Researchers discover new way to deliver DNA-based therapies for diseases
Drexel Medicine Researchers Develop New Technology to Target DNA Damage
DNA Testing
New DNA sequencing technique may help unravel genetic diversity of
IJMS
Genome Editing and Gene Therapy: New Opportunities to Correct Inherited
VIDEO
Gene therapy into brain helps kid with rare disease
How so called ‘junk DNA’ affects cancer risk
The Future is Now in Rare Disease Research
Turning One mRNA Discovery into a Cure for Many Diseases
Flipping the switch: Salk scientists shed light on genetic changes that turn "on" cancer genes
Revolutionizing Cancer Treatment: Targeted Small Molecule Kills All Solid Tumors!
COMMENTS
Artificial DNA breakthrough could lead to new treatments
Robert Lee Hotz May 7, 2014. Researchers for the first time have created microbes containing artificial DNA, expanding the universal genetic code that guides life. The advance one day could lead to new antibiotics, vaccines and other medical products. Raju Kucherlapati, the Paul C. Cabot Professor of Genetics, is quoted.
Four U.S. CRISPR Trials Editing Human DNA to Research New Treatments
The disease, which occurs most frequently in people of African descent, affects a protein called hemoglobin, which plays a critical role in helping red blood cells carry oxygen to different ...
Researchers uncover human DNA repair by nuclear metamorphosis
Researchers have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging.
Mayo research using DNA to catch cancer, other medical conditions
Dr. S. John Weroha discusses new treatments and research that are helping more people survive ovarian cancer. Mayo researchers invented a new class of AI to improve cancer research and treatments Hypothesis-driven AI offers an innovative way to use massive datasets to help discover the complex causes of diseases such as cancer and improve ...
Using gene editing to fight deadly genetic diseases
Experts share the latest advances at annual PQG conference . November 30, 2022 - Cutting-edge gene editing techniques hold enormous promise for tackling devastating diseases such as sickle cell disease, Huntington's disease, and heart disease, according to experts.. At the 16 th annual Program in Quantitative Genomics (PQG) conference, a two-day event held in early November and hosted by ...
Advances in CRISPR/Cas-based Gene Therapy in Human Genetic Diseases
Abstract. CRISPR/Cas genome editing is a simple, cost effective, and highly specific technique for introducing genetic variations. In mammalian cells, CRISPR/Cas can facilitate non-homologous end joining, homology- directed repair, and single-base exchanges. Cas9/Cas12a nuclease, dCas9 transcriptional regulators, base editors, PRIME editors and ...
Human Molecular Genetics and Genomics
The discovery of genes responsible for more than 5000 rare mendelian diseases has facilitated genetic diagnostics for many patients, pregnancy-related counseling, new drug treatments, and in some ...
Gene therapy and gene correction: targets, progress, and ...
The field of gene therapy has made significant strides over the last several decades toward the treatment of previously untreatable genetic disease. Gene therapy techniques have been aimed at ...
Newly discovered DNA repair mechanisms point to potential therapy
DNA damage repair is a double-edged sword: When it goes awry, it can lead to diseases such as cancer and degenerative motor disorders, but it can also be exploited to treat many forms of cancer using drugs that interfere with DNA's ability to fix itself, thereby causing cancerous cells to stop replicating and die.
From discovery through delivery: Patient-focused development ...
For people living with rare genetic diseases - many of which can be debilitating or life-threatening - the need for innovative treatments is urgent. Only 5% of the 7,000 known rare diseases ...
Updated DNA map better reflects human diversity
Researchers use it to identify genes involved in diseases so as to develop better treatments. It has led to improved cancer therapies and the development of tests to predict the onset of inherited ...
Modulating gene regulation to treat genetic disorders
Abstract. Over a thousand diseases are caused by mutations that alter gene expression levels. The potential of nuclease-deficient zinc fingers, TALEs or CRISPR fusion systems to treat these ...
Mapping Study Yields Novel Insights into DNA-Protein Connection, Paving
Proteins play a critical role in cellular function, and changes in protein mechanisms—often regulated by DNA variations—can lead to disease. DNA-to-protein mapping could help explain differences in the rates of some diseases in the two groups and help researchers understand some health disparities. The study appears May 2 in Nature Genetics.
Research reveals DNA-protecting gene's crucial role in brain disorders
University of Adelaide researchers now know more about a mysterious gene's role in maintaining healthy DNA—a crucial development that could lead to new treatments for life-threatening illnesses ...
DNA discovery can lead to new types of cancer drugs
"DNA discovery can lead to new types of cancer drugs." ScienceDaily. www.sciencedaily.com / releases / 2020 / 02 / 200228105218.htm (accessed May 4, 2024). Explore More
Scientists devise new technique that can pinpoint the causes and
Scientists devise new technique that can pinpoint the causes and treatments of autoimmune diseases. ScienceDaily . Retrieved May 1, 2024 from www.sciencedaily.com / releases / 2023 / 11 ...
New research advances understanding of DNA repair
The research improves the understanding of cellular genomic stability, drug efficacy and resistance associated with chemotherapy. "Cancer cells replicate at high speed, and their DNA endures a lot ...
PDF Scientists' research on RNA editing illuminates possible lifesaving
illuminates possible lifesaving treatments for genetic diseases ... the close chemical cousin to DNA, can be edited using ... lead to new lifesaving cures," said Wiedenheft. "Artem and Anna are
Exploring DNA Damage and Repair Mechanisms: A Review with Computational
Abstract. DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related disorders. DNA repair mechanisms play a pivotal role in safeguarding genetic integrity and preventing the onset of these ailments. Over the past decade, substantial progress ...
Newly discovered DNA repair mechanisms point to ...
Faulty DNA damage repair can lead to many types of cancer, neurodegenerative diseases, and other serious disorders. Investigators have developed high-throughput microscopy and machine learning ...
GoT-ChA: New tool reveals how gene mutations affect cells
The new achievement is the latest in a series of single-cell profiling innovations from Landau's research group. Such methods, also called "single-cell multi-omics" methods, enable researchers to characterize DNA mutations, gene activity patterns, cell-surface proteins and other layers of information - all in an individual cell, using ...
Research advances understanding of DNA repair
Jan. 20, 2022 — Faulty DNA damage repair can lead to many types of cancer, neurodegenerative diseases, and other serious disorders. Investigators have developed high-throughput microscopy and ...
RNA molecules control repair of human DNA in cancer cells
FULL STORY. A new study from Karolinska Institutet in Sweden shows how certain RNA molecules control the repair of damaged DNA in cancer cells, a discovery that could eventually give rise to ...
Understanding Eating Habits With Psychology
It can be easy to get into a habit of self-blame, shame, guilt and regret. But it's important that you understand your relationship with food: The how and why of what we eat.
Researchers target neurogenesis in new approach to treat Parkinson's
Researchers have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease, pointing toward a new approach for a disease with no cure and few ...
Dogma-challenging telomere findings may offer new ...
Jan. 20, 2022 — Faulty DNA damage repair can lead to many types of cancer, neurodegenerative diseases, and other serious disorders. Investigators have developed high-throughput microscopy and ...
Identification of disease-causing proteins leads to new potential
Identification of disease-causing proteins leads to new potential treatments for diseases like diabetes. ScienceDaily . Retrieved May 3, 2024 from www.sciencedaily.com / releases / 2023 / 02 ...
IMAGES
VIDEO
COMMENTS
Robert Lee Hotz May 7, 2014. Researchers for the first time have created microbes containing artificial DNA, expanding the universal genetic code that guides life. The advance one day could lead to new antibiotics, vaccines and other medical products. Raju Kucherlapati, the Paul C. Cabot Professor of Genetics, is quoted.
The disease, which occurs most frequently in people of African descent, affects a protein called hemoglobin, which plays a critical role in helping red blood cells carry oxygen to different ...
Researchers have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging.
Dr. S. John Weroha discusses new treatments and research that are helping more people survive ovarian cancer. Mayo researchers invented a new class of AI to improve cancer research and treatments Hypothesis-driven AI offers an innovative way to use massive datasets to help discover the complex causes of diseases such as cancer and improve ...
Experts share the latest advances at annual PQG conference . November 30, 2022 - Cutting-edge gene editing techniques hold enormous promise for tackling devastating diseases such as sickle cell disease, Huntington's disease, and heart disease, according to experts.. At the 16 th annual Program in Quantitative Genomics (PQG) conference, a two-day event held in early November and hosted by ...
Abstract. CRISPR/Cas genome editing is a simple, cost effective, and highly specific technique for introducing genetic variations. In mammalian cells, CRISPR/Cas can facilitate non-homologous end joining, homology- directed repair, and single-base exchanges. Cas9/Cas12a nuclease, dCas9 transcriptional regulators, base editors, PRIME editors and ...
The discovery of genes responsible for more than 5000 rare mendelian diseases has facilitated genetic diagnostics for many patients, pregnancy-related counseling, new drug treatments, and in some ...
The field of gene therapy has made significant strides over the last several decades toward the treatment of previously untreatable genetic disease. Gene therapy techniques have been aimed at ...
DNA damage repair is a double-edged sword: When it goes awry, it can lead to diseases such as cancer and degenerative motor disorders, but it can also be exploited to treat many forms of cancer using drugs that interfere with DNA's ability to fix itself, thereby causing cancerous cells to stop replicating and die.
For people living with rare genetic diseases - many of which can be debilitating or life-threatening - the need for innovative treatments is urgent. Only 5% of the 7,000 known rare diseases ...
Researchers use it to identify genes involved in diseases so as to develop better treatments. It has led to improved cancer therapies and the development of tests to predict the onset of inherited ...
Abstract. Over a thousand diseases are caused by mutations that alter gene expression levels. The potential of nuclease-deficient zinc fingers, TALEs or CRISPR fusion systems to treat these ...
Proteins play a critical role in cellular function, and changes in protein mechanisms—often regulated by DNA variations—can lead to disease. DNA-to-protein mapping could help explain differences in the rates of some diseases in the two groups and help researchers understand some health disparities. The study appears May 2 in Nature Genetics.
University of Adelaide researchers now know more about a mysterious gene's role in maintaining healthy DNA—a crucial development that could lead to new treatments for life-threatening illnesses ...
"DNA discovery can lead to new types of cancer drugs." ScienceDaily. www.sciencedaily.com / releases / 2020 / 02 / 200228105218.htm (accessed May 4, 2024). Explore More
Scientists devise new technique that can pinpoint the causes and treatments of autoimmune diseases. ScienceDaily . Retrieved May 1, 2024 from www.sciencedaily.com / releases / 2023 / 11 ...
The research improves the understanding of cellular genomic stability, drug efficacy and resistance associated with chemotherapy. "Cancer cells replicate at high speed, and their DNA endures a lot ...
illuminates possible lifesaving treatments for genetic diseases ... the close chemical cousin to DNA, can be edited using ... lead to new lifesaving cures," said Wiedenheft. "Artem and Anna are
Abstract. DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related disorders. DNA repair mechanisms play a pivotal role in safeguarding genetic integrity and preventing the onset of these ailments. Over the past decade, substantial progress ...
Faulty DNA damage repair can lead to many types of cancer, neurodegenerative diseases, and other serious disorders. Investigators have developed high-throughput microscopy and machine learning ...
The new achievement is the latest in a series of single-cell profiling innovations from Landau's research group. Such methods, also called "single-cell multi-omics" methods, enable researchers to characterize DNA mutations, gene activity patterns, cell-surface proteins and other layers of information - all in an individual cell, using ...
Jan. 20, 2022 — Faulty DNA damage repair can lead to many types of cancer, neurodegenerative diseases, and other serious disorders. Investigators have developed high-throughput microscopy and ...
FULL STORY. A new study from Karolinska Institutet in Sweden shows how certain RNA molecules control the repair of damaged DNA in cancer cells, a discovery that could eventually give rise to ...
It can be easy to get into a habit of self-blame, shame, guilt and regret. But it's important that you understand your relationship with food: The how and why of what we eat.
Researchers have found a way to better control the preclinical generation of key neurons depleted in Parkinson's disease, pointing toward a new approach for a disease with no cure and few ...
Jan. 20, 2022 — Faulty DNA damage repair can lead to many types of cancer, neurodegenerative diseases, and other serious disorders. Investigators have developed high-throughput microscopy and ...
Identification of disease-causing proteins leads to new potential treatments for diseases like diabetes. ScienceDaily . Retrieved May 3, 2024 from www.sciencedaily.com / releases / 2023 / 02 ...