Explained: Article 12 of the Indian Constitution

Manshi Sinha

  • May 12, 2021

Article 12

In this article, the author has explained the meaning of Article 12 of the Constitution with the help of Judicial precedents.

Table of Contents

Introduction

The present article discusses in detail Article 12 of the Indian Constitution, which defines ‘State’. The definition of State provided under Article 12 is inclusive but not exhaustive and there are certain authorities and instrumentalities that though not clearly mentioned under the said article, can be brought within the purview of the definition of the state.

The fundamental rights guaranteed by the Indian Constitution have been laid down in Part III of the constitution, starting from Article 12 to Article 35 .

The first article under Part III is Article 12, which does not guarantee any right but specifies the authorities and the bodies, that are deemed to be “state” and against whom the fundamental rights can be enforced.

Article 12 states that the Central Government, the Parliament, State Government, and State Legislatures come within the definition of “state”. Apart from these, certain local authorities and other authorities are also said to be “state”.

The apex court of the country through its various landmark judgments has laid down the tests for determining whether a body would fall within the meaning of the term local authorities and other authorities and hence would be considered “state” or not.

It has also been laid down that judiciary in the exercise of its administrative functions can come under the definition of “state” but not in the exercise of its judicial function. All of these are discussed below in detail.

Article 12 states

“ In this Part, unless the context otherwise requires, “the state” includes the Government and Parliament of India and the Government and the Legislature of each of the States and all local or other authorities within the territory of India or under the control of the Government of India. “

The authorities that are expressly included within the definition of Article 12 are as follows:

  • Government and Parliament of India;
  • Government and Legislature of each of the States;

These legislative and executive wings of the Union and the States are expressly and specifically mentioned in the concerned article.

However, the other two categories i.e., “local authorities” and “other authorities” are not quite specific. The bodies that come under these two categories have been analyzed by the Supreme Court through its various judgments.

Local Authorities

The expression “local authorities” usually refers to authorities such as municipalities, District Boards, Panchayats, mining settlement boards, etc. Anybody functioning under the state; owned; controlled and managed by the “state” and carrying out a public function is a local authority and comes within the definition of the state.

The Supreme Court in the case of Union of India v. R.C. Jain laid down the test for determining which bodies would be considered as a local authority under the definition of state enshrined under Article 12 of the constitution. The issue in this case broadly was ‘Whether Delhi Development Authority (DDA) is a local authority or not?’ The Court held that if an authority:

  • Has a separate legal existence
  • Functions in a defined area
  • Has the power to raise funds on its own
  • Enjoys autonomy i.e., self rule and
  • Is entrusted by statute with functions which are usually entrusted to municipalities, then such authorities would come under ‘local authorities’ and hence would be ‘state’ under Article 12 of the Constitution.

Other Authorities

The term ‘other authorities’ under Article 12 encompasses those authorities that do not fall within the first three categories. ‘Other Authorities’ though not defined in the constitution has been widely interpreted through various judgments and now includes a number of authorities under it.

The Supreme Court in the case of Rajasthan Electricity Board v. Mohan Lal laid down the conclusive test for determining the bodies that would come under the ambit of ‘other authorities’. The court held that if an authority

  • has the power to issue directions and any offense against them is punishable by law
  • has the power to make rules that would have statutory effect
  • is an agency or instrumentality of state for carrying out trade or business which otherwise would have been carried out by the state departments, such authorities would come within the purview of ‘other authorities’ and hence would be considered ‘state’.

In the case of Sukhdev Singh v. Bhagatram , the question before the court was ‘whether ONGC (Oil and Natural Gas Corporation), LIC (Life Insurance Corporation of India) and IFC (International Finance Corporation) created by statutes would come under the purview of ‘state’ under Article 12.’

The court, in this case, followed the test laid down by the court in the case of Rajasthan Electricity Board and held these authorities to be ‘state’ as they came within the meaning of ‘other authorities’ under Article 12.

Another case, Sabhajit Tewary v. Union of India was decided by the same bench and on the same day on which Sukhdev Singh’s case was decided.

The question before the court, in this case, was whether the Council of Industrial and Scientific Research(CISR), which is registered under the Societies Registration Act, 1898 would come within the definition of ‘state’ under Article 12. The Supreme Court observed that a body would be ‘state’ if :

  • It is performing essential state function and
  • It is under the pervasive control of the Government.

The court held CISR not to be ‘state’ as per the above said requirement.

In the case of R.D.Shetty v. The International Airport Authority of India , a similar question was raised before the court that whether International Airport Authority is a state. The court through J.Bhagwati laid down the following test to determine whether a body is included within ‘other authorities’ and comes within the definition of ‘state’ :

  • The financial assistance given by the State and magnitude of such assistance;
  • If any usual or extraordinary assistance is provided by the State’;
  • Nature and extent of control of management and policies of the corporation by the state;
  • The state conferred or state protected monopoly status;
  • The function carried out by the corporation would ascertain whether the body is an instrumentality or agency of the state or not;
  • If one of the body is transferred to the government.

The above-said parameters broadly determine whether an authority is ‘other authority’ as per the definition of ‘state’ under Article 12. Considering these tests, International Airport Authority was held to be ‘state’.

Again, in the case of Ajay Hasia v. Khalid Mujib , a similar question arose before the court that whether a college that was established by a registered society would come under the definition of ‘state’ or not.

The court, in this case, approved the tests for determining ‘other authorities’ as laid down in the case of R.D.Shetty. The court further observed that

“T hese tests are not final or conclusive in nature. It must be noted that ‘other authorities’ cannot include every autonomous body which has some connection with the government and that ‘other authorities’ is also subject to certain wise limitations”.

The court further held that on considering the factors mentioned in the case of R.D.Shetty, if a corporation is an instrumentality or agency of the government, it must become within the meaning of ‘other authority’ and would be ‘state’.

The next case that came before the court on a similar issue was Pradeep Kumar Biswas v. the Indian Institute of Chemical Biology . The question before the court was whether CISR was an instrumentality of the state or comes within ‘other authorities’ under Article 12 or not.

It was held that there is no strict rule that every registered society having any connection with the government, to be declared as ‘state’. If any of the objective tests laid down in the case of Ajay Hasia is not fulfilled, then the check must be whether the body is functionally, financially, and administratively held by the government. If this condition is fulfilled, then also the body would come under ‘other authority’ and hence would be ‘state’ under Article 12.

The case of Pradeep Kumar Biswas acts as a precedent for all further cases related to the interpretation of ‘other authorities’.

Further, in the case of Zee Telefilms v. Union of India, when the issue came before the court whether BCCI is a state or not, the court again applied the tests laid down in Ajay Hasia and Pradeep Kumar’s case and held BCCI, not a state.

It must be noted that Article 12 of the Constitution does not specifically talk about Judiciary. The answer to the question of whether the judiciary is a state or not is discussed below in detail.

Whether Judiciary is a state or not ?

Judiciary, though an organ of the state, is not specifically mentioned in Article 12, unlike the executive and the legislature. Whether the judiciary comes under the definition of ‘state’ or not depends on the type of function carried out by the courts.

In the exercise of non-judicial functions such as administrative or legislative, the courts fall within the definition of ‘state’. However, in the exercise of judicial functions, the courts cannot be brought within the definition of the state.

In the case of Naresh Sridhar Mirajkar v. the State of Maharashtra , the issue before the court was whether a judicial order could be in violation of fundamental rights and if such judicial order amenable to writ?

The court, in this case, held that

“ It is inappropriate to assume that a judicial decision pronounced by a court of competent jurisdiction can affect the fundamental rights of the citizens. What the judicial decisions purports to do is to decide the controversy between the parties brought before the court and nothing more.”

Therefore, the judiciary for discharge of its judicial functions cannot come under the definition of ‘state’ and is not amenable to the writ.

Further, in A.R.Antulay v. R.S.Naik , the court held that

“ If incidentally or indirectly, the judicial order of a competent court affects the fundamental rights of a person, then the remedy against such a mistake is not to allege a violation of the fundamental  rights and approach the courts under Article 32 or 226, but to allege that the decision of the court is not consistent with the fundamental rights and approach the appropriate court with such allegations in appeal or review.”

Considering these factors,court held that judiciary in exercise of its judicial functions does not come within the definition of ‘state’ under Article 12.

In the case of Riju Prasad Sarma v. State of Assam , it was held by the Supreme Court that when a court is acting in its judicial capacity, it cannot be considered as ‘state’. However, its administrative action is amenable to writ.

As per the interpretation of Article 12 by the apex court of the country, it can be concluded that Article 12 though inclusive is not exhaustive. Apart from the executive and the legislative organs of the state, it also includes certain authorities, which fulfills the condition of ‘local authorities’ and ‘other authorities’ within the definition of the state.

The scope of ‘other authorities’ has witnessed a drastic change. Judiciary has time and again tried to include more and more bodies within the definition of state so that maximum people can enforce their fundamental rights. Further, it has been held that the judiciary in the exercise of its judicial functions is not a state.

However, the judiciary is stated with respect to its administrative functions, and writs for enforcement of fundamental rights can be filed if the action of the judiciary is in contravention of it.

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How To Write A Research Paper

Step-By-Step Tutorial With Examples + FREE Template

By: Derek Jansen (MBA) | Expert Reviewer: Dr Eunice Rautenbach | March 2024

For many students, crafting a strong research paper from scratch can feel like a daunting task – and rightly so! In this post, we’ll unpack what a research paper is, what it needs to do , and how to write one – in three easy steps. 🙂 

Overview: Writing A Research Paper

What (exactly) is a research paper.

  • How to write a research paper
  • Stage 1 : Topic & literature search
  • Stage 2 : Structure & outline
  • Stage 3 : Iterative writing
  • Key takeaways

Let’s start by asking the most important question, “ What is a research paper? ”.

Simply put, a research paper is a scholarly written work where the writer (that’s you!) answers a specific question (this is called a research question ) through evidence-based arguments . Evidence-based is the keyword here. In other words, a research paper is different from an essay or other writing assignments that draw from the writer’s personal opinions or experiences. With a research paper, it’s all about building your arguments based on evidence (we’ll talk more about that evidence a little later).

Now, it’s worth noting that there are many different types of research papers , including analytical papers (the type I just described), argumentative papers, and interpretative papers. Here, we’ll focus on analytical papers , as these are some of the most common – but if you’re keen to learn about other types of research papers, be sure to check out the rest of the blog .

With that basic foundation laid, let’s get down to business and look at how to write a research paper .

Research Paper Template

Overview: The 3-Stage Process

While there are, of course, many potential approaches you can take to write a research paper, there are typically three stages to the writing process. So, in this tutorial, we’ll present a straightforward three-step process that we use when working with students at Grad Coach.

These three steps are:

  • Finding a research topic and reviewing the existing literature
  • Developing a provisional structure and outline for your paper, and
  • Writing up your initial draft and then refining it iteratively

Let’s dig into each of these.

Need a helping hand?

research paper on article 12

Step 1: Find a topic and review the literature

As we mentioned earlier, in a research paper, you, as the researcher, will try to answer a question . More specifically, that’s called a research question , and it sets the direction of your entire paper. What’s important to understand though is that you’ll need to answer that research question with the help of high-quality sources – for example, journal articles, government reports, case studies, and so on. We’ll circle back to this in a minute.

The first stage of the research process is deciding on what your research question will be and then reviewing the existing literature (in other words, past studies and papers) to see what they say about that specific research question. In some cases, your professor may provide you with a predetermined research question (or set of questions). However, in many cases, you’ll need to find your own research question within a certain topic area.

Finding a strong research question hinges on identifying a meaningful research gap – in other words, an area that’s lacking in existing research. There’s a lot to unpack here, so if you wanna learn more, check out the plain-language explainer video below.

Once you’ve figured out which question (or questions) you’ll attempt to answer in your research paper, you’ll need to do a deep dive into the existing literature – this is called a “ literature search ”. Again, there are many ways to go about this, but your most likely starting point will be Google Scholar .

If you’re new to Google Scholar, think of it as Google for the academic world. You can start by simply entering a few different keywords that are relevant to your research question and it will then present a host of articles for you to review. What you want to pay close attention to here is the number of citations for each paper – the more citations a paper has, the more credible it is (generally speaking – there are some exceptions, of course).

how to use google scholar

Ideally, what you’re looking for are well-cited papers that are highly relevant to your topic. That said, keep in mind that citations are a cumulative metric , so older papers will often have more citations than newer papers – just because they’ve been around for longer. So, don’t fixate on this metric in isolation – relevance and recency are also very important.

Beyond Google Scholar, you’ll also definitely want to check out academic databases and aggregators such as Science Direct, PubMed, JStor and so on. These will often overlap with the results that you find in Google Scholar, but they can also reveal some hidden gems – so, be sure to check them out.

Once you’ve worked your way through all the literature, you’ll want to catalogue all this information in some sort of spreadsheet so that you can easily recall who said what, when and within what context. If you’d like, we’ve got a free literature spreadsheet that helps you do exactly that.

Don’t fixate on an article’s citation count in isolation - relevance (to your research question) and recency are also very important.

Step 2: Develop a structure and outline

With your research question pinned down and your literature digested and catalogued, it’s time to move on to planning your actual research paper .

It might sound obvious, but it’s really important to have some sort of rough outline in place before you start writing your paper. So often, we see students eagerly rushing into the writing phase, only to land up with a disjointed research paper that rambles on in multiple

Now, the secret here is to not get caught up in the fine details . Realistically, all you need at this stage is a bullet-point list that describes (in broad strokes) what you’ll discuss and in what order. It’s also useful to remember that you’re not glued to this outline – in all likelihood, you’ll chop and change some sections once you start writing, and that’s perfectly okay. What’s important is that you have some sort of roadmap in place from the start.

You need to have a rough outline in place before you start writing your paper - or you’ll end up with a disjointed research paper that rambles on.

At this stage you might be wondering, “ But how should I structure my research paper? ”. Well, there’s no one-size-fits-all solution here, but in general, a research paper will consist of a few relatively standardised components:

  • Introduction
  • Literature review
  • Methodology

Let’s take a look at each of these.

First up is the introduction section . As the name suggests, the purpose of the introduction is to set the scene for your research paper. There are usually (at least) four ingredients that go into this section – these are the background to the topic, the research problem and resultant research question , and the justification or rationale. If you’re interested, the video below unpacks the introduction section in more detail. 

The next section of your research paper will typically be your literature review . Remember all that literature you worked through earlier? Well, this is where you’ll present your interpretation of all that content . You’ll do this by writing about recent trends, developments, and arguments within the literature – but more specifically, those that are relevant to your research question . The literature review can oftentimes seem a little daunting, even to seasoned researchers, so be sure to check out our extensive collection of literature review content here .

With the introduction and lit review out of the way, the next section of your paper is the research methodology . In a nutshell, the methodology section should describe to your reader what you did (beyond just reviewing the existing literature) to answer your research question. For example, what data did you collect, how did you collect that data, how did you analyse that data and so on? For each choice, you’ll also need to justify why you chose to do it that way, and what the strengths and weaknesses of your approach were.

Now, it’s worth mentioning that for some research papers, this aspect of the project may be a lot simpler . For example, you may only need to draw on secondary sources (in other words, existing data sets). In some cases, you may just be asked to draw your conclusions from the literature search itself (in other words, there may be no data analysis at all). But, if you are required to collect and analyse data, you’ll need to pay a lot of attention to the methodology section. The video below provides an example of what the methodology section might look like.

By this stage of your paper, you will have explained what your research question is, what the existing literature has to say about that question, and how you analysed additional data to try to answer your question. So, the natural next step is to present your analysis of that data . This section is usually called the “results” or “analysis” section and this is where you’ll showcase your findings.

Depending on your school’s requirements, you may need to present and interpret the data in one section – or you might split the presentation and the interpretation into two sections. In the latter case, your “results” section will just describe the data, and the “discussion” is where you’ll interpret that data and explicitly link your analysis back to your research question. If you’re not sure which approach to take, check in with your professor or take a look at past papers to see what the norms are for your programme.

Alright – once you’ve presented and discussed your results, it’s time to wrap it up . This usually takes the form of the “ conclusion ” section. In the conclusion, you’ll need to highlight the key takeaways from your study and close the loop by explicitly answering your research question. Again, the exact requirements here will vary depending on your programme (and you may not even need a conclusion section at all) – so be sure to check with your professor if you’re unsure.

Step 3: Write and refine

Finally, it’s time to get writing. All too often though, students hit a brick wall right about here… So, how do you avoid this happening to you?

Well, there’s a lot to be said when it comes to writing a research paper (or any sort of academic piece), but we’ll share three practical tips to help you get started.

First and foremost , it’s essential to approach your writing as an iterative process. In other words, you need to start with a really messy first draft and then polish it over multiple rounds of editing. Don’t waste your time trying to write a perfect research paper in one go. Instead, take the pressure off yourself by adopting an iterative approach.

Secondly , it’s important to always lean towards critical writing , rather than descriptive writing. What does this mean? Well, at the simplest level, descriptive writing focuses on the “ what ”, while critical writing digs into the “ so what ” – in other words, the implications . If you’re not familiar with these two types of writing, don’t worry! You can find a plain-language explanation here.

Last but not least, you’ll need to get your referencing right. Specifically, you’ll need to provide credible, correctly formatted citations for the statements you make. We see students making referencing mistakes all the time and it costs them dearly. The good news is that you can easily avoid this by using a simple reference manager . If you don’t have one, check out our video about Mendeley, an easy (and free) reference management tool that you can start using today.

Recap: Key Takeaways

We’ve covered a lot of ground here. To recap, the three steps to writing a high-quality research paper are:

  • To choose a research question and review the literature
  • To plan your paper structure and draft an outline
  • To take an iterative approach to writing, focusing on critical writing and strong referencing

Remember, this is just a b ig-picture overview of the research paper development process and there’s a lot more nuance to unpack. So, be sure to grab a copy of our free research paper template to learn more about how to write a research paper.

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How to Write a Research Paper

Last Updated: February 18, 2024 Fact Checked

This article was co-authored by Chris Hadley, PhD . Chris Hadley, PhD is part of the wikiHow team and works on content strategy and data and analytics. Chris Hadley earned his PhD in Cognitive Psychology from UCLA in 2006. Chris' academic research has been published in numerous scientific journals. There are 14 references cited in this article, which can be found at the bottom of the page. This article has been fact-checked, ensuring the accuracy of any cited facts and confirming the authority of its sources. This article has been viewed 4,187,186 times.

Whether you’re in a history, literature, or science class, you’ll probably have to write a research paper at some point. It may seem daunting when you’re just starting out, but staying organized and budgeting your time can make the process a breeze. Research your topic, find reliable sources, and come up with a working thesis. Then create an outline and start drafting your paper. Be sure to leave plenty of time to make revisions, as editing is essential if you want to hand in your best work!

Sample Research Papers and Outlines

research paper on article 12

Researching Your Topic

Step 1 Focus your research on a narrow topic.

  • For instance, you might start with a general subject, like British decorative arts. Then, as you read, you home in on transferware and pottery. Ultimately, you focus on 1 potter in the 1780s who invented a way to mass-produce patterned tableware.

Tip: If you need to analyze a piece of literature, your task is to pull the work apart into literary elements and explain how the author uses those parts to make their point.

Step 2 Search for credible sources online and at a library.

  • Authoritative, credible sources include scholarly articles (especially those other authors reference), government websites, scientific studies, and reputable news bureaus. Additionally, check your sources' dates, and make sure the information you gather is up to date.
  • Evaluate how other scholars have approached your topic. Identify authoritative sources or works that are accepted as the most important accounts of the subject matter. Additionally, look for debates among scholars, and ask yourself who presents the strongest evidence for their case. [3] X Trustworthy Source Purdue Online Writing Lab Trusted resource for writing and citation guidelines Go to source
  • You’ll most likely need to include a bibliography or works cited page, so keep your sources organized. List your sources, format them according to your assigned style guide (such as MLA or Chicago ), and write 2 or 3 summary sentences below each one. [4] X Research source

Step 3 Come up with a preliminary thesis.

  • Imagine you’re a lawyer in a trial and are presenting a case to a jury. Think of your readers as the jurors; your opening statement is your thesis and you’ll present evidence to the jury to make your case.
  • A thesis should be specific rather than vague, such as: “Josiah Spode’s improved formula for bone china enabled the mass production of transfer-printed wares, which expanded the global market for British pottery.”

Drafting Your Essay

Step 1 Create an outline

  • Your outline is your paper’s skeleton. After making the outline, all you’ll need to do is fill in the details.
  • For easy reference, include your sources where they fit into your outline, like this: III. Spode vs. Wedgewood on Mass Production A. Spode: Perfected chemical formula with aims for fast production and distribution (Travis, 2002, 43) B. Wedgewood: Courted high-priced luxury market; lower emphasis on mass production (Himmelweit, 2001, 71) C. Therefore: Wedgewood, unlike Spode, delayed the expansion of the pottery market.

Step 2 Present your thesis...

  • For instance, your opening line could be, “Overlooked in the present, manufacturers of British pottery in the eighteenth and nineteenth centuries played crucial roles in England’s Industrial Revolution.”
  • After presenting your thesis, lay out your evidence, like this: “An examination of Spode’s innovative production and distribution techniques will demonstrate the importance of his contributions to the industry and Industrial Revolution at large.”

Tip: Some people prefer to write the introduction first and use it to structure the rest of the paper. However, others like to write the body, then fill in the introduction. Do whichever seems natural to you. If you write the intro first, keep in mind you can tweak it later to reflect your finished paper’s layout.

Step 3 Build your argument in the body paragraphs.

  • After setting the context, you'd include a section on Josiah Spode’s company and what he did to make pottery easier to manufacture and distribute.
  • Next, discuss how targeting middle class consumers increased demand and expanded the pottery industry globally.
  • Then, you could explain how Spode differed from competitors like Wedgewood, who continued to court aristocratic consumers instead of expanding the market to the middle class.
  • The right number of sections or paragraphs depends on your assignment. In general, shoot for 3 to 5, but check your prompt for your assigned length.

Step 4 Address a counterargument to strengthen your case.

  • If you bring up a counterargument, make sure it’s a strong claim that’s worth entertaining instead of ones that's weak and easily dismissed.
  • Suppose, for instance, you’re arguing for the benefits of adding fluoride to toothpaste and city water. You could bring up a study that suggested fluoride produced harmful health effects, then explain how its testing methods were flawed.

Step 5 Summarize your argument...

  • Sum up your argument, but don’t simply rewrite your introduction using slightly different wording. To make your conclusion more memorable, you could also connect your thesis to a broader topic or theme to make it more relatable to your reader.
  • For example, if you’ve discussed the role of nationalism in World War I, you could conclude by mentioning nationalism’s reemergence in contemporary foreign affairs.

Revising Your Paper

Step 1 Ensure your paper...

  • This is also a great opportunity to make sure your paper fulfills the parameters of the assignment and answers the prompt!
  • It’s a good idea to put your essay aside for a few hours (or overnight, if you have time). That way, you can start editing it with fresh eyes.

Tip: Try to give yourself at least 2 or 3 days to revise your paper. It may be tempting to simply give your paper a quick read and use the spell-checker to make edits. However, revising your paper properly is more in-depth.

Step 2 Cut out unnecessary words and other fluff.

  • The passive voice, such as “The door was opened by me,” feels hesitant and wordy. On the other hand, the active voice, or “I opened the door,” feels strong and concise.
  • Each word in your paper should do a specific job. Try to avoid including extra words just to fill up blank space on a page or sound fancy.
  • For instance, “The author uses pathos to appeal to readers’ emotions” is better than “The author utilizes pathos to make an appeal to the emotional core of those who read the passage.”

Step 3 Proofread

  • Read your essay out loud to help ensure you catch every error. As you read, check for flow as well and, if necessary, tweak any spots that sound awkward. [13] X Trustworthy Source University of North Carolina Writing Center UNC's on-campus and online instructional service that provides assistance to students, faculty, and others during the writing process Go to source

Step 4 Ask a friend, relative, or teacher to read your work before you submit it.

  • It’s wise to get feedback from one person who’s familiar with your topic and another who’s not. The person who knows about the topic can help ensure you’ve nailed all the details. The person who’s unfamiliar with the topic can help make sure your writing is clear and easy to understand.

Community Q&A

Community Answer

  • Remember that your topic and thesis should be as specific as possible. Thanks Helpful 5 Not Helpful 0
  • Researching, outlining, drafting, and revising are all important steps, so do your best to budget your time wisely. Try to avoid waiting until the last minute to write your paper. Thanks Helpful 6 Not Helpful 2

research paper on article 12

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Get Started With a Research Project

  • ↑ https://writing.wisc.edu/handbook/assignments/planresearchpaper/
  • ↑ https://writingcenter.unc.edu/tips-and-tools/evaluating-print-sources/
  • ↑ https://owl.purdue.edu/owl/research_and_citation/conducting_research/research_overview/index.html
  • ↑ https://poorvucenter.yale.edu/writing/graduate-writing-lab/writing-through-graduate-school/working-sources
  • ↑ https://opentextbc.ca/writingforsuccess/chapter/chapter-5-putting-the-pieces-together-with-a-thesis-statement/
  • ↑ https://owl.purdue.edu/owl/general_writing/the_writing_process/developing_an_outline/index.html
  • ↑ https://writingcenter.unc.edu/tips-and-tools/introductions/
  • ↑ https://academicguides.waldenu.edu/writingcenter/writingprocess/counterarguments
  • ↑ https://writingcenter.fas.harvard.edu/pages/ending-essay-conclusions
  • ↑ https://writingcenter.unc.edu/tips-and-tools/revising-drafts/
  • ↑ https://academicguides.waldenu.edu/formandstyle/writing/scholarlyvoice/activepassive
  • ↑ https://writingcenter.unc.edu/tips-and-tools/editing-and-proofreading/
  • ↑ https://writingcenter.unc.edu/tips-and-tools/reading-aloud/
  • ↑ https://owl.purdue.edu/owl/general_writing/the_writing_process/proofreading/index.html

About This Article

Chris Hadley, PhD

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Development and Characterization of Fly Ash–BFS–Cement Composite for Engineering Applications

  • Original Research Paper
  • Published: 14 May 2024

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research paper on article 12

  • Harinandan Kumar 1 &
  • Muralidhar Singh Munisingh 2  

The paper deals with developing fly ash–Blast Furnace Slag (BFS) composite with additives like cement to utilize waste material in engineering applications. The additive-like cement with different proportions has gained particular attention worldwide because of the excellent bonding strength and enhancement of mechanical properties of fly ash composite with other admixtures. The geomechanical properties such as Unconfined Compressive Strength (UCS), Brazilian Tensile Strength (BTS), and California Bearing Ratio (CBR) of the developed composite at different curing periods (0, 7, 14, and 28 days) are reported in these studies. The optimum strength of the composite was determined at the maximum utilization of fly ash and BFS composite. The correlation among different strength parameters was established using the statistical approach. The composite with 80% fly ash, 12% BFS, and 8% cement showed the highest compressive strength. The results indicated an excellent bonding between the constituent materials of the composite with an adequate amount of strength. The strength parameters indicated the utilization of composite in haul road construction as a base or sub-base layer. Using composite will help the stable haul road and consume the bulk of fly ash and BFS to reduce environmental pollution.

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Department of Petroleum Engineering and Earth Sciences, University of Petroleum and Energy Studies, Bidholi, Via Prem Nagar, Dehradun, Uttarakhand, 248007, India

Harinandan Kumar

Department of Mechanical Engineering, RV Institute of Technology and Management, Chaithanya Layout, 8th Phase, J. P. Nagar, Bengaluru, Karnataka, 560076, India

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Kumar, H., Munisingh, M.S. Development and Characterization of Fly Ash–BFS–Cement Composite for Engineering Applications. Int. J. Pavement Res. Technol. (2024). https://doi.org/10.1007/s42947-024-00439-7

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Received : 12 June 2023

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DOI : https://doi.org/10.1007/s42947-024-00439-7

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13.1 Formatting a Research Paper

Learning objectives.

  • Identify the major components of a research paper written using American Psychological Association (APA) style.
  • Apply general APA style and formatting conventions in a research paper.

In this chapter, you will learn how to use APA style , the documentation and formatting style followed by the American Psychological Association, as well as MLA style , from the Modern Language Association. There are a few major formatting styles used in academic texts, including AMA, Chicago, and Turabian:

  • AMA (American Medical Association) for medicine, health, and biological sciences
  • APA (American Psychological Association) for education, psychology, and the social sciences
  • Chicago—a common style used in everyday publications like magazines, newspapers, and books
  • MLA (Modern Language Association) for English, literature, arts, and humanities
  • Turabian—another common style designed for its universal application across all subjects and disciplines

While all the formatting and citation styles have their own use and applications, in this chapter we focus our attention on the two styles you are most likely to use in your academic studies: APA and MLA.

If you find that the rules of proper source documentation are difficult to keep straight, you are not alone. Writing a good research paper is, in and of itself, a major intellectual challenge. Having to follow detailed citation and formatting guidelines as well may seem like just one more task to add to an already-too-long list of requirements.

Following these guidelines, however, serves several important purposes. First, it signals to your readers that your paper should be taken seriously as a student’s contribution to a given academic or professional field; it is the literary equivalent of wearing a tailored suit to a job interview. Second, it shows that you respect other people’s work enough to give them proper credit for it. Finally, it helps your reader find additional materials if he or she wishes to learn more about your topic.

Furthermore, producing a letter-perfect APA-style paper need not be burdensome. Yes, it requires careful attention to detail. However, you can simplify the process if you keep these broad guidelines in mind:

  • Work ahead whenever you can. Chapter 11 “Writing from Research: What Will I Learn?” includes tips for keeping track of your sources early in the research process, which will save time later on.
  • Get it right the first time. Apply APA guidelines as you write, so you will not have much to correct during the editing stage. Again, putting in a little extra time early on can save time later.
  • Use the resources available to you. In addition to the guidelines provided in this chapter, you may wish to consult the APA website at http://www.apa.org or the Purdue University Online Writing lab at http://owl.english.purdue.edu , which regularly updates its online style guidelines.

General Formatting Guidelines

This chapter provides detailed guidelines for using the citation and formatting conventions developed by the American Psychological Association, or APA. Writers in disciplines as diverse as astrophysics, biology, psychology, and education follow APA style. The major components of a paper written in APA style are listed in the following box.

These are the major components of an APA-style paper:

Body, which includes the following:

  • Headings and, if necessary, subheadings to organize the content
  • In-text citations of research sources
  • References page

All these components must be saved in one document, not as separate documents.

The title page of your paper includes the following information:

  • Title of the paper
  • Author’s name
  • Name of the institution with which the author is affiliated
  • Header at the top of the page with the paper title (in capital letters) and the page number (If the title is lengthy, you may use a shortened form of it in the header.)

List the first three elements in the order given in the previous list, centered about one third of the way down from the top of the page. Use the headers and footers tool of your word-processing program to add the header, with the title text at the left and the page number in the upper-right corner. Your title page should look like the following example.

Beyond the Hype: Evaluating Low-Carb Diets cover page

The next page of your paper provides an abstract , or brief summary of your findings. An abstract does not need to be provided in every paper, but an abstract should be used in papers that include a hypothesis. A good abstract is concise—about one hundred fifty to two hundred fifty words—and is written in an objective, impersonal style. Your writing voice will not be as apparent here as in the body of your paper. When writing the abstract, take a just-the-facts approach, and summarize your research question and your findings in a few sentences.

In Chapter 12 “Writing a Research Paper” , you read a paper written by a student named Jorge, who researched the effectiveness of low-carbohydrate diets. Read Jorge’s abstract. Note how it sums up the major ideas in his paper without going into excessive detail.

Beyond the Hype: Abstract

Write an abstract summarizing your paper. Briefly introduce the topic, state your findings, and sum up what conclusions you can draw from your research. Use the word count feature of your word-processing program to make sure your abstract does not exceed one hundred fifty words.

Depending on your field of study, you may sometimes write research papers that present extensive primary research, such as your own experiment or survey. In your abstract, summarize your research question and your findings, and briefly indicate how your study relates to prior research in the field.

Margins, Pagination, and Headings

APA style requirements also address specific formatting concerns, such as margins, pagination, and heading styles, within the body of the paper. Review the following APA guidelines.

Use these general guidelines to format the paper:

  • Set the top, bottom, and side margins of your paper at 1 inch.
  • Use double-spaced text throughout your paper.
  • Use a standard font, such as Times New Roman or Arial, in a legible size (10- to 12-point).
  • Use continuous pagination throughout the paper, including the title page and the references section. Page numbers appear flush right within your header.
  • Section headings and subsection headings within the body of your paper use different types of formatting depending on the level of information you are presenting. Additional details from Jorge’s paper are provided.

Cover Page

Begin formatting the final draft of your paper according to APA guidelines. You may work with an existing document or set up a new document if you choose. Include the following:

  • Your title page
  • The abstract you created in Note 13.8 “Exercise 1”
  • Correct headers and page numbers for your title page and abstract

APA style uses section headings to organize information, making it easy for the reader to follow the writer’s train of thought and to know immediately what major topics are covered. Depending on the length and complexity of the paper, its major sections may also be divided into subsections, sub-subsections, and so on. These smaller sections, in turn, use different heading styles to indicate different levels of information. In essence, you are using headings to create a hierarchy of information.

The following heading styles used in APA formatting are listed in order of greatest to least importance:

  • Section headings use centered, boldface type. Headings use title case, with important words in the heading capitalized.
  • Subsection headings use left-aligned, boldface type. Headings use title case.
  • The third level uses left-aligned, indented, boldface type. Headings use a capital letter only for the first word, and they end in a period.
  • The fourth level follows the same style used for the previous level, but the headings are boldfaced and italicized.
  • The fifth level follows the same style used for the previous level, but the headings are italicized and not boldfaced.

Visually, the hierarchy of information is organized as indicated in Table 13.1 “Section Headings” .

Table 13.1 Section Headings

A college research paper may not use all the heading levels shown in Table 13.1 “Section Headings” , but you are likely to encounter them in academic journal articles that use APA style. For a brief paper, you may find that level 1 headings suffice. Longer or more complex papers may need level 2 headings or other lower-level headings to organize information clearly. Use your outline to craft your major section headings and determine whether any subtopics are substantial enough to require additional levels of headings.

Working with the document you developed in Note 13.11 “Exercise 2” , begin setting up the heading structure of the final draft of your research paper according to APA guidelines. Include your title and at least two to three major section headings, and follow the formatting guidelines provided above. If your major sections should be broken into subsections, add those headings as well. Use your outline to help you.

Because Jorge used only level 1 headings, his Exercise 3 would look like the following:

Citation Guidelines

In-text citations.

Throughout the body of your paper, include a citation whenever you quote or paraphrase material from your research sources. As you learned in Chapter 11 “Writing from Research: What Will I Learn?” , the purpose of citations is twofold: to give credit to others for their ideas and to allow your reader to follow up and learn more about the topic if desired. Your in-text citations provide basic information about your source; each source you cite will have a longer entry in the references section that provides more detailed information.

In-text citations must provide the name of the author or authors and the year the source was published. (When a given source does not list an individual author, you may provide the source title or the name of the organization that published the material instead.) When directly quoting a source, it is also required that you include the page number where the quote appears in your citation.

This information may be included within the sentence or in a parenthetical reference at the end of the sentence, as in these examples.

Epstein (2010) points out that “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive” (p. 137).

Here, the writer names the source author when introducing the quote and provides the publication date in parentheses after the author’s name. The page number appears in parentheses after the closing quotation marks and before the period that ends the sentence.

Addiction researchers caution that “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive” (Epstein, 2010, p. 137).

Here, the writer provides a parenthetical citation at the end of the sentence that includes the author’s name, the year of publication, and the page number separated by commas. Again, the parenthetical citation is placed after the closing quotation marks and before the period at the end of the sentence.

As noted in the book Junk Food, Junk Science (Epstein, 2010, p. 137), “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive.”

Here, the writer chose to mention the source title in the sentence (an optional piece of information to include) and followed the title with a parenthetical citation. Note that the parenthetical citation is placed before the comma that signals the end of the introductory phrase.

David Epstein’s book Junk Food, Junk Science (2010) pointed out that “junk food cannot be considered addictive in the same way that we think of psychoactive drugs as addictive” (p. 137).

Another variation is to introduce the author and the source title in your sentence and include the publication date and page number in parentheses within the sentence or at the end of the sentence. As long as you have included the essential information, you can choose the option that works best for that particular sentence and source.

Citing a book with a single author is usually a straightforward task. Of course, your research may require that you cite many other types of sources, such as books or articles with more than one author or sources with no individual author listed. You may also need to cite sources available in both print and online and nonprint sources, such as websites and personal interviews. Chapter 13 “APA and MLA Documentation and Formatting” , Section 13.2 “Citing and Referencing Techniques” and Section 13.3 “Creating a References Section” provide extensive guidelines for citing a variety of source types.

Writing at Work

APA is just one of several different styles with its own guidelines for documentation, formatting, and language usage. Depending on your field of interest, you may be exposed to additional styles, such as the following:

  • MLA style. Determined by the Modern Languages Association and used for papers in literature, languages, and other disciplines in the humanities.
  • Chicago style. Outlined in the Chicago Manual of Style and sometimes used for papers in the humanities and the sciences; many professional organizations use this style for publications as well.
  • Associated Press (AP) style. Used by professional journalists.

References List

The brief citations included in the body of your paper correspond to the more detailed citations provided at the end of the paper in the references section. In-text citations provide basic information—the author’s name, the publication date, and the page number if necessary—while the references section provides more extensive bibliographical information. Again, this information allows your reader to follow up on the sources you cited and do additional reading about the topic if desired.

The specific format of entries in the list of references varies slightly for different source types, but the entries generally include the following information:

  • The name(s) of the author(s) or institution that wrote the source
  • The year of publication and, where applicable, the exact date of publication
  • The full title of the source
  • For books, the city of publication
  • For articles or essays, the name of the periodical or book in which the article or essay appears
  • For magazine and journal articles, the volume number, issue number, and pages where the article appears
  • For sources on the web, the URL where the source is located

The references page is double spaced and lists entries in alphabetical order by the author’s last name. If an entry continues for more than one line, the second line and each subsequent line are indented five spaces. Review the following example. ( Chapter 13 “APA and MLA Documentation and Formatting” , Section 13.3 “Creating a References Section” provides extensive guidelines for formatting reference entries for different types of sources.)

References Section

In APA style, book and article titles are formatted in sentence case, not title case. Sentence case means that only the first word is capitalized, along with any proper nouns.

Key Takeaways

  • Following proper citation and formatting guidelines helps writers ensure that their work will be taken seriously, give proper credit to other authors for their work, and provide valuable information to readers.
  • Working ahead and taking care to cite sources correctly the first time are ways writers can save time during the editing stage of writing a research paper.
  • APA papers usually include an abstract that concisely summarizes the paper.
  • APA papers use a specific headings structure to provide a clear hierarchy of information.
  • In APA papers, in-text citations usually include the name(s) of the author(s) and the year of publication.
  • In-text citations correspond to entries in the references section, which provide detailed bibliographical information about a source.

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Volume 629 Issue 8012, 16 May 2024

Damage control.

The cover shows the aftermath of the collapse of a nine-storey building in Guiyang, China, in 2015. Catastrophic building collapses have a huge cost and result in the loss of life. To try to mitigate problems, conventional building design aims to redistribute the load from any failed parts of a building to the rest of the structure, but this can cause sections of the building to collapse that would otherwise have been unaffected. In this week’s issue, Jose Adam and colleagues present an alternative approach to building design that isolates the failed part of a building thereby preventing catastrophic collapse. Called ‘hierarchy-based collapse isolation’, the approach was inspired by the way lizards isolate and shed their tails to escape predators. The design allows for controlled fracture along predetermined borders in parts of the building, which stops the initial failure from propagating to the entire building. The team suggests that this can prevent full-scale collapse, limiting the affected area and allowing more inhabitants to be rescued.

Cover image: Ou Dongqu/Xinhua/Alamy Live News

Forestry social science is failing the needs of the people who need it most

Rich nations’ fixation on forests as climate offsets has resulted in the needs of those who live in or make a living from these resources being ignored. A broader view and more collaboration between disciplines is required.

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A DARPA-like agency could boost EU innovation — but cannot come at the expense of existing schemes

If Europe wants to create a high-risk, high-reward research body, it needs grass-roots backing.

Why mathematics is set to be revolutionized by AI

Cheap data and the absence of coincidences make maths an ideal testing ground for AI-assisted discovery — but only humans will be able to tell good conjectures from bad ones.

  • Thomas Fink

Research Highlights

Old electric-vehicle batteries can find new purpose — on the grid.

An algorithm can monitor the health of retired vehicle batteries used to store surplus power fed into the electrical grid.

These parrots go on killing sprees over real-estate shortages

Scientists recorded green-rumped parrotlets pecking others’ chicks to death, probably to claim the nest space.

CRISPR therapy restores some vision to people with blindness

People with an inherited condition that causes vision loss in childhood had vision improvements after treatment to replace a mutated gene.

How the cauliflower got its curlicues

More than 2,000 years of domestication have given the popular vegetable its short stem and clumpy ‘curds’.

News in Focus

Major alphafold upgrade offers boost for drug discovery.

Latest version of the AI models how proteins interact with other molecules — but DeepMind restricts access to the tool.

  • Ewen Callaway

US funders to tighten oversight of controversial ‘gain of function’ research

New policy on high-risk biology studies aims to address criticism that previous rules were too vague.

Argentina’s pioneering nuclear research threatened by huge budget cuts

President Javier Milei is making moves to partially privatize the sector, but in the meantime, projects have paused.

  • Martín De Ambrosio
  • Fermín Koop

France’s research mega-campus faces leadership crisis

The contest to elect the next president of Paris-Saclay University has collapsed, reflecting wider issues at the giant research centre.

  • Barbara Casassus

Best ever clocks: breakthrough paves way for ultra-precise ‘nuclear’ timekeepers

A clock based on energy shifts in atomic nuclei could transform fundamental-physics research.

  • Elizabeth Gibney

Bird flu in US cows: where will it end?

Scientists worry that the H5N1 strain of avian influenza will become endemic in cattle, which would aid its spread in people.

  • Sara Reardon

How to kill the ‘zombie’ cells that make you age

Researchers are using new molecules, engineered immune cells and gene therapy to kill senescent cells and treat age-related diseases.

  • Carissa Wong

Lethal AI weapons are here: how can we control them?

Autonomous weapons guided by artificial intelligence are already in use. Researchers, legal experts and ethicists are struggling with what should be allowed on the battlefield.

Books & Arts

Book review, how men evolved to care for babies — before society got in the way.

An exploration of the evolution of male nurturing shows why, unlike fathers among other great apes, human dads are biologically wired to be hands-on parents.

  • Kermyt G. Anderson

Daniel Kahneman obituary: psychologist who revolutionized the way we think about thinking

Nobel prizewinner whose insights into the foibles of human decision-making launched the field of behavioural economics and sent ripples through all social sciences.

  • Eldar Shafir

Neglecting sex and gender in research is a public-health risk

The data are clear: taking sex and gender into account in research and using that knowledge to change health care could benefit billions of people.

  • Cheryl Carcel
  • Robyn Norton

Correspondence

Inequality is bad — but that doesn’t mean the rich are.

  • Henrik Ekelund

Interpersonal therapy can be an effective tool against the devastating effects of loneliness

  • Myrna M. Weissman
  • Jennifer J. Mootz

Standardized metadata for biological samples could unlock the potential of collections

  • Vojtěch Brlík

Real-world plastic-waste success stories can help to boost global treaty

  • Izni Zahidi

Scientists urged to collect royalties from the ‘magic money tree’

By joining a collecting society, researchers can ensure they are paid when copyrighted book content and papers are reproduced.

  • Oscar Allan

Career Guide:

Where I Work

Why my heart beats for nigeria’s endangered bats.

Iroro Tanshi works to better understand a number of threatened species.

  • Linda Nordling

News & Views

Strategic links save buildings from total collapse.

A design principle for buildings incorporates components that can control the propagation of failure by isolating parts of the structure as they fail — offering a way to prevent a partial collapse snowballing into complete destruction.

  • Sarah L. Orton

Tumours form without genetic mutations

Researchers find that brief and reversible inhibition of a gene-silencing mechanism leads to irreversible tumour formation in fruit flies, challenging the idea that cancer is caused only by permanent changes to DNA.

  • Anne-Kathrin Classen

Collection:

  • Cancer at Nature Portfolio

Dad’s gut microbes matter for pregnancy health and baby’s growth

Altering gut bacteria in male mice revealed that microorganisms are needed for normal sperm development and offspring health. Scientists discuss the implications in terms of understanding microbes, male fertility and pregnancy.

  • Liisa Veerus
  • Martin J. Blaser
  • Eldin Jašarević

Did atmospheric weathering help Earth’s earliest continents to survive?

What stabilized and strengthened the oldest, most robust blocks of continental crust billions of years ago during the Archaean eon has long been a mystery. It seems that a surprise helping hand might have come from the air above.

  • Claire E. Bucholz

Cells destroy donated mitochondria to build blood vessels

Organelles called mitochondria are transferred to blood-vessel-forming cells by support cells. Unexpectedly, these mitochondria are degraded, kick-starting the production of new ones and boosting vessel formation.

  • Chantell S. Evans

Microbubble ultrasound maps hidden signs of heart disease

Cardiovascular disease claims more lives each year than do the two next-deadliest diseases combined. An ultrasound technique that tracks tiny gas-filled bubbles could pave the way towards improved early detection.

  • Elisa E. Konofagou

Decoding the interplay between genetic and non-genetic drivers of metastasis

This Review discusses the importance of genetic and non-genetic reprogramming events during the metastatic cascade.

  • Panagiotis Karras
  • James R. M. Black
  • Jean-Christophe Marine

Refining the impact of genetic evidence on clinical success

Human genetic evidence increases the success rate of drugs from clinical development to approval but we are still far from reaching peak genetic insights to aid the discovery of targets for more effective drugs.

  • Eric Vallabh Minikel
  • Jeffery L. Painter
  • Matthew R. Nelson

A high-density and high-confinement tokamak plasma regime for fusion energy

A stable tokamak plasma has been demonstrated with a high plasma density and a high energy confinement quality, both of which are simultaneously important for fusion reactors.

  • A. M. Garofalo
  • J. M. Hanson

Probing entanglement in a 2D hard-core Bose–Hubbard lattice

By emulating a 2D hard-core Bose–Hubbard lattice using a controllable 4 × 4 array of superconducting qubits, volume-law entanglement scaling as well as area-law scaling at different locations in the energy spectrum are observed.

  • Amir H. Karamlou
  • Ilan T. Rosen
  • William D. Oliver

Fusion of deterministically generated photonic graph states

Using an optical resonator containing two individually addressable atoms in a single cavity, fusion of deterministically generated photonic graph states to create ring and tree graph states with up to eight qubits is demonstrated.

  • Philip Thomas
  • Leonardo Ruscio
  • Gerhard Rempe

Entanglement of nanophotonic quantum memory nodes in a telecom network

Entanglement of two nanophotonic quantum network nodes is demonstrated through 40  km spools of low-loss fibre and a 35-km long fibre loop deployed in the Boston area urban environment.

  • C. M. Knaut
  • A. Suleymanzade
  • M. D. Lukin

Creation of memory–memory entanglement in a metropolitan quantum network

A metropolitan-area quantum network based on the generation of pairwise entanglement is formed by three atomic quantum memories connected to a central photonic server.

  • Jian-Long Liu
  • Jian-Wei Pan

Long-range order enabled stability in quantum dot light-emitting diodes

Improving the long-range order of the quantum dots in perovskite LEDs can markedly enhance their operational stability.

  • Ya-Kun Wang
  • Liang-Sheng Liao

Arresting failure propagation in buildings through collapse isolation

A design approach arrests collapse propagation in buildings after major initial failures by ensuring that specific elements fail before the failure of the most important components for global stability.

  • Nirvan Makoond
  • Andri Setiawan
  • Jose M. Adam

Regioselective hydroformylation of propene catalysed by rhodium-zeolite

Rhodium catalysts confined in zeolite pores exhibit high regioselectivity in the hydroformylation process of propene to high-value n -butanal, surpassing the performance of all heterogeneous and most homogeneous catalysts developed so far.

  • Xiangjie Zhang

One-third of Southern Ocean productivity is supported by dust deposition

Nitrate observations over 11 years from autonomous biogeochemical ocean profiling combined with a Southern Hemisphere dust simulation find that iron supplied by dust supports about 30% of Southern Ocean productivity.

  • Zanna Chase
  • Sonya L. Fiddes

Subaerial weathering drove stabilization of continents

The geological histories of Archaean regions indicate that stabilization of the Earth’s continents and the formation of cratons was driven by continental emergence and subaerial weathering.

  • Jesse R. Reimink
  • Andrew J. Smye

Biogeographic response of marine plankton to Cenozoic environmental changes

Analysis of a global dataset reveals spatiotemporal patterns of marine plankton and their biogeographical responses during climatic and environmental changes across the Cenozoic era.

  • Anshuman Swain
  • Adam Woodhouse
  • Christopher M. Lowery

Retuning of hippocampal representations during sleep

Using a Bayesian learning approach, a study tracks the spatial representations by individual hippocampal cells over time in freely moving rats, and provides insights into how ensemble patterns form and reconfigure during sleep.

  • Kourosh Maboudi
  • Kamran Diba

Sleep pressure modulates single-neuron synapse number in zebrafish

Synapses are gained during spontaneous or forced periods of wake and lost during sleep in a neuron-subtype-dependent manner in zebrafish.

  • Anya Suppermpool
  • Declan G. Lyons
  • Jason Rihel

Mechanics of human embryo compaction

Using micropipette aspiration on donated human embryos, cell surface tensions during compaction were mapped, indicating a role for defective cell contractility in poor quality embryos.

  • Julie Firmin
  • Nicolas Ecker
  • Jean-Léon Maître

Paternal microbiome perturbations impact offspring fitness

Disturbances in the gut microbiota of male mice manifest as fitness defects in their offspring by affecting plancenta function, revealing a paternal gut–germline axis.

  • Ayele Argaw-Denboba
  • Thomas S. B. Schmidt
  • Jamie A. Hackett

Mitochondrial transfer mediates endothelial cell engraftment through mitophagy

Under stressful conditions, mesenchymal stromal cells transfer mitochondria to endothelial cells through tunnelling nanotubes, and artificially transplanting mitochondria into endothelial cells improves the ability of these cells to engraft and to revascularize ischaemic tissues.

  • Ruei-Zeng Lin
  • Gwang-Bum Im
  • Juan M. Melero-Martin

Distal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence

The murine enteropathogen Citrobacter rodentium targets a specific subset of absorptive intestinal epithelial cells in the mid–distal colon, which stimulate T cells to produce sustained IL-22 signals to mitigate further spread of the pathogen.

  • Carlene L. Zindl
  • C. Garrett Wilson
  • Casey T. Weaver

3D genomic mapping reveals multifocality of human pancreatic precancers

Quantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.

  • Alicia M. Braxton
  • Ashley L. Kiemen
  • Laura D. Wood

Transient loss of Polycomb components induces an epigenetic cancer fate

A transient perturbation of transcriptional silencing mediated by Polycomb proteins is sufficient to induce an epigenetic cancer cell fate in Drosophila in the absence of driver mutations.

  • V. Loubiere

Mechanism of single-stranded DNA annealing by RAD52–RPA complex

Single-stranded DNA annealing is driven by RAD52 open rings in association with RPA.

  • Chih-Chao Liang
  • Luke A. Greenhough
  • Stephen C. West

Structural and molecular basis of choline uptake into the brain by FLVCR2

FLVCR2 is expressed in the blood–brain barrier of mouse and human, and is the major mediator of choline uptake into the brain.

  • Rosemary J. Cater
  • Dibyanti Mukherjee
  • Filippo Mancia

Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1

A structural, biochemical and metabolomic analysis reveals the mechanistic basis for transport of extracellular choline and ethanolamine into cells by the human transport protein FLVCR1.

  • Timothy C. Kenny
  • Richard K. Hite

Amendments & Corrections

Author correction: targeting dcaf5 suppresses smarcb1 -mutant cancer by stabilizing swi/snf.

  • Sandi Radko-Juettner
  • Charles W. M. Roberts

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Research Method

Home » Research Paper Format – Types, Examples and Templates

Research Paper Format – Types, Examples and Templates

Table of Contents

Research Paper Formats

Research paper format is an essential aspect of academic writing that plays a crucial role in the communication of research findings . The format of a research paper depends on various factors such as the discipline, style guide, and purpose of the research. It includes guidelines for the structure, citation style, referencing , and other elements of the paper that contribute to its overall presentation and coherence. Adhering to the appropriate research paper format is vital for ensuring that the research is accurately and effectively communicated to the intended audience. In this era of information, it is essential to understand the different research paper formats and their guidelines to communicate research effectively, accurately, and with the required level of detail. This post aims to provide an overview of some of the common research paper formats used in academic writing.

Research Paper Formats

Research Paper Formats are as follows:

  • APA (American Psychological Association) format
  • MLA (Modern Language Association) format
  • Chicago/Turabian style
  • IEEE (Institute of Electrical and Electronics Engineers) format
  • AMA (American Medical Association) style
  • Harvard style
  • Vancouver style
  • ACS (American Chemical Society) style
  • ASA (American Sociological Association) style
  • APSA (American Political Science Association) style

APA (American Psychological Association) Format

Here is a general APA format for a research paper:

  • Title Page: The title page should include the title of your paper, your name, and your institutional affiliation. It should also include a running head, which is a shortened version of the title, and a page number in the upper right-hand corner.
  • Abstract : The abstract is a brief summary of your paper, typically 150-250 words. It should include the purpose of your research, the main findings, and any implications or conclusions that can be drawn.
  • Introduction: The introduction should provide background information on your topic, state the purpose of your research, and present your research question or hypothesis. It should also include a brief literature review that discusses previous research on your topic.
  • Methods: The methods section should describe the procedures you used to collect and analyze your data. It should include information on the participants, the materials and instruments used, and the statistical analyses performed.
  • Results: The results section should present the findings of your research in a clear and concise manner. Use tables and figures to help illustrate your results.
  • Discussion : The discussion section should interpret your results and relate them back to your research question or hypothesis. It should also discuss the implications of your findings and any limitations of your study.
  • References : The references section should include a list of all sources cited in your paper. Follow APA formatting guidelines for your citations and references.

Some additional tips for formatting your APA research paper:

  • Use 12-point Times New Roman font throughout the paper.
  • Double-space all text, including the references.
  • Use 1-inch margins on all sides of the page.
  • Indent the first line of each paragraph by 0.5 inches.
  • Use a hanging indent for the references (the first line should be flush with the left margin, and all subsequent lines should be indented).
  • Number all pages, including the title page and references page, in the upper right-hand corner.

APA Research Paper Format Template

APA Research Paper Format Template is as follows:

Title Page:

  • Title of the paper
  • Author’s name
  • Institutional affiliation
  • A brief summary of the main points of the paper, including the research question, methods, findings, and conclusions. The abstract should be no more than 250 words.

Introduction:

  • Background information on the topic of the research paper
  • Research question or hypothesis
  • Significance of the study
  • Overview of the research methods and design
  • Brief summary of the main findings
  • Participants: description of the sample population, including the number of participants and their characteristics (age, gender, ethnicity, etc.)
  • Materials: description of any materials used in the study (e.g., survey questions, experimental apparatus)
  • Procedure: detailed description of the steps taken to conduct the study
  • Presentation of the findings of the study, including statistical analyses if applicable
  • Tables and figures may be included to illustrate the results

Discussion:

  • Interpretation of the results in light of the research question and hypothesis
  • Implications of the study for the field
  • Limitations of the study
  • Suggestions for future research

References:

  • A list of all sources cited in the paper, in APA format

Formatting guidelines:

  • Double-spaced
  • 12-point font (Times New Roman or Arial)
  • 1-inch margins on all sides
  • Page numbers in the top right corner
  • Headings and subheadings should be used to organize the paper
  • The first line of each paragraph should be indented
  • Quotations of 40 or more words should be set off in a block quote with no quotation marks
  • In-text citations should include the author’s last name and year of publication (e.g., Smith, 2019)

APA Research Paper Format Example

APA Research Paper Format Example is as follows:

The Effects of Social Media on Mental Health

University of XYZ

This study examines the relationship between social media use and mental health among college students. Data was collected through a survey of 500 students at the University of XYZ. Results suggest that social media use is significantly related to symptoms of depression and anxiety, and that the negative effects of social media are greater among frequent users.

Social media has become an increasingly important aspect of modern life, especially among young adults. While social media can have many positive effects, such as connecting people across distances and sharing information, there is growing concern about its impact on mental health. This study aims to examine the relationship between social media use and mental health among college students.

Participants: Participants were 500 college students at the University of XYZ, recruited through online advertisements and flyers posted on campus. Participants ranged in age from 18 to 25, with a mean age of 20.5 years. The sample was 60% female, 40% male, and 5% identified as non-binary or gender non-conforming.

Data was collected through an online survey administered through Qualtrics. The survey consisted of several measures, including the Patient Health Questionnaire-9 (PHQ-9) for depression symptoms, the Generalized Anxiety Disorder-7 (GAD-7) for anxiety symptoms, and questions about social media use.

Procedure :

Participants were asked to complete the online survey at their convenience. The survey took approximately 20-30 minutes to complete. Data was analyzed using descriptive statistics, correlations, and multiple regression analysis.

Results indicated that social media use was significantly related to symptoms of depression (r = .32, p < .001) and anxiety (r = .29, p < .001). Regression analysis indicated that frequency of social media use was a significant predictor of both depression symptoms (β = .24, p < .001) and anxiety symptoms (β = .20, p < .001), even when controlling for age, gender, and other relevant factors.

The results of this study suggest that social media use is associated with symptoms of depression and anxiety among college students. The negative effects of social media are greater among frequent users. These findings have important implications for mental health professionals and educators, who should consider addressing the potential negative effects of social media use in their work with young adults.

References :

References should be listed in alphabetical order according to the author’s last name. For example:

  • Chou, H. T. G., & Edge, N. (2012). “They are happier and having better lives than I am”: The impact of using Facebook on perceptions of others’ lives. Cyberpsychology, Behavior, and Social Networking, 15(2), 117-121.
  • Twenge, J. M., Joiner, T. E., Rogers, M. L., & Martin, G. N. (2018). Increases in depressive symptoms, suicide-related outcomes, and suicide rates among U.S. adolescents after 2010 and links to increased new media screen time. Clinical Psychological Science, 6(1), 3-17.

Note: This is just a sample Example do not use this in your assignment.

MLA (Modern Language Association) Format

MLA (Modern Language Association) Format is as follows:

  • Page Layout : Use 8.5 x 11-inch white paper, with 1-inch margins on all sides. The font should be 12-point Times New Roman or a similar serif font.
  • Heading and Title : The first page of your research paper should include a heading and a title. The heading should include your name, your instructor’s name, the course title, and the date. The title should be centered and in title case (capitalizing the first letter of each important word).
  • In-Text Citations : Use parenthetical citations to indicate the source of your information. The citation should include the author’s last name and the page number(s) of the source. For example: (Smith 23).
  • Works Cited Page : At the end of your paper, include a Works Cited page that lists all the sources you used in your research. Each entry should include the author’s name, the title of the work, the publication information, and the medium of publication.
  • Formatting Quotations : Use double quotation marks for short quotations and block quotations for longer quotations. Indent the entire quotation five spaces from the left margin.
  • Formatting the Body : Use a clear and readable font and double-space your text throughout. The first line of each paragraph should be indented one-half inch from the left margin.

MLA Research Paper Template

MLA Research Paper Format Template is as follows:

  • Use 8.5 x 11 inch white paper.
  • Use a 12-point font, such as Times New Roman.
  • Use double-spacing throughout the entire paper, including the title page and works cited page.
  • Set the margins to 1 inch on all sides.
  • Use page numbers in the upper right corner, beginning with the first page of text.
  • Include a centered title for the research paper, using title case (capitalizing the first letter of each important word).
  • Include your name, instructor’s name, course name, and date in the upper left corner, double-spaced.

In-Text Citations

  • When quoting or paraphrasing information from sources, include an in-text citation within the text of your paper.
  • Use the author’s last name and the page number in parentheses at the end of the sentence, before the punctuation mark.
  • If the author’s name is mentioned in the sentence, only include the page number in parentheses.

Works Cited Page

  • List all sources cited in alphabetical order by the author’s last name.
  • Each entry should include the author’s name, title of the work, publication information, and medium of publication.
  • Use italics for book and journal titles, and quotation marks for article and chapter titles.
  • For online sources, include the date of access and the URL.

Here is an example of how the first page of a research paper in MLA format should look:

Headings and Subheadings

  • Use headings and subheadings to organize your paper and make it easier to read.
  • Use numerals to number your headings and subheadings (e.g. 1, 2, 3), and capitalize the first letter of each word.
  • The main heading should be centered and in boldface type, while subheadings should be left-aligned and in italics.
  • Use only one space after each period or punctuation mark.
  • Use quotation marks to indicate direct quotes from a source.
  • If the quote is more than four lines, format it as a block quote, indented one inch from the left margin and without quotation marks.
  • Use ellipses (…) to indicate omitted words from a quote, and brackets ([…]) to indicate added words.

Works Cited Examples

  • Book: Last Name, First Name. Title of Book. Publisher, Publication Year.
  • Journal Article: Last Name, First Name. “Title of Article.” Title of Journal, volume number, issue number, publication date, page numbers.
  • Website: Last Name, First Name. “Title of Webpage.” Title of Website, publication date, URL. Accessed date.

Here is an example of how a works cited entry for a book should look:

Smith, John. The Art of Writing Research Papers. Penguin, 2021.

MLA Research Paper Example

MLA Research Paper Format Example is as follows:

Your Professor’s Name

Course Name and Number

Date (in Day Month Year format)

Word Count (not including title page or Works Cited)

Title: The Impact of Video Games on Aggression Levels

Video games have become a popular form of entertainment among people of all ages. However, the impact of video games on aggression levels has been a subject of debate among scholars and researchers. While some argue that video games promote aggression and violent behavior, others argue that there is no clear link between video games and aggression levels. This research paper aims to explore the impact of video games on aggression levels among young adults.

Background:

The debate on the impact of video games on aggression levels has been ongoing for several years. According to the American Psychological Association, exposure to violent media, including video games, can increase aggression levels in children and adolescents. However, some researchers argue that there is no clear evidence to support this claim. Several studies have been conducted to examine the impact of video games on aggression levels, but the results have been mixed.

Methodology:

This research paper used a quantitative research approach to examine the impact of video games on aggression levels among young adults. A sample of 100 young adults between the ages of 18 and 25 was selected for the study. The participants were asked to complete a questionnaire that measured their aggression levels and their video game habits.

The results of the study showed that there was a significant correlation between video game habits and aggression levels among young adults. The participants who reported playing violent video games for more than 5 hours per week had higher aggression levels than those who played less than 5 hours per week. The study also found that male participants were more likely to play violent video games and had higher aggression levels than female participants.

The findings of this study support the claim that video games can increase aggression levels among young adults. However, it is important to note that the study only examined the impact of video games on aggression levels and did not take into account other factors that may contribute to aggressive behavior. It is also important to note that not all video games promote violence and aggression, and some games may have a positive impact on cognitive and social skills.

Conclusion :

In conclusion, this research paper provides evidence to support the claim that video games can increase aggression levels among young adults. However, it is important to conduct further research to examine the impact of video games on other aspects of behavior and to explore the potential benefits of video games. Parents and educators should be aware of the potential impact of video games on aggression levels and should encourage young adults to engage in a variety of activities that promote cognitive and social skills.

Works Cited:

  • American Psychological Association. (2017). Violent Video Games: Myths, Facts, and Unanswered Questions. Retrieved from https://www.apa.org/news/press/releases/2017/08/violent-video-games
  • Ferguson, C. J. (2015). Do Angry Birds make for angry children? A meta-analysis of video game influences on children’s and adolescents’ aggression, mental health, prosocial behavior, and academic performance. Perspectives on Psychological Science, 10(5), 646-666.
  • Gentile, D. A., Swing, E. L., Lim, C. G., & Khoo, A. (2012). Video game playing, attention problems, and impulsiveness: Evidence of bidirectional causality. Psychology of Popular Media Culture, 1(1), 62-70.
  • Greitemeyer, T. (2014). Effects of prosocial video games on prosocial behavior. Journal of Personality and Social Psychology, 106(4), 530-548.

Chicago/Turabian Style

Chicago/Turabian Formate is as follows:

  • Margins : Use 1-inch margins on all sides of the paper.
  • Font : Use a readable font such as Times New Roman or Arial, and use a 12-point font size.
  • Page numbering : Number all pages in the upper right-hand corner, beginning with the first page of text. Use Arabic numerals.
  • Title page: Include a title page with the title of the paper, your name, course title and number, instructor’s name, and the date. The title should be centered on the page and in title case (capitalize the first letter of each word).
  • Headings: Use headings to organize your paper. The first level of headings should be centered and in boldface or italics. The second level of headings should be left-aligned and in boldface or italics. Use as many levels of headings as necessary to organize your paper.
  • In-text citations : Use footnotes or endnotes to cite sources within the text of your paper. The first citation for each source should be a full citation, and subsequent citations can be shortened. Use superscript numbers to indicate footnotes or endnotes.
  • Bibliography : Include a bibliography at the end of your paper, listing all sources cited in your paper. The bibliography should be in alphabetical order by the author’s last name, and each entry should include the author’s name, title of the work, publication information, and date of publication.
  • Formatting of quotations: Use block quotations for quotations that are longer than four lines. Indent the entire quotation one inch from the left margin, and do not use quotation marks. Single-space the quotation, and double-space between paragraphs.
  • Tables and figures: Use tables and figures to present data and illustrations. Number each table and figure sequentially, and provide a brief title for each. Place tables and figures as close as possible to the text that refers to them.
  • Spelling and grammar : Use correct spelling and grammar throughout your paper. Proofread carefully for errors.

Chicago/Turabian Research Paper Template

Chicago/Turabian Research Paper Template is as folows:

Title of Paper

Name of Student

Professor’s Name

I. Introduction

A. Background Information

B. Research Question

C. Thesis Statement

II. Literature Review

A. Overview of Existing Literature

B. Analysis of Key Literature

C. Identification of Gaps in Literature

III. Methodology

A. Research Design

B. Data Collection

C. Data Analysis

IV. Results

A. Presentation of Findings

B. Analysis of Findings

C. Discussion of Implications

V. Conclusion

A. Summary of Findings

B. Implications for Future Research

C. Conclusion

VI. References

A. Bibliography

B. In-Text Citations

VII. Appendices (if necessary)

A. Data Tables

C. Additional Supporting Materials

Chicago/Turabian Research Paper Example

Title: The Impact of Social Media on Political Engagement

Name: John Smith

Class: POLS 101

Professor: Dr. Jane Doe

Date: April 8, 2023

I. Introduction:

Social media has become an integral part of our daily lives. People use social media platforms like Facebook, Twitter, and Instagram to connect with friends and family, share their opinions, and stay informed about current events. With the rise of social media, there has been a growing interest in understanding its impact on various aspects of society, including political engagement. In this paper, I will examine the relationship between social media use and political engagement, specifically focusing on how social media influences political participation and political attitudes.

II. Literature Review:

There is a growing body of literature on the impact of social media on political engagement. Some scholars argue that social media has a positive effect on political participation by providing new channels for political communication and mobilization (Delli Carpini & Keeter, 1996; Putnam, 2000). Others, however, suggest that social media can have a negative impact on political engagement by creating filter bubbles that reinforce existing beliefs and discourage political dialogue (Pariser, 2011; Sunstein, 2001).

III. Methodology:

To examine the relationship between social media use and political engagement, I conducted a survey of 500 college students. The survey included questions about social media use, political participation, and political attitudes. The data was analyzed using descriptive statistics and regression analysis.

Iv. Results:

The results of the survey indicate that social media use is positively associated with political participation. Specifically, respondents who reported using social media to discuss politics were more likely to have participated in a political campaign, attended a political rally, or contacted a political representative. Additionally, social media use was found to be associated with more positive attitudes towards political engagement, such as increased trust in government and belief in the effectiveness of political action.

V. Conclusion:

The findings of this study suggest that social media has a positive impact on political engagement, by providing new opportunities for political communication and mobilization. However, there is also a need for caution, as social media can also create filter bubbles that reinforce existing beliefs and discourage political dialogue. Future research should continue to explore the complex relationship between social media and political engagement, and develop strategies to harness the potential benefits of social media while mitigating its potential negative effects.

Vii. References:

  • Delli Carpini, M. X., & Keeter, S. (1996). What Americans know about politics and why it matters. Yale University Press.
  • Pariser, E. (2011). The filter bubble: What the Internet is hiding from you. Penguin.
  • Putnam, R. D. (2000). Bowling alone: The collapse and revival of American community. Simon & Schuster.
  • Sunstein, C. R. (2001). Republic.com. Princeton University Press.

IEEE (Institute of Electrical and Electronics Engineers) Format

IEEE (Institute of Electrical and Electronics Engineers) Research Paper Format is as follows:

  • Title : A concise and informative title that accurately reflects the content of the paper.
  • Abstract : A brief summary of the paper, typically no more than 250 words, that includes the purpose of the study, the methods used, the key findings, and the main conclusions.
  • Introduction : An overview of the background, context, and motivation for the research, including a clear statement of the problem being addressed and the objectives of the study.
  • Literature review: A critical analysis of the relevant research and scholarship on the topic, including a discussion of any gaps or limitations in the existing literature.
  • Methodology : A detailed description of the methods used to collect and analyze data, including any experiments or simulations, data collection instruments or procedures, and statistical analyses.
  • Results : A clear and concise presentation of the findings, including any relevant tables, graphs, or figures.
  • Discussion : A detailed interpretation of the results, including a comparison of the findings with previous research, a discussion of the implications of the results, and any recommendations for future research.
  • Conclusion : A summary of the key findings and main conclusions of the study.
  • References : A list of all sources cited in the paper, formatted according to IEEE guidelines.

In addition to these elements, an IEEE research paper should also follow certain formatting guidelines, including using 12-point font, double-spaced text, and numbered headings and subheadings. Additionally, any tables, figures, or equations should be clearly labeled and referenced in the text.

AMA (American Medical Association) Style

AMA (American Medical Association) Style Research Paper Format:

  • Title Page: This page includes the title of the paper, the author’s name, institutional affiliation, and any acknowledgments or disclaimers.
  • Abstract: The abstract is a brief summary of the paper that outlines the purpose, methods, results, and conclusions of the study. It is typically limited to 250 words or less.
  • Introduction: The introduction provides a background of the research problem, defines the research question, and outlines the objectives and hypotheses of the study.
  • Methods: The methods section describes the research design, participants, procedures, and instruments used to collect and analyze data.
  • Results: The results section presents the findings of the study in a clear and concise manner, using graphs, tables, and charts where appropriate.
  • Discussion: The discussion section interprets the results, explains their significance, and relates them to previous research in the field.
  • Conclusion: The conclusion summarizes the main points of the paper, discusses the implications of the findings, and suggests future research directions.
  • References: The reference list includes all sources cited in the paper, listed in alphabetical order by author’s last name.

In addition to these sections, the AMA format requires that authors follow specific guidelines for citing sources in the text and formatting their references. The AMA style uses a superscript number system for in-text citations and provides specific formats for different types of sources, such as books, journal articles, and websites.

Harvard Style

Harvard Style Research Paper format is as follows:

  • Title page: This should include the title of your paper, your name, the name of your institution, and the date of submission.
  • Abstract : This is a brief summary of your paper, usually no more than 250 words. It should outline the main points of your research and highlight your findings.
  • Introduction : This section should introduce your research topic, provide background information, and outline your research question or thesis statement.
  • Literature review: This section should review the relevant literature on your topic, including previous research studies, academic articles, and other sources.
  • Methodology : This section should describe the methods you used to conduct your research, including any data collection methods, research instruments, and sampling techniques.
  • Results : This section should present your findings in a clear and concise manner, using tables, graphs, and other visual aids if necessary.
  • Discussion : This section should interpret your findings and relate them to the broader research question or thesis statement. You should also discuss the implications of your research and suggest areas for future study.
  • Conclusion : This section should summarize your main findings and provide a final statement on the significance of your research.
  • References : This is a list of all the sources you cited in your paper, presented in alphabetical order by author name. Each citation should include the author’s name, the title of the source, the publication date, and other relevant information.

In addition to these sections, a Harvard Style research paper may also include a table of contents, appendices, and other supplementary materials as needed. It is important to follow the specific formatting guidelines provided by your instructor or academic institution when preparing your research paper in Harvard Style.

Vancouver Style

Vancouver Style Research Paper format is as follows:

The Vancouver citation style is commonly used in the biomedical sciences and is known for its use of numbered references. Here is a basic format for a research paper using the Vancouver citation style:

  • Title page: Include the title of your paper, your name, the name of your institution, and the date.
  • Abstract : This is a brief summary of your research paper, usually no more than 250 words.
  • Introduction : Provide some background information on your topic and state the purpose of your research.
  • Methods : Describe the methods you used to conduct your research, including the study design, data collection, and statistical analysis.
  • Results : Present your findings in a clear and concise manner, using tables and figures as needed.
  • Discussion : Interpret your results and explain their significance. Also, discuss any limitations of your study and suggest directions for future research.
  • References : List all of the sources you cited in your paper in numerical order. Each reference should include the author’s name, the title of the article or book, the name of the journal or publisher, the year of publication, and the page numbers.

ACS (American Chemical Society) Style

ACS (American Chemical Society) Style Research Paper format is as follows:

The American Chemical Society (ACS) Style is a citation style commonly used in chemistry and related fields. When formatting a research paper in ACS Style, here are some guidelines to follow:

  • Paper Size and Margins : Use standard 8.5″ x 11″ paper with 1-inch margins on all sides.
  • Font: Use a 12-point serif font (such as Times New Roman) for the main text. The title should be in bold and a larger font size.
  • Title Page : The title page should include the title of the paper, the authors’ names and affiliations, and the date of submission. The title should be centered on the page and written in bold font. The authors’ names should be centered below the title, followed by their affiliations and the date.
  • Abstract : The abstract should be a brief summary of the paper, no more than 250 words. It should be on a separate page and include the title of the paper, the authors’ names and affiliations, and the text of the abstract.
  • Main Text : The main text should be organized into sections with headings that clearly indicate the content of each section. The introduction should provide background information and state the research question or hypothesis. The methods section should describe the procedures used in the study. The results section should present the findings of the study, and the discussion section should interpret the results and provide conclusions.
  • References: Use the ACS Style guide to format the references cited in the paper. In-text citations should be numbered sequentially throughout the text and listed in numerical order at the end of the paper.
  • Figures and Tables: Figures and tables should be numbered sequentially and referenced in the text. Each should have a descriptive caption that explains its content. Figures should be submitted in a high-quality electronic format.
  • Supporting Information: Additional information such as data, graphs, and videos may be included as supporting information. This should be included in a separate file and referenced in the main text.
  • Acknowledgments : Acknowledge any funding sources or individuals who contributed to the research.

ASA (American Sociological Association) Style

ASA (American Sociological Association) Style Research Paper format is as follows:

  • Title Page: The title page of an ASA style research paper should include the title of the paper, the author’s name, and the institutional affiliation. The title should be centered and should be in title case (the first letter of each major word should be capitalized).
  • Abstract: An abstract is a brief summary of the paper that should appear on a separate page immediately following the title page. The abstract should be no more than 200 words in length and should summarize the main points of the paper.
  • Main Body: The main body of the paper should begin on a new page following the abstract page. The paper should be double-spaced, with 1-inch margins on all sides, and should be written in 12-point Times New Roman font. The main body of the paper should include an introduction, a literature review, a methodology section, results, and a discussion.
  • References : The reference section should appear on a separate page at the end of the paper. All sources cited in the paper should be listed in alphabetical order by the author’s last name. Each reference should include the author’s name, the title of the work, the publication information, and the date of publication.
  • Appendices : Appendices are optional and should only be included if they contain information that is relevant to the study but too lengthy to be included in the main body of the paper. If you include appendices, each one should be labeled with a letter (e.g., Appendix A, Appendix B, etc.) and should be referenced in the main body of the paper.

APSA (American Political Science Association) Style

APSA (American Political Science Association) Style Research Paper format is as follows:

  • Title Page: The title page should include the title of the paper, the author’s name, the name of the course or instructor, and the date.
  • Abstract : An abstract is typically not required in APSA style papers, but if one is included, it should be brief and summarize the main points of the paper.
  • Introduction : The introduction should provide an overview of the research topic, the research question, and the main argument or thesis of the paper.
  • Literature Review : The literature review should summarize the existing research on the topic and provide a context for the research question.
  • Methods : The methods section should describe the research methods used in the paper, including data collection and analysis.
  • Results : The results section should present the findings of the research.
  • Discussion : The discussion section should interpret the results and connect them back to the research question and argument.
  • Conclusion : The conclusion should summarize the main findings and implications of the research.
  • References : The reference list should include all sources cited in the paper, formatted according to APSA style guidelines.

In-text citations in APSA style use parenthetical citation, which includes the author’s last name, publication year, and page number(s) if applicable. For example, (Smith 2010, 25).

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research paper on article 12

Cultural Relativity and Acceptance of Embryonic Stem Cell Research

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research paper on article 12

Main Article Content

There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities.

INTRODUCTION

Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding of human development. Yet, ethical contention exists because of individuals’ perceptions of using human embryos based on their various cultural, moral, and social values. While these disagreements concerning policy, use, and general acceptance have prompted the development of an international ethics policy, such a uniform approach can overlook the nuanced ethical landscapes between cultures. With diverse viewpoints in public health, a single global policy, especially one reflecting Western ethics or the ethics prevalent in high-income countries, is impractical. This paper argues for a culturally sensitive, adaptable framework for the use of embryonic stem cells. Stem cell policy should accommodate varying ethical viewpoints and promote an effective global dialogue. With an extension of an ethics model that can adapt to various cultures, we recommend localized guidelines that reflect the moral views of the people those guidelines serve.

Stem cells, characterized by their unique ability to differentiate into various cell types, enable the repair or replacement of damaged tissues. Two primary types of stem cells are somatic stem cells (adult stem cells) and embryonic stem cells. Adult stem cells exist in developed tissues and maintain the body’s repair processes. [1] Embryonic stem cells (ESC) are remarkably pluripotent or versatile, making them valuable in research. [2] However, the use of ESCs has sparked ethics debates. Considering the potential of embryonic stem cells, research guidelines are essential. The International Society for Stem Cell Research (ISSCR) provides international stem cell research guidelines. They call for “public conversations touching on the scientific significance as well as the societal and ethical issues raised by ESC research.” [3] The ISSCR also publishes updates about culturing human embryos 14 days post fertilization, suggesting local policies and regulations should continue to evolve as ESC research develops. [4]  Like the ISSCR, which calls for local law and policy to adapt to developing stem cell research given cultural acceptance, this paper highlights the importance of local social factors such as religion and culture.

I.     Global Cultural Perspective of Embryonic Stem Cells

Views on ESCs vary throughout the world. Some countries readily embrace stem cell research and therapies, while others have stricter regulations due to ethical concerns surrounding embryonic stem cells and when an embryo becomes entitled to moral consideration. The philosophical issue of when the “someone” begins to be a human after fertilization, in the morally relevant sense, [5] impacts when an embryo becomes not just worthy of protection but morally entitled to it. The process of creating embryonic stem cell lines involves the destruction of the embryos for research. [6] Consequently, global engagement in ESC research depends on social-cultural acceptability.

a.     US and Rights-Based Cultures

In the United States, attitudes toward stem cell therapies are diverse. The ethics and social approaches, which value individualism, [7] trigger debates regarding the destruction of human embryos, creating a complex regulatory environment. For example, the 1996 Dickey-Wicker Amendment prohibited federal funding for the creation of embryos for research and the destruction of embryos for “more than allowed for research on fetuses in utero.” [8] Following suit, in 2001, the Bush Administration heavily restricted stem cell lines for research. However, the Stem Cell Research Enhancement Act of 2005 was proposed to help develop ESC research but was ultimately vetoed. [9] Under the Obama administration, in 2009, an executive order lifted restrictions allowing for more development in this field. [10] The flux of research capacity and funding parallels the different cultural perceptions of human dignity of the embryo and how it is socially presented within the country’s research culture. [11]

b.     Ubuntu and Collective Cultures

African bioethics differs from Western individualism because of the different traditions and values. African traditions, as described by individuals from South Africa and supported by some studies in other African countries, including Ghana and Kenya, follow the African moral philosophies of Ubuntu or Botho and Ukama , which “advocates for a form of wholeness that comes through one’s relationship and connectedness with other people in the society,” [12] making autonomy a socially collective concept. In this context, for the community to act autonomously, individuals would come together to decide what is best for the collective. Thus, stem cell research would require examining the value of the research to society as a whole and the use of the embryos as a collective societal resource. If society views the source as part of the collective whole, and opposes using stem cells, compromising the cultural values to pursue research may cause social detachment and stunt research growth. [13] Based on local culture and moral philosophy, the permissibility of stem cell research depends on how embryo, stem cell, and cell line therapies relate to the community as a whole. Ubuntu is the expression of humanness, with the person’s identity drawn from the “’I am because we are’” value. [14] The decision in a collectivistic culture becomes one born of cultural context, and individual decisions give deference to others in the society.

Consent differs in cultures where thought and moral philosophy are based on a collective paradigm. So, applying Western bioethical concepts is unrealistic. For one, Africa is a diverse continent with many countries with different belief systems, access to health care, and reliance on traditional or Western medicines. Where traditional medicine is the primary treatment, the “’restrictive focus on biomedically-related bioethics’” [is] problematic in African contexts because it neglects bioethical issues raised by traditional systems.” [15] No single approach applies in all areas or contexts. Rather than evaluating the permissibility of ESC research according to Western concepts such as the four principles approach, different ethics approaches should prevail.

Another consideration is the socio-economic standing of countries. In parts of South Africa, researchers have not focused heavily on contributing to the stem cell discourse, either because it is not considered health care or a health science priority or because resources are unavailable. [16] Each country’s priorities differ given different social, political, and economic factors. In South Africa, for instance, areas such as maternal mortality, non-communicable diseases, telemedicine, and the strength of health systems need improvement and require more focus [17] Stem cell research could benefit the population, but it also could divert resources from basic medical care. Researchers in South Africa adhere to the National Health Act and Medicines Control Act in South Africa and international guidelines; however, the Act is not strictly enforced, and there is no clear legislation for research conduct or ethical guidelines. [18]

Some parts of Africa condemn stem cell research. For example, 98.2 percent of the Tunisian population is Muslim. [19] Tunisia does not permit stem cell research because of moral conflict with a Fatwa. Religion heavily saturates the regulation and direction of research. [20] Stem cell use became permissible for reproductive purposes only recently, with tight restrictions preventing cells from being used in any research other than procedures concerning ART/IVF.  Their use is conditioned on consent, and available only to married couples. [21] The community's receptiveness to stem cell research depends on including communitarian African ethics.

c.     Asia

Some Asian countries also have a collective model of ethics and decision making. [22] In China, the ethics model promotes a sincere respect for life or human dignity, [23] based on protective medicine. This model, influenced by Traditional Chinese Medicine (TCM), [24] recognizes Qi as the vital energy delivered via the meridians of the body; it connects illness to body systems, the body’s entire constitution, and the universe for a holistic bond of nature, health, and quality of life. [25] Following a protective ethics model, and traditional customs of wholeness, investment in stem cell research is heavily desired for its applications in regenerative therapies, disease modeling, and protective medicines. In a survey of medical students and healthcare practitioners, 30.8 percent considered stem cell research morally unacceptable while 63.5 percent accepted medical research using human embryonic stem cells. Of these individuals, 89.9 percent supported increased funding for stem cell research. [26] The scientific community might not reflect the overall population. From 1997 to 2019, China spent a total of $576 million (USD) on stem cell research at 8,050 stem cell programs, increased published presence from 0.6 percent to 14.01 percent of total global stem cell publications as of 2014, and made significant strides in cell-based therapies for various medical conditions. [27] However, while China has made substantial investments in stem cell research and achieved notable progress in clinical applications, concerns linger regarding ethical oversight and transparency. [28] For example, the China Biosecurity Law, promoted by the National Health Commission and China Hospital Association, attempted to mitigate risks by introducing an institutional review board (IRB) in the regulatory bodies. 5800 IRBs registered with the Chinese Clinical Trial Registry since 2021. [29] However, issues still need to be addressed in implementing effective IRB review and approval procedures.

The substantial government funding and focus on scientific advancement have sometimes overshadowed considerations of regional cultures, ethnic minorities, and individual perspectives, particularly evident during the one-child policy era. As government policy adapts to promote public stability, such as the change from the one-child to the two-child policy, [30] research ethics should also adapt to ensure respect for the values of its represented peoples.

Japan is also relatively supportive of stem cell research and therapies. Japan has a more transparent regulatory framework, allowing for faster approval of regenerative medicine products, which has led to several advanced clinical trials and therapies. [31] South Korea is also actively engaged in stem cell research and has a history of breakthroughs in cloning and embryonic stem cells. [32] However, the field is controversial, and there are issues of scientific integrity. For example, the Korean FDA fast-tracked products for approval, [33] and in another instance, the oocyte source was unclear and possibly violated ethical standards. [34] Trust is important in research, as it builds collaborative foundations between colleagues, trial participant comfort, open-mindedness for complicated and sensitive discussions, and supports regulatory procedures for stakeholders. There is a need to respect the culture’s interest, engagement, and for research and clinical trials to be transparent and have ethical oversight to promote global research discourse and trust.

d.     Middle East

Countries in the Middle East have varying degrees of acceptance of or restrictions to policies related to using embryonic stem cells due to cultural and religious influences. Saudi Arabia has made significant contributions to stem cell research, and conducts research based on international guidelines for ethical conduct and under strict adherence to guidelines in accordance with Islamic principles. Specifically, the Saudi government and people require ESC research to adhere to Sharia law. In addition to umbilical and placental stem cells, [35] Saudi Arabia permits the use of embryonic stem cells as long as they come from miscarriages, therapeutic abortions permissible by Sharia law, or are left over from in vitro fertilization and donated to research. [36] Laws and ethical guidelines for stem cell research allow the development of research institutions such as the King Abdullah International Medical Research Center, which has a cord blood bank and a stem cell registry with nearly 10,000 donors. [37] Such volume and acceptance are due to the ethical ‘permissibility’ of the donor sources, which do not conflict with religious pillars. However, some researchers err on the side of caution, choosing not to use embryos or fetal tissue as they feel it is unethical to do so. [38]

Jordan has a positive research ethics culture. [39] However, there is a significant issue of lack of trust in researchers, with 45.23 percent (38.66 percent agreeing and 6.57 percent strongly agreeing) of Jordanians holding a low level of trust in researchers, compared to 81.34 percent of Jordanians agreeing that they feel safe to participate in a research trial. [40] Safety testifies to the feeling of confidence that adequate measures are in place to protect participants from harm, whereas trust in researchers could represent the confidence in researchers to act in the participants’ best interests, adhere to ethical guidelines, provide accurate information, and respect participants’ rights and dignity. One method to improve trust would be to address communication issues relevant to ESC. Legislation surrounding stem cell research has adopted specific language, especially concerning clarification “between ‘stem cells’ and ‘embryonic stem cells’” in translation. [41] Furthermore, legislation “mandates the creation of a national committee… laying out specific regulations for stem-cell banking in accordance with international standards.” [42] This broad regulation opens the door for future global engagement and maintains transparency. However, these regulations may also constrain the influence of research direction, pace, and accessibility of research outcomes.

e.     Europe

In the European Union (EU), ethics is also principle-based, but the principles of autonomy, dignity, integrity, and vulnerability are interconnected. [43] As such, the opportunity for cohesion and concessions between individuals’ thoughts and ideals allows for a more adaptable ethics model due to the flexible principles that relate to the human experience The EU has put forth a framework in its Convention for the Protection of Human Rights and Dignity of the Human Being allowing member states to take different approaches. Each European state applies these principles to its specific conventions, leading to or reflecting different acceptance levels of stem cell research. [44]

For example, in Germany, Lebenzusammenhang , or the coherence of life, references integrity in the unity of human culture. Namely, the personal sphere “should not be subject to external intervention.” [45]  Stem cell interventions could affect this concept of bodily completeness, leading to heavy restrictions. Under the Grundgesetz, human dignity and the right to life with physical integrity are paramount. [46] The Embryo Protection Act of 1991 made producing cell lines illegal. Cell lines can be imported if approved by the Central Ethics Commission for Stem Cell Research only if they were derived before May 2007. [47] Stem cell research respects the integrity of life for the embryo with heavy specifications and intense oversight. This is vastly different in Finland, where the regulatory bodies find research more permissible in IVF excess, but only up to 14 days after fertilization. [48] Spain’s approach differs still, with a comprehensive regulatory framework. [49] Thus, research regulation can be culture-specific due to variations in applied principles. Diverse cultures call for various approaches to ethical permissibility. [50] Only an adaptive-deliberative model can address the cultural constructions of self and achieve positive, culturally sensitive stem cell research practices. [51]

II.     Religious Perspectives on ESC

Embryonic stem cell sources are the main consideration within religious contexts. While individuals may not regard their own religious texts as authoritative or factual, religion can shape their foundations or perspectives.

The Qur'an states:

“And indeed We created man from a quintessence of clay. Then We placed within him a small quantity of nutfa (sperm to fertilize) in a safe place. Then We have fashioned the nutfa into an ‘alaqa (clinging clot or cell cluster), then We developed the ‘alaqa into mudgha (a lump of flesh), and We made mudgha into bones, and clothed the bones with flesh, then We brought it into being as a new creation. So Blessed is Allah, the Best of Creators.” [52]

Many scholars of Islam estimate the time of soul installment, marked by the angel breathing in the soul to bring the individual into creation, as 120 days from conception. [53] Personhood begins at this point, and the value of life would prohibit research or experimentation that could harm the individual. If the fetus is more than 120 days old, the time ensoulment is interpreted to occur according to Islamic law, abortion is no longer permissible. [54] There are a few opposing opinions about early embryos in Islamic traditions. According to some Islamic theologians, there is no ensoulment of the early embryo, which is the source of stem cells for ESC research. [55]

In Buddhism, the stance on stem cell research is not settled. The main tenets, the prohibition against harming or destroying others (ahimsa) and the pursuit of knowledge (prajña) and compassion (karuna), leave Buddhist scholars and communities divided. [56] Some scholars argue stem cell research is in accordance with the Buddhist tenet of seeking knowledge and ending human suffering. Others feel it violates the principle of not harming others. Finding the balance between these two points relies on the karmic burden of Buddhist morality. In trying to prevent ahimsa towards the embryo, Buddhist scholars suggest that to comply with Buddhist tenets, research cannot be done as the embryo has personhood at the moment of conception and would reincarnate immediately, harming the individual's ability to build their karmic burden. [57] On the other hand, the Bodhisattvas, those considered to be on the path to enlightenment or Nirvana, have given organs and flesh to others to help alleviate grieving and to benefit all. [58] Acceptance varies on applied beliefs and interpretations.

Catholicism does not support embryonic stem cell research, as it entails creation or destruction of human embryos. This destruction conflicts with the belief in the sanctity of life. For example, in the Old Testament, Genesis describes humanity as being created in God’s image and multiplying on the Earth, referencing the sacred rights to human conception and the purpose of development and life. In the Ten Commandments, the tenet that one should not kill has numerous interpretations where killing could mean murder or shedding of the sanctity of life, demonstrating the high value of human personhood. In other books, the theological conception of when life begins is interpreted as in utero, [59] highlighting the inviolability of life and its formation in vivo to make a religious point for accepting such research as relatively limited, if at all. [60] The Vatican has released ethical directives to help apply a theological basis to modern-day conflicts. The Magisterium of the Church states that “unless there is a moral certainty of not causing harm,” experimentation on fetuses, fertilized cells, stem cells, or embryos constitutes a crime. [61] Such procedures would not respect the human person who exists at these stages, according to Catholicism. Damages to the embryo are considered gravely immoral and illicit. [62] Although the Catholic Church officially opposes abortion, surveys demonstrate that many Catholic people hold pro-choice views, whether due to the context of conception, stage of pregnancy, threat to the mother’s life, or for other reasons, demonstrating that practicing members can also accept some but not all tenets. [63]

Some major Jewish denominations, such as the Reform, Conservative, and Reconstructionist movements, are open to supporting ESC use or research as long as it is for saving a life. [64] Within Judaism, the Talmud, or study, gives personhood to the child at birth and emphasizes that life does not begin at conception: [65]

“If she is found pregnant, until the fortieth day it is mere fluid,” [66]

Whereas most religions prioritize the status of human embryos, the Halakah (Jewish religious law) states that to save one life, most other religious laws can be ignored because it is in pursuit of preservation. [67] Stem cell research is accepted due to application of these religious laws.

We recognize that all religions contain subsets and sects. The variety of environmental and cultural differences within religious groups requires further analysis to respect the flexibility of religious thoughts and practices. We make no presumptions that all cultures require notions of autonomy or morality as under the common morality theory , which asserts a set of universal moral norms that all individuals share provides moral reasoning and guides ethical decisions. [68] We only wish to show that the interaction with morality varies between cultures and countries.

III.     A Flexible Ethical Approach

The plurality of different moral approaches described above demonstrates that there can be no universally acceptable uniform law for ESC on a global scale. Instead of developing one standard, flexible ethical applications must be continued. We recommend local guidelines that incorporate important cultural and ethical priorities.

While the Declaration of Helsinki is more relevant to people in clinical trials receiving ESC products, in keeping with the tradition of protections for research subjects, consent of the donor is an ethical requirement for ESC donation in many jurisdictions including the US, Canada, and Europe. [69] The Declaration of Helsinki provides a reference point for regulatory standards and could potentially be used as a universal baseline for obtaining consent prior to gamete or embryo donation.

For instance, in Columbia University’s egg donor program for stem cell research, donors followed standard screening protocols and “underwent counseling sessions that included information as to the purpose of oocyte donation for research, what the oocytes would be used for, the risks and benefits of donation, and process of oocyte stimulation” to ensure transparency for consent. [70] The program helped advance stem cell research and provided clear and safe research methods with paid participants. Though paid participation or covering costs of incidental expenses may not be socially acceptable in every culture or context, [71] and creating embryos for ESC research is illegal in many jurisdictions, Columbia’s program was effective because of the clear and honest communications with donors, IRBs, and related stakeholders.  This example demonstrates that cultural acceptance of scientific research and of the idea that an egg or embryo does not have personhood is likely behind societal acceptance of donating eggs for ESC research. As noted, many countries do not permit the creation of embryos for research.

Proper communication and education regarding the process and purpose of stem cell research may bolster comprehension and garner more acceptance. “Given the sensitive subject material, a complete consent process can support voluntary participation through trust, understanding, and ethical norms from the cultures and morals participants value. This can be hard for researchers entering countries of different socioeconomic stability, with different languages and different societal values. [72]

An adequate moral foundation in medical ethics is derived from the cultural and religious basis that informs knowledge and actions. [73] Understanding local cultural and religious values and their impact on research could help researchers develop humility and promote inclusion.

IV.     Concerns

Some may argue that if researchers all adhere to one ethics standard, protection will be satisfied across all borders, and the global public will trust researchers. However, defining what needs to be protected and how to define such research standards is very specific to the people to which standards are applied. We suggest that applying one uniform guide cannot accurately protect each individual because we all possess our own perceptions and interpretations of social values. [74] Therefore, the issue of not adjusting to the moral pluralism between peoples in applying one standard of ethics can be resolved by building out ethics models that can be adapted to different cultures and religions.

Other concerns include medical tourism, which may promote health inequities. [75] Some countries may develop and approve products derived from ESC research before others, compromising research ethics or drug approval processes. There are also concerns about the sale of unauthorized stem cell treatments, for example, those without FDA approval in the United States. Countries with robust research infrastructures may be tempted to attract medical tourists, and some customers will have false hopes based on aggressive publicity of unproven treatments. [76]

For example, in China, stem cell clinics can market to foreign clients who are not protected under the regulatory regimes. Companies employ a marketing strategy of “ethically friendly” therapies. Specifically, in the case of Beike, China’s leading stem cell tourism company and sprouting network, ethical oversight of administrators or health bureaus at one site has “the unintended consequence of shifting questionable activities to another node in Beike's diffuse network.” [77] In contrast, Jordan is aware of stem cell research’s potential abuse and its own status as a “health-care hub.” Jordan’s expanded regulations include preserving the interests of individuals in clinical trials and banning private companies from ESC research to preserve transparency and the integrity of research practices. [78]

The social priorities of the community are also a concern. The ISSCR explicitly states that guidelines “should be periodically revised to accommodate scientific advances, new challenges, and evolving social priorities.” [79] The adaptable ethics model extends this consideration further by addressing whether research is warranted given the varying degrees of socioeconomic conditions, political stability, and healthcare accessibilities and limitations. An ethical approach would require discussion about resource allocation and appropriate distribution of funds. [80]

While some religions emphasize the sanctity of life from conception, which may lead to public opposition to ESC research, others encourage ESC research due to its potential for healing and alleviating human pain. Many countries have special regulations that balance local views on embryonic personhood, the benefits of research as individual or societal goods, and the protection of human research subjects. To foster understanding and constructive dialogue, global policy frameworks should prioritize the protection of universal human rights, transparency, and informed consent. In addition to these foundational global policies, we recommend tailoring local guidelines to reflect the diverse cultural and religious perspectives of the populations they govern. Ethics models should be adapted to local populations to effectively establish research protections, growth, and possibilities of stem cell research.

For example, in countries with strong beliefs in the moral sanctity of embryos or heavy religious restrictions, an adaptive model can allow for discussion instead of immediate rejection. In countries with limited individual rights and voice in science policy, an adaptive model ensures cultural, moral, and religious views are taken into consideration, thereby building social inclusion. While this ethical consideration by the government may not give a complete voice to every individual, it will help balance policies and maintain the diverse perspectives of those it affects. Embracing an adaptive ethics model of ESC research promotes open-minded dialogue and respect for the importance of human belief and tradition. By actively engaging with cultural and religious values, researchers can better handle disagreements and promote ethical research practices that benefit each society.

This brief exploration of the religious and cultural differences that impact ESC research reveals the nuances of relative ethics and highlights a need for local policymakers to apply a more intense adaptive model.

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[5] Concerning the moral philosophies of stem cell research, our paper does not posit a personal moral stance nor delve into the “when” of human life begins. To read further about the philosophical debate, consider the following sources:

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[7] Socially, at its core, the Western approach to ethics is widely principle-based, autonomy being one of the key factors to ensure a fundamental respect for persons within research. For information regarding autonomy in research, see: Department of Health, Education, and Welfare, & National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1978). The Belmont Report. Ethical principles and guidelines for the protection of human subjects of research.; For a more in-depth review of autonomy within the US, see: Beauchamp, T. L., & Childress, J. F. (1994). Principles of Biomedical Ethics . Oxford University Press.

[8] Sherley v. Sebelius , 644 F.3d 388 (D.C. Cir. 2011), citing 45 C.F.R. 46.204(b) and [42 U.S.C. § 289g(b)]. https://www.cadc.uscourts.gov/internet/opinions.nsf/6c690438a9b43dd685257a64004ebf99/$file/11-5241-1391178.pdf

[9] Stem Cell Research Enhancement Act of 2005, H. R. 810, 109 th Cong. (2001). https://www.govtrack.us/congress/bills/109/hr810/text ; Bush, G. W. (2006, July 19). Message to the House of Representatives . National Archives and Records Administration. https://georgewbush-whitehouse.archives.gov/news/releases/2006/07/20060719-5.html

[10] National Archives and Records Administration. (2009, March 9). Executive order 13505 -- removing barriers to responsible scientific research involving human stem cells . National Archives and Records Administration. https://obamawhitehouse.archives.gov/the-press-office/removing-barriers-responsible-scientific-research-involving-human-stem-cells

[11] Hurlbut, W. B. (2006). Science, Religion, and the Politics of Stem Cells.  Social Research ,  73 (3), 819–834. http://www.jstor.org/stable/40971854

[12] Akpa-Inyang, Francis & Chima, Sylvester. (2021). South African traditional values and beliefs regarding informed consent and limitations of the principle of respect for autonomy in African communities: a cross-cultural qualitative study. BMC Medical Ethics . 22. 10.1186/s12910-021-00678-4.

[13] Source for further reading: Tangwa G. B. (2007). Moral status of embryonic stem cells: perspective of an African villager. Bioethics , 21(8), 449–457. https://doi.org/10.1111/j.1467-8519.2007.00582.x , see also Mnisi, F. M. (2020). An African analysis based on ethics of Ubuntu - are human embryonic stem cell patents morally justifiable? African Insight , 49 (4).

[14] Jecker, N. S., & Atuire, C. (2021). Bioethics in Africa: A contextually enlightened analysis of three cases. Developing World Bioethics , 22 (2), 112–122. https://doi.org/10.1111/dewb.12324

[15] Jecker, N. S., & Atuire, C. (2021). Bioethics in Africa: A contextually enlightened analysis of three cases. Developing World Bioethics, 22(2), 112–122. https://doi.org/10.1111/dewb.12324

[16] Jackson, C.S., Pepper, M.S. Opportunities and barriers to establishing a cell therapy programme in South Africa.  Stem Cell Res Ther   4 , 54 (2013). https://doi.org/10.1186/scrt204 ; Pew Research Center. (2014, May 1). Public health a major priority in African nations . Pew Research Center’s Global Attitudes Project. https://www.pewresearch.org/global/2014/05/01/public-health-a-major-priority-in-african-nations/

[17] Department of Health Republic of South Africa. (2021). Health Research Priorities (revised) for South Africa 2021-2024 . National Health Research Strategy. https://www.health.gov.za/wp-content/uploads/2022/05/National-Health-Research-Priorities-2021-2024.pdf

[18] Oosthuizen, H. (2013). Legal and Ethical Issues in Stem Cell Research in South Africa. In: Beran, R. (eds) Legal and Forensic Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32338-6_80 , see also: Gaobotse G (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[19] United States Bureau of Citizenship and Immigration Services. (1998). Tunisia: Information on the status of Christian conversions in Tunisia . UNHCR Web Archive. https://webarchive.archive.unhcr.org/20230522142618/https://www.refworld.org/docid/3df0be9a2.html

[20] Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[21] Kooli, C. Review of assisted reproduction techniques, laws, and regulations in Muslim countries.  Middle East Fertil Soc J   24 , 8 (2020). https://doi.org/10.1186/s43043-019-0011-0 ; Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[22] Pang M. C. (1999). Protective truthfulness: the Chinese way of safeguarding patients in informed treatment decisions. Journal of medical ethics , 25(3), 247–253. https://doi.org/10.1136/jme.25.3.247

[23] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[24] Wang, Y., Xue, Y., & Guo, H. D. (2022). Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction.  Frontiers in pharmacology ,  13 , 1013740. https://doi.org/10.3389/fphar.2022.1013740

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[29] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[30] Chen, H., Wei, T., Wang, H.  et al.  Association of China’s two-child policy with changes in number of births and birth defects rate, 2008–2017.  BMC Public Health   22 , 434 (2022). https://doi.org/10.1186/s12889-022-12839-0

[31] Azuma, K. Regulatory Landscape of Regenerative Medicine in Japan.  Curr Stem Cell Rep   1 , 118–128 (2015). https://doi.org/10.1007/s40778-015-0012-6

[32] Harris, R. (2005, May 19). Researchers Report Advance in Stem Cell Production . NPR. https://www.npr.org/2005/05/19/4658967/researchers-report-advance-in-stem-cell-production

[33] Park, S. (2012). South Korea steps up stem-cell work.  Nature . https://doi.org/10.1038/nature.2012.10565

[34] Resnik, D. B., Shamoo, A. E., & Krimsky, S. (2006). Fraudulent human embryonic stem cell research in South Korea: lessons learned.  Accountability in research ,  13 (1), 101–109. https://doi.org/10.1080/08989620600634193 .

[35] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

[36] Association for the Advancement of Blood and Biotherapies.  https://www.aabb.org/regulatory-and-advocacy/regulatory-affairs/regulatory-for-cellular-therapies/international-competent-authorities/saudi-arabia

[37] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia.  BMC medical ethics ,  21 (1), 35. https://doi.org/10.1186/s12910-020-00482-6

[38] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia. BMC medical ethics , 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

Culturally, autonomy practices follow a relational autonomy approach based on a paternalistic deontological health care model. The adherence to strict international research policies and religious pillars within the regulatory environment is a great foundation for research ethics. However, there is a need to develop locally targeted ethics approaches for research (as called for in Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6), this decision-making approach may help advise a research decision model. For more on the clinical cultural autonomy approaches, see: Alabdullah, Y. Y., Alzaid, E., Alsaad, S., Alamri, T., Alolayan, S. W., Bah, S., & Aljoudi, A. S. (2022). Autonomy and paternalism in Shared decision‐making in a Saudi Arabian tertiary hospital: A cross‐sectional study. Developing World Bioethics , 23 (3), 260–268. https://doi.org/10.1111/dewb.12355 ; Bukhari, A. A. (2017). Universal Principles of Bioethics and Patient Rights in Saudi Arabia (Doctoral dissertation, Duquesne University). https://dsc.duq.edu/etd/124; Ladha, S., Nakshawani, S. A., Alzaidy, A., & Tarab, B. (2023, October 26). Islam and Bioethics: What We All Need to Know . Columbia University School of Professional Studies. https://sps.columbia.edu/events/islam-and-bioethics-what-we-all-need-know

[39] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[40] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[41] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[42] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[43] The EU’s definition of autonomy relates to the capacity for creating ideas, moral insight, decisions, and actions without constraint, personal responsibility, and informed consent. However, the EU views autonomy as not completely able to protect individuals and depends on other principles, such as dignity, which “expresses the intrinsic worth and fundamental equality of all human beings.” Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[44] Council of Europe. Convention for the protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine (ETS No. 164) https://www.coe.int/en/web/conventions/full-list?module=treaty-detail&treatynum=164 (forbidding the creation of embryos for research purposes only, and suggests embryos in vitro have protections.); Also see Drabiak-Syed B. K. (2013). New President, New Human Embryonic Stem Cell Research Policy: Comparative International Perspectives and Embryonic Stem Cell Research Laws in France.  Biotechnology Law Report ,  32 (6), 349–356. https://doi.org/10.1089/blr.2013.9865

[45] Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[46] Tomuschat, C., Currie, D. P., Kommers, D. P., & Kerr, R. (Trans.). (1949, May 23). Basic law for the Federal Republic of Germany. https://www.btg-bestellservice.de/pdf/80201000.pdf

[47] Regulation of Stem Cell Research in Germany . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-germany

[48] Regulation of Stem Cell Research in Finland . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-finland

[49] Regulation of Stem Cell Research in Spain . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-spain

[50] Some sources to consider regarding ethics models or regulatory oversights of other cultures not covered:

Kara MA. Applicability of the principle of respect for autonomy: the perspective of Turkey. J Med Ethics. 2007 Nov;33(11):627-30. doi: 10.1136/jme.2006.017400. PMID: 17971462; PMCID: PMC2598110.

Ugarte, O. N., & Acioly, M. A. (2014). The principle of autonomy in Brazil: one needs to discuss it ...  Revista do Colegio Brasileiro de Cirurgioes ,  41 (5), 374–377. https://doi.org/10.1590/0100-69912014005013

Bharadwaj, A., & Glasner, P. E. (2012). Local cells, global science: The rise of embryonic stem cell research in India . Routledge.

For further research on specific European countries regarding ethical and regulatory framework, we recommend this database: Regulation of Stem Cell Research in Europe . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-europe   

[51] Klitzman, R. (2006). Complications of culture in obtaining informed consent. The American Journal of Bioethics, 6(1), 20–21. https://doi.org/10.1080/15265160500394671 see also: Ekmekci, P. E., & Arda, B. (2017). Interculturalism and Informed Consent: Respecting Cultural Differences without Breaching Human Rights.  Cultura (Iasi, Romania) ,  14 (2), 159–172.; For why trust is important in research, see also: Gray, B., Hilder, J., Macdonald, L., Tester, R., Dowell, A., & Stubbe, M. (2017). Are research ethics guidelines culturally competent?  Research Ethics ,  13 (1), 23-41.  https://doi.org/10.1177/1747016116650235

[52] The Qur'an  (M. Khattab, Trans.). (1965). Al-Mu’minun, 23: 12-14. https://quran.com/23

[53] Lenfest, Y. (2017, December 8). Islam and the beginning of human life . Bill of Health. https://blog.petrieflom.law.harvard.edu/2017/12/08/islam-and-the-beginning-of-human-life/

[54] Aksoy, S. (2005). Making regulations and drawing up legislation in Islamic countries under conditions of uncertainty, with special reference to embryonic stem cell research. Journal of Medical Ethics , 31: 399-403.; see also: Mahmoud, Azza. "Islamic Bioethics: National Regulations and Guidelines of Human Stem Cell Research in the Muslim World." Master's thesis, Chapman University, 2022. https://doi.org/10.36837/ chapman.000386

[55] Rashid, R. (2022). When does Ensoulment occur in the Human Foetus. Journal of the British Islamic Medical Association , 12 (4). ISSN 2634 8071. https://www.jbima.com/wp-content/uploads/2023/01/2-Ethics-3_-Ensoulment_Rafaqat.pdf.

[56] Sivaraman, M. & Noor, S. (2017). Ethics of embryonic stem cell research according to Buddhist, Hindu, Catholic, and Islamic religions: perspective from Malaysia. Asian Biomedicine,8(1) 43-52.  https://doi.org/10.5372/1905-7415.0801.260

[57] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[58] Lecso, P. A. (1991). The Bodhisattva Ideal and Organ Transplantation.  Journal of Religion and Health ,  30 (1), 35–41. http://www.jstor.org/stable/27510629 ; Bodhisattva, S. (n.d.). The Key of Becoming a Bodhisattva . A Guide to the Bodhisattva Way of Life. http://www.buddhism.org/Sutras/2/BodhisattvaWay.htm

[59] There is no explicit religious reference to when life begins or how to conduct research that interacts with the concept of life. However, these are relevant verses pertaining to how the fetus is viewed. (( King James Bible . (1999). Oxford University Press. (original work published 1769))

Jerimiah 1: 5 “Before I formed thee in the belly I knew thee; and before thou camest forth out of the womb I sanctified thee…”

In prophet Jerimiah’s insight, God set him apart as a person known before childbirth, a theme carried within the Psalm of David.

Psalm 139: 13-14 “…Thou hast covered me in my mother's womb. I will praise thee; for I am fearfully and wonderfully made…”

These verses demonstrate David’s respect for God as an entity that would know of all man’s thoughts and doings even before birth.

[60] It should be noted that abortion is not supported as well.

[61] The Vatican. (1987, February 22). Instruction on Respect for Human Life in Its Origin and on the Dignity of Procreation Replies to Certain Questions of the Day . Congregation For the Doctrine of the Faith. https://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_19870222_respect-for-human-life_en.html

[62] The Vatican. (2000, August 25). Declaration On the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells . Pontifical Academy for Life. https://www.vatican.va/roman_curia/pontifical_academies/acdlife/documents/rc_pa_acdlife_doc_20000824_cellule-staminali_en.html ; Ohara, N. (2003). Ethical Consideration of Experimentation Using Living Human Embryos: The Catholic Church’s Position on Human Embryonic Stem Cell Research and Human Cloning. Department of Obstetrics and Gynecology . Retrieved from https://article.imrpress.com/journal/CEOG/30/2-3/pii/2003018/77-81.pdf.

[63] Smith, G. A. (2022, May 23). Like Americans overall, Catholics vary in their abortion views, with regular mass attenders most opposed . Pew Research Center. https://www.pewresearch.org/short-reads/2022/05/23/like-americans-overall-catholics-vary-in-their-abortion-views-with-regular-mass-attenders-most-opposed/

[64] Rosner, F., & Reichman, E. (2002). Embryonic stem cell research in Jewish law. Journal of halacha and contemporary society , (43), 49–68.; Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[65] Schenker J. G. (2008). The beginning of human life: status of embryo. Perspectives in Halakha (Jewish Religious Law).  Journal of assisted reproduction and genetics ,  25 (6), 271–276. https://doi.org/10.1007/s10815-008-9221-6

[66] Ruttenberg, D. (2020, May 5). The Torah of Abortion Justice (annotated source sheet) . Sefaria. https://www.sefaria.org/sheets/234926.7?lang=bi&with=all&lang2=en

[67] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[68] Gert, B. (2007). Common morality: Deciding what to do . Oxford Univ. Press.

[69] World Medical Association (2013). World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA , 310(20), 2191–2194. https://doi.org/10.1001/jama.2013.281053 Declaration of Helsinki – WMA – The World Medical Association .; see also: National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. (1979).  The Belmont report: Ethical principles and guidelines for the protection of human subjects of research . U.S. Department of Health and Human Services.  https://www.hhs.gov/ohrp/regulations-and-policy/belmont-report/read-the-belmont-report/index.html

[70] Zakarin Safier, L., Gumer, A., Kline, M., Egli, D., & Sauer, M. V. (2018). Compensating human subjects providing oocytes for stem cell research: 9-year experience and outcomes.  Journal of assisted reproduction and genetics ,  35 (7), 1219–1225. https://doi.org/10.1007/s10815-018-1171-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063839/ see also: Riordan, N. H., & Paz Rodríguez, J. (2021). Addressing concerns regarding associated costs, transparency, and integrity of research in recent stem cell trial. Stem Cells Translational Medicine , 10 (12), 1715–1716. https://doi.org/10.1002/sctm.21-0234

[71] Klitzman, R., & Sauer, M. V. (2009). Payment of egg donors in stem cell research in the USA.  Reproductive biomedicine online ,  18 (5), 603–608. https://doi.org/10.1016/s1472-6483(10)60002-8

[72] Krosin, M. T., Klitzman, R., Levin, B., Cheng, J., & Ranney, M. L. (2006). Problems in comprehension of informed consent in rural and peri-urban Mali, West Africa.  Clinical trials (London, England) ,  3 (3), 306–313. https://doi.org/10.1191/1740774506cn150oa

[73] Veatch, Robert M.  Hippocratic, Religious, and Secular Medical Ethics: The Points of Conflict . Georgetown University Press, 2012.

[74] Msoroka, M. S., & Amundsen, D. (2018). One size fits not quite all: Universal research ethics with diversity.  Research Ethics ,  14 (3), 1-17.  https://doi.org/10.1177/1747016117739939

[75] Pirzada, N. (2022). The Expansion of Turkey’s Medical Tourism Industry.  Voices in Bioethics ,  8 . https://doi.org/10.52214/vib.v8i.9894

[76] Stem Cell Tourism: False Hope for Real Money . Harvard Stem Cell Institute (HSCI). (2023). https://hsci.harvard.edu/stem-cell-tourism , See also: Bissassar, M. (2017). Transnational Stem Cell Tourism: An ethical analysis.  Voices in Bioethics ,  3 . https://doi.org/10.7916/vib.v3i.6027

[77] Song, P. (2011) The proliferation of stem cell therapies in post-Mao China: problematizing ethical regulation,  New Genetics and Society , 30:2, 141-153, DOI:  10.1080/14636778.2011.574375

[78] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[79] International Society for Stem Cell Research. (2024). Standards in stem cell research . International Society for Stem Cell Research. https://www.isscr.org/guidelines/5-standards-in-stem-cell-research

[80] Benjamin, R. (2013). People’s science bodies and rights on the Stem Cell Frontier . Stanford University Press.

Mifrah Hayath

SM Candidate Harvard Medical School, MS Biotechnology Johns Hopkins University

Olivia Bowers

MS Bioethics Columbia University (Disclosure: affiliated with Voices in Bioethics)

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This work is licensed under a Creative Commons Attribution 4.0 International License .

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Sat / act prep online guides and tips, 113 great research paper topics.

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One of the hardest parts of writing a research paper can be just finding a good topic to write about. Fortunately we've done the hard work for you and have compiled a list of 113 interesting research paper topics. They've been organized into ten categories and cover a wide range of subjects so you can easily find the best topic for you.

In addition to the list of good research topics, we've included advice on what makes a good research paper topic and how you can use your topic to start writing a great paper.

What Makes a Good Research Paper Topic?

Not all research paper topics are created equal, and you want to make sure you choose a great topic before you start writing. Below are the three most important factors to consider to make sure you choose the best research paper topics.

#1: It's Something You're Interested In

A paper is always easier to write if you're interested in the topic, and you'll be more motivated to do in-depth research and write a paper that really covers the entire subject. Even if a certain research paper topic is getting a lot of buzz right now or other people seem interested in writing about it, don't feel tempted to make it your topic unless you genuinely have some sort of interest in it as well.

#2: There's Enough Information to Write a Paper

Even if you come up with the absolute best research paper topic and you're so excited to write about it, you won't be able to produce a good paper if there isn't enough research about the topic. This can happen for very specific or specialized topics, as well as topics that are too new to have enough research done on them at the moment. Easy research paper topics will always be topics with enough information to write a full-length paper.

Trying to write a research paper on a topic that doesn't have much research on it is incredibly hard, so before you decide on a topic, do a bit of preliminary searching and make sure you'll have all the information you need to write your paper.

#3: It Fits Your Teacher's Guidelines

Don't get so carried away looking at lists of research paper topics that you forget any requirements or restrictions your teacher may have put on research topic ideas. If you're writing a research paper on a health-related topic, deciding to write about the impact of rap on the music scene probably won't be allowed, but there may be some sort of leeway. For example, if you're really interested in current events but your teacher wants you to write a research paper on a history topic, you may be able to choose a topic that fits both categories, like exploring the relationship between the US and North Korea. No matter what, always get your research paper topic approved by your teacher first before you begin writing.

113 Good Research Paper Topics

Below are 113 good research topics to help you get you started on your paper. We've organized them into ten categories to make it easier to find the type of research paper topics you're looking for.

Arts/Culture

  • Discuss the main differences in art from the Italian Renaissance and the Northern Renaissance .
  • Analyze the impact a famous artist had on the world.
  • How is sexism portrayed in different types of media (music, film, video games, etc.)? Has the amount/type of sexism changed over the years?
  • How has the music of slaves brought over from Africa shaped modern American music?
  • How has rap music evolved in the past decade?
  • How has the portrayal of minorities in the media changed?

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Current Events

  • What have been the impacts of China's one child policy?
  • How have the goals of feminists changed over the decades?
  • How has the Trump presidency changed international relations?
  • Analyze the history of the relationship between the United States and North Korea.
  • What factors contributed to the current decline in the rate of unemployment?
  • What have been the impacts of states which have increased their minimum wage?
  • How do US immigration laws compare to immigration laws of other countries?
  • How have the US's immigration laws changed in the past few years/decades?
  • How has the Black Lives Matter movement affected discussions and view about racism in the US?
  • What impact has the Affordable Care Act had on healthcare in the US?
  • What factors contributed to the UK deciding to leave the EU (Brexit)?
  • What factors contributed to China becoming an economic power?
  • Discuss the history of Bitcoin or other cryptocurrencies  (some of which tokenize the S&P 500 Index on the blockchain) .
  • Do students in schools that eliminate grades do better in college and their careers?
  • Do students from wealthier backgrounds score higher on standardized tests?
  • Do students who receive free meals at school get higher grades compared to when they weren't receiving a free meal?
  • Do students who attend charter schools score higher on standardized tests than students in public schools?
  • Do students learn better in same-sex classrooms?
  • How does giving each student access to an iPad or laptop affect their studies?
  • What are the benefits and drawbacks of the Montessori Method ?
  • Do children who attend preschool do better in school later on?
  • What was the impact of the No Child Left Behind act?
  • How does the US education system compare to education systems in other countries?
  • What impact does mandatory physical education classes have on students' health?
  • Which methods are most effective at reducing bullying in schools?
  • Do homeschoolers who attend college do as well as students who attended traditional schools?
  • Does offering tenure increase or decrease quality of teaching?
  • How does college debt affect future life choices of students?
  • Should graduate students be able to form unions?

body_highschoolsc

  • What are different ways to lower gun-related deaths in the US?
  • How and why have divorce rates changed over time?
  • Is affirmative action still necessary in education and/or the workplace?
  • Should physician-assisted suicide be legal?
  • How has stem cell research impacted the medical field?
  • How can human trafficking be reduced in the United States/world?
  • Should people be able to donate organs in exchange for money?
  • Which types of juvenile punishment have proven most effective at preventing future crimes?
  • Has the increase in US airport security made passengers safer?
  • Analyze the immigration policies of certain countries and how they are similar and different from one another.
  • Several states have legalized recreational marijuana. What positive and negative impacts have they experienced as a result?
  • Do tariffs increase the number of domestic jobs?
  • Which prison reforms have proven most effective?
  • Should governments be able to censor certain information on the internet?
  • Which methods/programs have been most effective at reducing teen pregnancy?
  • What are the benefits and drawbacks of the Keto diet?
  • How effective are different exercise regimes for losing weight and maintaining weight loss?
  • How do the healthcare plans of various countries differ from each other?
  • What are the most effective ways to treat depression ?
  • What are the pros and cons of genetically modified foods?
  • Which methods are most effective for improving memory?
  • What can be done to lower healthcare costs in the US?
  • What factors contributed to the current opioid crisis?
  • Analyze the history and impact of the HIV/AIDS epidemic .
  • Are low-carbohydrate or low-fat diets more effective for weight loss?
  • How much exercise should the average adult be getting each week?
  • Which methods are most effective to get parents to vaccinate their children?
  • What are the pros and cons of clean needle programs?
  • How does stress affect the body?
  • Discuss the history of the conflict between Israel and the Palestinians.
  • What were the causes and effects of the Salem Witch Trials?
  • Who was responsible for the Iran-Contra situation?
  • How has New Orleans and the government's response to natural disasters changed since Hurricane Katrina?
  • What events led to the fall of the Roman Empire?
  • What were the impacts of British rule in India ?
  • Was the atomic bombing of Hiroshima and Nagasaki necessary?
  • What were the successes and failures of the women's suffrage movement in the United States?
  • What were the causes of the Civil War?
  • How did Abraham Lincoln's assassination impact the country and reconstruction after the Civil War?
  • Which factors contributed to the colonies winning the American Revolution?
  • What caused Hitler's rise to power?
  • Discuss how a specific invention impacted history.
  • What led to Cleopatra's fall as ruler of Egypt?
  • How has Japan changed and evolved over the centuries?
  • What were the causes of the Rwandan genocide ?

main_lincoln

  • Why did Martin Luther decide to split with the Catholic Church?
  • Analyze the history and impact of a well-known cult (Jonestown, Manson family, etc.)
  • How did the sexual abuse scandal impact how people view the Catholic Church?
  • How has the Catholic church's power changed over the past decades/centuries?
  • What are the causes behind the rise in atheism/ agnosticism in the United States?
  • What were the influences in Siddhartha's life resulted in him becoming the Buddha?
  • How has media portrayal of Islam/Muslims changed since September 11th?

Science/Environment

  • How has the earth's climate changed in the past few decades?
  • How has the use and elimination of DDT affected bird populations in the US?
  • Analyze how the number and severity of natural disasters have increased in the past few decades.
  • Analyze deforestation rates in a certain area or globally over a period of time.
  • How have past oil spills changed regulations and cleanup methods?
  • How has the Flint water crisis changed water regulation safety?
  • What are the pros and cons of fracking?
  • What impact has the Paris Climate Agreement had so far?
  • What have NASA's biggest successes and failures been?
  • How can we improve access to clean water around the world?
  • Does ecotourism actually have a positive impact on the environment?
  • Should the US rely on nuclear energy more?
  • What can be done to save amphibian species currently at risk of extinction?
  • What impact has climate change had on coral reefs?
  • How are black holes created?
  • Are teens who spend more time on social media more likely to suffer anxiety and/or depression?
  • How will the loss of net neutrality affect internet users?
  • Analyze the history and progress of self-driving vehicles.
  • How has the use of drones changed surveillance and warfare methods?
  • Has social media made people more or less connected?
  • What progress has currently been made with artificial intelligence ?
  • Do smartphones increase or decrease workplace productivity?
  • What are the most effective ways to use technology in the classroom?
  • How is Google search affecting our intelligence?
  • When is the best age for a child to begin owning a smartphone?
  • Has frequent texting reduced teen literacy rates?

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How to Write a Great Research Paper

Even great research paper topics won't give you a great research paper if you don't hone your topic before and during the writing process. Follow these three tips to turn good research paper topics into great papers.

#1: Figure Out Your Thesis Early

Before you start writing a single word of your paper, you first need to know what your thesis will be. Your thesis is a statement that explains what you intend to prove/show in your paper. Every sentence in your research paper will relate back to your thesis, so you don't want to start writing without it!

As some examples, if you're writing a research paper on if students learn better in same-sex classrooms, your thesis might be "Research has shown that elementary-age students in same-sex classrooms score higher on standardized tests and report feeling more comfortable in the classroom."

If you're writing a paper on the causes of the Civil War, your thesis might be "While the dispute between the North and South over slavery is the most well-known cause of the Civil War, other key causes include differences in the economies of the North and South, states' rights, and territorial expansion."

#2: Back Every Statement Up With Research

Remember, this is a research paper you're writing, so you'll need to use lots of research to make your points. Every statement you give must be backed up with research, properly cited the way your teacher requested. You're allowed to include opinions of your own, but they must also be supported by the research you give.

#3: Do Your Research Before You Begin Writing

You don't want to start writing your research paper and then learn that there isn't enough research to back up the points you're making, or, even worse, that the research contradicts the points you're trying to make!

Get most of your research on your good research topics done before you begin writing. Then use the research you've collected to create a rough outline of what your paper will cover and the key points you're going to make. This will help keep your paper clear and organized, and it'll ensure you have enough research to produce a strong paper.

What's Next?

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Christine graduated from Michigan State University with degrees in Environmental Biology and Geography and received her Master's from Duke University. In high school she scored in the 99th percentile on the SAT and was named a National Merit Finalist. She has taught English and biology in several countries.

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Cardiometabolic Effects of Omnivorous vs Vegan Diets in Identical Twins

Matthew j. landry.

1 Stanford Prevention Research Center, Department of Medicine, School of Medicine, Stanford University, Palo Alto, California

2 Department of Population Health and Disease Prevention, Program in Public Health, University of California, Irvine

Catherine P. Ward

Kristen m. cunanan.

3 Quantitative Sciences Unit, Department of Medicine, Stanford University, Palo Alto, California

Lindsay R. Durand

Dalia perelman, jennifer l. robinson, tayler hennings, christopher dant, amanda zeitlin, emily r. ebel.

4 Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford University, Palo Alto, California

Erica D. Sonnenburg

Justin l. sonnenburg.

5 Chan Zuckerberg Biohub, San Francisco, California

6 Center for Human Microbiome Studies, Stanford University School of Medicine, Stanford, California

Christopher D. Gardner

Accepted for Publication: October 12, 2023.

Published: November 30, 2023. doi:10.1001/jamanetworkopen.2023.44457

Open Access: This is an open access article distributed under the terms of the CC-BY License . © 2023 Landry MJ et al. JAMA Network Open .

Author Contributions: Dr Gardner had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Landry and Ward are co–first authors.

Concept and design: Landry, Cunanan, Perelman, Robinson, J. L. Sonnenburg, Gardner.

Acquisition, analysis, or interpretation of data: All authors.

Drafting of the manuscript: Landry, Ward, Cunanan, Durand, Perelman, Dant.

Critical review of the manuscript for important intellectual content: Landry, Ward, Cunanan, Robinson, Hennings, Koh, Dant, Zeitlin, Ebel, E. D. Sonnenburg, J. L. Sonnenburg, Gardner.

Statistical analysis: Landry, Ward, Durand, Zeitlin.

Obtained funding: J. L. Sonnenburg, Gardner.

Administrative, technical, or material support: Perelman, Robinson, Hennings, Dant, E. D. Sonnenburg, J. L. Sonnenburg.

Supervision: Cunanan, Dant, E. D. Sonnenburg, J. L. Sonnenburg, Gardner.

Conflict of Interest Disclosures: Dr Ebel reported receiving grants from the National Science Foundation Postdoctoral Research Fellowship in Biology during the conduct of the study. Dr Gardner reported receiving funding from Beyond Meat outside the submitted work. Dr J. L. Sonnenburg is a Chan Zuckerberg Biohub investigator. No other disclosures were reported.

Funding/Support: This study was funded by the Vogt Foundation (Drs Robinson, J. L. Sonnenburg, and Gardner and Ms Hennings), grants UL1TR001085 and TL1R001085 from the Stanford Clinical and Translational Science Award unit (Dr O’Hara), and grant T32HL161270 from the National Heart, Lung, and Blood Institute (Dr Ward).

Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Data Sharing Statement: See Supplement 3 .

Additional Contributions: We acknowledge the study participants without whom this investigation would not have been possible.

Associated Data

eResults. Supplementary Results

eAppendix. Plant-Based Dietary Intervention Reporting Checklist

eFigure 1. TwiNS Study Design

eTable 1. Twin Lifestyle Behaviors, n = 42 (21 Pairs of Twins)

eFigure 2. Macronutrient Distribution by Phase and Diet

eTable 2. Macronutrient Distribution by Phase and Diet

eFigure 3. Fat Distribution by Phase and Diet

eTable 3. Fat Distribution by Phase and Diet

eFigure 4. Grain Distribution by Phase and Diet

eTable 4. Grain Distribution by Phase and Diet

eFigure 5. Protein Distribution by Phase and Diet

eTable 5. Protein Distribution by Phase and Diet

eFigure 6. Carbohydrate Distribution by Phase and Diet

eTable 6. Carbohydrate Distribution by Phase and Diet

eFigure 7. Dietary Cholesterol Distribution by Phase and Diet

eTable 7. Dietary Cholesterol Distribution by Phase and Diet

eFigure 8. Dietary Vitamin B12 Distribution by Phase and Diet

eTable 8. Dietary Vitamin B12 Distribution by Phase and Diet

eFigure 9. Dietary Iron Distribution by Phase and Diet

eTable 9. Dietary Iron Distribution by Phase and Diet

eFigure 10. Vegetable Servings Distribution by Phase and Diet

eTable 10. Vegetable Servings Distribution by Phase and Diet

eFigure 11. Animal-Based Protein Distribution by Phase and Diet

eTable 11. Animal-Based Protein Distribution by Phase and Diet

eFigure 12. Meat Alternatives Distribution by Phase and Diet

eTable 12. Meat Alternatives Distribution by Phase and Diet

eTable 13. Diet Satisfaction (D-Sat28) of Participants by Diet Assignment and Phase

eTable 14. Self-Efficacy to Plan, Shop, Cook, and Choose Meals by Diet Assignment and Phase

eTable 15. Diet Preferences of Participants by Diet Assignment

eTable 16. Perceptions of Delivered, Pre-Prepared Meals by Diet Assignment

eTable 17. Barriers to Adherence to Study Eating Patterns by Diet Assignment

eTable 18. Factors that Improve Dietary Adherence and Sustainability by Diet Assignment

eTable 19. Average Self-Rated Dietary Adherence by Diet Assignment and Phase

eTable 20. Cardiovascular Health Outcomes at the End of 4 Weeks and Main Effect Model Estimates, Standard Errors, and 95% Confidence Interval for Primary and Secondary Outcome Analysis

eFigure 13. Sensitivity Analysis of the Change in Trimethylamine N-Oxide (TMAO) With Three Outliers Removed, (Mean ± SE)

eTable 21. Paired T-Tests of Cardiovascular Health Outcomes at the End of 8 Weeks

eTable 22. Unpaired T-Tests of Cardiovascular Health Outcomes at the End of 8 Weeks

eTable 23. Average Macronutrient and Micronutrient Composition of Trifecta Food Delivery Meals by Meal Type and Diet Assignment

eReferences

What are the cardiometabolic effects of a healthy plant-based (vegan) vs a healthy omnivorous diet among identical twins during an 8-week intervention?

In this randomized clinical trial of 22 healthy, adult, identical twin pairs, those consuming a healthy vegan diet showed significantly improved low-density lipoprotein cholesterol concentration, fasting insulin level, and weight loss compared with twins consuming a healthy omnivorous diet.

The findings from this trial suggest that a healthy plant-based diet offers a significant protective cardiometabolic advantage compared with a healthy omnivorous diet.

This randomized clinical trial of identical twin pairs compares the cardiometabolic effects of a healthy vegan diet with a healthy omnivorous diet.

Increasing evidence suggests that, compared with an omnivorous diet, a vegan diet confers potential cardiovascular benefits from improved diet quality (ie, higher consumption of vegetables, legumes, fruits, whole grains, nuts, and seeds).

To compare the effects of a healthy vegan vs healthy omnivorous diet on cardiometabolic measures during an 8-week intervention.

Design, Setting, and Participants

This single-center, population-based randomized clinical trial of 22 pairs of twins (N = 44) randomized participants to a vegan or omnivorous diet (1 twin per diet). Participant enrollment began March 28, 2022, and continued through May 5, 2022. The date of final follow-up data collection was July 20, 2022. This 8-week, open-label, parallel, dietary randomized clinical trial compared the health impact of a vegan diet vs an omnivorous diet in identical twins. Primary analysis included all available data.

Intervention

Twin pairs were randomized to follow a healthy vegan diet or a healthy omnivorous diet for 8 weeks. Diet-specific meals were provided via a meal delivery service from baseline through week 4, and from weeks 5 to 8 participants prepared their own diet-appropriate meals and snacks.

Main Outcomes and Measures

The primary outcome was difference in low-density lipoprotein cholesterol concentration from baseline to end point (week 8). Secondary outcome measures were changes in cardiometabolic factors (plasma lipids, glucose, and insulin levels and serum trimethylamine N -oxide level), plasma vitamin B 12 level, and body weight. Exploratory measures were adherence to study diets, ease or difficulty in following the diets, participant energy levels, and sense of well-being.

A total of 22 pairs (N = 44) of twins (34 [77.3%] female; mean [SD] age, 39.6 [12.7] years; mean [SD] body mass index, 25.9 [4.7]) were enrolled in the study. After 8 weeks, compared with twins randomized to an omnivorous diet, the twins randomized to the vegan diet experienced significant mean (SD) decreases in low-density lipoprotein cholesterol concentration (−13.9 [5.8] mg/dL; 95% CI, −25.3 to −2.4 mg/dL), fasting insulin level (−2.9 [1.3] μIU/mL; 95% CI, −5.3 to −0.4 μIU/mL), and body weight (−1.9 [0.7] kg; 95% CI, −3.3 to −0.6 kg).

Conclusions and Relevance

In this randomized clinical trial of the cardiometabolic effects of omnivorous vs vegan diets in identical twins, the healthy vegan diet led to improved cardiometabolic outcomes compared with a healthy omnivorous diet. Clinicians can consider this dietary approach as a healthy alternative for their patients.

Trial Registration

ClinicalTrials.gov Identifier: {"type":"clinical-trial","attrs":{"text":"NCT05297825","term_id":"NCT05297825"}} NCT05297825

Introduction

Plant-based diets have gained recent popularity not only for their lower environmental impact compared with an omnivorous dietary pattern but also for their health benefits. 1 , 2 The most significant global health crises affecting our generation are noncommunicable diseases and climate change, which are both inextricably linked to diet, 3 and dietary patterns high in plants and low in animal foods can maximize health and environmental benefits. 4 , 5 Plant-based diets contain a diverse family of dietary patterns, which encourage a reduced consumption of animal foods. 6 Abundant evidence from observational and intervention studies 7 , 8 , 9 , 10 , 11 , 12 , 13 indicates that vegan diets are associated with improved cardiovascular health and decreased risk of cardiovascular disease, likely because of the higher daily consumption of vegetables and fruits, legumes, whole grains and nuts, and seeds compared with other different types of dietary patterns. 14

A vegan dietary pattern is typically lower in energy density but higher in fiber, vitamins, minerals, and phytonutrients compared with other dietary patterns. 15 However, sometimes a vegan dietary pattern can limit specific nutrients, such as vitamin B 12 , iron, and calcium. 15 , 16 Most studies 17 , 18 examining vegan diets have been epidemiologic examinations, with a few reported clinical studies. 19 , 20 A confounding factor to consider in epidemiologic studies is the bias of self-decided vegans who may differ from nonvegans in factors that may influence diet and health. 21 In addition, a poorly formulated vegan diet can include low-quality plant foods, such as refined carbohydrates and added sugars. 22 To address these concerns, we designed a trial to compare the cardiometabolic effects of a healthy vegan diet with a healthy omnivorous diet, exposing both groups to vegetables, legumes, fruits, whole grains, nuts, and seeds. To control for genetic differences that might alter the cardiometabolic effects of diet, 23 we randomly assigned identical twins to follow the 2 diets for 8 weeks.

This study followed the ethical standards of the Declaration of Helsinki 24 and was approved by the Stanford University Human Subjects Committee on March 9, 2022. All study participants provided written informed consent. The trial protocol is given in Supplement 1 . Additional methods are available in the eMethods in Supplement 2 . This report follows the 25-item Consolidated Standards of Reporting Trials ( CONSORT ) reporting guideline of design, participants, interventions, outcomes, sample size, randomization, participant flow, baseline data, outcomes, ancillary analyses, limitations, and interpretation. Race and ethnicity data were collected via self-report and included to characterize the population for generalizability of findings.

Study Design

This single-site, parallel-group, dietary intervention randomized clinical trial randomized healthy, adult identical twins to a healthy vegan or omnivorous diet for 8 weeks. Participant enrollment began March 28, 2022, and continued through May 5, 2022. The date of final follow-up data collection was July 20, 2022.

The primary outcome was the difference from baseline to 8 weeks in low-density lipoprotein cholesterol (LDL-C) levels between the diet groups. Secondary outcomes included differences from baseline to 8 weeks in body weight and levels of fasting triglycerides, high-density lipoprotein cholesterol, glucose, insulin, trimethylamine N -oxide (TMAO), and vitamin B 12 . Exploratory assessments included diet quality, adherence, and qualitative factors to help interpret the study’s findings (eFigure 1 in Supplement 2 ).

Participants

We aimed to recruit 22 pairs of identical twins 18 years or older, a sample size determined by resource availability rather than a formal power calculation. Identical twins were recruited primarily from the Stanford Twin Registry and randomized using computerized random-number generation by a statistician (K.M.C.) blinded to the intervention, delivery, or data collection. Adult twins 18 years or older willing to consume a plant-based (vegan) or omnivore diet for 8 weeks were included. We excluded participants who weighed 45.36 kg (100 lb) or less, had a body mass index (calculated as weight in kilograms divided by height in meters squared) of 40 or higher, had an LDL-C level of 190 mg/dL or higher (to convert to millimoles per liter, multiply by 0.0259), had a systolic blood pressure of 160 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher, or were pregnant. Individuals self-reported race and ethnicity for the purpose of demographic reporting. Inclusion and exclusion criteria have been previously published. 25

Dietary Intervention

The study consisted of two 4-week phases: delivered meals and self-provided meals. Participants were provided all no-cost meals for the first 4 study weeks by a nationwide meal delivery company (Trifecta Nutrition). It was expected that after 4 weeks of food delivery and health educator counseling that participants would understand the amounts and types of foods they should purchase and prepare to achieve maximum adherence to the diets when self-providing meals.

Research staff worked with Trifecta Nutrition to develop menu offerings to match a healthy vegan and omnivorous diet, which emphasized vegetables, fruits, and whole grains while limiting added sugars and refined grains. During the initial 4 weeks, meals were delivered once each week, with 7 days of breakfast, lunch, and dinner meals. Participants also purchased and consumed snacks to meet their energy requirements following guidance from health educators.

Guiding principles were reinforced: (1) choose minimally processed foods; (2) build a balanced plate with vegetables, starch, protein, and healthy fats; (3) choose variety within each food group; and (4) individualize these guidelines to meet preferences and needs (eAppendix in Supplement 2 ). Although weight loss was not discouraged, our diet design did not include a prescribed energy restriction and was not intended to be a weight loss study. Participants were told to eat until they were satiated throughout the study.

Collection of Dietary Intake

Two types of dietary data were collected. For the primary reporting data, 3 unannounced 24-hour dietary recalls—a structured interview intended to capture detailed information about food and drink intakes—were administered within a 1-week window (2 weekdays and 1 weekend day) of each time point (baseline, week 4, and week 8). Data were collected via telephone by a registered dietitian (L.R.D.) using Nutrition Data System for Research (Nutrition Coordinating Center). For the secondary reporting data, participants were encouraged to log their food intake using the Cronometer app (Cronometer Pro, Nutrition Tracking Software for Professionals; Cronometer); these data were used by health educators for real-time guidance of participants.

Anthropometric and Metabolic Data

At 3 time points, participants visited the Stanford Clinical and Translational Research Unit after an overnight fast of 10 to 12 hours: baseline, 4 weeks (phase 1), and 8 weeks (phase 2). Blood draw and clinical measures were assessed using standard methods (eMethods in Supplement 2 ). Stool samples were collected for future analysis to examine changes to the gut microbiome (eg, microbial diversity), metabolites, inflammatory markers, and additional health factors.

Statistical Analysis

Descriptive statistics, mean (SD) or number (percentage), were used for continuous and categorical variables, respectively. Table 1 presents baseline summary statistics by study group. For the primary analysis, we investigated differences between groups in the change from baseline to week 8 for LDL-C between vegan and omnivorous diets among identical twins. Primary analysis included all available data. A linear mixed model was used and included fixed effects for diet and time (baseline as reference) and an interaction effect for diet × time and a random effect for twin pair to account for the correlation between identical twins (ie, random intercept allowed intercept to vary for each twin pair). A Wald test was used to evaluate a significant difference in diet at 8 weeks from baseline (interaction term). Finally, we present model estimates (95% CIs) for diet at 8 weeks. For each secondary outcome, we evaluated a statistical model similar to the primary model as described herein.

Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.

SI conversion factors: To convert HDL-C and LDL-C to mmol/L, multiply by 0.0259; triglycerides to mmol/L, multiply by 0.0113; glucose to mmol/L, multiply by 0.0555; insulin to pmol/L, multiply by 6.945; vitamin B 12 to pmol/L, multiply by 0.7378.

Analyses were completed using R Studio, version 2022.12.0 (Posit Software). A 2-sided P  ≤ .05 was considered to be statistically significant. No correction was applied for multiple comparisons, and secondary and exploratory analyses should be interpreted accordingly.

A total of 22 pairs of randomized twins (N = 44) were enrolled in the study. The CONSORT flow diagram of participants ( Figure 1 ) shows 22 twin pairs randomized to receive either a vegan or omnivorous diet (1 twin per diet); 21 pairs in both groups contributed to the final analyses. Baseline characteristics ( Table 1 ) included the following: mean (SD) age, 39.6 (12.7) years; 34 (77.3%) female and 10 (22.7%) male; 5 (11.4%) Asian, 2 (4.5%) Black/African American, 1 (2.3%) Native Hawaiian/Pacific Islander, 32 (72.7%) White, 4 (9.1%) multiracial, and mean (SD) body mass index, 26.9 (4.9). Most twins (33 of 42 [78.6%]) currently lived with their twin, and most reported being similar to their twin (29 of 42 [69.0%]) ( Table 2 ; eTable 1 in Supplement 2 ).

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Abbreviations: HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TMAO, trimethylamine N -oxide.

Diet and Nutrient Intake

Reported energy intake during each of the two 4-week phases (food delivery and self-provided) were lower compared with baseline for both groups (eFigures 1 to 5 and eTables 2 to 6 and 23 in Supplement 2 ). Intake of vegetables, animal-based protein sources, and plant-based protein sources by diet group and per intervention phase are provided in eFigures 6 to 12 and eTables 10 to 12 in Supplement 2 . Additional results are available in the eResults, eTables 7 to 9, and eFigures 7 to 9 in Supplement 2 .

Primary Outcome

Participants receiving the vegan diet showed a mean (SD) decrease of 13.9 (5.8) mg/dL (95% CI, −25.3 to −2.4 mg/dL) in the unadjusted mean LDL-C level at 8 weeks from baseline compared with participants receiving the omnivorous diet ( Table 2 ). As early as 4 weeks, we observed a significant decrease in mean LDL-C level among vegans compared with omnivores (eTable 20 in Supplement 2 ). The percentage of change from baseline to 8 weeks in primary and secondary outcomes between vegan and omnivorous diet groups ( Figure 2 ) showed a significant decrease in LDL-C level among the vegan compared with the omnivore group ( Table 2 ). Participants’ mean (SD) baseline LDL-C level was 114 (33.5) mg/dL, 26 leaving minimal room for participants to improve through diet alone.

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For primary and secondary outcomes, percent change and P values are presented. A Wald test was used to evaluate a significant difference in diet at 8 weeks from baseline (interaction term). Error bars indicate IQRs. HDL-C indicates high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; and TMAO, trimethylamine N -oxide.

Secondary Outcomes

Compared with participants receiving the omnivorous diet, participants receiving the vegan diet saw a significant mean (SD) decrease of 2.9 (1.3) μIU/mL in fasting insulin (95% CI, −5.3 to −0.4 μIU/mL) from baseline to 8 weeks ( P  = .03) (to convert to picomoles per liter, multiply by 6.945) ( Table 2 ). Vegan participants had a significant mean (SD) decrease of −1.9 (0.7) kg in body weight (95% CI, −3.3 to −0.6 kg) from baseline to 8 weeks compared with participants on the omnivorous diet ( P  = .01) ( Figure 2 ), although weight loss was observed for both diet groups. Vegans also experienced a larger but nonsignificant absolute median decrease in fasting high-density lipoprotein cholesterol, triglycerides, vitamin B 12 , glucose, and TMAO levels at 8 weeks from baseline compared with omnivores.

Sensitivity Analysis

Three outlier TMAO levels greater than 15 μM were noted: 2 at baseline and 1 at 8 weeks. After the outliers were eliminated, the TMAO level was significantly different between diet groups at 8 weeks: in this analysis, participants on the vegan diet showed a mean (SD) decrease of −2.1 (0.7) μM (95% CI, −3.5 to −0.7 μM) in the difference of TMAO from baseline to 8 weeks compared with participants on the omnivorous diet (eFigure 13 in Supplement 2 ).

Exploratory Analysis

Paired and unpaired 2-tailed t tests indicate minimal differences between statistical analysis approach (eTables 21 and 22 in Supplement 2 ). Participants receiving the omnivorous diet had nominally higher diet satisfaction at weeks 4 and 8 compared with vegan participants (eTable 13 in Supplement 2 ). Additional results are available in eResults and eTables 14 to 20 in Supplement 2 .

In this randomized clinical trial of healthy, adult identical twins, the 8-week change in LDL-C level—the primary outcome—was significantly lower for twins receiving the vegan diet compared with twins receiving the omnivorous diet. Insulin levels and weight were also significantly lower among the twins on the vegan diet from baseline to 8 weeks. Vegan-diet participants had total lower protein intake as a percentage of calories, lower dietary satisfaction, lower intake of dietary cholesterol, but higher intake of vegetable servings and intake of dietary iron. Vegans had lower intake of vitamin B 12 , yet serum vitamin B 12 levels were not statistically different than omnivores at 8 weeks, likely because of preserved stores. 27 Long-term vegans are typically encouraged to take a cyanocobalamin (vitamin B 12 ) supplement.

Two factors may have limited our opportunity to observe additional differences between the study groups. First, participants in both diet groups were assigned to eat a healthy diet, usually healthier compared with their prestudy dietary pattern demonstrated by increased vegetable intake and decreased refined grains intake. Even the omnivorous participants improved their diet quality during the 8-week intervention (eg, increased vegetables and whole grain intake and decreased added sugars and refined grains). Second, within both groups, potential differences in clinical end point changes may have been blunted because participants were healthy at baseline. For example, participants’ mean baseline LDL-C level was 114 mg/dL, 26 leaving minimal room for participants to improve through diet alone. Nonetheless, we observed significant improvements in 3 clinical outcomes (LDL-C, insulin, and weight) among the vegan participants.

Our results corroborate a previous finding showing that eating a vegan diet can improve cardiovascular health. 28 A larger body of evidence from randomized clinical trials suggests that vegetarian and other plant-based dietary patterns lower weight 29 , 30 , 31 and improve lipid management, 30 , 32 , 33 glucose metabolism, 33 , 34 blood pressure, 35 , 36 , 37 and cardiometabolic health. 38 Our results also mirror a recently completed 2-year dietary intervention trial among African Americans randomized to a vegan or low-fat omnivorous diet, finding improvements in body weight and cardiovascular disease risk factors. 39

Novel to this study was our population of identical twins, a valuable resource in scientific research that provided a unique opportunity to investigate the effects of a dietary intervention while controlling for genetic and environmental factors, 40 influences that can significantly impact health outcomes, including body weight, cardiovascular health, and metabolic function. 40 , 41 Because identical twins have nearly identical DNA and many shared experiences (eg, upbringing, geographic region growing up, and similar exposure to other variables), observed differences in health outcomes after adoption of different dietary patterns can largely be attributed to the diet itself.

We were surprised that TMAO concentrations did not significantly differ between diets at 8 weeks because of the higher meat content in the omnivorous diet and of the meat TMAO precursors choline and carnitine. 42 , 43 Although some studies 44 , 45 report a positive association between the concentration of serum TMAO and development of cardiovascular disease, whether TMAO is a bystander or mediator of disease remains unknown. In a sensitivity analysis that removed 3 TMAO outlier participants, lower TMAO levels were found in the vegan participants. Prior research 42 , 43 has suggested that vegans have lower TMAO levels than meat or fish eaters because of the TMAO precursors choline and carnitine in animal products. In a recent crossover dietary trial (Study With Appetizing Plantfood-Meat Eating Alternative Trial [SWAP-MEAT]), 46 participants consuming plant-based alternative meat vs animal meat had significantly lower TMAO concentrations. In addition to our 3 TMAO outliers, we observed variability among participants in TMAO concentration changes. Further investigation is needed on TMAO as a risk factor for cardiovascular disease and the association of dietary choline and carnitine vs fish with serum TMAO concentrations.

A recent meta-epidemiologic study 47 examining dietary recommendations from current clinical practice guidelines recommends diets rich in unrefined plant foods and low in refined and animal-based foods. Clinical practice guidelines from the American Heart Association recommend that practitioners encourage patients to choose healthy sources of protein, mostly from plants, to promote cardiovascular health. 11 , 48 Additionally, Dietary Guidelines for Americans, 2020-2025 49 includes a healthy, vegetarian-style dietary pattern that can be adopted for improved health and chronic disease prevention. Although our findings suggest that vegan diets offer a protective cardiometabolic advantage compared with a healthy, omnivorous diet, excluding all meats and/or dairy products may not be necessary because research 22 , 50 suggests that cardiovascular benefits can be achieved with modest reductions in animal foods and increases in healthy plant-based foods compared with typical diets. We believe lower dietary satisfaction in the vegan group may have been attributable to the strictness of the vegan diet, creating more barriers for people to follow the vegan diet guidelines. Some people may find a less restrictive diet preferable for LDL-C–lowering effects. Future studies assessing health benefits of less strict plant-based diets will be necessary to assess these benefits, especially in a study model limiting additional biases (eg, in twins). Within a clinical setting, patients should be supported in choosing a dietary pattern that fits their needs and preferences. 41 , 51 Clinicians should allow patients to make informed choices that support them to choose which dietary approach is most suitable for them. At a population level, wider adoption of a culturally appropriate dietary pattern that is higher in plant foods and lower in animal foods can promote health and environmental benefits. 3 , 4 , 10 , 52

Strengths and Limitations

Several aspects of our design and implementation were strengths. First, enrolling identical twins was beneficial because we were able to eliminate the confounding influences of age, sex, and genetic factors that may affect clinical outcomes. Identical twins often share a similar environment and lifestyle, reducing environmental factors on the study results. Second, the initial 4-week period of food delivery facilitated participants’ high adherence to the diet, whereas the latter 4 weeks of self-provided foods increased generalizability. Third, we used LDL-C, a well-established cardiometabolic clinical value, as the primary outcome. 26 Fourth, we assessed an extensive set of well-studied secondary clinical outcomes to evaluate overall cardiometabolic health. Fifth, diet data collection using the state-of-the-art Nutrition Data System for Research allowed us to assess and report on adherence—an important metric in free-living trials 53 —and compare macronutrient and micronutrient intakes. Sixth, previous trials 11 , 13 , 31 , 50 , 54 , 55 have reported similar metabolic and weight loss benefits of vegan diets yet tended to focus on very low–fat vegan diets, study populations with diabetes or overweight, and comparison diets with limited attention to equipoise. Novelties of the current trial were the use of a more moderate- and higher-fat vegan diet (unsaturated fat), 11 the generally healthy population without diabetes or overweight, and a healthy omnivorous comparison diet (eg, higher in vegetables and fiber than the baseline diet). Seventh, to provide fair and objective comparisons and avoid “straw man” comparators, we emphasized high-quality, exemplary dietary choices to participants on both diets.

The study also has some limitations. First, the adult twin population was generally healthy and may not be generalizable to other populations. Second, we studied a small sample size (N = 44); however, the use of monozygotic twins may reduce issues of reproducibility because the twins acted as their own controls. Third, study duration was short (8 weeks); however, in this study as well as several previous trials, 46 , 56 clinically relevant changes in cardiovascular risk factors (eg, LDL-C and weight) were observed as early as 4 weeks into the intervention. Fourth, there was no follow-up period, which limited insights of poststudy stability and sustainability of diet behaviors. Fifth, our study was not designed to be isocaloric; thus, changes to LDL-C cannot be separated from weight loss observed in the study. We designed this study as a “free-living” study; thus, the behavior of following a vegan diet may induce the physiological changes we observed. However, the biological mechanisms cannot be determined to be causally from solely the vegan diet alone because of confounding variables (weight loss, decrease in caloric intake, and increase in vegetable intake). Sixth, diversity in education and socioeconomic status was lacking.

Conclusions

In this randomized clinical trial, we observed cardiometabolic advantages for the healthy vegan vs the healthy omnivorous diet among healthy, adult identical twins. Clinicians may consider recommending plant-based diets to reduce cardiometabolic risk factors, as well as aligning with environmental benefits.

Supplement 1.

Trial Protocol

Supplement 2.

eMethods. Supplementary Methods

Supplement 3.

Data Sharing Statement

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  28. Cardiometabolic Effects of Omnivorous vs Vegan Diets in Identical Twins

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