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Free Springer Journals: Publish without publication fee

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Publish research papers without publication fee

Researchers can publish in reputed Springer journals without publication fees If an author is unable to pay publication fees, he can publish his paper without any publication fee. Almost all publishers allow authors to publish for free. Below, you can check the list of journals that publish for free through the given link.

List of Free Open Access Journals – 2023

Free (Non-Paid) Scopus Journals – 2023

Publish in Springer Journals without publication fee

You can also publish research papers in Springer for free. In this blog post, we are listing Springer Journals which publish articles without publication fees by selecting the Open Choice option.

How do publish articles for free in Springer Journals?

• Select a journal from the below list.
• Click on the journal title, it will lead you to the homepage of the journal title.
• Click “Submit Online” on the journal’s homepage and directly access the submission system used by that journal.

List of Springer Journals which publish without publication fee

Share this:, 7 thoughts on “free springer journals: publish without publication fee”.

Greetings Sir, Kindly send me the list of non paid education journals under the publication of Wiley Online Library for use please. Thanks

What are the differences between Hybrid and open choice. Are there any costs to either of the two Thank you Sir Dr. Njoku Moses [email protected]

Hybrid journals are subscription-based publications for which authors can pay an “open choice” fee to “unlock” their individual papers and make them freely available to any reader. Rather than making the entire journal open access, these publishers charge a fee to make individual articles openly available, while the rest are locked behind a subscription paywall.

Greetings Sir, Kindly send me the list of non paid medicine, public health, psychiatry journals under the publication of Wiley Online Library for publication please. could i get call for paper notifications of non paid springer journals. Thanks

Hi! This is my first visit to your blog! We are a group of volunteers and starting a new initiative in a community in the same niche. Your blog provided us beneficial information to work on. You have done a marvellous job!

Hello Dr. You assume that we all have educational affiliation to be able to publish for free…none of these apply to an individual without affiliation at a university.

dear, you can publish without any university affiliation.

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Home » How to Publish a Research Paper – Step by Step Guide

How to Publish a Research Paper – Step by Step Guide

Table of Contents

Publishing a research paper is an important step for researchers to disseminate their findings to a wider audience and contribute to the advancement of knowledge in their field. Whether you are a graduate student, a postdoctoral fellow, or an established researcher, publishing a paper requires careful planning, rigorous research, and clear writing. In this process, you will need to identify a research question , conduct a thorough literature review , design a methodology, analyze data, and draw conclusions. Additionally, you will need to consider the appropriate journals or conferences to submit your work to and adhere to their guidelines for formatting and submission. In this article, we will discuss some ways to publish your Research Paper.

How to Publish a Research Paper

To Publish a Research Paper follow the guide below:

• Conduct original research : Conduct thorough research on a specific topic or problem. Collect data, analyze it, and draw conclusions based on your findings.
• Write the paper : Write a detailed paper describing your research. It should include an abstract, introduction, literature review, methodology, results, discussion, and conclusion.
• Choose a suitable journal or conference : Look for a journal or conference that specializes in your research area. You can check their submission guidelines to ensure your paper meets their requirements.
• Prepare your submission: Follow the guidelines and prepare your submission, including the paper, abstract, cover letter, and any other required documents.
• Submit the paper: Submit your paper online through the journal or conference website. Make sure you meet the submission deadline.
• Peer-review process : Your paper will be reviewed by experts in the field who will provide feedback on the quality of your research, methodology, and conclusions.
• Revisions : Based on the feedback you receive, revise your paper and resubmit it.
• Acceptance : Once your paper is accepted, you will receive a notification from the journal or conference. You may need to make final revisions before the paper is published.
• Publication : Your paper will be published online or in print. You can also promote your work through social media or other channels to increase its visibility.

How to Choose Journal for Research Paper Publication

Here are some steps to follow to help you select an appropriate journal:

• Identify your research topic and audience : Your research topic and intended audience should guide your choice of journal. Identify the key journals in your field of research and read the scope and aim of the journal to determine if your paper is a good fit.
• Analyze the journal’s impact and reputation : Check the impact factor and ranking of the journal, as well as its acceptance rate and citation frequency. A high-impact journal can give your paper more visibility and credibility.
• Consider the journal’s publication policies : Look for the journal’s publication policies such as the word count limit, formatting requirements, open access options, and submission fees. Make sure that you can comply with the requirements and that the journal is in line with your publication goals.
• Look at recent publications : Review recent issues of the journal to evaluate whether your paper would fit in with the journal’s current content and style.
• Seek advice from colleagues and mentors: Ask for recommendations and suggestions from your colleagues and mentors in your field, especially those who have experience publishing in the same or similar journals.
• Be prepared to make changes : Be prepared to revise your paper according to the requirements and guidelines of the chosen journal. It is also important to be open to feedback from the editor and reviewers.

List of Journals for Research Paper Publications

There are thousands of academic journals covering various fields of research. Here are some of the most popular ones, categorized by field:

General/Multidisciplinary

• Nature: https://www.nature.com/
• Science: https://www.sciencemag.org/
• PLOS ONE: https://journals.plos.org/plosone/
• Proceedings of the National Academy of Sciences (PNAS): https://www.pnas.org/
• The Lancet: https://www.thelancet.com/
• JAMA (Journal of the American Medical Association): https://jamanetwork.com/journals/jama

Social Sciences/Humanities

• Journal of Personality and Social Psychology: https://www.apa.org/pubs/journals/psp
• Journal of Consumer Research: https://www.journals.uchicago.edu/journals/jcr
• Journal of Educational Psychology: https://www.apa.org/pubs/journals/edu
• Journal of Applied Psychology: https://www.apa.org/pubs/journals/apl
• Journal of Communication: https://academic.oup.com/joc
• American Journal of Political Science: https://ajps.org/
• Journal of International Business Studies: https://www.jibs.net/
• Journal of Marketing Research: https://www.ama.org/journal-of-marketing-research/

Natural Sciences

• Journal of Biological Chemistry: https://www.jbc.org/
• Cell: https://www.cell.com/
• Science Advances: https://advances.sciencemag.org/
• Chemical Reviews: https://pubs.acs.org/journal/chreay
• Angewandte Chemie: https://onlinelibrary.wiley.com/journal/15213765
• Physical Review Letters: https://journals.aps.org/prl/
• Journal of Geophysical Research: https://agupubs.onlinelibrary.wiley.com/journal/2156531X
• Journal of High Energy Physics: https://link.springer.com/journal/13130

Engineering/Technology

• IEEE Transactions on Neural Networks and Learning Systems: https://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=5962385
• IEEE Transactions on Power Systems: https://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=59
• IEEE Transactions on Medical Imaging: https://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=42
• IEEE Transactions on Control Systems Technology: https://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=87
• Journal of Engineering Mechanics: https://ascelibrary.org/journal/jenmdt
• Journal of Materials Science: https://www.springer.com/journal/10853
• Journal of Chemical Engineering of Japan: https://www.jstage.jst.go.jp/browse/jcej
• Journal of Mechanical Design: https://asmedigitalcollection.asme.org/mechanicaldesign

Medical/Health Sciences

• New England Journal of Medicine: https://www.nejm.org/
• The BMJ (formerly British Medical Journal): https://www.bmj.com/
• Journal of the American Medical Association (JAMA): https://jamanetwork.com/journals/jama
• Annals of Internal Medicine: https://www.acpjournals.org/journal/aim
• American Journal of Epidemiology: https://academic.oup.com/aje
• Journal of Clinical Oncology: https://ascopubs.org/journal/jco
• Journal of Infectious Diseases: https://academic.oup.com/jid

List of Conferences for Research Paper Publications

There are many conferences that accept research papers for publication. The specific conferences you should consider will depend on your field of research. Here are some suggestions for conferences in a few different fields:

Computer Science and Information Technology:

• IEEE International Conference on Computer Communications (INFOCOM): https://www.ieee-infocom.org/
• ACM SIGCOMM Conference on Data Communication: https://conferences.sigcomm.org/sigcomm/
• IEEE Symposium on Security and Privacy (SP): https://www.ieee-security.org/TC/SP/
• ACM Conference on Computer and Communications Security (CCS): https://www.sigsac.org/ccs/
• ACM Conference on Human-Computer Interaction (CHI): https://chi2022.acm.org/

Engineering:

• IEEE International Conference on Robotics and Automation (ICRA): https://www.ieee-icra.org/
• International Conference on Mechanical and Aerospace Engineering (ICMAE): http://www.icmae.org/
• International Conference on Civil and Environmental Engineering (ICCEE): http://www.iccee.org/
• International Conference on Materials Science and Engineering (ICMSE): http://www.icmse.org/
• International Conference on Energy and Power Engineering (ICEPE): http://www.icepe.org/

Natural Sciences:

• American Chemical Society National Meeting & Exposition: https://www.acs.org/content/acs/en/meetings/national-meeting.html
• American Physical Society March Meeting: https://www.aps.org/meetings/march/
• International Conference on Environmental Science and Technology (ICEST): http://www.icest.org/
• International Conference on Natural Science and Environment (ICNSE): http://www.icnse.org/
• International Conference on Life Science and Biological Engineering (LSBE): http://www.lsbe.org/

Social Sciences:

• Annual Meeting of the American Sociological Association (ASA): https://www.asanet.org/annual-meeting-2022
• International Conference on Social Science and Humanities (ICSSH): http://www.icssh.org/
• International Conference on Psychology and Behavioral Sciences (ICPBS): http://www.icpbs.org/
• International Conference on Education and Social Science (ICESS): http://www.icess.org/
• International Conference on Management and Information Science (ICMIS): http://www.icmis.org/

How to Publish a Research Paper in Journal

Publishing a research paper in a journal is a crucial step in disseminating scientific knowledge and contributing to the field. Here are the general steps to follow:

• Choose a research topic : Select a topic of your interest and identify a research question or problem that you want to investigate. Conduct a literature review to identify the gaps in the existing knowledge that your research will address.
• Conduct research : Develop a research plan and methodology to collect data and conduct experiments. Collect and analyze data to draw conclusions that address the research question.
• Write a paper: Organize your findings into a well-structured paper with clear and concise language. Your paper should include an introduction, literature review, methodology, results, discussion, and conclusion. Use academic language and provide references for your sources.
• Choose a journal: Choose a journal that is relevant to your research topic and audience. Consider factors such as impact factor, acceptance rate, and the reputation of the journal.
• Follow journal guidelines : Review the submission guidelines and formatting requirements of the journal. Follow the guidelines carefully to ensure that your paper meets the journal’s requirements.
• Submit your paper : Submit your paper to the journal through the online submission system or by email. Include a cover letter that briefly explains the significance of your research and why it is suitable for the journal.
• Wait for reviews: Your paper will be reviewed by experts in the field. Be prepared to address their comments and make revisions to your paper.
• Revise and resubmit: Make revisions to your paper based on the reviewers’ comments and resubmit it to the journal. If your paper is accepted, congratulations! If not, consider revising and submitting it to another journal.
• Address reviewer comments : Reviewers may provide comments and suggestions for revisions to your paper. Address these comments carefully and thoughtfully to improve the quality of your paper.
• Submit the final version: Once your revisions are complete, submit the final version of your paper to the journal. Be sure to follow any additional formatting guidelines and requirements provided by the journal.
• Publication : If your paper is accepted, it will be published in the journal. Some journals provide online publication while others may publish a print version. Be sure to cite your published paper in future research and communicate your findings to the scientific community.

How to Publish a Research Paper for Students

Here are some steps you can follow to publish a research paper as an Under Graduate or a High School Student:

• Select a topic: Choose a topic that is relevant and interesting to you, and that you have a good understanding of.
• Conduct research : Gather information and data on your chosen topic through research, experiments, surveys, or other means.
• Write the paper : Start with an outline, then write the introduction, methods, results, discussion, and conclusion sections of the paper. Be sure to follow any guidelines provided by your instructor or the journal you plan to submit to.
• Edit and revise: Review your paper for errors in spelling, grammar, and punctuation. Ask a peer or mentor to review your paper and provide feedback for improvement.
• Choose a journal : Look for journals that publish papers in your field of study and that are appropriate for your level of research. Some popular journals for students include PLOS ONE, Nature, and Science.
• Submit the paper: Follow the submission guidelines for the journal you choose, which typically include a cover letter, abstract, and formatting requirements. Be prepared to wait several weeks to months for a response.
• Address feedback : If your paper is accepted with revisions, address the feedback from the reviewers and resubmit your paper. If your paper is rejected, review the feedback and consider revising and resubmitting to a different journal.

How to Publish a Research Paper for Free

Publishing a research paper for free can be challenging, but it is possible. Here are some steps you can take to publish your research paper for free:

• Choose a suitable open-access journal: Look for open-access journals that are relevant to your research area. Open-access journals allow readers to access your paper without charge, so your work will be more widely available.
• Check the journal’s reputation : Before submitting your paper, ensure that the journal is reputable by checking its impact factor, publication history, and editorial board.
• Follow the submission guidelines : Every journal has specific guidelines for submitting papers. Make sure to follow these guidelines carefully to increase the chances of acceptance.
• Submit your paper : Once you have completed your research paper, submit it to the journal following their submission guidelines.
• Wait for the review process: Your paper will undergo a peer-review process, where experts in your field will evaluate your work. Be patient during this process, as it can take several weeks or even months.
• Revise your paper : If your paper is rejected, don’t be discouraged. Revise your paper based on the feedback you receive from the reviewers and submit it to another open-access journal.
• Promote your research: Once your paper is published, promote it on social media and other online platforms. This will increase the visibility of your work and help it reach a wider audience.

Journals and Conferences for Free Research Paper publications

Here are the websites of the open-access journals and conferences mentioned:

Open-Access Journals:

• PLOS ONE – https://journals.plos.org/plosone/
• BMC Research Notes – https://bmcresnotes.biomedcentral.com/
• Frontiers in… – https://www.frontiersin.org/
• Journal of Open Research Software – https://openresearchsoftware.metajnl.com/
• PeerJ – https://peerj.com/

Conferences:

• IEEE Global Communications Conference (GLOBECOM) – https://globecom2022.ieee-globecom.org/
• IEEE International Conference on Computer Communications (INFOCOM) – https://infocom2022.ieee-infocom.org/
• IEEE International Conference on Data Mining (ICDM) – https://www.ieee-icdm.org/
• ACM SIGCOMM Conference on Data Communication (SIGCOMM) – https://conferences.sigcomm.org/sigcomm/
• ACM Conference on Computer and Communications Security (CCS) – https://www.sigsac.org/ccs/CCS2022/

Importance of Research Paper Publication

Research paper publication is important for several reasons, both for individual researchers and for the scientific community as a whole. Here are some reasons why:

• Advancing scientific knowledge : Research papers provide a platform for researchers to present their findings and contribute to the body of knowledge in their field. These papers often contain novel ideas, experimental data, and analyses that can help to advance scientific understanding.
• Building a research career : Publishing research papers is an essential component of building a successful research career. Researchers are often evaluated based on the number and quality of their publications, and having a strong publication record can increase one’s chances of securing funding, tenure, or a promotion.
• Peer review and quality control: Publication in a peer-reviewed journal means that the research has been scrutinized by other experts in the field. This peer review process helps to ensure the quality and validity of the research findings.
• Recognition and visibility : Publishing a research paper can bring recognition and visibility to the researchers and their work. It can lead to invitations to speak at conferences, collaborations with other researchers, and media coverage.
• Impact on society : Research papers can have a significant impact on society by informing policy decisions, guiding clinical practice, and advancing technological innovation.

Advantages of Research Paper Publication

There are several advantages to publishing a research paper, including:

• Recognition: Publishing a research paper allows researchers to gain recognition for their work, both within their field and in the academic community as a whole. This can lead to new collaborations, invitations to conferences, and other opportunities to share their research with a wider audience.
• Career advancement : A strong publication record can be an important factor in career advancement, particularly in academia. Publishing research papers can help researchers secure funding, grants, and promotions.
• Dissemination of knowledge : Research papers are an important way to share new findings and ideas with the broader scientific community. By publishing their research, scientists can contribute to the collective body of knowledge in their field and help advance scientific understanding.
• Feedback and peer review : Publishing a research paper allows other experts in the field to provide feedback on the research, which can help improve the quality of the work and identify potential flaws or limitations. Peer review also helps ensure that research is accurate and reliable.
• Citation and impact : Published research papers can be cited by other researchers, which can help increase the impact and visibility of the research. High citation rates can also help establish a researcher’s reputation and credibility within their field.

About the author

Muhammad Hassan

Researcher, Academic Writer, Web developer

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Free, fast and fair: the global primary research record where researchers publish their work in full detail

Octopus is a new publishing platform for scholarly research. Funded by UKRI – the UK government research funder.

Here researchers can publish all their work for free, in full detail, enabling peer review and quality assessment, gaining credit for what they have done, and allowing the research community to build upon it.

Research Culture Report

Researchers at the University of Bristol have recently conducted an investigation into the current state of the research culture. They found academic researchers demoralised by a culture that disincentivises sharing and collaboration, encourages questionable research practices, and increases the risk of bias. These findings underline the need for a platform such as Octopus. Their results are detailed in the report "A snapshot of the academic research culture in 2023 and how it might be improved".

Recording your work on Octopus is different from publishing a paper. There are eight publication types that are aligned with the research process and designed to help researchers of all types share their work and be recognised for it.

Anyone can read anything in Octopus – it's designed to make primary research openly available to all.

Every publication in Octopus is linked to another, forming branching chains of research. You can navigate these chains from every publication page to browse areas of research and discover something new.

Before you can publish research work, you need to create an account via ORCID®. ORCID is a system of unique, persistent digital identifiers developed specifically for researchers.

Octopus is designed to incentivise best practice in research, utilise the opportunities of open access, and to improve the research culture.

Review our FAQs to find out more about how the platform works.

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Free Paper Publication

AIJR offers Free Paper Publication in the following international refereed journals with open access ( Free to Publish & Free to Read ) – No hidden charges

• Journal of Modern Materials  (Materials Science Journal)
• Journal of Modeling and Simulation of Materials  (Modeling & Simulation Journal)
• Advanced Journal of Graduate Research  (Bachelor / Master Degree Student’s Research Paper)
• Advanced Nano Research  (Nano Research Journal)
• Extensive Reviews (Review Articles from All Discipline)
• International Journal of Methodology  (Articles Discussing Research Method

Besides free paper publication (Normal Publication), the above journals are also offering various rapid review options through fast-track publication which is optional. The author needs to send an additional email request to consider articles under the fast track for rapid publication. All submitted paper to journals published by AIJR undergoes rigorous peer review and upon acceptance made available free for everyone to read and download as per end user license .

Authors are requested to read the author guidelines of the corresponding journal and follow them precisely to prepare the research paper. Author guideline is available at the homepage of each journal. The author will require to provide all information for each author in the manuscript and all author(s) specified in the manuscript must be added during online submission in step 3 with proper order and complete detail . Reference citation and reference list should be followed as specified in the author guideline of the journal. All relevant information regarding the journal is available in the About section of the journal at their homepage.

Manuscript submissions for possible publication to jour n als are invited from the worldwide research community. The manuscript should be original and formatted as per the author’s guidelines. All manuscripts should be submitted with all required detail.

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The 5 Best Platforms to Publish Your Academic Research

Academic research is a central component of scientific advancements and breakthrough innovations. However, your research journey is complex and ever-changing. You must take into consideration funding options, how to securely store your information, choosing where to publish your research, finding manuscript peer reviewers, and many more.

To keep up with the change, you and other researchers require modern, easy-to-navigate research platforms to help you uncover, store, verify, compile, and share content, data, and important insights to continue to carry out breakthrough research.

This article explains how to identify the best platforms for publishing your research and gives you a list of five platforms to help you publish. Towards the end, you’ll also see a mention of how Orvium can further assist you with publishing.

How to Identify the Best Platforms for Publishing

When trying to identify the best platforms for publishing your research, you have to consider several factors, including:

• Does the platform support your research journey ? Can you collaborate with other authors and researchers, discover public groups and research papers and manuscripts (including Open Access work), view interactive graphs, images, tables, etc., track citations, and build a professional research profile?
• Is the platform easy to use ? Does it offer rich functionalities that are easy to understand, and if so, which ones?
• Does it use artificial intelligence and machine learning ? Automated actions (email alerts, etc.) can help you unlock breakthroughs faster and deliver deeper insights.
• What security and governance does it have ? Platforms must be secure and compliant according to local regulations since researchers often deal with sensitive data.

The 5 Best Platforms to Publish Academic Research

Researchgate.

ResearchGate is a platform hosting over 135 million publication pages with a community of 20 million scientists. The platform allows you to show off your work, access papers and advice from other researchers, make contacts and even find jobs. Some of its more prominent features include:

• Dedicated Q&A section with searchable keywords to target experts in your particular field or area of study
• Ability to create a personal profile page where you can display all research-specific details about yourself, including up to five pieces of work (including datasets and conference papers)
• In-depth stats on who reads your work and the ability to track your citations
• A private messaging service that allows you to send messages to other researchers
• A comments section to provide feedback when viewing a paper
• A “projects” section to tell others about your upcoming work.

In addition, it's completely free to use!

Academia is a research-sharing platform with over 178 million users, 29 million papers uploaded, and 87 million visitors per month. Their goal is to accelerate research in all fields, ensure that all research is available for free and that the sharing of knowledge is available in multiple formats (videos, datasets, code, short-form content, etc.). Some of their more prominent features include:

• Mentions and search alerts that notify you when another researcher cites, thanks, or acknowledges your work, and automatic reports of search queries
• Ability to create a personal profile page
• “Profile visitor” and “readers” features let you know the title and location of those who visit your profile or read your papers so you can learn about their research interests and get in touch
• A “grants” feature to allow you to find new grants and fellowships in your field
• Advanced research discovery tools allow you to see full texts and citations of millions of papers.

The platform is based on a “freemium” business model, which provides free access to research for everyone, and paid capabilities to subscribers.

ScienceOpen

ScienceOpen is a discovery platform that empowers researchers to make an impact in their communities. The platform is committed to Open Science, combining decades of experience in traditional publishing, computing, and academic research to provide free access to knowledge to drive creativity, innovation, and development. Some of their more prominent features include:

• You can publish your most recent paper as a preprint that’s citable and includes a DOI to share with peers immediately and enhance visibility
• A multidimensional search feature for articles with 18 filters and the ability to sort results by Altmetric scores , citations, date, and rating
• Ability to create a personal profile with minimal upkeep necessary
• Access to a suite of metrics (usage, citations, etc.) of your publications
• Ability to follow other researchers to stay up-to-date on their work and expand your network.

The platform is free to use, although some features (like publishing your preprint) may cost money.

IOPscience is a platform that embraces innovative technologies to make it easier for researchers to discover and access technical, scientific, and medical content while managing their own research content. They participate in several programs that offer researchers in developing countries several ways to gain access to journals at little or no cost. Some of their other features include:

• An enhanced search filtering feature allows you to find relevant research faster
• A social bookmarking feature allows you to interact with other researchers and share articles
• Ability to create a personal profile, customize your alerts, view recently published articles within your field or area of interest, and save relevant papers or articles
• Ability to receive email alerts and RSS feeds once new content is published.

IOPscience is free to use and functions on an Open Access policy, which you can check here .

Orvium is an open, community-based research platform that allows researchers, reviewers, and publishers to share, publish, review, and manage their research. Orvium protects your work with built-in blockchain integration to ensure that you maintain the copyright of your work and not only. Some of our more notable features include:

• Access to a modern web platform with Google indexing, notifications, and mobile-ready features
• Ability to manage your entire publication process, with control over when you submit, receive peer reviews, and publish your paper
• “Collaboration” and “full traceability” features allow you to track your profile impact, get in touch with other researchers, and have ownership over your work
• Recognition badges or economic rewards are given when you peer-review.

Orvium is completely free to use.

Orvium Makes Choosing a Platform Easy

No matter what platform or community you choose to be a part of, you now know what you need to look for when choosing one. You also learned about five excellent platforms where you can publish your academic research. Orvium will remain your one-stop-shop platform for all your research needs. Do you want to know how Orvium and our communities work? Check out our platform or contact us with any questions you may have.

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How to Write and Publish Your Research in a Journal

Last Updated: February 26, 2024 Fact Checked

Choosing a Journal

Writing the research paper, editing & revising your paper, submitting your paper, navigating the peer review process, research paper help.

This article was co-authored by Matthew Snipp, PhD and by wikiHow staff writer, Cheyenne Main . C. Matthew Snipp is the Burnet C. and Mildred Finley Wohlford Professor of Humanities and Sciences in the Department of Sociology at Stanford University. He is also the Director for the Institute for Research in the Social Science’s Secure Data Center. He has been a Research Fellow at the U.S. Bureau of the Census and a Fellow at the Center for Advanced Study in the Behavioral Sciences. He has published 3 books and over 70 articles and book chapters on demography, economic development, poverty and unemployment. He is also currently serving on the National Institute of Child Health and Development’s Population Science Subcommittee. He holds a Ph.D. in Sociology from the University of Wisconsin—Madison. There are 13 references cited in this article, which can be found at the bottom of the page. This article has been fact-checked, ensuring the accuracy of any cited facts and confirming the authority of its sources. This article has been viewed 699,938 times.

Publishing a research paper in a peer-reviewed journal allows you to network with other scholars, get your name and work into circulation, and further refine your ideas and research. Before submitting your paper, make sure it reflects all the work you’ve done and have several people read over it and make comments. Keep reading to learn how you can choose a journal, prepare your work for publication, submit it, and revise it after you get a response back.

Things You Should Know

• Create a list of journals you’d like to publish your work in and choose one that best aligns with your topic and your desired audience.
• Prepare your manuscript using the journal’s requirements and ask at least 2 professors or supervisors to review your paper.
• Write a cover letter that “sells” your manuscript, says how your research adds to your field and explains why you chose the specific journal you’re submitting to.

• Ask your professors or supervisors for well-respected journals that they’ve had good experiences publishing with and that they read regularly.
• Many journals also only accept specific formats, so by choosing a journal before you start, you can write your article to their specifications and increase your chances of being accepted.
• If you’ve already written a paper you’d like to publish, consider whether your research directly relates to a hot topic or area of research in the journals you’re looking into.

• Review the journal’s peer review policies and submission process to see if you’re comfortable creating or adjusting your work according to their standards.
• Open-access journals can increase your readership because anyone can access them.

• Scientific research papers: Instead of a “thesis,” you might write a “research objective” instead. This is where you state the purpose of your research.
• “This paper explores how George Washington’s experiences as a young officer may have shaped his views during difficult circumstances as a commanding officer.”
• “This paper contends that George Washington’s experiences as a young officer on the 1750s Pennsylvania frontier directly impacted his relationship with his Continental Army troops during the harsh winter at Valley Forge.”

• Scientific research papers: Include a “materials and methods” section with the step-by-step process you followed and the materials you used. [5] X Research source
• Read other research papers in your field to see how they’re written. Their format, writing style, subject matter, and vocabulary can help guide your own paper. [6] X Research source

• If you’re writing about George Washington’s experiences as a young officer, you might emphasize how this research changes our perspective of the first president of the U.S.
• Link this section to your thesis or research objective.
• If you’re writing a paper about ADHD, you might discuss other applications for your research.

• Scientific research papers: You might include your research and/or analytical methods, your main findings or results, and the significance or implications of your research.
• Try to get as many people as you can to read over your abstract and provide feedback before you submit your paper to a journal.

• They might also provide templates to help you structure your manuscript according to their specific guidelines. [11] X Research source

• Not all journal reviewers will be experts on your specific topic, so a non-expert “outsider’s perspective” can be valuable.

• If you have a paper on the purification of wastewater with fungi, you might use both the words “fungi” and “mushrooms.”
• Use software like iThenticate, Turnitin, or PlagScan to check for similarities between the submitted article and published material available online. [15] X Research source

• Header: Address the editor who will be reviewing your manuscript by their name, include the date of submission, and the journal you are submitting to.
• First paragraph: Include the title of your manuscript, the type of paper it is (like review, research, or case study), and the research question you wanted to answer and why.
• Second paragraph: Explain what was done in your research, your main findings, and why they are significant to your field.
• Third paragraph: Explain why the journal’s readers would be interested in your work and why your results are important to your field.
• Conclusion: State the author(s) and any journal requirements that your work complies with (like ethical standards”).
• “We confirm that this manuscript has not been published elsewhere and is not under consideration by another journal.”
• “All authors have approved the manuscript and agree with its submission to [insert the name of the target journal].”

• Submit your article to only one journal at a time.
• When submitting online, use your university email account. This connects you with a scholarly institution, which can add credibility to your work.

• Accept: Only minor adjustments are needed, based on the provided feedback by the reviewers. A first submission will rarely be accepted without any changes needed.
• Revise and Resubmit: Changes are needed before publication can be considered, but the journal is still very interested in your work.
• Reject and Resubmit: Extensive revisions are needed. Your work may not be acceptable for this journal, but they might also accept it if significant changes are made.
• Reject: The paper isn’t and won’t be suitable for this publication, but that doesn’t mean it might not work for another journal.

• Try organizing the reviewer comments by how easy it is to address them. That way, you can break your revisions down into more manageable parts.
• If you disagree with a comment made by a reviewer, try to provide an evidence-based explanation when you resubmit your paper.

• If you’re resubmitting your paper to the same journal, include a point-by-point response paper that talks about how you addressed all of the reviewers’ comments in your revision. [22] X Research source
• If you’re not sure which journal to submit to next, you might be able to ask the journal editor which publications they recommend.

Expert Q&A

You might also like.

• If reviewers suspect that your submitted manuscript plagiarizes another work, they may refer to a Committee on Publication Ethics (COPE) flowchart to see how to move forward. [23] X Research source Thanks Helpful 0 Not Helpful 0

• ↑ https://www.wiley.com/en-us/network/publishing/research-publishing/choosing-a-journal/6-steps-to-choosing-the-right-journal-for-your-research-infographic
• ↑ https://link.springer.com/article/10.1007/s13187-020-01751-z
• ↑ https://libguides.unomaha.edu/c.php?g=100510&p=651627
• ↑ http://www.canberra.edu.au/library/start-your-research/research_help/publishing-research
• ↑ https://writingcenter.fas.harvard.edu/conclusions
• ↑ https://writing.wisc.edu/handbook/assignments/writing-an-abstract-for-your-research-paper/
• ↑ https://www.springer.com/gp/authors-editors/book-authors-editors/your-publication-journey/manuscript-preparation
• ↑ https://apus.libanswers.com/writing/faq/2391
• ↑ https://academicguides.waldenu.edu/library/keyword/search-strategy
• ↑ https://ifis.libguides.com/journal-publishing-guide/submitting-your-paper
• ↑ https://www.springer.com/kr/authors-editors/authorandreviewertutorials/submitting-to-a-journal-and-peer-review/cover-letters/10285574
• ↑ http://www.apa.org/monitor/sep02/publish.aspx
• ↑ Matthew Snipp, PhD. Research Fellow, U.S. Bureau of the Census. Expert Interview. 26 March 2020.

About This Article

To publish a research paper, ask a colleague or professor to review your paper and give you feedback. Once you've revised your work, familiarize yourself with different academic journals so that you can choose the publication that best suits your paper. Make sure to look at the "Author's Guide" so you can format your paper according to the guidelines for that publication. Then, submit your paper and don't get discouraged if it is not accepted right away. You may need to revise your paper and try again. To learn about the different responses you might get from journals, see our reviewer's explanation below. Did this summary help you? Yes No

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How To Write A Research Paper

Step-By-Step Tutorial With Examples + FREE Template

By: Derek Jansen (MBA) | Expert Reviewer: Dr Eunice Rautenbach | March 2024

For many students, crafting a strong research paper from scratch can feel like a daunting task – and rightly so! In this post, we’ll unpack what a research paper is, what it needs to do , and how to write one – in three easy steps. 🙂 

Overview: Writing A Research Paper

What (exactly) is a research paper.

• How to write a research paper
• Stage 1 : Topic & literature search
• Stage 2 : Structure & outline
• Stage 3 : Iterative writing
• Key takeaways

Let’s start by asking the most important question, “ What is a research paper? ”.

Simply put, a research paper is a scholarly written work where the writer (that’s you!) answers a specific question (this is called a research question ) through evidence-based arguments . Evidence-based is the keyword here. In other words, a research paper is different from an essay or other writing assignments that draw from the writer’s personal opinions or experiences. With a research paper, it’s all about building your arguments based on evidence (we’ll talk more about that evidence a little later).

Now, it’s worth noting that there are many different types of research papers , including analytical papers (the type I just described), argumentative papers, and interpretative papers. Here, we’ll focus on analytical papers , as these are some of the most common – but if you’re keen to learn about other types of research papers, be sure to check out the rest of the blog .

With that basic foundation laid, let’s get down to business and look at how to write a research paper .

Overview: The 3-Stage Process

While there are, of course, many potential approaches you can take to write a research paper, there are typically three stages to the writing process. So, in this tutorial, we’ll present a straightforward three-step process that we use when working with students at Grad Coach.

These three steps are:

• Finding a research topic and reviewing the existing literature
• Developing a provisional structure and outline for your paper, and
• Writing up your initial draft and then refining it iteratively

Let’s dig into each of these.

Need a helping hand?

Step 1: Find a topic and review the literature

As we mentioned earlier, in a research paper, you, as the researcher, will try to answer a question . More specifically, that’s called a research question , and it sets the direction of your entire paper. What’s important to understand though is that you’ll need to answer that research question with the help of high-quality sources – for example, journal articles, government reports, case studies, and so on. We’ll circle back to this in a minute.

The first stage of the research process is deciding on what your research question will be and then reviewing the existing literature (in other words, past studies and papers) to see what they say about that specific research question. In some cases, your professor may provide you with a predetermined research question (or set of questions). However, in many cases, you’ll need to find your own research question within a certain topic area.

Finding a strong research question hinges on identifying a meaningful research gap – in other words, an area that’s lacking in existing research. There’s a lot to unpack here, so if you wanna learn more, check out the plain-language explainer video below.

Once you’ve figured out which question (or questions) you’ll attempt to answer in your research paper, you’ll need to do a deep dive into the existing literature – this is called a “ literature search ”. Again, there are many ways to go about this, but your most likely starting point will be Google Scholar .

If you’re new to Google Scholar, think of it as Google for the academic world. You can start by simply entering a few different keywords that are relevant to your research question and it will then present a host of articles for you to review. What you want to pay close attention to here is the number of citations for each paper – the more citations a paper has, the more credible it is (generally speaking – there are some exceptions, of course).

Ideally, what you’re looking for are well-cited papers that are highly relevant to your topic. That said, keep in mind that citations are a cumulative metric , so older papers will often have more citations than newer papers – just because they’ve been around for longer. So, don’t fixate on this metric in isolation – relevance and recency are also very important.

Beyond Google Scholar, you’ll also definitely want to check out academic databases and aggregators such as Science Direct, PubMed, JStor and so on. These will often overlap with the results that you find in Google Scholar, but they can also reveal some hidden gems – so, be sure to check them out.

Once you’ve worked your way through all the literature, you’ll want to catalogue all this information in some sort of spreadsheet so that you can easily recall who said what, when and within what context. If you’d like, we’ve got a free literature spreadsheet that helps you do exactly that.

Step 2: Develop a structure and outline

With your research question pinned down and your literature digested and catalogued, it’s time to move on to planning your actual research paper .

It might sound obvious, but it’s really important to have some sort of rough outline in place before you start writing your paper. So often, we see students eagerly rushing into the writing phase, only to land up with a disjointed research paper that rambles on in multiple

Now, the secret here is to not get caught up in the fine details . Realistically, all you need at this stage is a bullet-point list that describes (in broad strokes) what you’ll discuss and in what order. It’s also useful to remember that you’re not glued to this outline – in all likelihood, you’ll chop and change some sections once you start writing, and that’s perfectly okay. What’s important is that you have some sort of roadmap in place from the start.

At this stage you might be wondering, “ But how should I structure my research paper? ”. Well, there’s no one-size-fits-all solution here, but in general, a research paper will consist of a few relatively standardised components:

• Introduction
• Literature review
• Methodology

Let’s take a look at each of these.

First up is the introduction section . As the name suggests, the purpose of the introduction is to set the scene for your research paper. There are usually (at least) four ingredients that go into this section – these are the background to the topic, the research problem and resultant research question , and the justification or rationale. If you’re interested, the video below unpacks the introduction section in more detail. 

The next section of your research paper will typically be your literature review . Remember all that literature you worked through earlier? Well, this is where you’ll present your interpretation of all that content . You’ll do this by writing about recent trends, developments, and arguments within the literature – but more specifically, those that are relevant to your research question . The literature review can oftentimes seem a little daunting, even to seasoned researchers, so be sure to check out our extensive collection of literature review content here .

With the introduction and lit review out of the way, the next section of your paper is the research methodology . In a nutshell, the methodology section should describe to your reader what you did (beyond just reviewing the existing literature) to answer your research question. For example, what data did you collect, how did you collect that data, how did you analyse that data and so on? For each choice, you’ll also need to justify why you chose to do it that way, and what the strengths and weaknesses of your approach were.

Now, it’s worth mentioning that for some research papers, this aspect of the project may be a lot simpler . For example, you may only need to draw on secondary sources (in other words, existing data sets). In some cases, you may just be asked to draw your conclusions from the literature search itself (in other words, there may be no data analysis at all). But, if you are required to collect and analyse data, you’ll need to pay a lot of attention to the methodology section. The video below provides an example of what the methodology section might look like.

By this stage of your paper, you will have explained what your research question is, what the existing literature has to say about that question, and how you analysed additional data to try to answer your question. So, the natural next step is to present your analysis of that data . This section is usually called the “results” or “analysis” section and this is where you’ll showcase your findings.

Depending on your school’s requirements, you may need to present and interpret the data in one section – or you might split the presentation and the interpretation into two sections. In the latter case, your “results” section will just describe the data, and the “discussion” is where you’ll interpret that data and explicitly link your analysis back to your research question. If you’re not sure which approach to take, check in with your professor or take a look at past papers to see what the norms are for your programme.

Alright – once you’ve presented and discussed your results, it’s time to wrap it up . This usually takes the form of the “ conclusion ” section. In the conclusion, you’ll need to highlight the key takeaways from your study and close the loop by explicitly answering your research question. Again, the exact requirements here will vary depending on your programme (and you may not even need a conclusion section at all) – so be sure to check with your professor if you’re unsure.

Step 3: Write and refine

Finally, it’s time to get writing. All too often though, students hit a brick wall right about here… So, how do you avoid this happening to you?

Well, there’s a lot to be said when it comes to writing a research paper (or any sort of academic piece), but we’ll share three practical tips to help you get started.

First and foremost , it’s essential to approach your writing as an iterative process. In other words, you need to start with a really messy first draft and then polish it over multiple rounds of editing. Don’t waste your time trying to write a perfect research paper in one go. Instead, take the pressure off yourself by adopting an iterative approach.

Secondly , it’s important to always lean towards critical writing , rather than descriptive writing. What does this mean? Well, at the simplest level, descriptive writing focuses on the “ what ”, while critical writing digs into the “ so what ” – in other words, the implications . If you’re not familiar with these two types of writing, don’t worry! You can find a plain-language explanation here.

Last but not least, you’ll need to get your referencing right. Specifically, you’ll need to provide credible, correctly formatted citations for the statements you make. We see students making referencing mistakes all the time and it costs them dearly. The good news is that you can easily avoid this by using a simple reference manager . If you don’t have one, check out our video about Mendeley, an easy (and free) reference management tool that you can start using today.

Recap: Key Takeaways

We’ve covered a lot of ground here. To recap, the three steps to writing a high-quality research paper are:

• To choose a research question and review the literature
• To plan your paper structure and draft an outline
• To take an iterative approach to writing, focusing on critical writing and strong referencing

Remember, this is just a b ig-picture overview of the research paper development process and there’s a lot more nuance to unpack. So, be sure to grab a copy of our free research paper template to learn more about how to write a research paper.

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Gluten: A Benefit or Harm to the Body?

The quick answer is that it can be either, but it all depends on the individual.

What is Gluten?

Gluten is a protein naturally found in some  grains  including wheat, barley, and rye. It acts like a binder, holding food together and adding a “stretchy” quality—think of a pizza maker tossing and stretching out a ball of dough. Without gluten, the dough would rip easily.

Other grains that contain gluten are wheat berries, spelt, durum, emmer, semolina, farina, farro, graham, khorasan wheat, einkorn, and triticale (a blend of wheat and rye). Oats—though naturally gluten free—often contain gluten from cross-contamination when they are grown near, or  processed in the same facilities as the grains listed above. Gluten is also sold as wheat gluten, or seitan, a popular vegan high-protein food. Less obvious sources of gluten include soy sauce and modified food starch, however gluten-free options of these products are available and labeled as such to comply with the U.S. Food and Drug Administration’s gluten-free labeling rule.

Gluten and Health Benefits

Gluten is most often associated with wheat and wheat-containing foods that are abundant in our food supply. Negative media attention on wheat and gluten has caused some people to doubt its place in a healthful diet. There is little published research to support these claims; in fact published research suggests the opposite.

In a 2017 study of over 100,000 participants without celiac disease, researchers found no association between long-term dietary gluten consumption and heart disease risk. [1] In fact, the findings also suggested that non-celiac individuals who avoid gluten may increase their risk of heart disease, due to the potential for reduced consumption of whole grains.

• Many studies have linked whole grain consumption with improved health outcomes. For example, groups with the highest intakes of whole grains including wheat (2-3 servings daily) compared with groups eating the lowest amounts (less than 2 servings daily) were found to have significantly lower rates of heart disease and stroke, development of type 2 diabetes, and deaths from all causes. [2-5]

Gluten may also act as a prebiotic, feeding the “good” bacteria in our bodies. Arabinoxylan oligosaccharide is a prebiotic carbohydrate derived from wheat bran that has been shown to stimulate the activity of bifidobacteria in the colon. These bacteria are normally found in a healthy human gut. Changes in their amount or activity have been associated with gastrointestinal diseases including inflammatory bowel disease, colorectal cancer, and irritable bowel syndrome. [6,7]

When Gluten Is a Problem

What’s not great about gluten is that it can cause serious side effects in certain individuals. Some people react differently to gluten, where the body senses it as a toxin, causing one’s immune cells to overreact and attack it. If an unknowingly sensitive person continues to eat gluten, this creates a kind of battle ground resulting in inflammation. The side effects can range from mild (fatigue, bloating, alternating constipation and diarrhea) to severe (unintentional weight loss, malnutrition, intestinal damage) as seen in the autoimmune disorder celiac disease . Estimates suggest that 1 in 133 Americans has celiac disease, or about 1% of the population, but about 83% of them are undiagnosed or misdiagnosed with other conditions. [8,9] Research shows that people with celiac disease also have a slightly higher risk of osteoporosis and anemia (due to malabsorption of calcium and iron, respectively); infertility; nerve disorders; and in rare cases cancer. [10] The good news is that removing gluten from the diet may reverse the damage. A gluten-free diet is the primary medical treatment for celiac disease. However, understanding and following a strict gluten-free diet can be challenging, possibly requiring the guidance of a registered dietitian to learn which foods contain gluten and to ensure that adequate nutrients are obtained from gluten-free alternatives. Other conditions that may require the reduction or elimination of gluten in the diet include:

• Non-celiac gluten sensitivity, also referred to as gluten sensitive enteropathy (GSE) or gluten intolerance —An intolerance to gluten with similar symptoms as seen with celiac disease, but without the accompanying elevated levels of antibodies and intestinal damage. There is not a diagnostic test for GSE but is determined by persistent symptoms and a negative diagnostic celiac test.
• Wheat allergy —An allergy to one or more of the proteins (albumin, gluten, gliadin, globulin) found in wheat, diagnosed with positive immunoglobulin E blood tests and a food challenge. Compare this with celiac disease, which is a single intolerance to gluten. Symptoms range from mild to severe and may include swelling or itching of the mouth or throat, hives, itchy eyes, shortness of breath, nausea, diarrhea, cramps, and anaphylaxis. People who test negative for this condition may still have gluten sensitivity. This condition is most often seen in children, which most outgrow by adulthood.
• Dermatitis herpetiformis (DH) —A skin rash that results from eating gluten. It is an autoimmune response that exhibits itself as a persistent red itchy skin rash that may produce blisters and bumps. Although people with celiac disease may have DH, the reverse is not always true.

It is important to note that gluten is a problem only for those who react negatively to it, or test positive for celiac disease. Most people can and have eaten gluten most of their lives, without any adverse side effects.

Does gluten cause brain fog?

But does this side effect occur in people without a true gluten intolerance, and can the reverse be suggested in that the avoidance of gluten might sharpen the mind? A large cohort study disagrees. Almost 13,500 middle-aged women from the Nurses’ Health Study II without celiac disease were followed for 28 years to observe any potential links between gluten intake and mental ability. [15]   No significant differences were found in cognitive scores (measuring reaction time, attention, memory, etc.) comparing women with the highest and lowest gluten intakes. The lack of association remained even after excluding women with a dementia or cancer diagnosis.

Unless a person has diagnosed celiac disease, a wheat allergy, or a gluten sensitivity, current evidence does not support that eating gluten increases inflammation in the brain or negatively affects brain health.

What Is a “Gluten-Free Diet”?

This is essentially a diet that removes all foods containing or contaminated with gluten . However, since gluten-containing whole grains contain fiber and nutrients including B vitamins , magnesium , and iron , it’s important to make up for these missing nutrients. Along with consuming naturally gluten-free foods in their whole form like fruits , vegetables , legumes, nuts , seeds, fish, eggs , and poultry, the following whole grains are also inherently gluten-free:

• Brown, black, or red rice
• Gluten-free oats

It’s also key not to rely on processed gluten-free foods that may be high in calories, sugar, saturated fat, and sodium and low in nutrients, such as gluten-free cookies, chips, and other snack foods. Often, these foods are made with processed unfortified rice, tapioca, corn, or potato flours.

The gluten-free food industry has grown 136% from 2013 to 2015 with almost $12 billion in sales in 2015. Interestingly, studies show that people who do not have celiac disease are the biggest purchasers of gluten-free products. [11] Consumer surveys show that the top three reasons people select gluten-free foods are for “no reason,” because they are a “healthier option,” and for “digestive health.” [12] For those who are not gluten-intolerant, there is no data to show a specific benefit in following a gluten-free diet, particularly if processed gluten-free products become the mainstay of the diet. In fact, research following patients with celiac disease who change to a gluten-free diet shows an increased risk of obesity and metabolic syndrome. This could be partly due to improved intestinal absorption, but speculation has also focused on the low nutritional quality of processed gluten-free foods that may contain refined sugars and saturated fats and have a higher glycemic index. [13,14]

• Diet Review: Gluten-Free for Weight Loss
• Whole Grains
• Lebwohl B, Cao Y, Zong G, Hu FB, Green PHR, Neugut AI, Rimm EB, Sampson L, Dougherty L, Giovannucci E, Willett WC, Sun Q, Chan AT. Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study.  BMJ . 2017 May 2;357:j1892.
• Liu S, Stampfer MJ, Hu FB, et al. Whole-grain consumption and risk of coronary heart disease: results from the Nurses’ Health Study. Am J Clin Nutr . 1999;70:412-9.
• Mellen PB, Walsh TF, Herrington DM. Whole grain intake and cardiovascular disease: a meta-analysis. Nutr Metab Cardiovasc Dis . 2008;18:283-90.
• de Munter JS, Hu FB, Spiegelman D, Franz M, van Dam RM. Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med . 2007;4:e261.
• Johnsen, N.F., et al. Whole-grain products and whole-grain types are associated with lower all-cause and cause-specific mortality in the Scandinavian HELGA cohort. British Journal of Nutrition , 114(4), 608-23.
• Neyrinck, A.M., et al. Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice. Nutr Diabetes . 2012 Jan; 2(1): e28.
• Tojo, R., et al. Intestinal microbiota in health and disease: role of bifidobacteria in gut homeostasis. World J Gastroenterol . 2014 Nov 7;20(41):15163-76.
• Beyond Celiac. Celiac Disease: Fast Facts https://www.beyondceliac.org/celiac-disease/facts-and-figures/ Accessed 4/1/2017.
• Riddle, M.S., Murray, J.A., Porter, C.K. The Incidence and Risk of Celiac Disease in a Healthy US Adult Population. Am J Gastroenterol . 2012;107(8):1248-1255.
• N., Freeman, H.J., Thomson, A.B.R. Celiac disease: Prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol . 2012 Nov 14; 18(42): 6036–6059.
• Topper A. Non-celiacs Drive Gluten-Free Market Growth. Mintel Group Ltd. Web. http://www.mintel.com/blog/food-market-news/gluten-free-consumption-trends . Accessed Mar 27, 2017.
• Reilly, N.R. The Gluten-Free Diet: Recognizing Fact, Fiction, and Fad. The Journal of Pediatrics. Volume 175, August 2016, pages 206–210.
• Tortora, R., et al. Metabolic syndrome in patients with celiac disease on a gluten-free diet. Aliment Pharmacol Ther . 2015 Feb;41(4):352-9.
• Kabbani, T.A., et al. Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet. Aliment Pharmacol Ther . 2012 Mar;35(6):723-9.
• Wang Y, Lebwohl B, Mehta R, Cao Y, Green PHR, Grodstein F, Jovani M, Lochhead P, Okereke OI, Sampson L, Willett WC, Sun Q, Chan AT. Long-term Intake of Gluten and Cognitive Function Among US Women. JAMA Netw Open. 2021 May 3;4(5):e2113020. Disclosures: B Lebwohl reported receiving personal fees from Takeda and Kanyos outside the submitted work. OI Okereke reported receiving royalties from Springer Publishing outside the submitted work and receiving honoraria from the AARP for participation at the Global Council on Brain Health meetings. AT Chan reported receiving personal fees from Pfizer, Boehringer Ingelheim, Bayer Pharma, and Zoe Global outside the submitted work.

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Researchers develop new tool for better classification of inherited disease-causing variants

by Children's Hospital of Philadelphia

Researchers from Children's Hospital of Philadelphia (CHOP), the Perelman School of Medicine at the University of Pennsylvania, and the National Cancer Institute (NCI) of the National Institutes of Health have developed a new tool that allows scientists to annotate variant data from large-scale studies with clinically-focused classifications for risk of childhood cancer and other diseases. This new tool brings older applications in line with current guidelines and is available for use—for free—in the research community. The tool was described in a paper recently published in the journal Bioinformatics .

Whole genome and exome sequencing have become more widely available tools for clinical research in identifying inherited (germline) genetic variants that could result in a variety of diseases. While guidelines from the American College of Medical Genetics-Association for Molecular Pathology (ACMG-AMP) are frequently updated to help clinicians determine if germline variants are likely responsible for a patient's disease, automated tools may not always keep pace with such updates.

"Our goal was to create a publicly available tool that could evolve with these guidelines while still using many of the critical databases and approaches the research community has come to know," said senior study author Sharon J. Diskin, Ph.D., a member of the faculty of the Department of Biomedical and Health Informatics at CHOP and Associate Professor of Pediatrics at Penn Medicine.

The new tool, Automated Germline Variant Pathogenicity (AutoGVP), integrates germline variant pathogenicity annotations—information about whether identified variants cause disease—from the ClinVar database and sequence variant classifications from a modified version of the tool InterVar. AutoGVP returns pathogenicity classifications based on evolving ACMG-AMP guidelines through integration of ClinVar and InterVar. It addresses the InterVar tool's potential to overinterpret pathogenicity from loss-of-function variants that reduce the activity of a particular gene.

The need for AutoGVP became clear following a study published by Diskin and colleagues last year in the Journal of the National Cancer Institute that analyzed the germline DNA sequencing of 786 neuroblastoma patients and identified 116 pathogenic or likely pathogenic variants. The authors also reported that patients carrying these germline variants had a worse survival probability and identified BARD1 as an important neuroblastoma predisposition gene with both common and rare germline pathogenic or likely pathogenic variations.

A team including authors from the JNCI paper collaborated on the development of AutoGVP, to facilitate large-scale annotation of germline variants and assign pathogenicity automatically. They are applying AutoGVP to genetic data from pediatric brain tumor patients and larger neuroblastoma cohorts.

"Many samples we use for identifying pathogenic variants in pediatric brain tumors come from the centralized resource of the Children's Brain Tumor Network (CBTN), and we would like to be able to share new findings with the CBTN sites in a more streamlined manner," said Jo Lynne Rokita, Ph.D., a Supervisory Bioinformatics Scientist at the Center for Data-Driven Discovery (D3B) at CHOP and co-senior author of the study.

"With AutoGVP, we can streamline variant classification and swiftly incorporate new information as more and more biobanks release large sequencing data," said first author Jung Kim, Ph.D., a staff scientist at Division of Cancer Epidemiology and Genetics at the NCI. "Furthermore, AutoGVP reduces hands-on curating of variants and allows for reproducibility of the variant curation."

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TONA futures offer ‘greater precision’ for policy-led strategies – paper

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The emergence of exchange traded Japanese risk-free rate contracts has provided market participants with the ability to more precisely hedge possible rates hikes in the future, research published by Japan Exchange Group (JPX) has shown

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