is still no consensus. [2]  Traditionally, the term malnutrition has been used in the context of lack of energy intake or deficiencies of nutrients, under which two main conditions, namely marasmus, and kwashiorkor, are discussed. Marasmus primarily refers to energy or calorie deficiency, whereas kwashiorkor refers to protein deficiency characterized by peripheral edema. [3] [4]  

However, the term malnutrition now includes conditions caused by both insufficient as well as excess intake of macronutrients and micronutrients. [5]  As per WHO guidelines, malnutrition encompasses three categories, namely,

• Undernutrition (low weight-for-height, low height-for-age, and low weight-for-age),
• Micronutrient (vitamins and minerals) deficiency or excess, and
• Overnutrition (overweight, obesity, and other diet-related health conditions such as type 2 diabetes mellitus, cardiovascular disorders, etc.).

The presentation of malnutrition can be acute, sub-acute, or chronic and may or may not be associated with underlying inflammation. Furthermore, the double burden of malnutrition has also been emphasized in various studies. This involves the dual manifestation of overnutrition and undernutrition, which makes the diagnosis of malnutrition a challenge. [6] [7]  

Hence, a comprehensive, multi-faceted evaluation of a patient's nutritional status is warranted. A comprehensive nutritional assessment, however, should be differentiated from nutritional screening. Nutritional screening is done to quickly identify individuals at risk of developing malnutrition. [8]  

For example, the mini nutritional assessment (MNA) is used in the geriatric patient population to screen for individuals at risk of malnutrition. This screening tool consists of a questionnaire and has a scoring system that helps identify at-risk individuals. On the other hand, a comprehensive nutritional assessment is performed to evaluate the nutritional status of patients already identified at nutritional risk. Nutritional assessment allows healthcare providers to systematically assess the overall nutritional status of patients, diagnose malnutrition, identify underlying pathologies that lead to malnutrition, and plan necessary interventions.

While performing nutritional assessment, it is important to understand that there is no single best test to evaluate nutritional status. Information should be collected systematically, and an evaluation of nutritional status should be done based on the overall data collected. As per the American Society for Parenteral and Enteral Nutrition (ASPEN) guidelines, a comprehensive nutritional assessment involves a thorough clinical examination (history and physical examination), anthropometric measurements, diagnostic tests, and dietary assessments. [5]  

Additional clinical examinations or diagnostic tests may be necessary for different groups of populations and individuals with specific underlying pathology. As per the International Consensus guidelines committee, the diagnosis of malnutrition in adults can be categorized as (i) starvation-related malnutrition (chronic, non-inflammatory), (ii) acute disease or injury-related malnutrition (mild to severe inflammation), or (iii) chronic disease-related malnutrition (chronic mild to moderate inflammation). [9]  

Given below are the components of a comprehensive nutritional assessment that need to be performed while evaluating the nutritional status of individuals.

Clinical History:  Patients' clinical history is a crucial component of nutritional assessment. Clinical history aims to look for indications of malnutrition and identify underlying factors that may lead to malnutrition or increase the risk of malnutrition.

• Once patient identification markers (name, age, sex) are noted, take a detailed history of chief complaints.
• If not mentioned in chief complaints, ask for other constitutional symptoms, such as fever, fatigue, malaise, loss of appetite, or sleep disturbances. The presence of these symptoms can be an indication of underlying pathologies. For example, fever suggests active infection or inflammation.
• Inquire about the patient’s usual weight and ask if there have been any weight changes. Weight loss of >10% of body weight can signify underlying pathology. Weight gain can be suggestive of various underlying endocrine pathologies. Weight gain can also lead to insulin resistance contributing to metabolic syndrome.
• Ask if there are any symptoms suggestive of malnutrition other than weight changes, such as rashes, sores in the mouth, dryness of skin and eyes, loss of night vision, hair loss, bleeding gums, poor healing of wounds, swelling of extremities, tingling, or numbness.
• Ask about eating habits and dietary preferences. For example, ask about the number of meals eaten in a day, approximate portion sizes, whether they are following any restrictive diets, whether they are vegan or vegetarian, or if they are allergic to any food items. This can help in diagnosing a possible nutritional deficiency. For example, a vegan diet may be associated with vitamin B12 (cobalamin) deficiency. [10]  A detailed dietary assessment is also warranted and is discussed below. If patients are on parenteral or enteral diets, they should be interviewed accordingly.
• Ask about any factors affecting food intake, like poor dentition, ulceration in the oral cavity, difficulty in swallowing, loss of appetite, heartburn, nausea, and/or vomiting. Further, inquire about bowel habits, which help assess the general functioning of the gastrointestinal system. Also, ask if there is any abdominal pain, abdominal distention, diarrhea, flatulence, or constipation, which can indicate underlying gastrointestinal pathologies that affect nutritional status.
• Ask about any current major clinical or surgical illnesses, including mental illnesses. Also, ask if they are taking any medications, either prescribed or over the counter. Ask if there is any history of chronic illnesses, hospitalization, trauma, or malignancies. The impact of current or past illnesses on nutritional status is discussed below.
• In female patients, detailed menstrual history should be taken. Amenorrhea in child-bearing aged women can indicate pregnancy, chronic infection, chronic illness, eating disorder, etc., which can affect the nutritional status of patients. History suggestive of menorrhagia can reveal the presence of anemia. Also, a history of contraceptive use is essential. Women on oral contraceptive pills have different nutritional requirements. Oral contraceptive pills have been shown to deplete B vitamins, vitamin C, and some minerals, such as magnesium, selenium, and zinc. [11]
• Next, ask questions related to lifestyle habits (active vs. sedentary), daily physical activities, and exercise routine.
• History about social habits such as drinking, smoking, tobacco consumption, or other non-prescription drugs should also be taken.
• Since socioeconomic conditions can affect nutritional status, request information related to this as well.
• Finally, family history can also be useful for the early diagnosis of conditions that can affect a patient's nutritional status or help identify underlying predisposing conditions.

Dietary Assessment:  Dietary assessment is necessary to ensure adequate nutrition and hydration intake. It is advised to consult a qualified registered dietitian-nutritionist (RDN), if available, to obtain a thorough dietary assessment.

• The information can be collected from various sources such as the patients themselves, family members, caregivers, or medical records.
• History about dietary habits, frequency of meals, and serving sizes needs to be collected. As mentioned earlier, details about food preferences, restrictive diets, and allergies should be noted.
• Current nutrient and fluid intake should be recorded. Methods such as the 24-hour recall method, food frequency questionnaire (FFQ), diet charts, observation, etc., can be used. Wearable monitoring devices, phone apps, or nutrition analysis software can be used as aids. [8]
• If patients are on any nutritional supplements, care must be taken to record the frequency and dosage to limit the risk of nutrient insufficiency and toxicity.
• If patients are on parenteral or enteral diets, information on feeding regimens (quantity and frequency) should be noted. Factors affecting these feedings, such as displacement of feeding tubes, site irritation, or infections, should be considered.

Physical examination: The next component of the nutritional assessment is physical examination. The physical examination aims to identify signs of malnutrition and factors affecting nutritional status.

• General condition: General condition and appearance of the patient should be observed. Look for any signs of emaciation. Note whether the patient is conscious, alert, and ambulatory. Make a note of whether a patient is being examined in a hospital or outpatient setting. An initial observation of the patient's cognitive, mental, and emotional status should be noted. Also, note any parenteral or enteral feeding devices being used. A patient's general condition can help determine whether a patient can meet their nutritional needs and/or whether their condition is causing their malnutrition or putting them at a higher risk of nutrition deficiencies.
• Vital signs: Vital signs (body temperature, pulse, blood pressure, and respiratory rate) should be checked. Temperature > 100.4 degrees Fahrenheit or 38 degrees Celsius can signify active inflammation/infection. Hypothermia (temperature < 95 degrees Fahrenheit or 35 degrees Celsius) can be associated with conditions causing impaired nutritional status, such as sepsis, trauma, burns, stroke, alcohol intoxication, and metabolic disorders like hypothyroidism, adrenal insufficiency, and Wernicke encephalopathy. [12]  High pulse rates, apart from cardiac conditions, can indicate hyperdynamic circulation. Some causes of hyperdynamic circulation that are associated with altered nutritional status are fever, anemia, pregnancy, hyperthyroidism, septic shock, Beriberi, and anxiety. High blood pressure or hypertension is one of the risk criteria for metabolic syndrome. Abnormal rate and patterns of respiration can be indicative of various pathologies. For example, Kussmaul's breathing is associated with diabetic ketoacidosis (DKA).
• Height and Weight: Measure the height and weight of the patient. Body mass index (BMI) calculated from these variables can help determine whether an individual is undernourished or overnourished. Details about BMI and other anthropometric measurements are discussed later.
• Eyes: Look for pallor, which may be indicative of various nutrient deficiencies (iron, vitamin B12, folic acid, vitamin B6, vitamin C, or protein deficiency), as well as various chronic illnesses. Look for icterus, suggesting metabolic disturbances associated with the hepatobiliary system. The presence of Bitot spots and xerosis is indicative of vitamin A deficiency. Xanthelasmas, yellow-colored plaques on eyelids, can suggest obesity, hypercholesterolemia, or diabetes mellitus.
• Oral cavity and perioral region: Assess the general health of the oral cavity and look for pathologies that can affect the adequate intake of nutrients. Also, look for glossitis, angular stomatitis, and cheilosis, which can indicate vitamin B complex deficiency. Bleeding gums and gingivitis are suggestive of vitamin C deficiency. Again, look for pallor. If an eating disorder is suspected, look for vomiting-related oral damage, for example, discoloration of teeth, loss of enamel, cavities, and enlarged salivary glands. [13]  A consultation with a dentist may be helpful. Look for loss of buccal fat pads or sunken facial appearance. This can be associated with various conditions such as eating disorders, marasmus, tuberculosis (TB), or HIV/AIDS.
• Skin: Assess the general health of the skin. Xeroderma (extremely dry skin) can signify vitamin A and/or essential fatty acid deficiencies. Petechia, purpura, and ecchymosis may be associated with vitamin C and vitamin K deficiencies. Vitamin C deficiency can also present with perifollicular hemorrhage. Poorly healed wounds indicate vitamin C, protein, and/or zinc deficiencies. Pigmentation and rashes in sun-exposed areas (around the neck and on extremities in glove and stocking patterns) can be due to niacin deficiency. [14]  The yellow-orange discoloration of the skin can be detected in cases of excessive consumption of carotenoids (pigments found in carrots, pumpkin, tomatoes, etc.). Xanthomas, which are localized lipid deposits, can be seen in individuals with obesity, hypercholesterolemia, or diabetes mellitus. Look for loss of subcutaneous adipose tissue in axillary folds, buttocks, and extremities. This can be associated with energy-deficient states like marasmus, TB, HIV, and eating disorders.
• Hair: Various nutrients are required to maintain the health of hair and hair follicles. Dry hair can be a sign of vitamin A or vitamin E deficiency. Biotin deficiency can make hair brittle. Severe undernutrition, especially protein deficiency, can lead to discolored and easily pluckable hair, eventually resulting in hair loss. Rapid hair loss can also be indicative of underlying systemic illnesses.
• Nails: Assess the general health of nails and nailbeds. Dry and brittle nails can be associated with various nutritional deficiencies, such as deficiencies in biotin, zinc, and proteins. Discoloration of nails is another sign of poor nutrition. [15]  Koilonychia can be a sign of iron deficiency anemia. While clubbing is associated with many pathologies, it may also be observed with malnutrition, chronic alcohol use disorder, and chronic laxative use, often seen in individuals with eating disorders.
• Extremities: Examine all extremities carefully. Protein or thiamine deficiency can lead to edema. Vitamin B12, thiamine, vitamin E, and vitamin B6 deficiencies can present with paresthesia and muscle weakness. Loss of vibration and position sensation can also be observed in individuals with vitamin B12 and/or vitamin E deficiencies. Patients with diabetes mellitus may also show signs of peripheral neuropathy, foot ulceration, or gangrene. Severe undernutrition, as well as chronic illnesses, can lead to muscle atrophy and wasting. Bowing of lower limbs can be seen in children with vitamin D deficiency rickets.
• Odors: Certain odors can be suggestive of specific disorders or substance use. Detection of fruity acetone odor in patients with ketoacidosis, musty odor in patients with phenylketonuria, sweet burnt sugary odor in patients with Maple syrup disorder, or the smell of alcohol can also be helpful during the examination of patients.
• Functional assessment: It is essential to do a functional assessment of patients. Observe whether patients are ambulatory and whether they can eat and drink with or without assistance. Examine the strength of extremities to determine whether they can perform activities of daily living (ADLs) or other physical activities. Mental assessment is also crucial, along with physical assessment. For example, elderly patients with severe malnutrition may be physically (due to weakness) and mentally (due to dementia) incapable of maintaining healthy nutritional status. Similarly, patients with thiamine deficiency may develop Wernicke encephalopathy and Korsakoff psychosis and may become incapable of meeting their own dietary needs.
• Systemic evaluation: An appropriate systemic examination should be performed based on the history and general examination findings.

Anthropometric Measurements

• Height, weight, and BMI: Measure the weight and height of the patient, as mentioned above. Patients should be advised to avoid wearing heavy garments or shoes while these measurements are taken. Bed or chair scales may be needed if patients are not ambulatory or cannot stand. In pediatric age groups, these parameters are plotted on growth charts to assess growth and nutritional status. BMI (weight in kilograms divided by height in meters squared) is also calculated using these parameters, and the state of nutrition can be assessed. In adults, BMI < 18.5 kg/m^2: underweight; BMI = 18.5 to 24.9 kg/m^2: within normal range; BMI > 24.9 to 29.9 kg/m^2: overweight; and BMI ≥ 30 kg/m^2: obesity. [16]  
• Factors such as edema and hydration should be considered while making these determinations, as they can affect the weight and BMI values. BMI cannot differentiate between muscle mass and adipose tissue/fat mass. And finally, BMI does not take into account micronutrient deficiencies. 
• Other anthropometric measurements: Circumference (arm, abdomen, and thigh) measurements and skinfold (biceps skinfold, triceps skinfold, subscapular skinfold, and suprailiac skinfold) thickness measurements can also help with the evaluation of nutritional status. Skinfold thickness measurements are considered indicators of energy stores (mainly lipid stores). Circumference measurement, namely midarm circumference (MAC), can be used to derive midarm muscle circumference (MAMC=MAC-3.1414 X triceps skinfold thickness), which is an indicator of protein stores. While these tests can quickly be done at the bedside without additional cost, subjectivity in terms of measurements and the applicability of results across various populations can make these tests less reliable.
• A complete anthropometric assessment may also involve body composition measurements, which are discussed in diagnostic tests.

Diagnostic tests: The next component of the nutritional assessment is diagnostic tests, which are done to validate the results of the clinical presentation.

Laboratory Tests

• Routine clinical tests: Routine clinical tests can help evaluate the patient's overall status (as well as nutritional status). [17]  These include serum electrolytes, blood urea nitrogen (BUN), creatinine, blood glucose levels, lipid profile, liver enzymes, and complete blood count. Serum electrolytes and hydration status may be deranged in malnourished individuals. BUN and serum creatinine are also predictors of nitrogen balance along with being indicators of renal function, and lower levels of these can be seen in malnourished patients. Low levels of serum creatinine can be indicative of lower muscle mass. Both BUN and creatinine levels, however, can be affected by hydration levels and kidney function. Elevated blood glucose levels and lipid profile (triglycerides and cholesterol) levels are indicators of metabolic syndrome. Hyperglycemia can also be a nonspecific indicator of the inflammatory response. [18]  
• Low cholesterol levels can be seen in undernourished individuals. Low hemoglobin is suggestive of anemia. Lymphocyte functioning and proliferation are affected in chronic malnutrition and may manifest as decreased lymphocyte count. [19]  Undernutrition and protein deficiency, in general, lead to impaired immune response. Taken together, an impaired, delayed hypersensitivity response (anergic or no reaction) may be seen in undernourished individuals. For example, malnourished individuals with TB may show an anergic tuberculin skin test. [20]
• Visceral proteins: [21]  Levels of visceral proteins such as albumin, prealbumin, transferrin, and retinol-binding protein can help evaluate nutritional status. However, none of these tests alone are specific for detecting malnutrition, and their levels can be affected by multiple factors. For example, low serum albumin levels suggest protein deficiency due to malnutrition and other pathologies that affect the protein status, such as liver cirrhosis or nephrotic syndrome. High levels of serum albumin could be associated with dehydration. Albumin has a long half-life (up to 20 days) and, hence, cannot be used for monitoring frequent changes in nutritional status during refeeding. Prealbumin (or transthyretin), a thyroid hormone carrier, is preferred in such cases as it has a shorter half-life (2 to 3 days), which allows for the detection of acute alterations in nutritional status. Retinol-binding protein is another protein with a very short half-life (12 hours) and can be used for monitoring changes in nutritional status. However, its levels are affected by vitamin A levels. Transferrin, an iron transport protein, is another nutritional indicator as well as an acute phase reactant. It has a half-life of approximately ten days, and its levels are affected by serum iron levels.
• Micronutrient levels: If specific micronutrient deficiencies are suspected, individual micronutrient levels can be measured. For example, levels of B vitamins (thiamine, riboflavin, niacin, pyridoxine, folic acid, B12), vitamins A, C, D, E, and K, iron, zinc, selenium, homocysteine, etc., can be measured. More specific tests such as the Schilling test for B12 deficiency or iron panel to differentiate between different types of anemia can also be performed based on clinical presentation.
• Other non-nutrition-specific markers can also be used; for example, C-reactive protein (CRP) can be used to indicate inflammation. [21]

Body Composition Studies

Apart from laboratory tests, body composition studies can be performed to estimate the body's composition in terms of water, air, muscle, bones, and fat mass.

• Bioelectrical impedance analysis (BIA): This helps analyze the body composition based on the ability of different body tissues to conduct electricity. Conductance is higher in tissues with more water and electrolytes (for example, blood) and less in adipose and bone tissues. This is an easy, non-invasive test that can be done at the bedside using low-cost equipment. However, in patients with extremely high BMI or fluid overload, the results may be less accurate.
• Dual-Energy X-ray absorptiometry (DEXA or DXA): This is a standard method used to determine body composition and is also used as a reference to compare other body composition tests. However, it is expensive, requires a specialized machine, and involves exposure to X-rays. It is more commonly used in clinical research than in routine clinical practice. [22]
• Other tests, such as computed tomography (CT) scan and magnetic resonance imaging (MRI), can also be used to determine body composition but are expensive options for routine nutritional assessment. Body composition, however, can be determined when imaging is done for other diagnostic purposes.
• Issues of Concern

Despite multiple studies on malnutrition and the knowledge that malnutrition affects clinical outcomes, the term malnutrition still has different interpretations and usages. In the consensus statement focusing on undernutrition by the Academy of Nutrition and Dietetics and ASPEN, adult malnutrition was used interchangeably with adult undernutrition for discussion. [23]  

Also, there is no single best test that can give a complete picture of an individual's nutritional status. Additionally, various factors may affect the interpretation of individual tests or examinations, or the tests may have some shortcomings. Furthermore, the nutritional status of individuals itself is affected by multiple interdependent factors discussed below. Hence a holistic, team-based approach that takes into consideration overall data from clinical examination, dietary assessment, and diagnostic tests is necessary to determine the comprehensive nutritional status of a patient. At the same time, different nutritional screening or assessment tools may be required for different types of patient populations (i.e., children vs. elderly) or settings (i.e., hospital vs. outpatient).

Specialized tests may also be required in any patient, based on the underlying pathology. Another challenge with nutrition evaluation is dual manifestations of malnutrition, in which overnutrition and undernutrition can coexist. This further complicates the diagnostic process. The entire team of healthcare providers should be aware of these concerns to enhance the outcomes of nutritional screening and assessment.

Factors Affecting Nutritional Status

It is important to consider the following factors affecting the nutritional status of individuals while performing a comprehensive nutritional assessment. It is also crucial to remember that these factors can be interdependent. The factors can be classified as physiological, pathological, and psychosocial factors. 

Physiological factors:  Physiological factors such as age, sex, growth, pregnancy, and lactation can influence nutritional needs and should be considered while performing a nutritional assessment. For example, as a child grows, its nutritional requirements will increase. The recommended nutritional requirements for male and female children of the same age are equal early in life, but as they approach adolescence, males require additional nutritional intake. On reaching adulthood, the rise in nutritional requirements of individuals plateaus off in their respective ranges. However, the caloric and nutritional needs of females increase during pregnancy and lactation. Hence, along with a balanced diet, a pregnant or lactating mother may also require additional supplementation of micronutrients, such as iron, folic acid, calcium, and vitamin D. [24]  Maternal age at the time of pregnancy can further affect these requirements. For example, the calcium requirements of pregnant teens are higher than those of pregnant adults. [25]  Physical activity also determines the recommended macronutrient (carbohydrate, protein, and/or fat) nutritional requirements. Individuals with an active lifestyle require higher nutritional needs than individuals with a sedentary lifestyle. Failure to meet the additional nutritional needs in any of the situations mentioned above increases the risk of malnutrition, especially if other health conditions coexist. On the other hand, as age advances, the energy needs of elderly individuals decrease due to less mobility and loss of lean tissue leading to decreased appetite. Factors such as poor dentition, increased prevalence of chronic conditions, and adverse effects of polypharmacy combined with psychosocial factors, like poor socioeconomic conditions or dementia, can further decrease intake of nutritious food, thus leading to impairment of nutritional status. [26]

Pathological factors:  While performing nutritional assessment, it is important to understand how underlying pathologies can affect nutritional status. Some of these factors are discussed below.

• Genetics: Genetics play a significant role in maintaining an individual's nutritional status. Genetic predisposition combined with lack of physical activity and a high-energy diet can lead to obesity and metabolic syndrome, thus putting individuals at higher risk of developing cardiometabolic diseases. In various genetic disorders, multiple factors could be responsible for the pathogenesis of malnutrition. For example, in cystic fibrosis, malabsorption of nutrients results from decreased uptake by the intestines and reduced secretion of pancreatic enzymes. This, coupled with increased energy needs, can contribute to malnutrition in these patients. [27]  Similarly, many other genetic disorders, such as phenylketonuria, Prader-Willi syndrome, maple syrup urine disease, abetalipoproteinemia, and lysosomal storage disorders, significantly affect the nutritional status of individuals.
• Infections: Malnourished individuals are more susceptible to infections and related complications. Interestingly, both acute and chronic infections adversely affect the nutritional status of individuals and can precipitate malnutrition. For example, in measles, an acute viral infection, severe deterioration of the nutritional status of children is observed due to acute inflammatory response, increased energy needs, and decreased intake of nutrients due to sore throat or oral lesions. The coexistence of malnutrition increases the severity of measles infection, susceptibility to secondary infections, and mortality rate. Measles is also associated with vitamin A deficiency, which can lead to xerosis, keratomalacia, and corneal ulceration, contributing to ophthalmological complications. [28]  Chronic infections, such as tuberculosis (TB) and human immunodeficiency virus (HIV) infection, are associated with anorexia and cachexia. The underlying proinflammatory cytokine response and metabolic alterations are mainly responsible for this. [29]  Other factors, like the adverse effects of drugs, can also contribute to this, thus aggravating malnutrition. Malnutrition, on the other hand, increases the severity of the infection, leading to a bidirectional relationship between infection and malnutrition. Parasitic infestations also severely affect the nutritional status of individuals. [30]  For example, intestinal parasite infestation, such as ascariasis, leads to a deficiency of macronutrients and micronutrients.
• Medical and surgical illnesses: Various medical and surgical illnesses affect the nutritional status of individuals through multiple mechanisms and may lead to malnutrition. An important mechanism that leads to malnutrition in patients with systemic disorders is the underlying inflammatory response. Many conditions like cardiovascular diseases, chronic obstructive pulmonary disorders, rheumatoid arthritis, chronic pancreatitis, neuromuscular disorders, etc., have some underlying chronic inflammatory response, which leads to an altered metabolic state. Another mechanism that could lead to nutritional disturbances is malabsorption. Many gastrointestinal pathologies such as inflammatory bowel disease, pernicious anemia, celiac disease, gastrointestinal obstruction, pancreatitis, and liver cirrhosis can lead to malnutrition through this mechanism. Malabsorption can also occur because of conditions affecting other organ systems. For example, right-sided congestive cardiac failure may be associated with intestinal edema, resulting in malabsorption and malnutrition in these patients. The next mechanism is metabolic disturbances observed in conditions characterized by dysfunction of the liver, gallbladder, and pancreas and endocrine disorders like diabetes mellitus, Cushing syndrome, and hyperthyroidism. Malnutrition also occurs due to decreased nutrient intake or loss of nutrients. Poor intake of nutrients can be seen in local pathologies affecting ingestion of food, as well as diseases that have dementia as one of the clinical features, such as Parkinson and Alzheimer diseases. [31]  Recurrent nausea or vomiting, which leads to either decrease in the nutrient intake or loss of nutrients, can be seen in gastrointestinal pathologies, cyclic vomiting syndrome, brain tumors, Meniere disease, allergies, migraines, and motion sickness. Similarly, conditions characterized by recurrent diarrhea or steatorrhea can also be associated with malnutrition due to loss of nutrients. Mental illnesses (also discussed in psychosocial factors) affect nutritional status too. The mental status of these patients, adverse reactions to prescription drugs, loss of appetite as part of the disease process, etc., can all lead to malnutrition in these individuals. [32]
• Surgery: Malnutrition before surgery can increase the risk of complications, including increased need for ICU admission, longer recovery time, infections, and higher rates of morbidity and mortality. Hence, a nutritional assessment before surgery is crucial. Surgery alone can be a risk factor for malnutrition due to various factors, such as pre- and post-operative fasting, hypermetabolism, adverse effects due to drugs, pain, and other factors specific to the type of surgery. [33] [34] [33]
• Trauma: Severe trauma cases, including head injuries, burns, and multiple fractures, can put patients at high risk of malnutrition. The initial acute inflammatory response and increased energy needs following trauma lead to a hypermetabolic phase. [35]  This, followed by a prolonged period of immobility, leads to muscle atrophy and protein breakdown, causing additional metabolic disturbances. The severe condition of these patients also affects food intake. Altogether, these factors often lead to malnutrition. Furthermore, malnutrition can adversely affect the recovery phase and increase the risk of complications, thus worsening clinical outcomes. [36]
• Malignancies: Malnutrition in malignancies is multi-factorial. Inflammatory mediators, increased energy needs, adverse effects of drugs/therapy (like mouth ulceration, nausea, and vomiting), mental stress, anxiety, and depression can lead to deterioration of nutritional status. Furthermore, malnutrition can inhibit the effectiveness of therapy and worsen the prognosis of the disease. [37]
• Medications: Adverse effects of various drugs, such as nausea, gastric irritation, or loss of appetite, can contribute to decreased food/nutrient intake. Commonly taken over-the-counter (OTC) drugs, such as NSAIDs, can lead to gastrointestinal irritation. Similarly, iron tablets can also cause gastrointestinal irritation and constipation as side effects. Some medications can lead to specific deficiencies, such as the drug isoniazid, which can lead to vitamin B6 (pyridoxine) deficiency. Hence, detailed drug-related history is needed as some drugs can cause drug-nutrient interactions.

Psychosocial factors:  Often, the above-mentioned physiological and pathological factors may coexist with psychosocial elements, resulting in further deterioration of nutritional status and eventually leading to malnutrition.

• Factors such as socioeconomic conditions, natural and man-made calamities, cultural norms, religious beliefs, etc., can affect nutritional intake. Undernutrition is the major concern in impoverished areas, famine-stricken, war zones, or refugee camps. Though it may seem obvious that overnutrition is mainly observed in affluent groups due to access to resources, the relationship between obesity and socioeconomic status is complicated. While undernutrition is one of the outcomes of lower socioeconomic status, paradoxically, individuals from these groups are also susceptible to developing obesity. This is due to limited access to fresh, nutrient-dense, and relatively more expensive food on the one hand and easy availability of less expensive, energy-dense food on the other hand. Malnutrition with dual manifestation may especially be seen in these groups of individuals.
• Other factors such as eating disorders, mental illnesses, and unhealthy diet trends can also drastically affect nutritional status and increase the risk of malnutrition.
• Alcohol and substance use are other major factors that need to be considered. Excessive alcohol consumption affects macronutrient and micronutrient metabolism, leading to nutritional deficiencies. [38]  Excessive alcohol consumption is associated with multi-organ tissue injury, which leads to inflammation. Alcohol consumption can also affect fluid balance. Furthermore, patients' food habits with chronic alcohol use disorder may further contribute to malnutrition. Similarly, illicit drugs affect the metabolism of nutrients as well. Substance use also affects patients' food habits and emotional and mental status, potentially contributing to malnutrition.
• Clinical Significance

Imbalanced nutritional status adversely affects the health and wellness of individuals. By evaluating the nutritional status of individuals early on, nutritional screening and assessment allow for timely intervention and thus help maintain the health and wellness of individuals and improve quality of life. Timely interventions, especially in specific groups of individuals, such as infants, growing children, pregnant and lactating mothers, etc., help prevent long-term complications.

Nutritional assessment and intervention together break the vicious cycle between malnutrition and various diseases or conditions, in which malnutrition aggravates a disease/condition, and the disease/condition, in turn, precipitates malnutrition. Breaking this cycle helps in improving clinical outcomes. Nutritional and clinical management based on comprehensive nutritional assessment results in positive healthcare outcomes by reducing the recovery period, hospital length of stay, risk of complications, susceptibility to infections, and mortality associated with clinical and surgical illnesses. The use of standardized, systematic nutrition risk screening and assessment in the clinical setting also helps in reducing overall healthcare costs.

• Enhancing Healthcare Team Outcomes

Malnutrition adversely affects the health status of individuals, clinical outcomes, and overall healthcare costs. Since malnutrition is a public health concern, it should be addressed accordingly. To prevent this condition, efforts should be made at multiple system levels (public health, community, and individual). Establishing sustainable food systems, educating individuals about healthy diets and lifestyles, maintaining governmental and local food assistance programs, and arranging nutritional screening programs at schools, housing shelters, nursing facilities, and retirement homes, are just a few ways to improve nutritional status and reduce the burden of malnutrition on the healthcare system.

From a clinical standpoint, a systematic team-based nutritional evaluation helps detect malnutrition or factors causing it early, which allows for early intervention and better clinical outcomes. This requires the involvement of physicians (generalists and specialty care physicians), nurses, dietitians, nutrition specialists/technicians, pharmacists, dentists, and laboratory personnel. The primary attending physician is responsible for overall patient care. Since nutritional status is an important predictor of healthcare outcomes, the primary attending physician’s involvement in nutritional assessment and intervention is critical. 

Nutrition specialists/technicians and dietitians also play vital roles in nutritional assessment. For example, dietetic technicians, registered (DTRs) are qualified to assist with general nutrition screenings and may also assist dietitians and other members of the healthcare team with identifying patients at risk for malnutrition in the clinical setting. Clinical dietitians or RDNs are trained to perform medical nutrition therapy (MNT) using the Nutrition Care Process (NCP), which includes nutrition assessment as the first step in identifying potential nutrition problems in patients, such as the risk factors of malnutrition mentioned throughout this article. Many of the components of nutritional assessment in the NCP are synonymous with those mentioned above.

The five domains of nutrition assessment outlined in the NCP include 1) food or nutrition-related history, 2) biochemical data, medical tests, and procedures, 3) anthropometric measurements, 4) nutrition-focused physical findings, and 5) client history. [39]  By being involved in the diagnostic process and contributing to the planning and monitoring of steps of the intervention, nutrition specialists/technicians and dietitians help enhance overall healthcare outcomes.

Nurses also help with early nutritional screening to identify nutrition risk factors and monitor the patient's condition to maintain timely documentation records of clinical status. Pharmacists may also provide information about potential drug side effects or conditions that may impact the risk of malnutrition. They may also provide suggestions to help prevent drug-nutrient interactions that could influence a patient's nutrition status (i.e., antiepileptic drugs and potential impact on vitamin D levels).

Dental professionals can also play a unique role in identifying malnutrition risk factors in patients. For example, a child or adult with multiple dental caries and poor dentition will likely be at higher risk for malnutrition due to limitations with oral intake; a dental professional can assist with alleviating these concerns, thus promoting better overall nutrition. Consultations with specialty physicians may be required not only for the management of underlying conditions but also for the improvement of the nutritional status of patients. Other healthcare team members' services and expert opinions are also essential based on a patient's clinical presentation.

Overall, effective collaboration between each healthcare team member is essential to provide a thorough, comprehensive nutritional assessment. While each collaborating member may not function within the same healthcare system, modern technology and dynamic electronic medical records allow clinicians to communicate remotely to provide better overall care, which can manifest into more detailed nutritional assessment data collection and utilization.

As this article highlights, there are many different components of nutritional assessment, and it would be an overwhelming task for one member of the healthcare team to assume responsibility for performing all of these components alone. Therefore, it is to the benefit of the physicians, nursing staff, and allied health professionals to coordinate the facilitation of obtaining appropriate nutrition assessment data that can be used to enhance healthcare outcomes for patients' health and safety.

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Disclosure: Aditi Kesari declares no relevant financial relationships with ineligible companies.

Disclosure: Julia Noel declares no relevant financial relationships with ineligible companies.

This book is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ), which permits others to distribute the work, provided that the article is not altered or used commercially. You are not required to obtain permission to distribute this article, provided that you credit the author and journal.

• Cite this Page Kesari A, Noel JY. Nutritional Assessment. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

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Jarace Walker getting more chances for Indiana Pacers as feel for the game improves

Walker has been much better of late

• Author: Tony East

INDIANAPOLIS — After being out of the Indiana Pacers rotation for much of the season, rookie forward Jarace Walker has played in 12 of his team's past 17 games. And while at first he was needed due to injuries, Walker is now earning rotation minutes for the blue and gold.

The 20-year old was unproven early in the season. He would gamble often on defense, which left him out of position. Walker couldn't quite keep up with the speed of the game. His reads were too slow, so it was hard to involve him in actions on either end of the floor.

That is usually how things go for a first-year player in the NBA. Their first few appearances are full of ups and downs. Walker is growing past that. The eighth overall pick in the 2023 draft has been much more effective in his recent outings, and it is clear that he has made progress throughout the season.

"He gets better all the time," Pacers head coach Rick Carlisle said of Walker during his team's recent road trip. "More physical. Better understanding of leverage. More solid defensively. Learning what we need from him offensively. Just working at the adjustments."

Walker started to get more opportunities as injuries piled up. In late February, both Aaron Nesmith and Doug McDermott were sidelined for the blue and gold. Walker grabbed spot minutes during that stretch, including 26:41 of playing time in New Orleans on March 1.

Nesmith returned around that time, but then the Pacers lost reserve ball handler Bennedict Mathurin for the season. The team still needed Walker to play, and sometimes play often. He was going to be in the rotation a few times.

Some nights, it looked rocky. In Orlando earlier this month, for example, the Houston product played for just three minutes in a win. In other games, though, Walker added a ton of value. He defended DeMar DeRozan when Indiana hosted Chicago earlier this month, and he was solid when the Minnesota Timberwolves came to Indianapolis a few days prior.

Walker acknowledged after that outing against the Bulls that his confidence level has risen. Between playing more often and having more important assignments, it's clear that Indiana trusts him to contribute in ways that they didn't earlier in the season, and Walker is more self-assured with those roles.

"The confidence comes from the work you put in every single day," Walker said that night. He had 10 points and four rebounds, and the Pacers outscored the Bulls by 14 in his minutes. He frequently was given the assignment of containing DeRozan, something that wouldn't have been an option in the first few months of this campaign.

"If I was guarding DeMar early in the season, I probably would have fouled out," the rookie said after the game. He can feel his progress.

Walker played for almost 10 minutes in the Pacers next game when they hosted the Brooklyn Nets, and his opportunities continued as the blue and gold embarked on a road trip over the past week. The five-game, eight-day trek was going to be taxing. Reserves were going to play and be relied on during that stretch.

That became even more true on Monday when Nesmith was dealing with a knee injury and missed Indiana's tilt with the LA Clippers. It was the second night of a back-to-back for the Pacers. Walker was going to be needed on the wing, and often.

He was up for the task. The Baltimore native played for 29:23, a career high in minutes. He defended star players like Kawhi Leonard and Paul George without making too many mistakes. All of his shots went in — he finished with eight points on 3/3 shooting.

Walker also added four rebounds and a career-high seven assists. He was reading the game well, and the Pacers couldn't take him off the floor. He played the entire second quarter and started the second half after not opening the game for the team. Carlisle couldn't afford to get Walker off the floor and lose his effectiveness.

The 20-year old told AllPacers in Detroit that the game is finally slowing down for him. "For sure. I feel like early on, the game was a lot faster than I anticipated," He said. Now, with more minutes, he can feel what is going on more effectively.

Everything is easier when the game slows down, which Walker explained in more detail. "I think it's just like the literal speed. You can watch it, but I feel like until you're out there, the speed that players go at, the intensity that they go is a different level," he shared. He believes his offensive reads are better and his recognition of various patterns on the defensive end have improved. He doesn't have to think as much.

"I feel like the more time out there, I just kind of try to hoop, play my game," he said. The more the rookie plays, the more confident he feels, and Walker believes he has gained the trust of his teammates.

Since Mathurin's season-ending injury, Walker is averaging 3.5 points, 2.3 rebounds, and 1.3 assists per game. Those numbers aren't eye-popping, but they are improvements and are coming far more consistently. He's also been much better on the defensive end and is shooting 40% from deep in that stretch.

In a season full of ups and downs, Jarace Walker is finally turning a corner. During the Pacers last game — a road loss to the Chicago Bulls — Walker was in the playing rotation despite both McDermott and Nesmith being healthy. He had an off night, but that was the first time that substitution pattern happened all season.

"He's going to be a tremendous player for us," Carlisle said of Walker. The lottery pick is starting to show flashes of being that contributor.

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When James Carville criticized the “preachy females” at the forefront of Democratic politics, he kicked off a firestorm of outrage and perhaps a little introspection. Did “The Ragin’ Cajun” have a point, however impolitely made? Do Democrats have a problem with men? Especially Black men and other men of color? Jamil Smith is an award-winning writer and the new editor-in-chief of The Emancipator , a nonprofit newsroom run by the Center for Antiracist Research at Boston University, co-founded by Dr. Ibram X. Kendi.

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Crisis (IPC Phase 3) outcomes expected in deficit-producing areas in the post-harvest period

• Key Message Update

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• Key Messages
• Following the premature cessation of the rainy season around mid-January, significantly below-normal to failed harvests, high food and other commodity prices, and constrained access to markets are expected to continue to drive area-level Crisis (IPC Phase 3) outcomes in deficit-producing areas into the post-harvest period. An increase in the number of households facing Stressed (IPC Phase 2) outcomes is also likely in typical surplus-producing areas in the north. Additionally, the ongoing macroeconomic issues are expected to further compound the impact of the poor harvests across the country through the post-harvest period as households largely remain dependent on market purchases for food. 
• The  historically dry conditions since mid-January and very high temperatures continue to reduce potential crop yields further as crops permanently wilt or face  increased water stress across the country. Rainfall received through the remainder of the typical rainy season is unlikely to support the recovery of crops in most areas. Water and pasture conditions are also deteriorating in most areas, especially in typical semi-arid areas, with urban areas like Bulawayo experiencing critical water supplies. Many farmers in typical semi-arid areas are increasingly destocking their livestock, especially cattle, in response to poor water and pasture availability, constrained access to supplementary feeds, and deteriorating livestock body conditions. This has caused significant cattle price reductions, with most buyers offering less than 50 percent of normal prices for this time of the year, depriving farmers of potential income.  
• The local currency further depreciated in March, with formal exchange rates increasing by nearly 50 percent and parallel market rates by 40-70 percent to 22,055 ZWL and 26,000-32,000 ZWL to the USD by March 28, respectively, compared to the end of February 2024. The rapid depreciation is driving further increases in ZWL prices of goods and services, which are now increasingly too expensive for low-income and other households earning in ZWL. In March, ZIMSTAT reported an over 60 percent increase in the ZWL cost of living, with the blended USD-ZWL annual inflation rate rising to 55.3 percent in March. Most poor households engaged in petty trade, casual labor, self-employment, and other income-earning activities are earning in USD, but overall USD household income remains low. Similarly, most typical and seasonal agricultural and non-agricultural labor opportunities and other income sources remain below normal.
• Staple grain prices are higher than normal as demand and staple grain scarcity on the open market increases. In March, maize grain prices remained significantly above normal and continued to increase in some areas, ranging between 8 to 12 USD compared to 5 to 8 USD in a normal season. The government has increased the buying price for maize grain harvested in 2023 to 390 USD/MT from 335 USD/MT to attract farmers still holding onto surplus grain to sell. However, the maize grain producer price for the upcoming harvest has been set at 360 USD/MT. Maize meal prices for ZWL and USD also remain above normal, ranging between 5.5 to 8 USD per 10 kg bag compared to 4.5 to 6 USD last year. In mid-March, the government announced the removal, effective July 2024, of import duties for rice (a substitute for maize and maize meal) and other products such as potato seed, cooking oil, and genetically modified maize for stock feed production as part of measures to enhance food availability and access. 
• The 2024 tobacco marketing season opened in mid-March and is expected to improve household access to income for tobacco farmers and other households. The average price of 3.34 USD/kg during the first seven days of the auction was about 13 percent higher than last year (2.95 USD/kg). However, the 2024 estimated 265 million kg tobacco harvest will be around 9 percent lower than last year due to the erratic and below-average rainfall. Almost 95 percent of tobacco is grown through contract farming, where the leaf-buying companies provide inputs and finances at the start of the season and then deduct the high cost of crop inputs and any services provided from the payment offered at the end of the season, keeping farmer earnings low. 

Recommended citation: FEWS NET. Zimbabwe Key Message Update March 2024: Crisis (IPC Phase 3) outcomes expected in deficit-producing areas in the post-harvest period, 2024.

This Key Message Update provides a high-level analysis of current acute food insecurity conditions and any changes to FEWS NET's latest projection of acute food insecurity outcomes in the specified geography. Learn more  here .

The information provided on this Website is not official U.S. Government information and does not represent the views or positions of the U.S. Agency for International Development or the U.S. Government.

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CS224S Assignment 1: Speech Systems and Phonetics

Spring 2024.

Time and Location

Mon. & Wed. 12:30 PM - 1:20 PM Pacific Time Jordan Hall room 040 (420-040)

Please read this entire handout before beginning. We advise you to start early and to make use of the TAs by coming to office hours and asking questions! For collaboration and the late day policy, please refer to the home page.

About the Assignment

In this assignment you will become familiar with some easily available spoken language processing systems and perform some basic analysis and manipulation of speech audio. The goal of this assignment is to familiarize yourself with some of the basic tools/libraries available and get you thinking about challenges in building spoken language systems.

Submission Instructions

This assignment is due on 04/15/2024 by 11:59PM pacific (or at latest on 04/18/2024 with three late days) and has three parts. For parts 1-2, you should submit a PDF to Gradescope and mark in the PDF which page corresponds to which question . For part 3, you will submit your filled-in/executed Colab Notebook with all code/output.

You will submit your materials for parts 1-2 and part 3 to Gradescope. Please tag your question responses.

Part 1: Speech APIs and Personal Assistants

For the first part of your assignment, you will be investigating the performance of popular speech transcription and personal assistant services. Your task will be to interact with three different speech systems, document your results, and describe the types of failures or issues you discover in the writeup.

Speech Transcription (10 points)

First, compose some short (2-4 sentence) emails or text messages using the speech input button on your mobile keyboard (usually in the email or messaging app). Try your best to limit yourself to “everyday” sentences and “optimal” conditions (no obscure vocabulary, low background noise, etc) to gauge how well the system could work at its best. Try composing messages that include different domain-specific words (e.g. machine learning jargon) or proper nouns (e.g. restaurant or actor names) to challenge the system.

• Paste the results for one message in your writeup including any errors the system generated.
• What is the rough number of errors per word in your results? We can count an error as anything you would manually correct before sending the message/email.
• Describe how the system handles punctuation. Does it guess, insert no punctuation, or allow punctuation commands?
• Try composing a message where you correct yourself (e.g. “I’m leaving at five – delete that I meant 6”). Include the resulting text and comment on how the system handles attempts to edit the utterance and to quickly correct partial words.
• Try to break the system . For instance, speak in a different pitch, volume, or distance to the microphone. Try talking with background noises. If you know a different language, try speaking in that language. Show 2 example utterances and describe what types of errors the system makes, along with what you did to cause those errors. Can you consistently produce different types of errors using different approaches to break the system?

Personal Assistants (10 points)

Use Siri, Google Assistant, Amazon Alexa or any kind of similar speech-based personal assistant. In this section, you will try to perform a few goal-oriented interactions and describe how the system handles your requests. For each of the below, include a description or screenshot of the interaction. Depending on what system you are using, try to describe the interaction or include a screenshot if possible (not necessary to provide a verbatim description)

• Ask some factual questions about a favorite book, show/movie, sports team. Is the system accurate in its responses? How does the system handle follow-on questions? (e.g. “Who wrote The Great Gatsby? … When was that book published?”)
• Pretend you are searching for a restaurant for take-out food today. Try to explore possible restaurants, learn about their ratings/food, and start an order if possible. How many turns did you take in this interaction (a turn in dialog is each time you speak)? Were you able to explore new places and learn about them? Was the interaction completely speech-driven, or does your assistant prompt you to look at options visually?
• Create some calendar events that involve a meeting name and add details (location, attendees, or similar). If you offer a lengthy initial command, does the system add all the details you specify? If you start with a simple “make a calendar event” prompt, what questions does the system ask?
• Using any of the above themes, try an interaction where you “barge in” to edit or correct something (barging in is talking while the system is talking to you). Does the system allow for you to barge-in for corrections? Does it detect that you had something to add while it was speaking?
• Describe any types of error you found while completing the tasks above. When the system didn’t achieve the result you hoped, can you attribute issues to limited functionality (e.g. not allowing calendar events to have notes attached), issues with speech recognition, or knowledge of concepts in the world?

Part 2: Phonetic Transcription

In this section you will do some basic creation and editing of phonetic pronunciations.

ARPAbet Transcriptions (20 points)

• three [dh r i]
• sing [s ih n g]
• eyes [ay s]
• study [s t uh d i]
• though [th ow]
• planning [p pl aa n ih ng]
• slight [s l iy t]
• action [ae k t ah n]
• tangle [t ae ng g l]
• higher [hh ay g er]

Part 3: Audio analysis toolkits

Audio analysis notebook (70 points).

Complete the exercises described in the Colab notebook provided via Google Drive folder . Turn in a PDF of your fully executed Colab notebook, showing the plots you created. Remember to make a copy of the Colab notebook before you start working so changes will save!

Baltimore Port: What impact will bridge collapse have on shipping?

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Trapped vessels start moving out of Baltimore after bridge collapse

The Port of Baltimore opened a temporary channel on Monday, freeing some tugs and barges that had been trapped by last week's bridge collapse, but officials said wider restoration of commercial shipping remained frustrated by unyielding conditions.

Several people were injured in a drone attack on industrial sites in Russia's Tatarstan, local authorities said on Tuesday.