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28 Best Academic Search Engines That make your research easier

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If you’re a researcher or scholar, you know that conducting effective online research is a critical part of your job. And if you’re like most people, you’re always on the lookout for new and better ways to do it. 

I’m sure you are familiar with some research databases. But, top researchers keep an open mind and are always looking for inspiration in unexpected places. 

This article aims to give you an edge over researchers that rely mainly on Google for their entire research process.

Our list of 28 academic search engines will start with the more familiar to less.

Table of Contents

#1. Google Scholar

Google Scholar is an academic search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

Great for academic research, you can use Google Scholar to find articles from academic journals, conference proceedings, theses, and dissertations. The results returned by Google Scholar are typically more relevant and reliable than those from regular search engines like Google.

Tip: You can restrict your results to peer-reviewed articles only by clicking on the “Scholarly”

• Scholarly results are typically more relevant and reliable than those from regular search engines like Google.
• You can restrict your results to peer-reviewed articles only by clicking on the “Scholarly” tab.
• Google Scholar database Coverage is extensive, with approx. 200 million articles indexed.
• Abstracts are available for most articles.
• Related articles are shown, as well as the number of times an article has been cited.
• Links to full text are available for many articles.
• Abstracts are only a snippet of the full article, so you might need to do additional searching to get the full information you need.
• Not all articles are available in full text.

Google Scholar is completely free.

#2. ERIC (Education Resources Information Center) 

ERIC (short for educational resources information center) is a great academic search engine that focuses on education-related literature. It is sponsored by the U.S. Department of Education and produced by the Institute of Education Sciences. 

ERIC indexes over a million articles, reports, conference papers, and other resources on all aspects of education from early childhood to higher education. So, search results are more relevant to Education on ERIC. 

• Extensive coverage: ERIC indexes over a million articles, reports, and other resources on all aspects of education from early childhood to higher education.
• You can limit your results to peer-reviewed journals by clicking on the “Peer-Reviewed” tab.
• Great search engine for educators, as abstracts are available for most articles.

ERIC is a free online database of education-related literature. 

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#3. Wolfram Alpha

Wolfram Alpha is a “computational knowledge engine” that can answer factual questions posed in natural language. It can be a useful search tool. 

Type in a question like “What is the square root of 64?” or “What is the boiling point of water?” and Wolfram Alpha will give you an answer.

Wolfram Alpha can also be used to find academic articles. Just type in your keywords and Wolfram Alpha will generate a list of academic articles that match your query.

Tip: You can restrict your results to peer-reviewed journals by clicking on the “Scholarly” tab.

• Can answer factual questions posed in natural language.
• Can be used to find academic articles.
• Results are ranked by relevance.
• Results can be overwhelming, so it’s important to narrow down your search criteria as much as possible.
• The experience feels a bit more structured but it could also be a bit restrictive

Wolfram Alpha offers a few pricing options, including a “Pro” subscription that gives you access to additional features, such as the ability to create custom reports. You can also purchase individual articles or download them for offline use.

Pro costs $5.49 and Pro Premium costs $9.99

#4. iSEEK Education 

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iSEEK is a search engine targeting students, teachers, administrators, and caregiver. It’s designed to be safe with editor-reviewed content.

iSEEK Education also includes a “Cited by” feature which shows you how often an article has been cited by other researchers.

• Editor-reviewed content.
• “Cited by” feature shows how often an article has been cited by other researchers.
• Limited to academic content.
• Doesn’t have the breadth of coverage that some of the other academic search engines have.

iSEEK Education is free to use.

#5. BASE (Bielefeld Academic Search Engine)

BASE is hosted at Bielefeld University in Germany and that’s where it name stems from (Bielefeld Academic Search Engine). 

Known as “one of the most comprehensive academic web search engines,” it contains over 100 million documents from 4,000 different sources. 

Users can narrow their search using the advanced search option, so regardless of whether you need a book, a review, a lecture, a video or a thesis, BASE has what you need.

BASE indexes academic articles from a variety of disciplines, including the arts, humanities, social sciences, and natural sciences.

• One of the world’s most voluminous search engines, 
• Indexes academic articles from a variety of disciplines, especially for academic web resources
• Includes an “Advanced Search” feature that lets you restrict your results to peer-reviewed journals.
• Doesn’t include abstracts for most articles.
• Doesn’t have related articles, references, cited by

BASE is free to use.

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CORE is an academic search engine that focuses on open access research papers. A link to the full text PDF or complete text web page is supplied for each search result. It’s academic search engine dedicated to open access research papers.

• Focused on open access research papers.
• Links to full text PDF or complete text web page are supplied for each search result.
• Export formats include BibTeX, Endnote, RefWorks, Zotero.
• Coverage is limited to open access research papers.
• No abstracts are available for most articles.
• No related articles, references, or cited by features.

CORE is free to use.

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#7. Science.gov

Science.gov is a search engine developed and managed by the United States government. It includes results from a variety of scientific databases, including NASA, EPA, USGS, and NIST. 

US students are more likely to have early exposure to this tool for scholarly research. 

• Coverage from a variety of scientific databases (200 million articles and reports).
• Links to full text are available for some articles.

Science.gov is free to use.

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#8. Semantic Scholar

Semantic Scholar is a recent entrant to the field. Its goal is to provide more relevant and effective search results via artificial intelligence-powered methods that detect hidden relationships and connections between research topics.

• Powered by artificial intelligence, which enhances search results.
• Covers a large number of academic articles (approx. 40 million).
• Related articles, references, and cited by features are all included.
• Links to full text are available for most articles.

Semantic Scholar is free to use.

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#9. RefSeek

RefSeek searches more than five billion documents, including web pages, books, encyclopedias, journals, and newspapers.

This is one of the free search engines that feels like Yahoo with a massive directory. It could be good when you are just looking for research ideas from unexpected angles. It could lead you to some other database that you might not know such as the CIA The World Factbook, which is a great reference tool.

• Searches more than five billion documents.
• The Documents tab is very focused on research papers and easy to use.
• Results can be filtered by date, type of document, and language.
• Good source for free academic articles, open access journals, and technical reports.
• The navigation and user experience is very dated even to millenials…
• It requires more than 3 clicks to dig up interesting references (which is how it could lead to you something beyond the 1st page of Google)
• The top part of the results are ALL ads (well… it’s free to use)

RefSeek is free to use.

#10. ResearchGate 

A mixture of social networking site + forum + content databases where researchers can build their profile, share research papers, and interact with one another.

Although it is not an academic search engine that goes outside of its site, ResearchGate ‘s library of works offers an excellent choice for any curious scholar.

There are more than 100 million publications available on the site from over 11 million researchers. It is possible to search by publication, data, and author, as well as to ask the researchers questions. 

• A great place to find research papers and researchers.
• Can follow other researchers and get updates when they share new papers or make changes to their profile.
• The network effect can be helpful in finding people who have expertise in a particular topic.
• Interface is not as user friendly
• Can be overwhelming when trying to find relevant papers.
• Some papers are behind a paywall.

ResearchGate is free to use.

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#11. DataONE Search (formerly CiteULike) 

A social networking site for academics who want to share and discover academic articles and papers.

• A great place to find academic papers that have been shared by other academics.
• Some papers are behind a paywall

CiteULike is free to use.

#12. DataElixir 

DataElixir is deigned to help you find, understand and use data. It includes a curated list of the best open datasets, tools and resources for data science.

• Dedicated resource for finding open data sets, tools, and resources for data science.
• The website is easy to navigate.
• The content is updated regularly
• The resources are grouped by category.
• Not all of the resources are applicable to academic research.
• Some of the content is outdated.

DataElixir is free to use.

#13. LazyScholar – browser extension

LazyScholar is a free browser plugin that helps you discover free academic full texts, metrics, and instant citation and sharing links. Lazy Scholar is created Colby Vorland, a postdoctoral fellow at Indiana University.

• It can integrate with your library to find full texts even when you’re off-campus.
• Saves your history and provides an interface to find it.
• A pre-formed citation is availlable in over 900 citation styles.
• Can recommend you topics and scans new PubMed listings to suggest new papers
• Results can be a bit hit or miss

LazyScholar is free to use.

#14. CiteseerX – digital library from PenState

CiteseerX is a digital library stores and indexes research articles in Computer Science and related fields. The site has a robust search engine that allows you to filter results by date, author.

• Searches a large number of academic papers.
• Results can be filtered by date, author, and topic.
• The website is easy to use.
• You can create an account and save your searches for future reference.

CiteseerX is free to use.

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#15. The Lens – patents search 

The Lens or the Patent Lens is an online patent and scholarly literature search facility, provided by Cambia, an Australia-based non-profit organization.

• Searches for a large number of academic papers.

The price range can be free for non-profit use to $5,000 for commercial enterprise.

#16. Fatcat – wiki for bibliographic catalog 

Fatcat is an open bibliographic catalog of written works. The scope of works is somewhat flexible, with a focus on published research outputs like journal articles, pre-prints, and conference proceedings. Records are collaboratively editable, versioned, available in bulk form, and include URL-agnostic file-level metadata.

• Open source and collaborative
• You can be part of the community that is very focused on its mission
• The archival file-level metadata (verified digests and long-term copies) is a great feature.
• Could prove to be another rabbit hole
• People either love or hate the text-only interface

#17. Lexis Web – Legal database

Are you researching legal topics? You can turn to Lexis Web for any law-related questions you may have. The results are drawn from legal sites and can be filtered based on criteria such as news, blogs, government, and commercial. Additionally, users can filter results by jurisdiction, practice area, source and file format.

• Results are drawn from legal sites.
• Filters are available based on criteria such as news, blogs, government, and commercial.
• Users can filter results by jurisdiction, practice area, source and file format.
• Not all law-related questions will be answered by this search engine.
• Coverage is limited to legal sites only.

Lexis Web is free for up to three searches per day. After that, a subscription is required.

#18. Infotopia – part of the VLRC family

Infotopia touts itself as an “alternative to Google safe search.” Scholarly book results are curated by librarians, teachers, and other educational workers. Users can select from a range of topics such as art, health, and science and technology, and then see a list of resources pertaining to the topic. 

Consequently, if you aren’t able to find what you are looking for within Infotopia’s pages, you will probably find it on one of its many suggested websites.

#19. Virtual Learning Resources Center

Virtual Learning Resources Center (VLRC) is an academic search engine that features thousands of academic sites chosen by educators and librarians worldwide. Using an index generated from a research portal, university, and library internet subject guides, students and instructors can find current, authoritative information for school.

• Thousands of academic information websites indexed by it. You will also be able to get more refined results with custom Google search, which will speed up your research. 
• Many people consider VLRC as one of the best free search engines to start looking for research material. 
• TeachThought rated the Virtual LRC #3 in it’s list of 100 Search Engines For Academic Research
• More relevant to education 
• More relevant to students

Powered by Google Custom Search Engine (CSE), Jurn is a free online search engine for accessing and downloading free full-text scholarly papers. It was created by David Haden in a public open beta version in February 2009, initially for locating open access electronic journal articles in the arts and humanities.

After the indexing process was completed, a website containing additional public directories of web links to indexed publications was introduced in mid-2009. The Jurn search service and directory has been regularly modified and cleaned since then.

• A great resource for finding academic papers that are behind paywalls.
• The content is updated regularly.uren

Jurn is free to use.

#21. WorldWideScience

The Office of Scientific and Technical Information—a branch of the Office of Science within the U.S. Department of Energy—hosts the portal WorldWideScience , which has dubbed itself “The Global Science Gateway.”

Over 70 countries’ databases are used on the website. When a user enters a query, it contacts databases from all across the world and shows results in both English and translated journals and academic resources.

• Results can be filtered by language and type of resource
• Interface is easy to use
• Contains both academic journal articles and translated academic resources 
• The website can be difficult to navigate.

WorldWideScience is free to use.

#22. Google Books

A user can browse thousands of books on Google Books, from popular titles to old titles, to find pages that include their search terms. You can look through pages, read online reviews, and find out where to buy a hard copy once you find the book you are interested in.

#23. DOAJ (Directory of Open Access Journals)

DOAJ is a free search engine for scientific and scholarly materials. It is a searchable database with over 8,000 peer-reviewed research papers organized by subject. It’s one of the most comprehensive libraries of scientific and scholarly resources, with over 8,000 journals available on a variety of themes.

#24. Baidu Scholar

Baidu Xueshu (Academic) is the Chinese version for Google Scholar. IDU Scholar indexes academic papers from a variety of disciplines in both Chinese and English.

• Articles are available in full text PDF.
• Covers a variety of academic disciplines.
• No abstracts are available for most articles, but summaries are provided for some.
• A great portal that takes you to different specialized research platform
• You need to be able to read Chinese to use the site
• Since 2021 there is a rise of focus on China and the Chinese Communist Party

Baidu Scholar is free to use.

#25. PubMed Central

PubMed is a free search engine that provides references and abstracts for medical, life sciences, and biomedical topics.

If you’re studying anything related to healthcare or science, this site is perfect. PublicMed Central is operated by the National Center for Biotechnology Information, a division of the U.S. National Library of Medicine. It contains more than 3 million full-text journal articles. 

It’s similar to PubMed Health, which focuses on health-related research and includes abstracts and citations to over 26 million articles.

#26. MEDLINE®

MEDLINE® is a paid subscription database for life sciences and biomedicine that includes more than 28 million citations to journal articles. For finding reliable, carefully chosen health information, Medline Plus provides a powerful search tool and even a dictionary.

• A great database for life sciences and biomedicine.
• Contains more than 28 million references to journal articles.
• References can be filtered by date, type of document, and language.
• The database is expensive to access.
• Some people find it difficult to navigate and find what they are looking for.

MEDLINE is not free to use ( pricing information ).

Defunct Academic Search Engines 

#27. microsoft academic  .

Microsoft Academic

Microsoft Academic Search seemed to be a failure from the beginning. It ended in 2012, then re-launched in 2016 as Microsoft Academic. It provides the researcher with the opportunity to search academic publications,

Microsoft Academic used to be the second-largest academic search engine after Google Scholar. Microsoft Academic provides a wealth of data for free, but Microsoft has announced that it will shut Microsoft Academic down in by 2022. 

#28. Scizzle

Designed to help researchers stay on top of the literature by setting up email alerts, based on key terms, for newspapers.

Unfortunately, academic search engines come and go. These are two that are no longer available.

Final Thoughts

There are many academic search engines that can help researchers and scholars find the information they need. This list provides a variety of options, starting with more familiar engines and moving on to less well-known ones. 

Keeping an open mind and exploring different sources is essential for conducting effective online research. With so much information at our fingertips, it’s important to make sure we’re using the best tools available to us.

Tell us in the comment below which academic search engine have you not heard of? Which database do you think we should add? What database do your professional societies use? What are the most useful academic websites for research in your opinion?

There is more.

Check out our other articles on the Best Academic Tools Series for Research below.

• Learn how to get more done with these Academic Writing Tools  
• Learn how to proofread your work with these Proofreading Tools
• Learn how to broaden your research landscape with these Academic Search Engines
• Learn how to manage multiple research projects with these Project Management Tools
• Learn how to run effective survey research with these Survey Tools for Research
• Learn how get more insights from important conversations and interviews with Transcription Tools
• Learn how to manage the ever-growing list of references with these Reference Management Software
• Learn how to double your productivity with literature reviews with these AI-Based Summary Generators
• Learn how to build and develop your audience with these Academic Social Network Sites
• Learn how to make sure your content is original and trustworthy with these Plagiarism Checkers
• Learn how to talk about your work effectively with these Science Communication Tools

10 thoughts on “28 Best Academic Search Engines That make your research easier”

Thank you so much Joannah..I have found this information useful to me as librarian in an academic library

You are welcome! We are happy to hear that!

Thank You Team, for providing a comprehensive list of academic search engines that can help make research easier for students and scholars. The variety of search engines included offers a range of options for finding scholarly articles, journals, and other academic resources. The article also provides a brief summary of each search engine’s features, which helps in determining which one is the best fit for a specific research topic. Overall, this article is a valuable resource for anyone looking for a quick and easy way to access a wealth of academic information.

Thank you for taking the time to share your feedback with us. We are delighted to hear that you found our list of academic search engines helpful in making research easier for students and scholars. We understand the importance of having a variety of options when it comes to finding scholarly articles, journals, and other academic resources, and we strive to provide a comprehensive list of resources to meet those needs.

We are glad that you found the brief summary of each search engine’s features helpful in determining which one is the best fit for a specific research topic. Our goal is to make it easy for our readers to access valuable academic information and we’re glad that we were able to achieve that for you.

We appreciate your support and thank you for your kind words. We will continue to provide valuable resources for students and researchers in the future. Please let us know if you have any further questions or suggestions.

No more questions Thank You

I cannot thank you enough!!! thanks alot 🙂

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Hi Joannah! Here’s another one you may want to add! Expontum ( https://www.expontum.com/ ) – Helps researchers quickly find knowledge gaps and identify what research projects have been completed before. Thanks!

Expontum – Helps researchers quickly find knowledge gaps and identify what research projects have been completed before. Expontum is free, open access, and available to all globally with no paid versions of the site. Automated processes scan research article information 24/7 so this website is constantly updating. By looking at over 35 million research publications (240 million by the end of 2023), the site has 146 million tagged research subjects and 122 million tagged research attributes. Learn more about methodology and sources on the Expontum About Page ( https://www.expontum.com/about.php )

Hey Ryan, I clicked and checked your site and thought it was very relevant to our reader. Thank you for sharing. And, we will be reviewing your site soon.

Sounds good! Thanks, Joannah!

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Reference management. Clean and simple.

The top list of academic research databases

2. Web of Science

5. ieee xplore, 6. sciencedirect, 7. directory of open access journals (doaj), get the most out of your academic research database, frequently asked questions about academic research databases, related articles.

Whether you are writing a thesis , dissertation, or research paper it is a key task to survey prior literature and research findings. More likely than not, you will be looking for trusted resources, most likely peer-reviewed research articles.

Academic research databases make it easy to locate the literature you are looking for. We have compiled the top list of trusted academic resources to help you get started with your research:

Scopus is one of the two big commercial, bibliographic databases that cover scholarly literature from almost any discipline. Besides searching for research articles, Scopus also provides academic journal rankings, author profiles, and an h-index calculator .

• Coverage: 90.6 million core records
• References: N/A
• Discipline: Multidisciplinary
• Access options: Limited free preview, full access by institutional subscription only
• Provider: Elsevier

Web of Science also known as Web of Knowledge is the second big bibliographic database. Usually, academic institutions provide either access to Web of Science or Scopus on their campus network for free.

• Coverage: approx. 100 million items
• References: 1.4 billion
• Access options: institutional subscription only
• Provider: Clarivate (formerly Thomson Reuters)

PubMed is the number one resource for anyone looking for literature in medicine or biological sciences. PubMed stores abstracts and bibliographic details of more than 30 million papers and provides full text links to the publisher sites or links to the free PDF on PubMed Central (PMC) .

• Coverage: approx. 35 million items
• Discipline: Medicine and Biological Sciences
• Access options: free
• Provider: NIH

For education sciences, ERIC is the number one destination. ERIC stands for Education Resources Information Center, and is a database that specifically hosts education-related literature.

• Coverage: approx. 1.6 million items
• Discipline: Education
• Provider: U.S. Department of Education

IEEE Xplore is the leading academic database in the field of engineering and computer science. It's not only journal articles, but also conference papers, standards and books that can be search for.

• Coverage: approx. 6 million items
• Discipline: Engineering
• Provider: IEEE (Institute of Electrical and Electronics Engineers)

ScienceDirect is the gateway to the millions of academic articles published by Elsevier, 1.4 million of which are open access. Journals and books can be searched via a single interface.

• Coverage: approx. 19.5 million items

The DOAJ is an open-access academic database that can be accessed and searched for free.

• Coverage: over 8 million records
• Provider: DOAJ

JSTOR is another great resource to find research papers. Any article published before 1924 in the United States is available for free and JSTOR also offers scholarships for independent researchers.

• Coverage: more than 12 million items
• Provider: ITHAKA

Start using a reference manager like Paperpile to save, organize, and cite your references. Paperpile integrates with PubMed and many popular databases, so you can save references and PDFs directly to your library using the Paperpile buttons:

Scopus is one of the two big commercial, bibliographic databases that cover scholarly literature from almost any discipline. Beside searching for research articles, Scopus also provides academic journal rankings, author profiles, and an h-index calculator .

PubMed is the number one resource for anyone looking for literature in medicine or biological sciences. PubMed stores abstracts and bibliographic details of more than 30 million papers and provides full text links to the publisher sites or links to the free PDF on PubMed Central (PMC)

Eight Ways (and More) To Find and Access Research Papers

This blog is part of our Research Smarter series. You’ll discover the various search engines, databases and data repositories to help you along the way. Click on any of the following links for in an in-depth look at how to find relevant research papers, journals , and authors for your next project using the Web of Science™. You can  also check out our ultimate guides here , which include tips to speed up the writing process.

If you’re in the early stages of your research career, you’re likely struggling to learn all you can about your chosen field and evaluate your options. You also need an easy and convenient way to find the right research papers upon which to build your own work and keep you on the proper path toward your goals.

Fortunately, most institutions have access to thousands of journals, so your first step should be to be to check with library staff  and find out what is available via your institutional subscriptions.

For those who may be unfamiliar with other means of access, this blog post – the first in a series devoted to helping you “research smarter” – will provide a sampling of established data sources for scientific research. These include search engines, databases, and data repositories.

Search Engines and Databases

You may have already discovered that the process of searching for research papers offers many choices and scenarios. Some search engines, for example, can be accessed free of charge. Others require a subscription. The latter group generally includes services that index the contents of thousands of published journals, allowing for detailed searches on data fields such as author name, institution, title or keyword, and even funding sources. Because many journals operate on a subscription model too, the process of obtaining full-text versions of papers can be complicated.

On the other hand, a growing number of publishers follow the practice of Open Access (OA) , making their journal content freely available. Similarly, some authors publish their results in the form of preprints, posting them to preprint servers for immediate and free access. These repositories, like indexing services, differ in that some concentrate in a given discipline or broad subject area, while others cover the full range of research.

Search Engines

Following is a brief selection of reputable search engines by which to locate articles relevant to your research.

Google Scholar is a free search engine that provides access to research in multiple disciplines. The sources include academic publishers, universities, online repositories, books, and even judicial opinions from court cases. Based on its indexing, Google Scholar provides citation counts to allow authors and others to track the impact of their work.  

The Directory of Open Access Journals ( DOAJ ) allows users to search and retrieve the article contents of nearly 10,000 OA journals in science, technology, medicine, social sciences, and humanities. All journals must adhere to quality-control standards, including peer review.

PubMed , maintained by the US National Library of Medicine, is a free search engine covering the biomedical and life sciences. Its coverage derives primarily from the MEDLINE database, covering materials as far back as 1951.

JSTOR affords access to more than 12 million journal articles in upwards of 75 disciplines, providing full-text searches of more than 2,000 journals, and access to more than 5,000 OA books.

Selected Databases

The following selection samples a range of resources, including databases which, as discussed above, index the contents of journals either in a given specialty area or the full spectrum of research. Others listed below offer consolidated coverage of multiple databases. Your institution is likely subscribed to a range of research databases, speak to your librarian to see which databases you have access to, and how to go about your search.

Web of Science includes The Web of Science Core Collection, which covers more than 20,000 carefully selected journals, along with books, conference proceedings, and other sources. The indexing also captures citation data, permitting users to follow the thread of an idea or development over time, as well as to track a wide range of research-performance metrics. The Web of Science also features EndNote™ Click , a free browser plugin that offers one-click access to the best available legal and legitimate full-text versions of papers. See here for our ultimate guide to finding relevant research papers on the Web of Science .

Science.gov covers the vast territory of United States federal science, including more than 60 databases and 2,200-plus websites. The many allied agencies whose research is reflected include NASA, the US Department of Agriculture, and the US Environmental Protection Agency.

CiteSeerx is devoted primarily to information and computer science. The database includes a feature called Autonomous Citation Indexing, designed to extract citations and create a citation index for literature searching and evaluation.

Preprint and Data Repositories

An early form of OA literature involved authors, as noted above,  making electronic, preprint versions of their papers freely available. This practice has expanded widely today. You can find archives devoted to a single main specialty area, as well as general repositories connected with universities and other institutions.

The specialty archive is perhaps best exemplified by arXiv (conveniently pronounced “archive,” and one of the earliest examples of a preprint repository). Begun in 1991 as a physics repository, ArXiv has expanded to embrace mathematics, astronomy, statistics, economics, and other disciplines. The success of ArXiv spurred the development of, for example, bioArXiv devoted to an array of topics within biology, and for chemistry, ChemRxiv .

Meanwhile, thousands of institutional repositories hold a variety of useful materials. In addition to research papers, these archives store raw datasets, graphics, notes, and other by-products of investigation. Currently, the Registry of Open Access Repositories lists more than 4,700 entries.

Reach Out Yourself?

If the resources above don’t happen to result in a free and full-text copy of the research you seek, you can also try reaching out to the authors yourself.

To find who authored a paper, you can search indexing platforms like the Web of Science , or research profiling systems like Publons™ , or ResearchGate , then look to reach out to the authors directly.

So, although the sheer volume of research can pose a challenge to identifying and securing needed papers, plenty of options are available.

Related posts

Reimagining research impact: introducing web of science research intelligence.

Beyond discovery: AI and the future of the Web of Science

Clarivate welcomes the Barcelona Declaration on Open Research Information

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Resources for Academic Research: 12 Best Websites & Tools

It is best to use scholarly or professional resources that are reliable, accurate, and valid for academic coursework and resources for academic research project assignments.

These are typically books and articles that have been reviewed before publication, but they can also be media and websites from reputable organizations and institutions.

When you do a research project, write a paper, or start a blog, you would then read articles to see what other people have done and then build on their work.

What are Resources for Academic Research?

Resources for academic research are the tools, materials, and information sources that scholars, students, and researchers use to conduct thorough and accurate research on a given topic.

Academic journals, books, online databases, primary and secondary sources, and research tools such as citation generators, reference managers, and statistical analysis software are examples of these resources .

Access to reliable and diverse resources is essential for producing high-quality academic work that is credible, informative, and current.

12 Best Websites, Tools & Resources for Academic Research

What sources will lead you to trustworthy resources for academic research? When you need to find sources, use these academic resources instead of scrolling through pages of search results.

• Google Scholar

Google Scholar offers a wide range of scholarly literature, including articles, theses, books, and conference papers, making it a great resource for academic study.

Google Scholar allows researchers to search for information on a topic, find relevant material for their literature review, track citations of their work, remain up-to-date on new research in their field, and evaluate their work using metrics like the h-index and i10-index.

It’s a comprehensive, user-friendly academic research resource with powerful search capabilities, email alerts, and Google integration. This important website helps researchers find, access, and manage research data.

Features: 

• Keyword, author, or title search box for scholarly literature.
• Tracking your work’s citations.
• Advanced search filters by publication date, author, or journal.
• Full-text articles and papers for convenient reference.
• Email alerts for keywords or topics to remain current on research in your profession.
• Work impact metrics like the h-index and i10-index.
• Google Books and Google Drive integration for saving and organizing research resources.

JSTOR is an online library with academic journals, books, and primary sources from many fields. It was started in 1995 as a non-profit organization by JSTOR Inc. and a number of academic institutions.

More than 12 million academic articles and books from more than 2,000 publishers are in JSTOR’s online library. Content on JSTOR comes from many different fields, such as the humanities, social sciences, and natural sciences.

Individuals and institutions can subscribe to JSTOR’s digital library, and researchers, students, and scholars worldwide use it as a reliable and complete resource for academic research.

• JSTOR offers scholarly journals, books, and primary materials.
• JSTOR material spans humanities, social sciences, and natural sciences.
• JSTOR’s stored content, including historical records, gives academics a broad perspective.
• Users can search the platform’s huge database for keywords, authors, titles, and more.
• PDFs of JSTOR articles can be downloaded.
• Sharing, citation, and exporting options help scholars collaborate on the platform.
• JSTOR’s pricing makes it’s content affordable for all sizes and budgets.

ProQuest is a global information content and technology company that gives access to research databases, electronic books, and digital archives. Eugene B. Power started it in 1938 as University Microfilms to store and distribute dissertations and theses on microfilm.

Today, ProQuest gives you access to a wide range of content, such as academic journals, newspapers, dissertations, and primary sources. The databases on ProQuest cover a wide range of subjects, including the social sciences, the humanities, and the natural sciences.

Researchers, students, and scholars worldwide use ProQuest because it is a reliable, all-inclusive resource for academic research.

Features : 

• Offers access to research databases, e-books, and digital archives in a wide range of fields.
• There are a lot of academic journals, newspapers, dissertations, and primary sources in this collection.
• Included are the social sciences, the humanities, and the natural sciences.
• Users can search by author, title, keyword, subject, and other criteria.
• Many of its databases let you read articles and other materials in full text.
• Includes tools for saving research, organizing it, and sharing it with others.
• Offers different pricing options so that people and organizations of all sizes and budgets can use it.
• Offers easy access to ProQuest’s services through mobile apps and the web so that they can be used from anywhere.
• Users can get a lot of help with customer service and training.
• ResearchGate

ResearchGate is a social networking site for academics and researchers to cooperate. In 2008, a group of scientists founded it to allow researchers to share their work, communicate, and network.

One of the largest research communities online, ResearchGate has over 17 million users. The platform lets scholars create profiles, share publications, ask and answer questions, and network with like-minded researchers.

A citation tracker and reputation score help scholars manage their research activity on ResearchGate.

• A social network for scientists and researchers.
• Enables scholars to create profiles, share work, and network.
• Researcher cooperation and discussion platform.
• A citation tracker, online reputation score , and analytics assist scholars in managing their research.
• Job board and career resource for researchers.
• Allows field researchers to ask and answer questions.
• Offers a news feed on cutting-edge research.
• Provides scholars with peer assessment and feedback.
• Allows researchers to advertise their work and gain academic recognition.
• Provides free and premium memberships.

Zotero, a free, open-source reference manager, helps scholars organize and credit their sources. The George Mason University Roy Rosenzweig Center for History and New Media was founded in 2006.

Zotero lets users organize and search papers, books, web pages, and other study materials. It connects with various online browsers to gather and save research sources when surfing.

Researchers may easily format their citations and bibliographies in their discipline’s style with Zotero’s several citation formats. As a handy and effective tool for managing research resources, researchers, students, and scholars worldwide use it.

• A free, open-source reference manager.
• Organizes, stores, and cites research sources.
• Organizes and stores research items in a searchable database.
• It connects with various online browsers to gather and save research sources when surfing.
• Offers a variety of citation styles for producing citations and bibliographies.
• Enables people to share their research.
• Provides note-taking, labeling, and research source highlighting features.
• Automatically refreshes and syncs devices for easy research access.
• Provides many plugins and add-ons to increase functionality.
• Includes excellent documentation and a helpful user community.

Mendeley, a free reference management and academic, social network, lets researchers organize and share their articles and resources. It was started in 2008 by academicians and software developers and acquired by Elsevier in 2013.

Mendeley lets users create a searchable database of research papers, books, and other resources, including citation management, collaboration, and discovery capabilities. It offers groups, profiles, and suggestions to assist the researcher’s network.

Mendeley is a convenient and effective research management tool used by academics, students, and intellectuals worldwide.

• Free academic networking and reference management.
• Helps scholars organize and share papers and resources.
• Provides a searchable database of research papers, books, etc.
• Citation, collaboration, and discovery tools.
• Helps researchers network with groups, profiles, and recommendations.
• Annotates, highlights, and organizes research.
• Formats citations and bibliographies in several fields.
• Plugins and add-ons for major word processing and research applications.
• Automatic updates and device syncing make research materials accessible anywhere.
• Has a strong user community and substantial documentation.

Grammarly is a real-time writing tool that checks spelling, punctuation, and style. It was created in 2009 by linguists and software engineers and is now one of the most popular writing tools.

Grammarly is available as a browser extension, a desktop program for Windows and macOS, and a web app. It comes in free and premium versions, with the premium version adding genre-specific writing style advice, plagiarism detection, and readability scoring.

Grammarly improves writing for millions of writers, students, and professionals worldwide.

• Real-time grammar and spelling checker for writers.
• Helps writers improve style and tone.
• Software engineers and linguists created it.
• Use a web app, browser extension, or desktop software.
• Free and paid versions are available.
• The premium edition includes genre-specific writing style suggestions, plagiarism detection, and a readability score.
• Helps writers improve their writing quality and clarity.
• Available in English and others.
• Compatible with Google Documents, Microsoft Word, and others.
• Provides thorough grammar and writing instructions in an easy-to-use interface.
• Helps non-native English speakers improve their writing.
• Microsoft Academic

Microsoft Research created the free public search engine Microsoft Academic. It offers scientific, technological, engineering, mathematical, social science, and humanities research papers, journals, conference proceedings, and other scholarly publications.

Microsoft Academic leverages advanced natural language processing and machine learning to recognize author, publication, and research domain relationships, making it easier for scholars to find relevant material and track field changes. Citation analysis, research network visualization, and author profile management are also available.

• A free public search engine built by Microsoft Research.
• Accesses academic journals, conference proceedings, research papers, and other scholarly publications.
• Understands authors, publications, and research fields using advanced natural language processing and machine learning.
• Helps researchers find relevant literature and follow industry trends.
• Citation analysis, visualization of research networks, and author profile creation and management are available.
• Has powerful filters and semantic search in a user-friendly interface.
• Citation counts, trends, and co-authorship networks are provided.
• Enables users to set personalized research alerts.
• APIs enable developers to access data and functionality.
• Zotero and Mendeley integration supported.

Evernote lets users capture, organize, and share notes and information across devices. It helps users recall everything from personal notes and to-do lists to business documents and research notes.

Evernote lets users make and save notes in text, photos, audio, and site clippings. Tagging, search, and device synchronization make it easy for users to find and retrieve their notes anytime, anywhere.

The premium edition of Evernote includes PDF annotation, presentation mode, and team collaboration.

• Note-taking app for multiple platforms.
• Enables users to take, organize, and share notes across devices.
• Helps users recall anything from personal notes and to-do lists to research and business paperwork.
• Enables users to make and save notes in numerous formats, including text, photos, audio, and site clippings.
• Allows users to find and retrieve their notes anytime, anywhere, with labeling, search, and device syncing.
• Has configurable notebooks and notes and a simple interface.
• Offers note formatting, annotation, and editing features.
• Supports Google Drive, Slack, and other productivity apps.
• Provides a free version with limited functionality and a paid version with PDF annotation, presentation mode, and team collaboration.
• Search notes, journals, and tags with a sophisticated search function.
• To keep organized, lets users set reminders and make to-do lists.

The US National Library of Medicine (NLM) of the National Institutes of Health (NIH) maintains PubMed, a free biomedical literature and research article database (NIH). It comprises over 32 million citations and abstracts of papers from more than 8,000 biomedical journals and books, dissertations, and other health and medicine-related resources.

PubMed covers a wide range of medical issues, including clinical research, genetics, nursing, and pharmacology. Medical researchers, students, and professionals can use it to find the newest medical research.

• Free biomedical research article database.
• Managed by the US National Library of Medicine (NLM) at the NIH (NIH)
• 32 million citations and abstracts from over 8,000 biomedical journals.
• Clinical research, genetics, nursing, pharmacology, and more.
• Obtains full-text articles from PubMed Central (PMC)
• Includes Boolean operators, search fields, and filters.
• Accesses MeSH, a fully controlled vocabulary for indexing articles.
• Saves and exports search results and send email alerts for new publications matching search criteria.
• Has a simple interface and search tools.
• Links to important publications, citations, and other resources.
• PubMed has a smartphone app.
• QuestionPro Insight Hub

QuestionPro Insight Hub connects businesses and organizations to millions of consumers and expert panelists globally for market research. The platform allows users to build surveys, run polls, conduct focus groups, and collect data from social media, email, mobile devices, and websites. Advanced analytics and reporting options enable users to evaluate data and understand customer behavior, preferences, and opinions.

Businesses may use QuestionPro Insight Hub to acquire real-time feedback from their target audience, optimize their products and services, and make informed business decisions based on consumer insights. The platform is appropriate for startups to enterprise-level enterprises in fields including healthcare, education, finance, and more.

• Access to millions of professional and consumer panelists all over the world
• Customizable surveys with different types of questions, themes, and templates
• Advanced logic and branching options for surveys
• Integration with many data collection sources, like social media, email, mobile devices, and websites
• Text analytics and sentiment analysis are built in for free-form responses.
• Real-time reporting and analytics with dashboards and charts that the user can change
• Collaboration tools that let team members share surveys, results, and insights
• Survey participants can get invitations and reminders by email that they can customize.
• Tools for running moderated and unmoderated discussions in online focus groups
• Polling tools to get quick feedback from customers and stakeholders and to get them involved
• Targeting options that make it easier to reach specific groups and demographics
• Compliance with GDPR and CCPA for privacy and security of data
• API and the ability to connect to other business platforms and applications.
• QuestionPro Live polls

QuestionPro Live Polls lets presenters communicate with their audience by running live polls during presentations, meetings, webinars, and other events that require real-time input. Presenters can modify QuestionPro Live Polls and obtain rapid audience reactions.

QuestionPro Live Polls include:

• Different question kinds.
• Configurable designs.
• Real-time live polling results.
• Multiple distribution choices.
• Audience engagement tools.
• Analytics and reporting.
• Integration with other platforms.

The solution lets presenters generate multiple-choice, rating scales, and open-ended polls.

SMS, email, QR codes, and social media to distribute QuestionPro Live Polls. Presenters and guests can instantly see real-time polling results on the screen. Presenters can quickly poll their audience regardless of location or device.

QuestionPro Live Polls encourages audience participation with countdown timers, animations, and gamification. Presenters can learn about audience opinions, preferences, and habits using poll analytics and reporting.

QuestionPro Live Polls is great for audience engagement, real-time feedback, and interactive presentations and events.

Features:  

• Multiple question types, including multiple-choice, rating scales, and open-ended questions
• Poll designs that can be changed to fit the theme of the presentation or event
• The results of the poll were shown on the screen right away.
• Several ways to spread the word, like SMS, email, QR codes, and social media
• Tools for getting people to pay attention, such as countdown timers, animations, and gamification elements
• Analytics and reporting tools can help you determine what your audience thinks, likes, and does.
• Integration with other platforms, like PowerPoint, Zoom, and other video conferencing tools
• You can target your audience based on different demographic and psychographic factors to get more accurate feedback and insights.

LEARN ABOUT: Speaker evaluation form

In conclusion, the 12 best websites, tools, and resources for academic research offer students, scholars, and researchers a wealth of information and tools to help them in their quest for knowledge. Databases, search engines, citation generators, and collaboration tools are just a few of the features these resources offer.

Using these resources, researchers can improve their research and produce high-quality academic work. Researchers should keep up with the latest tools and technologies, as these can greatly improve their research and help their field advance.

QuestionPro’s Insight Hub and Livepolls are powerful data collection tools. These tools have various features, such as doing surveys, visualizing data, and polling in real-time, which can greatly improve the research process.

With the ability to collect data from a wide range of sources, researchers can gain valuable insights and come to conclusions that are based on facts. Combining these two tools can help researchers do high-quality research and make important contributions to their field. So get more help for your academic research with the help of QuestionPro.

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Research websites come in handy in all kinds of situations, whether you're looking for the average rainfall in the Amazon rainforest, researching Roman history, or just having fun learning to find information.

This list of the best research websites will help greatly, and most of them are updated daily with new information.

I like to pair these sites with free research organizational tools to keep track of everything I gather online.

Best Research Websites

• Library of Congress : LOC.gov lets you not only ask a librarian for help , but also search catalogs of libraries from all over the world. This is truly a huge resource that should be on your Top 10 best research sites list. Anything from Academia Sinica in Taiwan to Yale University in the U.S. is here and ready to be searched.
• ReferenceDesk.org : Dubbed "The Internet's Best Reference Source," this extremely useful web directory provides everything from business and finance information to federal government resources, scholarship details, links to newspapers and calendars, search engines, and more.
• Ask the Space Expert: NASA's source for space and science research help. Use the video links to listen to questions answered by experts. These are from 2013 through 2015.
• USA.gov : This is where you should start when looking for specific U.S. government information. Learn about the country in general or education, housing, disability services, jobs, taxes, laws, and more.
• Reference.com : Extremely simple to use with a basic layout, this reference website lets you browse by category or search by keywords to research everything from food and health to history, beauty, education, technology, vehicles, art, and more.
• Refdesk.com : Billing itself as the internet's fact-checker, this site includes in-depth research links to breaking news, editorials, Today in History, Word of the Day, and other references.
• Encyclopedia.com : The #1 online encyclopedia that lets you search over 200 reference books and encyclopedias at once. The Picks of the week is a neat section to examine each week.
• Encyclopedia Britannica : One of the world's oldest encyclopedias online; has featured posts and category listings. The company launched in the 18th century and has been publishing exclusively online since 2011.
• Purdue University Quick Reference : This site has tons of information that includes resources specific to Purdue University and surrounding areas in Indiana. It also includes an Ask a Librarian service.
• Prescriber's Digital Reference : A wonderful research tool when gathering detailed medical information. The drug name browser includes summaries (dosage, description, and more) for hundreds of drugs.
• iTools.com : Serves as a gateway for reference and research links. It uses other websites for its searches, like YouTube and Google.
• ResearchGate : Scientific knowledge from over 160 million publication pages; browse topics in categories like engineering, biology, climate change, medicine, math, and more.
• Baseball-Reference.com : Here's everything you ever wanted to know about baseball.
• FOLDOC : Free Online Dictionary of Computing is a detailed computing dictionary for researching the meaning behind computer-related tools, standards, jargon, languages, and more. The "random" button is a fun way to learn new concepts.

Depending on the type of research you're doing or how you need to reference the information, you may need quick access to books. There are lots of places to find free book downloads , textbooks , and educational movies .

Other Ways to Do Research

Search engines like Google are a great way to perform online research. You can locate books, articles, interviews, and lots more. Learn how to search better to get the most out of your research.

Another top source of expert information is your local librarian— search for libraries near you at WorldCat . Librarians are trained to find answers to obscure questions, they're friendly, and best of all, you can talk with them face to face. They often ask you questions you might not have considered, leading to even better results. You can get help from librarians online, too, through some of the sources above.

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• Published: 08 May 2024

Accurate structure prediction of biomolecular interactions with AlphaFold 3

• Josh Abramson   ORCID: orcid.org/0009-0000-3496-6952 1   na1 ,
• Jonas Adler   ORCID: orcid.org/0000-0001-9928-3407 1   na1 ,
• Jack Dunger 1   na1 ,
• Richard Evans   ORCID: orcid.org/0000-0003-4675-8469 1   na1 ,
• Tim Green   ORCID: orcid.org/0000-0002-3227-1505 1   na1 ,
• Alexander Pritzel   ORCID: orcid.org/0000-0002-4233-9040 1   na1 ,
• Olaf Ronneberger   ORCID: orcid.org/0000-0002-4266-1515 1   na1 ,
• Lindsay Willmore   ORCID: orcid.org/0000-0003-4314-0778 1   na1 ,
• Andrew J. Ballard   ORCID: orcid.org/0000-0003-4956-5304 1 ,
• Joshua Bambrick   ORCID: orcid.org/0009-0003-3908-0722 2 ,
• Sebastian W. Bodenstein 1 ,
• David A. Evans 1 ,
• Chia-Chun Hung   ORCID: orcid.org/0000-0002-5264-9165 2 ,
• Michael O’Neill 1 ,
• David Reiman   ORCID: orcid.org/0000-0002-1605-7197 1 ,
• Kathryn Tunyasuvunakool   ORCID: orcid.org/0000-0002-8594-1074 1 ,
• Zachary Wu   ORCID: orcid.org/0000-0003-2429-9812 1 ,
• Akvilė Žemgulytė 1 ,
• Eirini Arvaniti 3 ,
• Charles Beattie   ORCID: orcid.org/0000-0003-1840-054X 3 ,
• Ottavia Bertolli   ORCID: orcid.org/0000-0001-8578-3216 3 ,
• Alex Bridgland 3 ,
• Alexey Cherepanov   ORCID: orcid.org/0000-0002-5227-0622 4 ,
• Miles Congreve 4 ,
• Alexander I. Cowen-Rivers 3 ,
• Andrew Cowie   ORCID: orcid.org/0000-0002-4491-1434 3 ,
• Michael Figurnov   ORCID: orcid.org/0000-0003-1386-8741 3 ,
• Fabian B. Fuchs 3 ,
• Hannah Gladman 3 ,
• Rishub Jain 3 ,
• Yousuf A. Khan   ORCID: orcid.org/0000-0003-0201-2796 3 ,
• Caroline M. R. Low 4 ,
• Kuba Perlin 3 ,
• Anna Potapenko 3 ,
• Pascal Savy 4 ,
• Sukhdeep Singh 3 ,
• Adrian Stecula   ORCID: orcid.org/0000-0001-6914-6743 4 ,
• Ashok Thillaisundaram 3 ,
• Catherine Tong   ORCID: orcid.org/0000-0001-7570-4801 4 ,
• Sergei Yakneen   ORCID: orcid.org/0000-0001-7827-9839 4 ,
• Ellen D. Zhong   ORCID: orcid.org/0000-0001-6345-1907 3 ,
• Michal Zielinski 3 ,
• Augustin Žídek   ORCID: orcid.org/0000-0002-0748-9684 3 ,
• Victor Bapst 1   na2 ,
• Pushmeet Kohli   ORCID: orcid.org/0000-0002-7466-7997 1   na2 ,
• Max Jaderberg   ORCID: orcid.org/0000-0002-9033-2695 2   na2 ,
• Demis Hassabis   ORCID: orcid.org/0000-0003-2812-9917 1 , 2   na2 &
• John M. Jumper   ORCID: orcid.org/0000-0001-6169-6580 1   na2  

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• Drug discovery
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• Protein structure predictions
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The introduction of AlphaFold 2 1 has spurred a revolution in modelling the structure of proteins and their interactions, enabling a huge range of applications in protein modelling and design 2–6 . In this paper, we describe our AlphaFold 3 model with a substantially updated diffusion-based architecture, which is capable of joint structure prediction of complexes including proteins, nucleic acids, small molecules, ions, and modified residues. The new AlphaFold model demonstrates significantly improved accuracy over many previous specialised tools: far greater accuracy on protein-ligand interactions than state of the art docking tools, much higher accuracy on protein-nucleic acid interactions than nucleic-acid-specific predictors, and significantly higher antibody-antigen prediction accuracy than AlphaFold-Multimer v2.3 7,8 . Together these results show that high accuracy modelling across biomolecular space is possible within a single unified deep learning framework.

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These authors contributed equally: Josh Abramson, Jonas Adler, Jack Dunger, Richard Evans, Tim Green, Alexander Pritzel, Olaf Ronneberger, Lindsay Willmore

These authors jointly supervised this work: Victor Bapst, Pushmeet Kohli, Max Jaderberg, Demis Hassabis, John M. Jumper

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Core Contributor, Google DeepMind, London, UK

Josh Abramson, Jonas Adler, Jack Dunger, Richard Evans, Tim Green, Alexander Pritzel, Olaf Ronneberger, Lindsay Willmore, Andrew J. Ballard, Sebastian W. Bodenstein, David A. Evans, Michael O’Neill, David Reiman, Kathryn Tunyasuvunakool, Zachary Wu, Akvilė Žemgulytė, Victor Bapst, Pushmeet Kohli, Demis Hassabis & John M. Jumper

Core Contributor, Isomorphic Labs, London, UK

Joshua Bambrick, Chia-Chun Hung, Max Jaderberg & Demis Hassabis

Google DeepMind, London, UK

Eirini Arvaniti, Charles Beattie, Ottavia Bertolli, Alex Bridgland, Alexander I. Cowen-Rivers, Andrew Cowie, Michael Figurnov, Fabian B. Fuchs, Hannah Gladman, Rishub Jain, Yousuf A. Khan, Kuba Perlin, Anna Potapenko, Sukhdeep Singh, Ashok Thillaisundaram, Ellen D. Zhong, Michal Zielinski & Augustin Žídek

Isomorphic Labs, London, UK

Alexey Cherepanov, Miles Congreve, Caroline M. R. Low, Pascal Savy, Adrian Stecula, Catherine Tong & Sergei Yakneen

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Correspondence to Max Jaderberg , Demis Hassabis or John M. Jumper .

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This Supplementary Information file contains the following 9 sections: (1) Notation; (2) Data pipeline; (3) Model architecture; (4) Auxiliary heads; (5) Training and inference; (6) Evaluation; (7) Differences to AlphaFold2 and AlphaFold-Multimer; (8) Supplemental Results; and (9) Appendix: CCD Code and PDB ID tables.

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Abramson, J., Adler, J., Dunger, J. et al. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature (2024). https://doi.org/10.1038/s41586-024-07487-w

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Cultural Relativity and Acceptance of Embryonic Stem Cell Research

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There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities.

INTRODUCTION

Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding of human development. Yet, ethical contention exists because of individuals’ perceptions of using human embryos based on their various cultural, moral, and social values. While these disagreements concerning policy, use, and general acceptance have prompted the development of an international ethics policy, such a uniform approach can overlook the nuanced ethical landscapes between cultures. With diverse viewpoints in public health, a single global policy, especially one reflecting Western ethics or the ethics prevalent in high-income countries, is impractical. This paper argues for a culturally sensitive, adaptable framework for the use of embryonic stem cells. Stem cell policy should accommodate varying ethical viewpoints and promote an effective global dialogue. With an extension of an ethics model that can adapt to various cultures, we recommend localized guidelines that reflect the moral views of the people those guidelines serve.

Stem cells, characterized by their unique ability to differentiate into various cell types, enable the repair or replacement of damaged tissues. Two primary types of stem cells are somatic stem cells (adult stem cells) and embryonic stem cells. Adult stem cells exist in developed tissues and maintain the body’s repair processes. [1] Embryonic stem cells (ESC) are remarkably pluripotent or versatile, making them valuable in research. [2] However, the use of ESCs has sparked ethics debates. Considering the potential of embryonic stem cells, research guidelines are essential. The International Society for Stem Cell Research (ISSCR) provides international stem cell research guidelines. They call for “public conversations touching on the scientific significance as well as the societal and ethical issues raised by ESC research.” [3] The ISSCR also publishes updates about culturing human embryos 14 days post fertilization, suggesting local policies and regulations should continue to evolve as ESC research develops. [4]  Like the ISSCR, which calls for local law and policy to adapt to developing stem cell research given cultural acceptance, this paper highlights the importance of local social factors such as religion and culture.

I.     Global Cultural Perspective of Embryonic Stem Cells

Views on ESCs vary throughout the world. Some countries readily embrace stem cell research and therapies, while others have stricter regulations due to ethical concerns surrounding embryonic stem cells and when an embryo becomes entitled to moral consideration. The philosophical issue of when the “someone” begins to be a human after fertilization, in the morally relevant sense, [5] impacts when an embryo becomes not just worthy of protection but morally entitled to it. The process of creating embryonic stem cell lines involves the destruction of the embryos for research. [6] Consequently, global engagement in ESC research depends on social-cultural acceptability.

a.     US and Rights-Based Cultures

In the United States, attitudes toward stem cell therapies are diverse. The ethics and social approaches, which value individualism, [7] trigger debates regarding the destruction of human embryos, creating a complex regulatory environment. For example, the 1996 Dickey-Wicker Amendment prohibited federal funding for the creation of embryos for research and the destruction of embryos for “more than allowed for research on fetuses in utero.” [8] Following suit, in 2001, the Bush Administration heavily restricted stem cell lines for research. However, the Stem Cell Research Enhancement Act of 2005 was proposed to help develop ESC research but was ultimately vetoed. [9] Under the Obama administration, in 2009, an executive order lifted restrictions allowing for more development in this field. [10] The flux of research capacity and funding parallels the different cultural perceptions of human dignity of the embryo and how it is socially presented within the country’s research culture. [11]

b.     Ubuntu and Collective Cultures

African bioethics differs from Western individualism because of the different traditions and values. African traditions, as described by individuals from South Africa and supported by some studies in other African countries, including Ghana and Kenya, follow the African moral philosophies of Ubuntu or Botho and Ukama , which “advocates for a form of wholeness that comes through one’s relationship and connectedness with other people in the society,” [12] making autonomy a socially collective concept. In this context, for the community to act autonomously, individuals would come together to decide what is best for the collective. Thus, stem cell research would require examining the value of the research to society as a whole and the use of the embryos as a collective societal resource. If society views the source as part of the collective whole, and opposes using stem cells, compromising the cultural values to pursue research may cause social detachment and stunt research growth. [13] Based on local culture and moral philosophy, the permissibility of stem cell research depends on how embryo, stem cell, and cell line therapies relate to the community as a whole . Ubuntu is the expression of humanness, with the person’s identity drawn from the “’I am because we are’” value. [14] The decision in a collectivistic culture becomes one born of cultural context, and individual decisions give deference to others in the society.

Consent differs in cultures where thought and moral philosophy are based on a collective paradigm. So, applying Western bioethical concepts is unrealistic. For one, Africa is a diverse continent with many countries with different belief systems, access to health care, and reliance on traditional or Western medicines. Where traditional medicine is the primary treatment, the “’restrictive focus on biomedically-related bioethics’” [is] problematic in African contexts because it neglects bioethical issues raised by traditional systems.” [15] No single approach applies in all areas or contexts. Rather than evaluating the permissibility of ESC research according to Western concepts such as the four principles approach, different ethics approaches should prevail.

Another consideration is the socio-economic standing of countries. In parts of South Africa, researchers have not focused heavily on contributing to the stem cell discourse, either because it is not considered health care or a health science priority or because resources are unavailable. [16] Each country’s priorities differ given different social, political, and economic factors. In South Africa, for instance, areas such as maternal mortality, non-communicable diseases, telemedicine, and the strength of health systems need improvement and require more focus. [17] Stem cell research could benefit the population, but it also could divert resources from basic medical care. Researchers in South Africa adhere to the National Health Act and Medicines Control Act in South Africa and international guidelines; however, the Act is not strictly enforced, and there is no clear legislation for research conduct or ethical guidelines. [18]

Some parts of Africa condemn stem cell research. For example, 98.2 percent of the Tunisian population is Muslim. [19] Tunisia does not permit stem cell research because of moral conflict with a Fatwa. Religion heavily saturates the regulation and direction of research. [20] Stem cell use became permissible for reproductive purposes only recently, with tight restrictions preventing cells from being used in any research other than procedures concerning ART/IVF.  Their use is conditioned on consent, and available only to married couples. [21] The community's receptiveness to stem cell research depends on including communitarian African ethics.

c.     Asia

Some Asian countries also have a collective model of ethics and decision making. [22] In China, the ethics model promotes a sincere respect for life or human dignity, [23] based on protective medicine. This model, influenced by Traditional Chinese Medicine (TCM), [24] recognizes Qi as the vital energy delivered via the meridians of the body; it connects illness to body systems, the body’s entire constitution, and the universe for a holistic bond of nature, health, and quality of life. [25] Following a protective ethics model, and traditional customs of wholeness, investment in stem cell research is heavily desired for its applications in regenerative therapies, disease modeling, and protective medicines. In a survey of medical students and healthcare practitioners, 30.8 percent considered stem cell research morally unacceptable while 63.5 percent accepted medical research using human embryonic stem cells. Of these individuals, 89.9 percent supported increased funding for stem cell research. [26] The scientific community might not reflect the overall population. From 1997 to 2019, China spent a total of $576 million (USD) on stem cell research at 8,050 stem cell programs, increased published presence from 0.6 percent to 14.01 percent of total global stem cell publications as of 2014, and made significant strides in cell-based therapies for various medical conditions. [27] However, while China has made substantial investments in stem cell research and achieved notable progress in clinical applications, concerns linger regarding ethical oversight and transparency. [28] For example, the China Biosecurity Law, promoted by the National Health Commission and China Hospital Association, attempted to mitigate risks by introducing an institutional review board (IRB) in the regulatory bodies. 5800 IRBs registered with the Chinese Clinical Trial Registry since 2021. [29] However, issues still need to be addressed in implementing effective IRB review and approval procedures.

The substantial government funding and focus on scientific advancement have sometimes overshadowed considerations of regional cultures, ethnic minorities, and individual perspectives, particularly evident during the one-child policy era. As government policy adapts to promote public stability, such as the change from the one-child to the two-child policy, [30] research ethics should also adapt to ensure respect for the values of its represented peoples.

Japan is also relatively supportive of stem cell research and therapies. Japan has a more transparent regulatory framework, allowing for faster approval of regenerative medicine products, which has led to several advanced clinical trials and therapies. [31] South Korea is also actively engaged in stem cell research and has a history of breakthroughs in cloning and embryonic stem cells. [32] However, the field is controversial, and there are issues of scientific integrity. For example, the Korean FDA fast-tracked products for approval, [33] and in another instance, the oocyte source was unclear and possibly violated ethical standards. [34] Trust is important in research, as it builds collaborative foundations between colleagues, trial participant comfort, open-mindedness for complicated and sensitive discussions, and supports regulatory procedures for stakeholders. There is a need to respect the culture’s interest, engagement, and for research and clinical trials to be transparent and have ethical oversight to promote global research discourse and trust.

d.     Middle East

Countries in the Middle East have varying degrees of acceptance of or restrictions to policies related to using embryonic stem cells due to cultural and religious influences. Saudi Arabia has made significant contributions to stem cell research, and conducts research based on international guidelines for ethical conduct and under strict adherence to guidelines in accordance with Islamic principles. Specifically, the Saudi government and people require ESC research to adhere to Sharia law. In addition to umbilical and placental stem cells, [35] Saudi Arabia permits the use of embryonic stem cells as long as they come from miscarriages, therapeutic abortions permissible by Sharia law, or are left over from in vitro fertilization and donated to research. [36] Laws and ethical guidelines for stem cell research allow the development of research institutions such as the King Abdullah International Medical Research Center, which has a cord blood bank and a stem cell registry with nearly 10,000 donors. [37] Such volume and acceptance are due to the ethical ‘permissibility’ of the donor sources, which do not conflict with religious pillars. However, some researchers err on the side of caution, choosing not to use embryos or fetal tissue as they feel it is unethical to do so. [38]

Jordan has a positive research ethics culture. [39] However, there is a significant issue of lack of trust in researchers, with 45.23 percent (38.66 percent agreeing and 6.57 percent strongly agreeing) of Jordanians holding a low level of trust in researchers, compared to 81.34 percent of Jordanians agreeing that they feel safe to participate in a research trial. [40] Safety testifies to the feeling of confidence that adequate measures are in place to protect participants from harm, whereas trust in researchers could represent the confidence in researchers to act in the participants’ best interests, adhere to ethical guidelines, provide accurate information, and respect participants’ rights and dignity. One method to improve trust would be to address communication issues relevant to ESC. Legislation surrounding stem cell research has adopted specific language, especially concerning clarification “between ‘stem cells’ and ‘embryonic stem cells’” in translation. [41] Furthermore, legislation “mandates the creation of a national committee… laying out specific regulations for stem-cell banking in accordance with international standards.” [42] This broad regulation opens the door for future global engagement and maintains transparency. However, these regulations may also constrain the influence of research direction, pace, and accessibility of research outcomes.

e.     Europe

In the European Union (EU), ethics is also principle-based, but the principles of autonomy, dignity, integrity, and vulnerability are interconnected. [43] As such, the opportunity for cohesion and concessions between individuals’ thoughts and ideals allows for a more adaptable ethics model due to the flexible principles that relate to the human experience The EU has put forth a framework in its Convention for the Protection of Human Rights and Dignity of the Human Being allowing member states to take different approaches. Each European state applies these principles to its specific conventions, leading to or reflecting different acceptance levels of stem cell research. [44]

For example, in Germany, Lebenzusammenhang , or the coherence of life, references integrity in the unity of human culture. Namely, the personal sphere “should not be subject to external intervention.” [45]  Stem cell interventions could affect this concept of bodily completeness, leading to heavy restrictions. Under the Grundgesetz, human dignity and the right to life with physical integrity are paramount. [46] The Embryo Protection Act of 1991 made producing cell lines illegal. Cell lines can be imported if approved by the Central Ethics Commission for Stem Cell Research only if they were derived before May 2007. [47] Stem cell research respects the integrity of life for the embryo with heavy specifications and intense oversight. This is vastly different in Finland, where the regulatory bodies find research more permissible in IVF excess, but only up to 14 days after fertilization. [48] Spain’s approach differs still, with a comprehensive regulatory framework. [49] Thus, research regulation can be culture-specific due to variations in applied principles. Diverse cultures call for various approaches to ethical permissibility. [50] Only an adaptive-deliberative model can address the cultural constructions of self and achieve positive, culturally sensitive stem cell research practices. [51]

II.     Religious Perspectives on ESC

Embryonic stem cell sources are the main consideration within religious contexts. While individuals may not regard their own religious texts as authoritative or factual, religion can shape their foundations or perspectives.

The Qur'an states:

“And indeed We created man from a quintessence of clay. Then We placed within him a small quantity of nutfa (sperm to fertilize) in a safe place. Then We have fashioned the nutfa into an ‘alaqa (clinging clot or cell cluster), then We developed the ‘alaqa into mudgha (a lump of flesh), and We made mudgha into bones, and clothed the bones with flesh, then We brought it into being as a new creation. So Blessed is Allah, the Best of Creators.” [52]

Many scholars of Islam estimate the time of soul installment, marked by the angel breathing in the soul to bring the individual into creation, as 120 days from conception. [53] Personhood begins at this point, and the value of life would prohibit research or experimentation that could harm the individual. If the fetus is more than 120 days old, the time ensoulment is interpreted to occur according to Islamic law, abortion is no longer permissible. [54] There are a few opposing opinions about early embryos in Islamic traditions. According to some Islamic theologians, there is no ensoulment of the early embryo, which is the source of stem cells for ESC research. [55]

In Buddhism, the stance on stem cell research is not settled. The main tenets, the prohibition against harming or destroying others (ahimsa) and the pursuit of knowledge (prajña) and compassion (karuna), leave Buddhist scholars and communities divided. [56] Some scholars argue stem cell research is in accordance with the Buddhist tenet of seeking knowledge and ending human suffering. Others feel it violates the principle of not harming others. Finding the balance between these two points relies on the karmic burden of Buddhist morality. In trying to prevent ahimsa towards the embryo, Buddhist scholars suggest that to comply with Buddhist tenets, research cannot be done as the embryo has personhood at the moment of conception and would reincarnate immediately, harming the individual's ability to build their karmic burden. [57] On the other hand, the Bodhisattvas, those considered to be on the path to enlightenment or Nirvana, have given organs and flesh to others to help alleviate grieving and to benefit all. [58] Acceptance varies on applied beliefs and interpretations.

Catholicism does not support embryonic stem cell research, as it entails creation or destruction of human embryos. This destruction conflicts with the belief in the sanctity of life. For example, in the Old Testament, Genesis describes humanity as being created in God’s image and multiplying on the Earth, referencing the sacred rights to human conception and the purpose of development and life. In the Ten Commandments, the tenet that one should not kill has numerous interpretations where killing could mean murder or shedding of the sanctity of life, demonstrating the high value of human personhood. In other books, the theological conception of when life begins is interpreted as in utero, [59] highlighting the inviolability of life and its formation in vivo to make a religious point for accepting such research as relatively limited, if at all. [60] The Vatican has released ethical directives to help apply a theological basis to modern-day conflicts. The Magisterium of the Church states that “unless there is a moral certainty of not causing harm,” experimentation on fetuses, fertilized cells, stem cells, or embryos constitutes a crime. [61] Such procedures would not respect the human person who exists at these stages, according to Catholicism. Damages to the embryo are considered gravely immoral and illicit. [62] Although the Catholic Church officially opposes abortion, surveys demonstrate that many Catholic people hold pro-choice views, whether due to the context of conception, stage of pregnancy, threat to the mother’s life, or for other reasons, demonstrating that practicing members can also accept some but not all tenets. [63]

Some major Jewish denominations, such as the Reform, Conservative, and Reconstructionist movements, are open to supporting ESC use or research as long as it is for saving a life. [64] Within Judaism, the Talmud, or study, gives personhood to the child at birth and emphasizes that life does not begin at conception: [65]

“If she is found pregnant, until the fortieth day it is mere fluid,” [66]

Whereas most religions prioritize the status of human embryos, the Halakah (Jewish religious law) states that to save one life, most other religious laws can be ignored because it is in pursuit of preservation. [67] Stem cell research is accepted due to application of these religious laws.

We recognize that all religions contain subsets and sects. The variety of environmental and cultural differences within religious groups requires further analysis to respect the flexibility of religious thoughts and practices. We make no presumptions that all cultures require notions of autonomy or morality as under the common morality theory , which asserts a set of universal moral norms that all individuals share provides moral reasoning and guides ethical decisions. [68] We only wish to show that the interaction with morality varies between cultures and countries.

III.     A Flexible Ethical Approach

The plurality of different moral approaches described above demonstrates that there can be no universally acceptable uniform law for ESC on a global scale. Instead of developing one standard, flexible ethical applications must be continued. We recommend local guidelines that incorporate important cultural and ethical priorities.

While the Declaration of Helsinki is more relevant to people in clinical trials receiving ESC products, in keeping with the tradition of protections for research subjects, consent of the donor is an ethical requirement for ESC donation in many jurisdictions including the US, Canada, and Europe. [69] The Declaration of Helsinki provides a reference point for regulatory standards and could potentially be used as a universal baseline for obtaining consent prior to gamete or embryo donation.

For instance, in Columbia University’s egg donor program for stem cell research, donors followed standard screening protocols and “underwent counseling sessions that included information as to the purpose of oocyte donation for research, what the oocytes would be used for, the risks and benefits of donation, and process of oocyte stimulation” to ensure transparency for consent. [70] The program helped advance stem cell research and provided clear and safe research methods with paid participants. Though paid participation or covering costs of incidental expenses may not be socially acceptable in every culture or context, [71] and creating embryos for ESC research is illegal in many jurisdictions, Columbia’s program was effective because of the clear and honest communications with donors, IRBs, and related stakeholders.  This example demonstrates that cultural acceptance of scientific research and of the idea that an egg or embryo does not have personhood is likely behind societal acceptance of donating eggs for ESC research. As noted, many countries do not permit the creation of embryos for research.

Proper communication and education regarding the process and purpose of stem cell research may bolster comprehension and garner more acceptance. “Given the sensitive subject material, a complete consent process can support voluntary participation through trust, understanding, and ethical norms from the cultures and morals participants value. This can be hard for researchers entering countries of different socioeconomic stability, with different languages and different societal values. [72]

An adequate moral foundation in medical ethics is derived from the cultural and religious basis that informs knowledge and actions. [73] Understanding local cultural and religious values and their impact on research could help researchers develop humility and promote inclusion.

IV.     Concerns

Some may argue that if researchers all adhere to one ethics standard, protection will be satisfied across all borders, and the global public will trust researchers. However, defining what needs to be protected and how to define such research standards is very specific to the people to which standards are applied. We suggest that applying one uniform guide cannot accurately protect each individual because we all possess our own perceptions and interpretations of social values. [74] Therefore, the issue of not adjusting to the moral pluralism between peoples in applying one standard of ethics can be resolved by building out ethics models that can be adapted to different cultures and religions.

Other concerns include medical tourism, which may promote health inequities. [75] Some countries may develop and approve products derived from ESC research before others, compromising research ethics or drug approval processes. There are also concerns about the sale of unauthorized stem cell treatments, for example, those without FDA approval in the United States. Countries with robust research infrastructures may be tempted to attract medical tourists, and some customers will have false hopes based on aggressive publicity of unproven treatments. [76]

For example, in China, stem cell clinics can market to foreign clients who are not protected under the regulatory regimes. Companies employ a marketing strategy of “ethically friendly” therapies. Specifically, in the case of Beike, China’s leading stem cell tourism company and sprouting network, ethical oversight of administrators or health bureaus at one site has “the unintended consequence of shifting questionable activities to another node in Beike's diffuse network.” [77] In contrast, Jordan is aware of stem cell research’s potential abuse and its own status as a “health-care hub.” Jordan’s expanded regulations include preserving the interests of individuals in clinical trials and banning private companies from ESC research to preserve transparency and the integrity of research practices. [78]

The social priorities of the community are also a concern. The ISSCR explicitly states that guidelines “should be periodically revised to accommodate scientific advances, new challenges, and evolving social priorities.” [79] The adaptable ethics model extends this consideration further by addressing whether research is warranted given the varying degrees of socioeconomic conditions, political stability, and healthcare accessibilities and limitations. An ethical approach would require discussion about resource allocation and appropriate distribution of funds. [80]

While some religions emphasize the sanctity of life from conception, which may lead to public opposition to ESC research, others encourage ESC research due to its potential for healing and alleviating human pain. Many countries have special regulations that balance local views on embryonic personhood, the benefits of research as individual or societal goods, and the protection of human research subjects. To foster understanding and constructive dialogue, global policy frameworks should prioritize the protection of universal human rights, transparency, and informed consent. In addition to these foundational global policies, we recommend tailoring local guidelines to reflect the diverse cultural and religious perspectives of the populations they govern. Ethics models should be adapted to local populations to effectively establish research protections, growth, and possibilities of stem cell research.

For example, in countries with strong beliefs in the moral sanctity of embryos or heavy religious restrictions, an adaptive model can allow for discussion instead of immediate rejection. In countries with limited individual rights and voice in science policy, an adaptive model ensures cultural, moral, and religious views are taken into consideration, thereby building social inclusion. While this ethical consideration by the government may not give a complete voice to every individual, it will help balance policies and maintain the diverse perspectives of those it affects. Embracing an adaptive ethics model of ESC research promotes open-minded dialogue and respect for the importance of human belief and tradition. By actively engaging with cultural and religious values, researchers can better handle disagreements and promote ethical research practices that benefit each society.

This brief exploration of the religious and cultural differences that impact ESC research reveals the nuances of relative ethics and highlights a need for local policymakers to apply a more intense adaptive model.

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[5] Concerning the moral philosophies of stem cell research, our paper does not posit a personal moral stance nor delve into the “when” of human life begins. To read further about the philosophical debate, consider the following sources:

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[7] Socially, at its core, the Western approach to ethics is widely principle-based, autonomy being one of the key factors to ensure a fundamental respect for persons within research. For information regarding autonomy in research, see: Department of Health, Education, and Welfare, & National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1978). The Belmont Report. Ethical principles and guidelines for the protection of human subjects of research.; For a more in-depth review of autonomy within the US, see: Beauchamp, T. L., & Childress, J. F. (1994). Principles of Biomedical Ethics . Oxford University Press.

[8] Sherley v. Sebelius , 644 F.3d 388 (D.C. Cir. 2011), citing 45 C.F.R. 46.204(b) and [42 U.S.C. § 289g(b)]. https://www.cadc.uscourts.gov/internet/opinions.nsf/6c690438a9b43dd685257a64004ebf99/$file/11-5241-1391178.pdf

[9] Stem Cell Research Enhancement Act of 2005, H. R. 810, 109 th Cong. (2001). https://www.govtrack.us/congress/bills/109/hr810/text ; Bush, G. W. (2006, July 19). Message to the House of Representatives . National Archives and Records Administration. https://georgewbush-whitehouse.archives.gov/news/releases/2006/07/20060719-5.html

[10] National Archives and Records Administration. (2009, March 9). Executive order 13505 -- removing barriers to responsible scientific research involving human stem cells . National Archives and Records Administration. https://obamawhitehouse.archives.gov/the-press-office/removing-barriers-responsible-scientific-research-involving-human-stem-cells

[11] Hurlbut, W. B. (2006). Science, Religion, and the Politics of Stem Cells.  Social Research ,  73 (3), 819–834. http://www.jstor.org/stable/40971854

[12] Akpa-Inyang, Francis & Chima, Sylvester. (2021). South African traditional values and beliefs regarding informed consent and limitations of the principle of respect for autonomy in African communities: a cross-cultural qualitative study. BMC Medical Ethics . 22. 10.1186/s12910-021-00678-4.

[13] Source for further reading: Tangwa G. B. (2007). Moral status of embryonic stem cells: perspective of an African villager. Bioethics , 21(8), 449–457. https://doi.org/10.1111/j.1467-8519.2007.00582.x , see also Mnisi, F. M. (2020). An African analysis based on ethics of Ubuntu - are human embryonic stem cell patents morally justifiable? African Insight , 49 (4).

[14] Jecker, N. S., & Atuire, C. (2021). Bioethics in Africa: A contextually enlightened analysis of three cases. Developing World Bioethics , 22 (2), 112–122. https://doi.org/10.1111/dewb.12324

[15] Jecker, N. S., & Atuire, C. (2021). Bioethics in Africa: A contextually enlightened analysis of three cases. Developing World Bioethics, 22(2), 112–122. https://doi.org/10.1111/dewb.12324

[16] Jackson, C.S., Pepper, M.S. Opportunities and barriers to establishing a cell therapy programme in South Africa.  Stem Cell Res Ther   4 , 54 (2013). https://doi.org/10.1186/scrt204 ; Pew Research Center. (2014, May 1). Public health a major priority in African nations . Pew Research Center’s Global Attitudes Project. https://www.pewresearch.org/global/2014/05/01/public-health-a-major-priority-in-african-nations/

[17] Department of Health Republic of South Africa. (2021). Health Research Priorities (revised) for South Africa 2021-2024 . National Health Research Strategy. https://www.health.gov.za/wp-content/uploads/2022/05/National-Health-Research-Priorities-2021-2024.pdf

[18] Oosthuizen, H. (2013). Legal and Ethical Issues in Stem Cell Research in South Africa. In: Beran, R. (eds) Legal and Forensic Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32338-6_80 , see also: Gaobotse G (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[19] United States Bureau of Citizenship and Immigration Services. (1998). Tunisia: Information on the status of Christian conversions in Tunisia . UNHCR Web Archive. https://webarchive.archive.unhcr.org/20230522142618/https://www.refworld.org/docid/3df0be9a2.html

[20] Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[21] Kooli, C. Review of assisted reproduction techniques, laws, and regulations in Muslim countries.  Middle East Fertil Soc J   24 , 8 (2020). https://doi.org/10.1186/s43043-019-0011-0 ; Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[22] Pang M. C. (1999). Protective truthfulness: the Chinese way of safeguarding patients in informed treatment decisions. Journal of medical ethics , 25(3), 247–253. https://doi.org/10.1136/jme.25.3.247

[23] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[24] Wang, Y., Xue, Y., & Guo, H. D. (2022). Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction.  Frontiers in pharmacology ,  13 , 1013740. https://doi.org/10.3389/fphar.2022.1013740

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[27] Luo, D., Xu, Z., Wang, Z., & Ran, W. (2021). China's Stem Cell Research and Knowledge Levels of Medical Practitioners and Students.  Stem cells international ,  2021 , 6667743. https://doi.org/10.1155/2021/6667743

[28] Zhang, J. Y. (2017). Lost in translation? accountability and governance of Clinical Stem Cell Research in China. Regenerative Medicine , 12 (6), 647–656. https://doi.org/10.2217/rme-2017-0035

[29] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[30] Chen, H., Wei, T., Wang, H.  et al.  Association of China’s two-child policy with changes in number of births and birth defects rate, 2008–2017.  BMC Public Health   22 , 434 (2022). https://doi.org/10.1186/s12889-022-12839-0

[31] Azuma, K. Regulatory Landscape of Regenerative Medicine in Japan.  Curr Stem Cell Rep   1 , 118–128 (2015). https://doi.org/10.1007/s40778-015-0012-6

[32] Harris, R. (2005, May 19). Researchers Report Advance in Stem Cell Production . NPR. https://www.npr.org/2005/05/19/4658967/researchers-report-advance-in-stem-cell-production

[33] Park, S. (2012). South Korea steps up stem-cell work.  Nature . https://doi.org/10.1038/nature.2012.10565

[34] Resnik, D. B., Shamoo, A. E., & Krimsky, S. (2006). Fraudulent human embryonic stem cell research in South Korea: lessons learned.  Accountability in research ,  13 (1), 101–109. https://doi.org/10.1080/08989620600634193 .

[35] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

[36] Association for the Advancement of Blood and Biotherapies.  https://www.aabb.org/regulatory-and-advocacy/regulatory-affairs/regulatory-for-cellular-therapies/international-competent-authorities/saudi-arabia

[37] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia.  BMC medical ethics ,  21 (1), 35. https://doi.org/10.1186/s12910-020-00482-6

[38] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia. BMC medical ethics , 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

Culturally, autonomy practices follow a relational autonomy approach based on a paternalistic deontological health care model. The adherence to strict international research policies and religious pillars within the regulatory environment is a great foundation for research ethics. However, there is a need to develop locally targeted ethics approaches for research (as called for in Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6), this decision-making approach may help advise a research decision model. For more on the clinical cultural autonomy approaches, see: Alabdullah, Y. Y., Alzaid, E., Alsaad, S., Alamri, T., Alolayan, S. W., Bah, S., & Aljoudi, A. S. (2022). Autonomy and paternalism in Shared decision‐making in a Saudi Arabian tertiary hospital: A cross‐sectional study. Developing World Bioethics , 23 (3), 260–268. https://doi.org/10.1111/dewb.12355 ; Bukhari, A. A. (2017). Universal Principles of Bioethics and Patient Rights in Saudi Arabia (Doctoral dissertation, Duquesne University). https://dsc.duq.edu/etd/124; Ladha, S., Nakshawani, S. A., Alzaidy, A., & Tarab, B. (2023, October 26). Islam and Bioethics: What We All Need to Know . Columbia University School of Professional Studies. https://sps.columbia.edu/events/islam-and-bioethics-what-we-all-need-know

[39] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[40] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[41] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[42] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[43] The EU’s definition of autonomy relates to the capacity for creating ideas, moral insight, decisions, and actions without constraint, personal responsibility, and informed consent. However, the EU views autonomy as not completely able to protect individuals and depends on other principles, such as dignity, which “expresses the intrinsic worth and fundamental equality of all human beings.” Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[44] Council of Europe. Convention for the protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine (ETS No. 164) https://www.coe.int/en/web/conventions/full-list?module=treaty-detail&treatynum=164 (forbidding the creation of embryos for research purposes only, and suggests embryos in vitro have protections.); Also see Drabiak-Syed B. K. (2013). New President, New Human Embryonic Stem Cell Research Policy: Comparative International Perspectives and Embryonic Stem Cell Research Laws in France.  Biotechnology Law Report ,  32 (6), 349–356. https://doi.org/10.1089/blr.2013.9865

[45] Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[46] Tomuschat, C., Currie, D. P., Kommers, D. P., & Kerr, R. (Trans.). (1949, May 23). Basic law for the Federal Republic of Germany. https://www.btg-bestellservice.de/pdf/80201000.pdf

[47] Regulation of Stem Cell Research in Germany . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-germany

[48] Regulation of Stem Cell Research in Finland . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-finland

[49] Regulation of Stem Cell Research in Spain . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-spain

[50] Some sources to consider regarding ethics models or regulatory oversights of other cultures not covered:

Kara MA. Applicability of the principle of respect for autonomy: the perspective of Turkey. J Med Ethics. 2007 Nov;33(11):627-30. doi: 10.1136/jme.2006.017400. PMID: 17971462; PMCID: PMC2598110.

Ugarte, O. N., & Acioly, M. A. (2014). The principle of autonomy in Brazil: one needs to discuss it ...  Revista do Colegio Brasileiro de Cirurgioes ,  41 (5), 374–377. https://doi.org/10.1590/0100-69912014005013

Bharadwaj, A., & Glasner, P. E. (2012). Local cells, global science: The rise of embryonic stem cell research in India . Routledge.

For further research on specific European countries regarding ethical and regulatory framework, we recommend this database: Regulation of Stem Cell Research in Europe . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-europe   

[51] Klitzman, R. (2006). Complications of culture in obtaining informed consent. The American Journal of Bioethics, 6(1), 20–21. https://doi.org/10.1080/15265160500394671 see also: Ekmekci, P. E., & Arda, B. (2017). Interculturalism and Informed Consent: Respecting Cultural Differences without Breaching Human Rights.  Cultura (Iasi, Romania) ,  14 (2), 159–172.; For why trust is important in research, see also: Gray, B., Hilder, J., Macdonald, L., Tester, R., Dowell, A., & Stubbe, M. (2017). Are research ethics guidelines culturally competent?  Research Ethics ,  13 (1), 23-41.  https://doi.org/10.1177/1747016116650235

[52] The Qur'an  (M. Khattab, Trans.). (1965). Al-Mu’minun, 23: 12-14. https://quran.com/23

[53] Lenfest, Y. (2017, December 8). Islam and the beginning of human life . Bill of Health. https://blog.petrieflom.law.harvard.edu/2017/12/08/islam-and-the-beginning-of-human-life/

[54] Aksoy, S. (2005). Making regulations and drawing up legislation in Islamic countries under conditions of uncertainty, with special reference to embryonic stem cell research. Journal of Medical Ethics , 31: 399-403.; see also: Mahmoud, Azza. "Islamic Bioethics: National Regulations and Guidelines of Human Stem Cell Research in the Muslim World." Master's thesis, Chapman University, 2022. https://doi.org/10.36837/ chapman.000386

[55] Rashid, R. (2022). When does Ensoulment occur in the Human Foetus. Journal of the British Islamic Medical Association , 12 (4). ISSN 2634 8071. https://www.jbima.com/wp-content/uploads/2023/01/2-Ethics-3_-Ensoulment_Rafaqat.pdf.

[56] Sivaraman, M. & Noor, S. (2017). Ethics of embryonic stem cell research according to Buddhist, Hindu, Catholic, and Islamic religions: perspective from Malaysia. Asian Biomedicine,8(1) 43-52.  https://doi.org/10.5372/1905-7415.0801.260

[57] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[58] Lecso, P. A. (1991). The Bodhisattva Ideal and Organ Transplantation.  Journal of Religion and Health ,  30 (1), 35–41. http://www.jstor.org/stable/27510629 ; Bodhisattva, S. (n.d.). The Key of Becoming a Bodhisattva . A Guide to the Bodhisattva Way of Life. http://www.buddhism.org/Sutras/2/BodhisattvaWay.htm

[59] There is no explicit religious reference to when life begins or how to conduct research that interacts with the concept of life. However, these are relevant verses pertaining to how the fetus is viewed. (( King James Bible . (1999). Oxford University Press. (original work published 1769))

Jerimiah 1: 5 “Before I formed thee in the belly I knew thee; and before thou camest forth out of the womb I sanctified thee…”

In prophet Jerimiah’s insight, God set him apart as a person known before childbirth, a theme carried within the Psalm of David.

Psalm 139: 13-14 “…Thou hast covered me in my mother's womb. I will praise thee; for I am fearfully and wonderfully made…”

These verses demonstrate David’s respect for God as an entity that would know of all man’s thoughts and doings even before birth.

[60] It should be noted that abortion is not supported as well.

[61] The Vatican. (1987, February 22). Instruction on Respect for Human Life in Its Origin and on the Dignity of Procreation Replies to Certain Questions of the Day . Congregation For the Doctrine of the Faith. https://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_19870222_respect-for-human-life_en.html

[62] The Vatican. (2000, August 25). Declaration On the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells . Pontifical Academy for Life. https://www.vatican.va/roman_curia/pontifical_academies/acdlife/documents/rc_pa_acdlife_doc_20000824_cellule-staminali_en.html ; Ohara, N. (2003). Ethical Consideration of Experimentation Using Living Human Embryos: The Catholic Church’s Position on Human Embryonic Stem Cell Research and Human Cloning. Department of Obstetrics and Gynecology . Retrieved from https://article.imrpress.com/journal/CEOG/30/2-3/pii/2003018/77-81.pdf.

[63] Smith, G. A. (2022, May 23). Like Americans overall, Catholics vary in their abortion views, with regular mass attenders most opposed . Pew Research Center. https://www.pewresearch.org/short-reads/2022/05/23/like-americans-overall-catholics-vary-in-their-abortion-views-with-regular-mass-attenders-most-opposed/

[64] Rosner, F., & Reichman, E. (2002). Embryonic stem cell research in Jewish law. Journal of halacha and contemporary society , (43), 49–68.; Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[65] Schenker J. G. (2008). The beginning of human life: status of embryo. Perspectives in Halakha (Jewish Religious Law).  Journal of assisted reproduction and genetics ,  25 (6), 271–276. https://doi.org/10.1007/s10815-008-9221-6

[66] Ruttenberg, D. (2020, May 5). The Torah of Abortion Justice (annotated source sheet) . Sefaria. https://www.sefaria.org/sheets/234926.7?lang=bi&with=all&lang2=en

[67] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[68] Gert, B. (2007). Common morality: Deciding what to do . Oxford Univ. Press.

[69] World Medical Association (2013). World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA , 310(20), 2191–2194. https://doi.org/10.1001/jama.2013.281053 Declaration of Helsinki – WMA – The World Medical Association .; see also: National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. (1979).  The Belmont report: Ethical principles and guidelines for the protection of human subjects of research . U.S. Department of Health and Human Services.  https://www.hhs.gov/ohrp/regulations-and-policy/belmont-report/read-the-belmont-report/index.html

[70] Zakarin Safier, L., Gumer, A., Kline, M., Egli, D., & Sauer, M. V. (2018). Compensating human subjects providing oocytes for stem cell research: 9-year experience and outcomes.  Journal of assisted reproduction and genetics ,  35 (7), 1219–1225. https://doi.org/10.1007/s10815-018-1171-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063839/ see also: Riordan, N. H., & Paz Rodríguez, J. (2021). Addressing concerns regarding associated costs, transparency, and integrity of research in recent stem cell trial. Stem Cells Translational Medicine , 10 (12), 1715–1716. https://doi.org/10.1002/sctm.21-0234

[71] Klitzman, R., & Sauer, M. V. (2009). Payment of egg donors in stem cell research in the USA.  Reproductive biomedicine online ,  18 (5), 603–608. https://doi.org/10.1016/s1472-6483(10)60002-8

[72] Krosin, M. T., Klitzman, R., Levin, B., Cheng, J., & Ranney, M. L. (2006). Problems in comprehension of informed consent in rural and peri-urban Mali, West Africa.  Clinical trials (London, England) ,  3 (3), 306–313. https://doi.org/10.1191/1740774506cn150oa

[73] Veatch, Robert M.  Hippocratic, Religious, and Secular Medical Ethics: The Points of Conflict . Georgetown University Press, 2012.

[74] Msoroka, M. S., & Amundsen, D. (2018). One size fits not quite all: Universal research ethics with diversity.  Research Ethics ,  14 (3), 1-17.  https://doi.org/10.1177/1747016117739939

[75] Pirzada, N. (2022). The Expansion of Turkey’s Medical Tourism Industry.  Voices in Bioethics ,  8 . https://doi.org/10.52214/vib.v8i.9894

[76] Stem Cell Tourism: False Hope for Real Money . Harvard Stem Cell Institute (HSCI). (2023). https://hsci.harvard.edu/stem-cell-tourism , See also: Bissassar, M. (2017). Transnational Stem Cell Tourism: An ethical analysis.  Voices in Bioethics ,  3 . https://doi.org/10.7916/vib.v3i.6027

[77] Song, P. (2011) The proliferation of stem cell therapies in post-Mao China: problematizing ethical regulation,  New Genetics and Society , 30:2, 141-153, DOI:  10.1080/14636778.2011.574375

[78] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[79] International Society for Stem Cell Research. (2024). Standards in stem cell research . International Society for Stem Cell Research. https://www.isscr.org/guidelines/5-standards-in-stem-cell-research

[80] Benjamin, R. (2013). People’s science bodies and rights on the Stem Cell Frontier . Stanford University Press.

Mifrah Hayath

SM Candidate Harvard Medical School, MS Biotechnology Johns Hopkins University

Olivia Bowers

MS Bioethics Columbia University (Disclosure: affiliated with Voices in Bioethics)

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This work is licensed under a Creative Commons Attribution 4.0 International License .

5 Best AI Research Paper Summarizers (May 2024)

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Table Of Contents

In the fast-paced world of academic research, keeping up with the ever-growing body of literature can be a daunting task. Researchers and students often find themselves inundated with lengthy research papers, making it challenging to quickly grasp the core ideas and insights. AI-powered research paper summarizers have emerged as powerful tools, leveraging advanced algorithms to condense lengthy documents into concise and readable summaries.

In this article, we will explore the top AI research paper summarizers, each designed to streamline the process of understanding and synthesizing academic literature:

1. Tenorshare AI PDF Tool

Tenorshare AI PDF Tool is a cutting-edge solution that harnesses the power of artificial intelligence to simplify the process of summarizing research papers. With its user-friendly interface and advanced AI algorithms, this tool quickly analyzes and condenses lengthy papers into concise, readable summaries, allowing researchers to grasp the core ideas without having to read the entire document.

One of the standout features of Tenorshare AI PDF Tool is its interactive chat interface, powered by ChatGPT. This innovative functionality enables users to ask questions and retrieve specific information from the PDF document, making it easier to navigate and understand complex research papers. The tool also efficiently extracts critical sections and information, such as the abstract, methodology, results, and conclusions, streamlining the reading process and helping users focus on the most relevant parts of the document.

Key features of Tenorshare AI PDF Tool:

• AI-driven summarization that quickly condenses lengthy research papers
• Interactive chat interface powered by ChatGPT for retrieving specific information
• Automatic extraction of critical sections and information from the paper
• Batch processing capabilities for handling multiple PDF files simultaneously
• Secure and private, with SSL encryption and the option to delete uploaded files

Visit Tenorshare AI PDF →

Elicit is an AI-powered research assistant that improves the way users find and summarize academic papers. With its intelligent search capabilities and advanced natural language processing, Elicit helps researchers quickly identify the most relevant papers and understand their core ideas through automatically generated summaries.

By simply entering keywords, phrases, or questions, users can leverage Elicit's AI algorithms to search through its extensive database and retrieve the most pertinent papers. The tool offers various filters and sorting options, such as publication date, study types, and citation count, enabling users to refine their search results and find exactly what they need. One of Elicit's most impressive features is its ability to generate concise summaries of the top papers related to the search query, capturing the key findings and conclusions and saving researchers valuable time.

Key features of Elicit:

• Intelligent search that understands the context and meaning of search queries
• Filters and sorting options for refining search results
• Automatic summarization of the top papers related to the search query
• Detailed paper insights, including tested outcomes, participant information, and trustworthiness assessment
• Inline referencing for transparency and accuracy verification

Visit Elicit →

3. QuillBot

QuillBot is an AI-powered writing platform that offers a comprehensive suite of tools to enhance and streamline the writing process, including a powerful Summarizer tool that is particularly useful for condensing research papers. By leveraging advanced natural language processing and machine learning algorithms, QuillBot's Summarizer quickly analyzes lengthy articles, research papers, or documents and generates concise summaries that capture the core ideas and key points.

One of the key advantages of QuillBot's Summarizer is its ability to perform extractive summarization, which involves identifying and extracting the most critical sentences and information from the research paper while maintaining the original context. Users can customize the summary length to be either short (key sentences) or long (paragraph format) based on their needs, and the output can be generated in either a bullet point list format or as a coherent paragraph. This flexibility allows researchers to tailor the summary to their specific requirements and preferences.

Key features of QuillBot's Summarizer:

• AI-powered extractive summarization that identifies and extracts key information
• Customizable summary length (short or long) to suit different needs
• Bullet point or paragraph output for flexible formatting
• Improved reading comprehension by condensing the paper into its core concepts
• Integration with other QuillBot tools, such as Paraphraser and Grammar Checker, for further enhancement

Visit Quillbot →

4. Semantic Scholar

Semantic Scholar is a free, AI-powered research tool developed by the Allen Institute for AI that improves the way researchers search for and discover scientific literature. By employing advanced natural language processing, machine learning, and machine vision techniques, Semantic Scholar provides a smarter and more efficient way to navigate the vast landscape of academic publications.

One of the standout features of Semantic Scholar is its ability to generate concise, one-sentence summaries of research papers, capturing the essence of the content and allowing researchers to quickly grasp the main ideas without reading lengthy abstracts. This feature is particularly useful when browsing on mobile devices or when time is limited. Additionally, Semantic Scholar highlights the most important and influential citations within a paper, helping researchers focus on the most relevant information and understand the impact of the research.

Key features of Semantic Scholar:

• Concise one-sentence summaries of research papers for quick comprehension
• Identification of the most influential citations within a paper
• Personalized paper recommendations through the “Research Feed” feature
• Semantic Reader for in-line citation cards with summaries and “skimming highlights”
• Personal library management with the ability to save and organize papers

Visit Semantic Scholar →

5. IBM Watson Discovery

IBM Watson Discovery is a powerful AI-driven tool designed to analyze and summarize large volumes of unstructured data, including research papers, articles, and scientific publications. By harnessing the power of cognitive computing, natural language processing, and machine learning, Watson Discovery enables researchers to quickly find relevant information and gain valuable insights from complex documents.

One of the key strengths of IBM Watson Discovery is its ability to understand the context, concepts, and relationships within the text, allowing it to identify patterns, trends, and connections that may be overlooked by human readers. This makes it easier to navigate and summarize complex research papers, as the tool can highlight important entities, relationships, and topics within the document. Users can create customizable queries, filter, and categorize data to generate summaries of the most relevant research findings, and the tool's advanced search capabilities enable precise searches and retrieval of specific information from large document libraries.

Key features of IBM Watson Discovery:

• Cognitive capabilities that understand context, concepts, and relationships within the text
• Customizable queries and filtering for generating summaries of relevant research findings
• Relationship identification to highlight important entities, relationships, and topics
• Significant time-saving by automating the discovery of information and insight

Visit IBM Watson Discovery →

Empowering Researchers with AI-Driven Summarization Tools

The emergence of AI-powered research summarizers has transformed the way researchers and academics approach scientific literature. By leveraging advanced natural language processing, machine learning, and cognitive computing, these innovative tools enable users to quickly find, understand, and summarize complex research papers, saving valuable time and effort.

Each of these AI research summarizers offers unique features and benefits that cater to researchers' diverse needs. As these tools continue to evolve and improve, they will undoubtedly play an increasingly crucial role in empowering researchers to navigate the ever-expanding universe of scientific knowledge more efficiently and effectively.

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Alex McFarland is an AI journalist and writer exploring the latest developments in artificial intelligence. He has collaborated with numerous AI startups and publications worldwide.

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Study Suggests Genetics as a Cause, Not Just a Risk, for Some Alzheimer’s

People with two copies of the gene variant APOE4 are almost certain to get Alzheimer’s, say researchers, who proposed a framework under which such patients could be diagnosed years before symptoms.

By Pam Belluck

Scientists are proposing a new way of understanding the genetics of Alzheimer’s that would mean that up to a fifth of patients would be considered to have a genetically caused form of the disease.

Currently, the vast majority of Alzheimer’s cases do not have a clearly identified cause. The new designation, proposed in a study published Monday, could broaden the scope of efforts to develop treatments, including gene therapy, and affect the design of clinical trials.

It could also mean that hundreds of thousands of people in the United States alone could, if they chose, receive a diagnosis of Alzheimer’s before developing any symptoms of cognitive decline, although there currently are no treatments for people at that stage.

The new classification would make this type of Alzheimer’s one of the most common genetic disorders in the world, medical experts said.

“This reconceptualization that we’re proposing affects not a small minority of people,” said Dr. Juan Fortea, an author of the study and the director of the Sant Pau Memory Unit in Barcelona, Spain. “Sometimes we say that we don’t know the cause of Alzheimer’s disease,” but, he said, this would mean that about 15 to 20 percent of cases “can be tracked back to a cause, and the cause is in the genes.”

The idea involves a gene variant called APOE4. Scientists have long known that inheriting one copy of the variant increases the risk of developing Alzheimer’s, and that people with two copies, inherited from each parent, have vastly increased risk.

The new study , published in the journal Nature Medicine, analyzed data from over 500 people with two copies of APOE4, a significantly larger pool than in previous studies. The researchers found that almost all of those patients developed the biological pathology of Alzheimer’s, and the authors say that two copies of APOE4 should now be considered a cause of Alzheimer’s — not simply a risk factor.

The patients also developed Alzheimer’s pathology relatively young, the study found. By age 55, over 95 percent had biological markers associated with the disease. By 65, almost all had abnormal levels of a protein called amyloid that forms plaques in the brain, a hallmark of Alzheimer’s. And many started developing symptoms of cognitive decline at age 65, younger than most people without the APOE4 variant.

“The critical thing is that these individuals are often symptomatic 10 years earlier than other forms of Alzheimer’s disease,” said Dr. Reisa Sperling, a neurologist at Mass General Brigham in Boston and an author of the study.

She added, “By the time they are picked up and clinically diagnosed, because they’re often younger, they have more pathology.”

People with two copies, known as APOE4 homozygotes, make up 2 to 3 percent of the general population, but are an estimated 15 to 20 percent of people with Alzheimer’s dementia, experts said. People with one copy make up about 15 to 25 percent of the general population, and about 50 percent of Alzheimer’s dementia patients.

The most common variant is called APOE3, which seems to have a neutral effect on Alzheimer’s risk. About 75 percent of the general population has one copy of APOE3, and more than half of the general population has two copies.

Alzheimer’s experts not involved in the study said classifying the two-copy condition as genetically determined Alzheimer’s could have significant implications, including encouraging drug development beyond the field’s recent major focus on treatments that target and reduce amyloid.

Dr. Samuel Gandy, an Alzheimer’s researcher at Mount Sinai in New York, who was not involved in the study, said that patients with two copies of APOE4 faced much higher safety risks from anti-amyloid drugs.

When the Food and Drug Administration approved the anti-amyloid drug Leqembi last year, it required a black-box warning on the label saying that the medication can cause “serious and life-threatening events” such as swelling and bleeding in the brain, especially for people with two copies of APOE4. Some treatment centers decided not to offer Leqembi, an intravenous infusion, to such patients.

Dr. Gandy and other experts said that classifying these patients as having a distinct genetic form of Alzheimer’s would galvanize interest in developing drugs that are safe and effective for them and add urgency to current efforts to prevent cognitive decline in people who do not yet have symptoms.

“Rather than say we have nothing for you, let’s look for a trial,” Dr. Gandy said, adding that such patients should be included in trials at younger ages, given how early their pathology starts.

Besides trying to develop drugs, some researchers are exploring gene editing to transform APOE4 into a variant called APOE2, which appears to protect against Alzheimer’s. Another gene-therapy approach being studied involves injecting APOE2 into patients’ brains.

The new study had some limitations, including a lack of diversity that might make the findings less generalizable. Most patients in the study had European ancestry. While two copies of APOE4 also greatly increase Alzheimer’s risk in other ethnicities, the risk levels differ, said Dr. Michael Greicius, a neurologist at Stanford University School of Medicine who was not involved in the research.

“One important argument against their interpretation is that the risk of Alzheimer’s disease in APOE4 homozygotes varies substantially across different genetic ancestries,” said Dr. Greicius, who cowrote a study that found that white people with two copies of APOE4 had 13 times the risk of white people with two copies of APOE3, while Black people with two copies of APOE4 had 6.5 times the risk of Black people with two copies of APOE3.

“This has critical implications when counseling patients about their ancestry-informed genetic risk for Alzheimer’s disease,” he said, “and it also speaks to some yet-to-be-discovered genetics and biology that presumably drive this massive difference in risk.”

Under the current genetic understanding of Alzheimer’s, less than 2 percent of cases are considered genetically caused. Some of those patients inherited a mutation in one of three genes and can develop symptoms as early as their 30s or 40s. Others are people with Down syndrome, who have three copies of a chromosome containing a protein that often leads to what is called Down syndrome-associated Alzheimer’s disease .

Dr. Sperling said the genetic alterations in those cases are believed to fuel buildup of amyloid, while APOE4 is believed to interfere with clearing amyloid buildup.

Under the researchers’ proposal, having one copy of APOE4 would continue to be considered a risk factor, not enough to cause Alzheimer’s, Dr. Fortea said. It is unusual for diseases to follow that genetic pattern, called “semidominance,” with two copies of a variant causing the disease, but one copy only increasing risk, experts said.

The new recommendation will prompt questions about whether people should get tested to determine if they have the APOE4 variant.

Dr. Greicius said that until there were treatments for people with two copies of APOE4 or trials of therapies to prevent them from developing dementia, “My recommendation is if you don’t have symptoms, you should definitely not figure out your APOE status.”

He added, “It will only cause grief at this point.”

Finding ways to help these patients cannot come soon enough, Dr. Sperling said, adding, “These individuals are desperate, they’ve seen it in both of their parents often and really need therapies.”

Pam Belluck is a health and science reporter, covering a range of subjects, including reproductive health, long Covid, brain science, neurological disorders, mental health and genetics. More about Pam Belluck

The Fight Against Alzheimer’s Disease

Alzheimer’s is the most common form of dementia, but much remains unknown about this daunting disease..

How is Alzheimer’s diagnosed? What causes Alzheimer’s? We answered some common questions .

A study suggests that genetics can be a cause of Alzheimer’s , not just a risk, raising the prospect of diagnosis years before symptoms appear.

Determining whether someone has Alzheimer’s usually requires an extended diagnostic process . But new criteria could lead to a diagnosis on the basis of a simple blood test .

The F.D.A. has given full approval to the Alzheimer’s drug Leqembi. Here is what to know about i t.

Alzheimer’s can make communicating difficult. We asked experts for tips on how to talk to someone with the disease .

Suggestions or feedback?

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Using ideas from game theory to improve the reliability of language models

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Imagine you and a friend are playing a game where your goal is to communicate secret messages to each other using only cryptic sentences. Your friend's job is to guess the secret message behind your sentences. Sometimes, you give clues directly, and other times, your friend has to guess the message by asking yes-or-no questions about the clues you've given. The challenge is that both of you want to make sure you're understanding each other correctly and agreeing on the secret message.

MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) researchers have created a similar "game" to help improve how AI understands and generates text. It is known as a “consensus game” and it involves two parts of an AI system — one part tries to generate sentences (like giving clues), and the other part tries to understand and evaluate those sentences (like guessing the secret message).

The researchers discovered that by treating this interaction as a game, where both parts of the AI work together under specific rules to agree on the right message, they could significantly improve the AI's ability to give correct and coherent answers to questions. They tested this new game-like approach on a variety of tasks, such as reading comprehension, solving math problems, and carrying on conversations, and found that it helped the AI perform better across the board.

Traditionally, large language models answer one of two ways: generating answers directly from the model (generative querying) or using the model to score a set of predefined answers (discriminative querying), which can lead to differing and sometimes incompatible results. With the generative approach, "Who is the president of the United States?" might yield a straightforward answer like "Joe Biden." However, a discriminative query could incorrectly dispute this fact when evaluating the same answer, such as "Barack Obama."

So, how do we reconcile mutually incompatible scoring procedures to achieve coherent, efficient predictions? 

"Imagine a new way to help language models understand and generate text, like a game. We've developed a training-free, game-theoretic method that treats the whole process as a complex game of clues and signals, where a generator tries to send the right message to a discriminator using natural language. Instead of chess pieces, they're using words and sentences," says Athul Jacob, an MIT PhD student in electrical engineering and computer science and CSAIL affiliate. "Our way to navigate this game is finding the 'approximate equilibria,' leading to a new decoding algorithm called 'equilibrium ranking.' It's a pretty exciting demonstration of how bringing game-theoretic strategies into the mix can tackle some big challenges in making language models more reliable and consistent."

When tested across many tasks, like reading comprehension, commonsense reasoning, math problem-solving, and dialogue, the team's algorithm consistently improved how well these models performed. Using the ER algorithm with the LLaMA-7B model even outshone the results from much larger models. "Given that they are already competitive, that people have been working on it for a while, but the level of improvements we saw being able to outperform a model that's 10 times the size was a pleasant surprise," says Jacob. 

"Diplomacy," a strategic board game set in pre-World War I Europe, where players negotiate alliances, betray friends, and conquer territories without the use of dice — relying purely on skill, strategy, and interpersonal manipulation — recently had a second coming. In November 2022, computer scientists, including Jacob, developed “Cicero,” an AI agent that achieves human-level capabilities in the mixed-motive seven-player game, which requires the same aforementioned skills, but with natural language. The math behind this partially inspired the Consensus Game. 

While the history of AI agents long predates when OpenAI's software entered the chat in November 2022, it's well documented that they can still cosplay as your well-meaning, yet pathological friend. 

The consensus game system reaches equilibrium as an agreement, ensuring accuracy and fidelity to the model's original insights. To achieve this, the method iteratively adjusts the interactions between the generative and discriminative components until they reach a consensus on an answer that accurately reflects reality and aligns with their initial beliefs. This approach effectively bridges the gap between the two querying methods. 

In practice, implementing the consensus game approach to language model querying, especially for question-answering tasks, does involve significant computational challenges. For example, when using datasets like MMLU, which have thousands of questions and multiple-choice answers, the model must apply the mechanism to each query. Then, it must reach a consensus between the generative and discriminative components for every question and its possible answers. 

The system did struggle with a grade school right of passage: math word problems. It couldn't generate wrong answers, which is a critical component of understanding the process of coming up with the right one. 

“The last few years have seen really impressive progress in both strategic decision-making and language generation from AI systems, but we’re just starting to figure out how to put the two together. Equilibrium ranking is a first step in this direction, but I think there’s a lot we’ll be able to do to scale this up to more complex problems,” says Jacob.   

An avenue of future work involves enhancing the base model by integrating the outputs of the current method. This is particularly promising since it can yield more factual and consistent answers across various tasks, including factuality and open-ended generation. The potential for such a method to significantly improve the base model's performance is high, which could result in more reliable and factual outputs from ChatGPT and similar language models that people use daily. 

"Even though modern language models, such as ChatGPT and Gemini, have led to solving various tasks through chat interfaces, the statistical decoding process that generates a response from such models has remained unchanged for decades," says Google Research Scientist Ahmad Beirami, who was not involved in the work. "The proposal by the MIT researchers is an innovative game-theoretic framework for decoding from language models through solving the equilibrium of a consensus game. The significant performance gains reported in the research paper are promising, opening the door to a potential paradigm shift in language model decoding that may fuel a flurry of new applications."

Jacob wrote the paper with MIT-IBM Watson Lab researcher Yikang Shen and MIT Department of Electrical Engineering and Computer Science assistant professors Gabriele Farina and Jacob Andreas, who is also a CSAIL member. They presented their work at the International Conference on Learning Representations (ICLR) earlier this month, where it was highlighted as a "spotlight paper." The research also received a “best paper award” at the NeurIPS R0-FoMo Workshop in December 2023.

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Press mentions, quanta magazine.

MIT researchers have developed a new procedure that uses game theory to improve the accuracy and consistency of large language models (LLMs), reports Steve Nadis for Quanta Magazine . “The new work, which uses games to improve AI, stands in contrast to past approaches, which measured an AI program’s success via its mastery of games,” explains Nadis. 

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